[Hub]/) : Traits : Impedance of arm (right) : ← →

chr7:71,652,312-75,842,792

Best TWAS P=8.75e-21 · Best GWAS P=5.15e-21 conditioned to 3.93e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
58	GTEx	Thyroid	MLXIPL	0.23	0.14	lasso	7	0.15	2.1e-11	-8.2	-9.4	8.8e-21	0.95	0.02	0.98	TRUE
2	CommonMind	Brain Pre-frontal Cortex	STAG3L1	0.23	0.14	enet	13	0.17	1.0e-19	5.8	6.2	7.6e-10	-0.05	0.00	1.00	TRUE
61	GTEx	Thyroid	POM121	0.06	0.01	enet	13	0.03	2.5e-03	-5.1	-6.1	8.1e-10	0.23	0.09	0.04	TRUE
9	GTEx	Artery Aorta	STAG3L2	0.18	0.18	lasso	6	0.16	3.0e-09	-5.3	5.3	1.2e-07	0.01	0.00	1.00	TRUE
48	GTEx	Skin Sun Exposed Lower leg	MLXIPL	0.12	0.09	lasso	4	0.06	6.1e-06	-9.4	-9.3	9.9e-21	0.98	0.00	1.00	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	MLXIPL	0.11	0.11	lasso	3	0.06	2.7e-04	-9.3	-9.3	2.1e-20	0.97	0.01	0.98	FALSE
20	GTEx	Cells Transformed fibroblasts	MLXIPL	0.13	0.06	enet	6	0.09	2.2e-07	-9.3	-9.2	3.8e-20	0.93	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	MLXIPL	0.11	0.07	enet	16	0.07	1.6e-06	-8.2	-9.1	6.0e-20	0.94	0.01	0.99	FALSE
6	GTEx	Adipose Visceral Omentum	MLXIPL	0.16	0.02	lasso	3	0.03	7.8e-03	-9.0	-9.1	7.2e-20	0.95	0.08	0.92	FALSE
65	METSIM	Adipose	MLXIPL	0.12	0.14	lasso	4	0.13	1.8e-19	-7.9	-8.8	1.5e-18	0.86	0.31	0.69	FALSE
7	GTEx	Adipose Visceral Omentum	NSUN5	0.07	0.03	enet	11	0.04	4.0e-03	-8.2	-8.6	9.1e-18	0.71	0.04	0.49	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	MLXIPL	0.04	0.03	lasso	1	0.02	2.3e-03	-8.1	-8.1	4.2e-16	0.78	0.00	0.98	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	MLXIPL	0.06	0.05	lasso	2	0.05	5.1e-10	-8.1	-7.8	4.4e-15	0.77	0.00	1.00	FALSE
64	METSIM	Adipose	BCL7B	0.10	0.02	enet	20	0.05	1.2e-07	-9.0	-7.5	6.3e-14	0.72	0.01	0.99	FALSE
51	GTEx	Spleen	NCF1B	0.22	0.10	enet	9	0.08	5.1e-03	-7.3	7.5	7.9e-14	-0.71	0.04	0.29	FALSE
31	GTEx	Esophagus Muscularis	MLXIPL	0.06	0.03	enet	10	0.03	1.1e-02	-4.0	-7.2	4.2e-13	0.57	0.10	0.70	FALSE
55	GTEx	Testis	MLXIPL	0.10	0.00	lasso	3	0.00	3.3e-01	-5.2	-7.1	1.0e-12	0.66	0.04	0.31	FALSE
37	GTEx	Lung	MLXIPL	0.10	0.07	enet	14	0.07	6.3e-06	-8.2	-6.8	1.1e-11	0.69	0.08	0.80	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	MLXIPL	0.08	0.05	enet	4	0.05	5.3e-06	-8.1	-6.7	2.5e-11	0.71	0.00	1.00	FALSE
34	GTEx	Heart Left Ventricle	MLXIPL	0.14	0.00	enet	24	0.01	1.3e-01	-4.0	-6.5	8.3e-11	0.60	0.10	0.50	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	BCL7B	0.05	0.01	blup	5	0.03	1.3e-03	-8.1	6.2	7.1e-10	-0.46	0.00	0.63	FALSE
66	METSIM	Adipose	POM121	0.05	0.03	blup	130	0.03	5.4e-06	-4.2	-6.1	1.0e-09	0.38	0.80	0.07	FALSE
57	GTEx	Testis	STAG3L1	0.24	0.24	enet	14	0.27	1.4e-12	5.8	6.1	1.2e-09	-0.04	0.00	1.00	FALSE
71	ROSMAP	Brain Pre-frontal Cortex	PMS2P2	0.17	0.08	enet	8	0.08	6.0e-10	5.8	6.0	2.0e-09	-0.03	0.00	1.00	FALSE
40	GTEx	Muscle Skeletal	TRIM73	0.08	0.05	enet	11	0.06	3.4e-06	5.8	6.0	2.6e-09	0.00	0.00	1.00	FALSE
27	GTEx	Esophagus Mucosa	PMS2P3	0.14	0.15	lasso	2	0.14	9.7e-10	5.8	5.9	3.4e-09	-0.01	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	POM121C	0.08	0.05	lasso	2	0.04	1.1e-05	5.8	5.9	3.6e-09	-0.02	0.00	1.00	FALSE
49	GTEx	Skin Sun Exposed Lower leg	PMS2P3	0.38	0.30	lasso	3	0.29	1.9e-24	5.8	5.9	4.4e-09	-0.01	0.00	1.00	FALSE
12	GTEx	Artery Tibial	POM121C	0.12	0.10	lasso	1	0.10	6.8e-08	5.8	5.8	5.5e-09	-0.02	0.00	1.00	FALSE
18	GTEx	Breast Mammary Tissue (Female)	STAG3L1	0.04	0.12	lasso	1	0.04	2.9e-02	5.8	5.8	5.5e-09	-0.02	0.00	0.95	FALSE
25	GTEx	Colon Transverse	STAG3L1	0.22	0.18	lasso	1	0.16	4.0e-08	5.8	5.8	5.5e-09	-0.02	0.00	1.00	FALSE
28	GTEx	Esophagus Mucosa	POM121C	0.13	0.10	lasso	1	0.07	1.0e-05	5.8	5.8	5.5e-09	-0.02	0.00	1.00	FALSE
30	GTEx	Esophagus Mucosa	STAG3L1	0.19	0.19	lasso	1	0.18	2.4e-12	5.8	5.8	5.5e-09	-0.02	0.00	1.00	FALSE
35	GTEx	Heart Left Ventricle	POM121C	0.13	0.12	lasso	1	0.09	2.2e-05	5.8	5.8	5.5e-09	-0.02	0.00	1.00	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	STAG3L1	0.13	0.19	lasso	1	0.18	2.6e-10	5.8	5.8	5.5e-09	-0.02	0.00	1.00	FALSE
67	METSIM	Adipose	POM121C	0.11	0.08	lasso	1	0.08	1.6e-11	5.8	5.8	5.5e-09	-0.02	0.00	1.00	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	PMS2P3	0.05	0.04	lasso	1	0.03	4.6e-05	5.8	5.8	5.5e-09	-0.02	0.00	1.00	FALSE
13	GTEx	Artery Tibial	STAG3L1	0.25	0.19	lasso	4	0.19	8.3e-15	5.8	5.8	5.7e-09	-0.01	0.00	1.00	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	GTF2IP1	0.09	0.06	lasso	3	0.05	1.7e-07	5.8	5.8	6.1e-09	-0.02	0.30	0.68	FALSE
39	GTEx	Muscle Skeletal	PMS2P3	0.07	0.07	lasso	2	0.06	3.8e-06	5.8	5.8	6.3e-09	-0.01	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	PMS2P3	0.15	0.12	lasso	3	0.10	9.8e-09	5.7	5.8	6.9e-09	-0.01	0.00	1.00	FALSE
63	GTEx	Whole Blood	STAG3L1	0.08	0.06	lasso	3	0.07	2.8e-07	5.8	5.8	6.9e-09	-0.01	0.00	1.00	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	STAG3L1	0.46	0.32	lasso	4	0.32	2.2e-42	5.8	5.8	6.9e-09	-0.01	0.00	1.00	FALSE
8	GTEx	Adipose Visceral Omentum	STAG3L1	0.20	0.19	lasso	3	0.17	2.3e-09	5.8	5.8	7.8e-09	-0.02	0.00	1.00	FALSE
5	GTEx	Adipose Subcutaneous	STAG3L1	0.30	0.24	enet	24	0.27	2.4e-22	5.8	5.8	8.0e-09	0.00	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	POM121C	0.04	0.04	lasso	2	0.03	1.2e-07	5.8	5.8	8.4e-09	-0.01	0.00	1.00	FALSE
33	GTEx	Esophagus Muscularis	STAG3L1	0.30	0.15	lasso	4	0.16	4.3e-10	5.8	5.7	9.7e-09	-0.03	0.00	1.00	FALSE
56	GTEx	Testis	TRIM73	0.20	0.21	lasso	2	0.19	6.2e-09	5.8	5.7	9.7e-09	-0.01	0.00	1.00	FALSE
38	GTEx	Lung	POM121C	0.13	0.10	lasso	3	0.10	7.8e-08	5.8	5.7	9.9e-09	-0.02	0.00	1.00	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	STAG3L1	0.43	0.21	enet	21	0.23	3.8e-08	5.8	5.7	1.0e-08	0.02	0.00	1.00	FALSE
41	GTEx	Muscle Skeletal	STAG3L1	0.16	0.10	enet	24	0.10	3.7e-10	5.8	5.7	1.0e-08	-0.03	0.00	1.00	FALSE
50	GTEx	Skin Sun Exposed Lower leg	STAG3L1	0.27	0.15	lasso	5	0.15	1.3e-12	5.8	5.7	1.0e-08	-0.01	0.00	1.00	FALSE
10	GTEx	Artery Aorta	STAG3L1	0.18	0.03	lasso	4	0.08	3.9e-05	5.8	5.7	1.1e-08	-0.02	0.00	1.00	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	STAG3L1	0.36	0.16	lasso	5	0.16	1.7e-06	5.8	5.7	1.1e-08	-0.04	0.00	1.00	FALSE
14	GTEx	Brain Cerebellar Hemisphere	POM121C	0.33	0.32	lasso	3	0.30	1.4e-08	5.8	5.7	1.2e-08	-0.02	0.00	1.00	FALSE
16	GTEx	Breast Mammary Tissue	STAG3L1	0.16	0.15	lasso	2	0.14	8.7e-08	5.8	5.7	1.2e-08	-0.02	0.00	1.00	FALSE
22	GTEx	Cells Transformed fibroblasts	POM121C	0.15	0.06	lasso	5	0.07	1.2e-05	5.8	5.7	1.2e-08	-0.01	0.00	1.00	FALSE
32	GTEx	Esophagus Muscularis	TRIM73	0.12	0.07	lasso	2	0.05	3.5e-04	5.7	5.7	1.2e-08	-0.02	0.00	0.99	FALSE
23	GTEx	Cells Transformed fibroblasts	STAG3L1	0.22	0.17	lasso	4	0.18	2.6e-13	5.8	5.7	1.3e-08	-0.01	0.00	1.00	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	PMS2P3	0.26	0.19	lasso	3	0.17	1.3e-09	5.8	5.7	1.3e-08	-0.02	0.00	1.00	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	POM121C	0.08	0.07	lasso	3	0.07	3.6e-07	5.8	5.7	1.4e-08	-0.01	0.00	1.00	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	FZD9	0.06	0.04	enet	3	0.04	7.1e-06	-4.2	-5.7	1.5e-08	0.39	0.70	0.03	FALSE
17	GTEx	Breast Mammary Tissue (Female)	POM121C	0.17	-0.01	lasso	3	0.02	6.3e-02	5.8	5.7	1.6e-08	-0.05	0.01	0.54	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	POM121C	0.36	0.26	lasso	7	0.27	2.8e-34	5.8	5.6	1.7e-08	-0.01	0.00	1.00	FALSE
24	GTEx	Colon Sigmoid	STAG3L1	0.30	0.18	lasso	4	0.18	8.5e-07	5.8	5.6	2.5e-08	-0.02	0.00	1.00	FALSE
52	GTEx	Stomach	PMS2P3	0.16	0.07	lasso	5	0.09	3.7e-05	5.2	5.6	2.6e-08	0.01	0.00	1.00	FALSE
21	GTEx	Cells Transformed fibroblasts	PMS2P3	0.23	0.15	lasso	6	0.15	1.4e-11	5.7	5.5	3.1e-08	0.00	0.00	1.00	FALSE
15	GTEx	Breast Mammary Tissue	PMS2P3	0.19	0.14	lasso	4	0.19	3.5e-10	5.7	5.5	3.5e-08	-0.01	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PMS2L3	0.23	0.14	lasso	2	0.14	1.3e-04	5.8	5.5	4.0e-08	-0.01	0.00	0.91	FALSE
43	GTEx	Nerve Tibial	POM121C	0.22	0.14	lasso	5	0.14	6.9e-10	5.8	5.5	4.3e-08	-0.01	0.00	1.00	FALSE
59	GTEx	Thyroid	POM121C	0.14	0.08	lasso	3	0.07	3.4e-06	5.8	5.4	7.2e-08	-0.01	0.00	1.00	FALSE
42	GTEx	Nerve Tibial	PMS2P3	0.29	0.13	enet	4	0.18	1.1e-12	5.2	5.3	1.1e-07	-0.03	0.00	1.00	FALSE
11	GTEx	Artery Coronary	STAG3L1	0.28	0.13	lasso	4	0.17	1.8e-06	5.2	5.3	1.2e-07	0.02	0.01	0.99	FALSE
60	GTEx	Thyroid	GTF2IRD2	0.08	0.07	lasso	1	0.04	2.4e-04	-5.3	-5.3	1.4e-07	-0.01	0.00	0.98	FALSE
44	GTEx	Nerve Tibial	GTF2IRD2	0.08	0.09	lasso	2	0.08	5.4e-06	-5.3	-5.2	2.0e-07	0.00	0.00	1.00	FALSE
54	GTEx	Stomach	STAG3L1	0.35	0.20	lasso	5	0.18	4.2e-09	5.2	5.2	2.2e-07	0.02	0.01	0.99	FALSE
68	METSIM	Adipose	TRIM73	0.11	0.11	lasso	5	0.12	8.6e-18	5.7	5.2	2.2e-07	-0.01	0.00	1.00	FALSE
29	GTEx	Esophagus Mucosa	STAG3L2	0.23	0.16	lasso	3	0.16	1.0e-10	-5.3	5.2	2.4e-07	0.00	0.00	1.00	FALSE
53	GTEx	Stomach	TRIM73	0.23	0.09	lasso	5	0.09	3.2e-05	5.8	5.2	2.5e-07	0.00	0.00	0.99	FALSE
62	GTEx	Thyroid	STAG3L1	0.36	0.24	enet	17	0.27	8.0e-21	5.8	5.1	2.8e-07	-0.02	0.00	1.00	FALSE
36	GTEx	Heart Left Ventricle	STAG3L2	0.20	0.12	lasso	3	0.09	1.9e-05	-5.3	5.1	3.0e-07	0.00	0.00	0.99	FALSE