Hub : Genes

DTX2P1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.156	0.0550	4.7e-04	0.033	NA	0.051	NA	0.033	8.7e-04	NA	4.8e-05	NA	8.9e-04
2	GTEx	Whole Blood	0.159	0.0460	4.9e-05	0.009	NA	0.032	NA	0.016	4.8e-02	NA	5.6e-04	NA	1.1e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.121	0.0366	1.5e-05	0.048	0.035	0.044	0.038	0.054	7.7e-07	2.5e-05	2.1e-06	9.3e-06	1.7e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.0	0.0	0.1	0.0	-0.3	0.0
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	0.2	0.6	0.0
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	-0.0	0.1	-0.1
Depression (Nagel 2018)	0.1	0.1	0.1	-0.4	0.3	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.7	1.3	0.2	0.0
Neuroticism (Nagel 2018)	0.2	0.5	1.3	-1.1	0.4	0.1
Schizophrenia (2018)	0.1	0.1	0.4	-0.1	0.7	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.8	1.6	4.8	-2.2	-0.2	-0.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.6	0.4	0.5
Alzheimer’s Disease (in father)	0.8	0.8	2.1	-1.5	0.1	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	1.7	-1.3	0.6	0.8
Crohns Disease (2017)	0.8	1.8	3.0	1.5	-1.7	-0.5
Irritable Bowel Disease (IBD)	1.2	2.9	5.3	2.3	-1.3	-1.3
Ulcerative Colitis (UC)	2.0	3.7	7.0	2.6	-0.1	-2.0
Major Depression (MDD)	0.7	0.9	1.3	-0.3	1.1	1.1
Reaction Time	0.1	0.3	0.7	-0.9	-0.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.5	1.2	-0.1	0.1
Breast Cancer	0.5	1.2	1.9	-0.7	-1.4	-1.1
Ovarian Cancer	1.6	2.2	3.3	-1.6	-0.7	1.8
Prostate Cancer	0.3	0.4	0.9	1.0	-0.2	-0.5
Age at First Birth	0.1	0.2	0.2	0.4	0.4	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.3	0.0
Body Mass Index (BMI) (2010)	2.3	3.1	9.4	3.1	-0.1	-0.1
Coronary Artery Disease (CAD)	0.1	0.2	0.3	0.4	0.2	0.5
Crohns Disease (2012)	0.5	0.7	2.2	0.0	-1.5	0.0
Mean Putamen Volume	1.0	1.2	2.1	1.5	-0.9	-0.7
Fasting Glucose	0.8	1.0	1.3	-1.1	1.1	0.6
HbA1C	0.1	0.1	0.2	0.2	-0.5	-0.1
HDL Cholesterol	0.7	1.2	2.3	-0.6	-1.5	-0.9
LDL Cholesterol	0.1	0.2	0.4	0.6	0.2	-0.3
Lupus	1.3	1.9	4.7	2.2	-0.2	-1.0
Neuroticism (2016)	0.9	1.3	2.6	-0.9	1.6	-0.7
Primary Biliary Cirrhosis	0.2	0.2	0.7	0.0	-0.8	0.0
Rheumatoid Arthritis	0.1	0.2	0.5	0.0	0.0	0.7
Schizophrenia (2014)	0.0	0.1	0.1	-0.3	-0.3	0.0
Triglycerides	0.3	0.5	1.0	1.0	0.8	-0.1
Type 2 Diabetes (T2D) (2012)	5.4	6.2	6.4	2.5	2.5	-2.4
Ulcerative Colitis	0.1	0.1	0.3	0.0	0.5	0.0
Blood Eosinophil Count	1.1	8.7	12.2	3.2	3.5	-1.8
Blood Platelet Count	0.2	2.1	3.8	-1.9	-1.4	0.8
Blood Red Count	0.3	3.2	7.1	-0.4	-2.7	-1.5
Blood White Count	0.3	1.9	4.0	1.2	2.0	0.6
Heel T-Score	0.1	1.2	1.7	0.7	-1.2	-1.3
BMI	3.1	18.0	42.1	6.5	-0.8	-3.3
Height	0.0	0.4	0.8	-0.6	-0.0	0.9
Waist Hip Ratio (WHR)	0.5	2.2	5.1	0.2	1.2	2.2
Systolic Blood Pressure	0.1	0.3	0.7	-0.8	0.5	0.1
Smoking Status	0.1	0.1	0.4	0.6	-0.0	0.2
Allergy or Eczema	0.4	1.1	2.8	-1.7	0.3	-0.7
Cardiovascular Disease	0.3	1.1	2.2	0.9	-0.7	-1.5
Hypothyroidism (self reported)	0.7	1.6	2.7	-0.2	-1.6	-1.4
Respiratory disease	1.0	2.1	3.6	-1.6	-1.9	-0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.2	1.8	-0.2	-0.3
Lung FEV1/FVC ratio	0.7	3.7	8.3	0.1	2.9	1.6
Lung FVC	0.5	2.4	5.0	-2.2	-1.4	0.1
Neuroticism	0.2	0.6	1.5	-1.2	0.5	0.2
Chronotype (morning person)	0.6	1.3	3.4	1.8	-0.1	-0.8
Hair Pigment	0.0	0.9	2.0	-0.5	0.6	1.4
Tanning	0.0	0.0	0.1	0.3	0.1	-0.1
Hand grip strength (left)	0.8	2.1	4.2	-1.4	-0.5	2.0
Number of treatments/medications taken	0.5	0.9	2.4	0.6	-0.3	-1.5
Average weekly spirits intake	0.3	0.4	0.9	-0.9	-0.4	-0.2
Sensitivity / hurt feelings	0.0	0.1	0.2	-0.2	0.0	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	0.8	-0.8	-0.7	0.9
Hearing difficulty/problems: Yes	0.6	0.9	1.4	-1.0	1.2	-0.6
Relative age of first facial hair	0.8	1.6	2.4	1.6	1.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.4	0.5	-0.7	0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.3	0.1	-0.6
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	-0.5	0.3	-0.7
Systolic blood pressure, automated reading	0.2	0.7	1.3	0.7	-1.2	-0.5
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.6	-1.4	-0.8	1.6
Angina	0.8	1.1	2.5	-0.6	-1.6	-0.5
Medication for hormone replacement therapy	0.5	0.6	1.3	-0.6	0.1	-1.1
Vitamin and mineral supplements	0.2	0.3	0.5	-0.6	-0.7	-0.1
Supplements: Zinc	0.9	1.0	2.4	1.5	0.4	-0.7
Medication: Co-codamol	0.7	0.8	1.7	-1.3	0.8	-0.0
Medication: Metformin	0.5	0.6	1.6	0.4	-1.3	0.3
Diabetes (father)	0.7	0.8	2.0	0.0	-1.4	-0.7
Diabetes (mother)	0.4	0.5	1.6	0.1	-1.3	-0.1
Severe depression (siblings)	0.6	0.6	1.2	-1.1	-0.8	-0.4
Pack years adult smoking proportion	0.7	1.1	2.2	-1.0	0.0	1.5
Impedance of leg (right)	3.2	15.4	39.1	-6.3	-0.7	2.5
Leg fat-free mass (left)	2.4	12.6	33.2	5.8	0.4	-2.1
Trunk fat percentage	0.4	1.5	2.2	1.5	-1.3	-0.7
Hand grip strength (right)	0.5	1.3	2.4	-1.5	-0.4	1.2
Townsend deprivation index at recruitment	0.1	0.2	0.5	0.2	0.2	0.7
Current tobacco smoking	0.2	0.3	0.6	0.3	-0.1	0.8
Average weekly fortified wine intake	0.9	1.1	1.5	-0.7	-1.2	-1.1
Maternal smoking around birth	0.4	0.5	0.7	-0.9	-0.7	0.6
Fed-up feelings	0.0	0.1	0.2	-0.2	-0.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.4	-0.2	1.0
Relative age voice broke	1.9	2.9	5.3	2.3	1.5	1.1
Taking other prescription medications	0.6	0.9	1.7	-0.2	-1.3	-0.9
Age when periods started (menarche)	0.2	0.4	0.8	-0.9	-0.4	0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	-1.2	0.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	3.0	1.7	0.7	-1.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.0	1.0	0.0	-0.3
Qualifications: CSEs or equivalent	1.4	1.8	4.8	-0.5	-2.2	-0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.6	-0.8	0.4	0.3
High blood pressure	1.2	3.5	4.2	1.7	-1.8	-2.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	-0.6	1.0	-0.2
Multivitamins +/- minerals	0.4	0.5	1.3	1.1	0.3	0.2
Stomach or abdominal pain in last month	1.5	1.8	3.9	0.2	-1.2	-2.0
Supplements: Glucosamine	0.8	1.1	2.1	0.9	-1.5	-0.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.4	2.3	1.0	1.5	-0.9
Medication: Atenolol	0.9	1.1	1.6	-0.2	-1.3	-1.3
Medication: Levothyroxine sodium	0.7	1.2	2.4	0.1	-1.6	-1.1
Sitting height	0.1	0.8	2.5	-1.6	-0.2	0.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.0	-1.0	-0.5	0.9
High blood pressure (mother)	0.5	0.7	1.0	0.3	-1.0	-0.9
Body mass index (BMI)	2.7	11.5	25.9	5.1	-1.0	-2.8
Impedance of leg (left)	4.0	19.3	46.9	-6.8	-0.7	3.2
Leg predicted mass (left)	2.5	13.0	34.0	5.8	0.4	-2.2
Trunk fat mass	0.9	3.8	8.8	3.0	-1.0	-1.2
Waist circumference	1.8	6.5	18.1	4.2	-0.8	-1.0
Number of incorrect matches in round	0.8	1.3	2.8	-1.7	-0.9	0.5
Past tobacco smoking	0.0	0.0	0.1	0.1	0.3	0.0
Alcohol usually taken with meals	0.1	0.1	0.3	0.5	0.2	0.2
Nervous feelings	0.8	1.5	4.1	-2.0	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.4	0.6	-0.3
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.1	0.3	-0.4
Hair/balding pattern: Pattern 2	0.9	1.1	2.8	-1.7	-0.4	0.6
Had menopause	0.3	0.4	0.9	0.6	-0.0	-0.9
Had other major operations	0.4	0.5	1.0	1.0	0.1	-0.8
Forced vital capacity (FVC)	0.8	3.2	4.8	-2.2	0.4	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.7	1.3	-0.6	-0.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.4	-0.5	-1.6	-0.6
Qualifications: None of the above	0.7	1.4	3.0	-1.7	-0.4	1.0
Financial difficulties in last 2 years	1.4	1.9	4.0	1.0	-0.8	-2.0
Mouth/teeth dental problems	0.2	0.4	0.9	1.0	-0.4	-0.1
Heart attack	0.4	0.5	1.0	-1.0	0.7	0.4
Allergy	0.4	0.9	2.3	1.5	-0.1	-0.6
Pain all over the body in last month	2.3	2.5	3.1	1.7	1.8	-1.2
Diabetes (self-reported)	0.4	0.6	0.7	0.8	-0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	-0.2	0.6	-0.6
Medication: Ramipril	0.0	0.1	0.1	0.3	0.1	-0.2
Medication: Simvastatin	1.4	2.0	4.7	-1.2	-2.2	-0.2
Fluid intelligence score	0.1	0.2	0.5	0.7	-0.2	0.2
Illnesses of siblings	0.8	1.1	1.6	-1.2	0.6	1.3
Neuroticism score	0.6	1.3	2.4	-1.6	0.1	1.2
Weight	1.8	8.6	21.6	4.7	-0.3	-2.0
Impedance of arm (right)	3.5	16.3	39.0	-6.2	-1.5	2.8
Arm fat percentage (right)	1.0	4.1	7.2	2.7	-1.6	-1.6
Trunk fat-free mass	2.1	11.8	29.5	5.4	1.1	-2.1
Hip circumference	1.4	5.9	11.7	3.4	-0.8	-2.3
Time employed in main current job	0.3	0.3	0.6	-0.0	-0.5	-0.8
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.2	-0.3	-0.6
Father’s age at death	0.7	1.0	2.6	-1.6	-0.3	0.4
Worrier / anxious feelings	0.4	0.8	2.1	-0.5	-0.2	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.1	-1.0	-1.0	0.1
Falls in the last year	0.2	0.3	0.6	0.5	-0.2	0.7
Hair/balding pattern: Pattern 3	2.8	4.2	7.1	-2.0	-2.7	1.3
Number of live births	0.2	0.3	0.5	-0.7	0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	4.6	-1.9	1.1	2.1
Pulse rate	0.2	0.4	0.7	-0.6	-0.8	0.1
Happiness	0.3	0.3	0.7	-0.5	-0.4	0.8
Noisy workplace	0.5	0.6	1.1	-1.1	-0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.9	1.9	2.8	-1.2	-1.7	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	4.6	-0.5	-2.1	0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.3	-0.1	-0.6
Asthma	0.9	1.7	4.0	-2.0	-0.9	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	-0.5	0.7	0.4
Medication: Cholesterol lowering	0.3	0.5	1.3	0.1	-1.2	-0.5
Depression (self-reported)	0.3	0.3	0.6	-0.2	-0.5	0.8
Medication: Lansoprazole	0.2	0.2	0.6	0.2	-0.2	-0.8
Prospective memory result	1.3	1.6	3.1	-0.8	1.1	1.8
Lung cancer (father)	0.7	0.9	1.5	0.9	1.2	0.5
Illnesses of mother	0.3	0.4	0.6	0.4	0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.4	-1.2	1.1	1.0
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	1.0	0.5	0.1
Impedance of arm (left)	3.6	16.5	41.0	-6.4	-1.2	2.7
Arm fat mass (right)	1.8	7.4	16.4	4.0	-1.3	-2.0
Trunk predicted mass	2.0	11.5	28.8	5.4	1.1	-2.2
Standing height	0.1	1.3	1.9	-0.4	1.3	1.4
Length of working week for main job	0.4	0.4	1.3	1.1	-0.1	0.2
Exposure to tobacco smoke at home	1.0	1.1	1.9	1.4	1.1	-0.5
Breastfed as a baby	0.2	0.3	0.4	0.5	-0.5	-0.6
Tense / ‘highly strung’	1.2	1.9	5.0	-2.2	-0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.7	-0.6	-1.3	-0.2
Hair/balding pattern: Pattern 4	0.6	1.5	2.0	0.7	1.4	1.4
Birth weight of first child	0.0	0.1	0.2	0.4	-0.0	0.2
Peak expiratory flow (PEF)	1.5	3.5	6.2	-1.0	1.8	2.5
Pulse wave reflection index	0.7	0.9	2.3	1.5	-0.2	-0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.5	0.4	-0.4	-1.6
Loud music exposure frequency	2.8	3.0	7.5	-2.7	-0.9	0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.8	0.1	-0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.4	1.1	0.1
Blood clot in the leg (DVT)	0.3	0.3	0.6	-0.5	0.4	0.8
Medication: Paracetamol	1.1	1.8	4.4	-2.1	-0.8	-0.7
Headache pain in last month	0.1	0.2	0.6	-0.4	0.7	0.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.5	-0.8	1.6	1.0
Glaucoma (self-reported)	1.7	2.0	3.8	1.9	1.4	-0.5
Gout (self-reported)	0.2	0.2	0.4	0.7	0.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.9	-0.4	-1.4	-0.8
Medication: Amlodipine	2.0	2.8	6.3	2.5	1.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.2	0.3	-0.6
Birth weight	0.1	0.3	0.7	-0.4	0.9	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-0.7	-0.5	1.0
High blood pressure (siblings)	3.2	4.7	8.6	2.9	0.4	-2.3
Forced vital capacity (FVC), Best measure	0.4	1.3	2.1	-1.4	0.7	1.1
Body fat percentage	0.6	2.2	3.8	1.9	-1.3	-1.1
Leg fat percentage (right)	1.2	4.4	7.7	2.8	-1.7	-1.6
Arm fat-free mass (right)	2.5	13.1	31.6	5.6	1.1	-2.5
Exposure to tobacco smoke outside home	1.3	1.7	2.6	1.4	0.8	1.6
Comparative body size at age 10	3.0	8.3	23.6	4.9	-0.1	-1.1
Number of full brothers	0.2	0.2	0.4	-0.6	0.0	-0.6
Worry too long after embarrassment	0.6	1.1	2.9	-0.1	0.5	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.4	0.1	-0.2
Wheeze or whistling in the chest in last year	0.6	1.1	1.8	-0.4	-1.2	-1.3
Number of children fathered	0.8	0.9	1.4	-0.2	1.2	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.4	0.2	0.6	0.1
Age at first live birth	1.5	2.6	5.1	2.3	1.4	-0.8
Pulse wave peak to peak time	0.5	0.6	1.3	-1.1	-0.7	0.2
Health satisfaction	0.5	0.6	1.8	0.1	-0.2	-1.3
Shortness of breath walking on level ground	0.8	1.0	2.0	-1.4	-0.1	0.9
Qualifications: College or University degree	0.4	1.3	3.6	0.4	1.9	0.1
Eye problems/disorders: None of the above	0.9	1.0	1.6	-1.1	-1.3	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.2	-1.5	-0.3	-0.2
Emphysema/chronic bronchitis	0.7	0.8	2.1	-0.5	-1.4	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	1.0	0.6	0.5
Neck or shoulder pain in last month	0.5	0.7	1.7	-1.3	-0.1	-0.7
Medication: Blood pressure	0.8	1.4	2.4	0.7	-1.6	-1.2
Angina (self-reported)	1.1	1.5	3.7	-0.8	-1.9	-0.3
Migraine (self-reported)	0.6	0.7	1.0	-1.0	0.4	1.0
Medication: Ibuprofen	1.0	1.2	3.0	-0.5	1.7	0.6
Medication: Allopurinol	0.9	1.2	3.4	1.8	0.3	-0.3
Medication: Omeprazole	1.1	1.3	2.1	1.1	0.9	-1.5
Medication: Seretide 50 evohaler	0.6	0.6	1.3	-0.8	0.2	1.1
Mean time to correctly identify matches	0.4	0.8	2.1	-1.5	-0.3	0.3
Heart disease (mother)	0.6	0.7	1.0	0.6	1.0	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	5.8	-1.8	-0.0	2.4
Whole body fat mass	1.3	5.6	13.0	3.6	-1.0	-1.7
Leg fat mass (right)	2.3	9.1	20.3	4.5	-1.1	-2.4
Arm predicted mass (right)	2.5	12.8	31.9	5.7	1.0	-2.3
Pulse rate, automated reading	0.0	0.1	0.3	-0.6	-0.2	-0.0
Alcohol intake frequency.	0.3	0.8	2.2	0.2	1.5	-0.0
Comparative height size at age 10	0.0	0.1	0.2	-0.4	-0.5	-0.1
Number of full sisters	0.7	0.9	2.3	0.2	-1.5	0.6
Suffer from ‘nerves’	0.9	1.4	3.4	-1.8	0.8	-0.4
Overall health rating	0.1	0.3	0.8	0.2	-0.9	-0.2
Chest pain or discomfort	0.2	0.2	0.5	-0.1	0.7	0.5
Had major operations	0.9	1.0	1.9	0.9	-1.4	0.6
Age at last live birth	2.2	3.2	5.2	2.3	2.0	-0.6
Family relationship satisfaction	2.0	2.4	3.8	0.0	-2.0	1.9
Leg pain on walking	1.4	1.8	4.2	-0.7	-2.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	0.1	-0.2	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	-0.2	0.7	1.4
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.3	1.5	1.5	-0.5
Medication: Aspirin	0.4	0.5	1.3	-0.3	-1.1	-0.2
Supplements: Vitamin C	1.4	1.7	4.1	0.7	2.0	-0.6
Knee pain experienced in last month	1.1	1.7	3.8	2.0	0.1	-1.1
Hypertension (Self-reported)	1.1	3.0	3.5	1.7	-1.6	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.1	0.1	0.1
Illnesses of father: Heart disease	0.5	0.7	1.5	1.2	-0.7	0.1
Illnesses of siblings: Diabetes	0.3	0.4	1.2	0.2	0.2	1.1
Smoking status: Previous	0.2	0.3	0.5	-0.0	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.2	-0.5	1.1	0.8
Whole body fat-free mass	2.2	12.7	32.6	5.7	0.7	-2.2
Leg fat-free mass (right)	2.0	10.6	28.5	5.3	0.6	-1.8
Arm fat percentage (left)	1.0	4.2	7.6	2.8	-1.5	-1.6
Average weekly red wine intake	0.2	0.3	0.5	0.4	0.7	0.3
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.7	-1.3	-0.4	0.9
Mood swings	0.6	1.0	2.0	-1.0	-0.2	1.4
Loneliness, isolation	0.8	1.1	2.3	1.5	0.9	-0.2
Long-standing illness, disability or infirmity	1.2	1.9	3.3	1.8	1.1	-1.1
Ever had bowel cancer screening	1.4	1.6	4.1	-2.0	-0.6	-0.5
Diabetes diagnosed by doctor	0.8	1.3	1.9	1.3	-1.4	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.1	1.5	1.3	-0.8
Friendships satisfaction	1.5	1.8	3.0	-1.7	-1.0	1.3
Qualifications: nursing, teaching	1.6	2.4	5.8	-1.1	0.5	2.4
Commuting to job workplace: Walk	0.8	0.9	1.3	-1.1	1.0	-0.5
Eye problems/disorders: Cataract	1.5	1.7	2.7	1.6	0.3	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.8	-1.3	1.0	0.8
Medication for cholesterol	0.2	0.3	0.6	0.2	0.7	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	0.4	1.1	0.8
Back pain experienced in last month	0.8	1.1	2.2	0.4	-1.0	-1.5
Mineral and other dietary supplements	0.6	0.8	1.3	-1.1	0.2	1.0
Breast cancer (self-reported)	0.2	0.2	0.5	-0.7	-0.0	-0.3
Asthma (self-reported)	1.1	2.1	4.6	-2.1	-1.2	0.6
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.5	0.1	0.2
Osteoarthritis (self-reported)	0.9	1.1	1.7	1.3	0.0	-1.3
Medication: Aspirin	0.5	0.6	1.5	-0.5	-1.2	0.3
Medication: Gliclazide	0.7	0.8	2.2	-0.0	-0.6	1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	-0.5	0.5	1.1
Smoking status: Current	0.1	0.1	0.2	0.4	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	-0.9	0.3	-0.8
Whole body water mass	2.2	12.5	32.4	5.7	0.7	-2.1
Leg predicted mass (right)	2.0	10.4	27.8	5.3	0.5	-1.8
Arm fat mass (left)	1.6	6.6	14.9	3.9	-1.2	-1.9
Number of self-reported non-cancer illnesses	0.3	0.4	0.7	0.2	-0.8	-0.8
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.4	0.7	-0.4
Miserableness	0.4	0.7	1.1	-1.0	-0.2	1.0
Guilty feelings	0.7	1.0	1.2	0.9	0.9	-1.1
Wears glasses or contact lenses	0.1	0.1	0.2	-0.2	0.2	0.4
Ever taken oral contraceptive pill	1.8	2.0	4.5	-0.6	2.1	-1.1
Hearing aid user	0.6	0.7	1.6	-1.3	-0.7	-0.2
Mother’s age at death	1.7	2.1	4.6	1.3	-0.1	-2.1
Financial situation satisfaction	0.8	1.0	2.7	-0.1	-1.6	0.6
Tinnitus: Yes, now most or all of the time	2.9	3.4	9.2	-3.0	0.0	1.0
Commuting to job workplace: Public transport	0.4	0.5	1.2	-0.1	0.4	-1.1
Eye problems/disorders: Glaucoma	1.0	1.2	2.9	0.9	1.7	-0.0
Medication: Blood pressure	0.7	1.4	1.7	1.3	-0.9	-1.3
Pain type(s) experienced in last month: Hip pain	1.3	1.6	1.9	1.2	-1.4	-1.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.3	0.1	-0.4
High cholesterol (Self-reported)	0.7	1.2	2.6	-1.1	-1.6	0.0
Medication: Bendroflumethiazide	1.6	2.5	5.3	0.7	-1.3	-2.3
Medication: Paracetamol	0.8	1.2	3.2	-1.8	-0.5	-0.3
Medication: Lisinopril	0.3	0.4	0.7	-0.8	-0.8	-0.2
Medication: Atorvastatin	0.9	1.2	2.8	-1.7	0.1	0.8
Illnesses of father: High blood pressure	0.7	0.9	2.1	0.2	-0.7	-1.4
Alcohol drinker status: Never	0.4	0.5	1.1	0.2	1.1	-0.5
Ever smoked	0.2	0.3	0.5	-0.6	-0.2	0.7
Basal metabolic rate	2.2	12.1	31.5	5.6	0.5	-2.1
Leg fat percentage (left)	0.9	3.3	6.1	2.5	-1.6	-1.1
Arm fat-free mass (left)	2.5	12.4	31.6	5.6	0.4	-2.4
Number of operations (self-reported)	0.2	0.3	0.3	0.5	-0.6	-0.5
Average weekly beer plus cider intake	0.6	0.9	1.3	-0.9	-1.2	0.7
Irritability	1.9	3.2	5.1	-2.1	0.1	2.3
Risk taking	0.3	0.4	1.0	-0.5	0.1	1.0
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.1	1.8	0.2	-1.4
Fractured/broken bones in last 5 years	0.5	0.6	0.9	0.8	1.0	0.5
Age started oral contraceptive pill	0.7	0.9	2.0	-0.6	-1.4	-0.6
Diastolic blood pressure, automated reading	0.3	1.0	1.2	0.9	-1.1	-1.0
Ever depressed for a whole week	0.5	0.7	1.4	-0.5	-1.2	-0.6
Unable to work because of sickness or disability	0.6	0.7	1.5	-0.2	0.8	1.2
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.2	-0.6	1.2
Myopia	1.0	1.4	3.8	-0.7	-0.1	1.9
Vascular/heart problems diagnosed by doctor	0.9	2.3	3.5	-0.9	1.9	1.6
Cholesterol lowering medication	2.6	3.8	6.5	-2.5	-1.6	1.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	0.3	0.5	-0.8
Pain experienced in last month	1.7	2.8	4.9	-1.8	0.4	2.2
Supplements: Calcium	1.0	1.1	2.1	0.9	1.5	-0.6
Basal cell carcinoma (self-reported)	2.9	3.4	4.8	2.2	2.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.7	1.0	2.1	-1.5	0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.7	0.2	0.8
Heart disease (siblings)	1.8	2.2	3.8	-1.6	-2.0	0.2
Alcohol drinker status: Previous	1.8	2.1	4.9	1.1	2.2	0.0
Pack years of smoking	0.3	0.4	0.8	-0.7	-0.2	0.9
Impedance of whole body	4.3	21.6	53.2	-7.3	-1.1	3.2
Leg fat mass (left)	2.0	7.8	18.3	4.3	-1.0	-2.0
Arm predicted mass (left)	2.3	11.8	30.2	5.5	0.5	-2.2