Best TWAS P=8.47e-21 · Best GWAS P=3.09e-18 conditioned to 0.508
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 7.6 | -8.0 | 1.2e-15 | 0.61 | 0.10 | 0.90 | FALSE |
2 | GTEx | Adipose Subcutaneous | RMI1 | 0.11 | 0.03 | lasso | 3 | 0.04 | 3.8e-04 | -8.6 | -8.3 | 8.7e-17 | 0.86 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Aorta | GKAP1 | 0.15 | 0.02 | enet | 24 | 0.03 | 6.0e-03 | 3.5 | -7.8 | 4.7e-15 | 0.14 | 0.20 | 0.16 | FALSE |
4 | GTEx | Testis | UBQLN1 | 0.10 | 0.02 | enet | 20 | 0.04 | 1.1e-02 | 2.7 | -6.1 | 1.2e-09 | 0.28 | 0.18 | 0.27 | FALSE |
5 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | -8.6 | -9.4 | 8.5e-21 | 0.93 | 0.01 | 0.99 | TRUE |
6 | METSIM | Adipose | RMI1 | 0.04 | 0.02 | lasso | 7 | 0.01 | 4.9e-03 | -8.3 | -7.8 | 5.0e-15 | 0.88 | 0.01 | 0.98 | FALSE |
7 | YFS | Blood | GKAP1 | 0.02 | 0.01 | blup | 614 | 0.01 | 3.2e-04 | 7.7 | -5.7 | 1.2e-08 | 0.36 | 0.16 | 0.76 | FALSE |
8 | YFS | Blood | RMI1 | 0.07 | 0.09 | bslmm | 528 | 0.09 | 1.5e-27 | 8.2 | 7.3 | 3.2e-13 | -0.48 | 0.09 | 0.91 | FALSE |
9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UBQLN1 | 0.03 | 0.02 | lasso | 2 | 0.01 | 2.3e-02 | 7.6 | -5.9 | 3.9e-09 | 0.24 | 0.03 | 0.61 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 8.3 | -9.1 | 6.0e-20 | 0.78 | 0.02 | 0.81 | FALSE |
11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMI1 | 0.05 | 0.04 | lasso | 2 | 0.00 | 1.8e-01 | -8.6 | -8.6 | 6.6e-18 | 0.97 | 0.00 | 0.79 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMI1 | 0.40 | 0.03 | lasso | 2 | 0.06 | 1.9e-04 | -8.7 | -8.3 | 7.7e-17 | 0.87 | 0.00 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 8.3 | -9.3 | 1.3e-20 | 0.81 | 0.05 | 0.83 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 8.2 | -8.7 | 5.1e-18 | 0.66 | 0.10 | 0.60 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf64 | 0.07 | 0.03 | enet | 14 | 0.03 | 3.3e-04 | -8.3 | 6.6 | 4.4e-11 | -0.73 | 0.01 | 0.85 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RMI1 | 0.08 | 0.05 | blup | 31 | 0.06 | 1.8e-06 | -5.5 | -5.8 | 5.0e-09 | 0.83 | 0.03 | 0.92 | FALSE |
17 | The Cancer Genome Atlas | Rectum Adenocarcinoma | UBQLN1 | 0.22 | 0.02 | lasso | 3 | 0.09 | 3.5e-03 | 7.7 | -9.0 | 2.4e-19 | 0.35 | 0.02 | 0.45 | TRUE |
18 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMI1 | 0.05 | 0.06 | enet | 5 | 0.06 | 2.2e-05 | -8.3 | -9.3 | 1.1e-20 | 0.82 | 0.01 | 0.95 | FALSE |
19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | UBQLN1 | 0.06 | 0.00 | blup | 62 | 0.02 | 1.3e-02 | -4.4 | -8.4 | 4.4e-17 | 0.43 | 0.04 | 0.22 | FALSE |
20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf64 | 0.17 | 0.05 | enet | 8 | 0.09 | 4.5e-04 | -8.5 | 7.4 | 1.7e-13 | -0.84 | 0.02 | 0.80 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf64 | 0.04 | 0.00 | blup | 34 | 0.02 | 6.1e-03 | -8.3 | 6.5 | 6.3e-11 | -0.75 | 0.01 | 0.58 | FALSE |