TWAS hub - UBQLN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.166	0.034	4.1e-09	0.122	0.107	0.126	0.119	0.127	1.2e-14	5.7e-13	4.5e-15	2.5e-14	3.2e-15
2	GTEx	Testis	0.104	0.045	9.4e-03	0.017	NA	0.035	NA	0.027	5.8e-02	NA	1.1e-02	NA	2.4e-02
3	TCGA	Bladder Urothelial Carcinoma	0.035	0.023	6.8e-03	0.023	0.012	0.011	NA	0.014	4.5e-03	2.9e-02	3.4e-02	NA	2.3e-02
4	TCGA	Pancreatic Adenocarcinoma	0.126	0.064	1.6e-04	0.087	0.102	0.093	NA	0.091	1.7e-04	4.9e-05	9.9e-05	NA	1.2e-04
5	TCGA	Rectum Adenocarcinoma	0.221	0.098	2.7e-03	0.025	0.086	0.043	NA	0.093	8.7e-02	4.8e-03	3.7e-02	NA	3.5e-03
6	TCGA	Stomach Adenocarcinoma	0.064	0.045	3.3e-03	-0.002	0.020	0.012	NA	0.004	4.7e-01	1.3e-02	4.1e-02	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Impedance of arm (right)	8.2	38.3	80.9	-2.2	-6.1	-5.9	-1.2	-9.0	-8.4
Alcohol usually taken with meals	7.4	11.9	22.8	-1.0	-3.0	-4.8	-1.8	-4.8	-3.6
Impedance of arm (left)	7.3	34.0	71.9	-2.2	-5.4	-6.1	-1.9	-8.5	-7.5
Relative age of first facial hair	5.3	11.0	18.0	1.7	-4.1	-2.4	-3.1	-3.5	-4.2
Frequency of unenthusiasm / disinterest in last 2 weeks	5.2	7.0	9.2	-1.9	3.0	2.9	2.7	2.4	2.7
Severe depression (siblings)	4.9	5.5	10.3	2.3	-1.7	-2.8	-3.2	-1.8	-1.9
Financial difficulties in last 2 years	4.5	6.0	13.0	-0.2	2.4	3.6	1.9	2.9	2.3
Ever depressed for a whole week	4.5	5.6	12.2	2.4	-2.7	-1.9	-3.5	-1.3	-1.8
Impedance of whole body	4.5	23.1	48.6	-1.4	-4.9	-4.4	-1.5	-7.0	-6.5
Age when periods started (menarche)	4.2	10.0	17.9	-0.8	-3.3	-3.0	-2.3	-4.2	-4.0
Heart attack	4.2	5.3	12.5	-2.4	3.5	1.8	2.4	1.1	1.9
Heart attack/myocardial infarction (self-reported)	4.0	5.2	11.6	-2.1	3.4	2.1	2.5	1.2	1.7
Chest pain or discomfort	3.6	5.2	11.0	-1.6	2.4	2.8	3.3	1.5	1.4
Supplements: Vitamin C	3.6	4.2	7.3	0.0	-2.3	-2.4	-0.9	-2.5	-2.7
Ever had prostate specific antigen (PSA) test	3.6	4.2	6.0	1.0	-2.3	-2.5	-1.9	-1.9	-2.3
Age started oral contraceptive pill	3.6	4.5	9.4	-0.6	-2.4	-2.1	-0.0	-3.1	-2.7
Townsend deprivation index at recruitment	3.4	4.8	7.1	-1.6	2.6	2.2	2.7	1.8	2.0
Relative age voice broke	3.4	5.2	8.3	1.1	-2.9	-1.2	-2.7	-2.3	-2.8
Angina (self-reported)	3.4	4.4	10.2	-1.6	3.2	1.7	2.0	1.9	1.8
Angina	3.3	4.4	9.7	-1.5	3.1	1.8	1.9	2.0	1.8
Heart disease (siblings)	3.3	4.0	10.9	-2.4	1.9	1.5	3.3	0.7	0.9
Noisy workplace	3.2	4.0	7.2	-0.5	2.4	1.9	1.2	2.4	2.7
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.4	11.7	1.3	-1.9	-3.4	-2.9	-2.7	-2.4
Standing height	2.8	27.7	47.3	0.1	-4.7	-6.1	-3.5	-6.9	-6.9
Worry (Nagel 2018)	2.7	5.8	15.5	1.4	-2.9	-0.7	-2.0	-2.1	-3.9
Height	2.7	52.7	92.4	-0.9	-6.3	-8.7	-4.5	-9.6	-9.3
Medication for hormone replacement therapy	2.7	3.0	6.3	1.6	-2.1	-1.5	-2.5	-0.7	-1.5
Maternal smoking around birth	2.7	3.8	7.4	-2.7	2.4	1.4	2.2	0.6	1.7
Worrier / anxious feelings	2.6	4.8	10.8	0.2	-1.9	-2.0	-1.3	-3.0	-3.3
Illnesses of mother	2.6	3.2	5.5	-0.9	2.2	1.5	1.2	2.0	2.3
Fed-up feelings	2.5	4.5	9.4	-0.1	1.9	3.1	1.3	2.8	2.0
Bipolar Disorder (2011)	2.4	2.3	4.2	-1.7	1.9	1.3	2.0	1.0	1.1
Hypothyroidism (self reported)	2.4	5.5	12.1	-3.1	2.6	1.7	3.5	0.5	0.9
Average weekly spirits intake	2.4	3.0	7.2	-2.7	1.8	0.9	2.6	-0.2	0.1
Current tobacco smoking	2.3	3.7	6.8	-1.3	2.3	1.2	1.8	2.0	2.6
Mean time to correctly identify matches	2.3	4.3	8.5	-1.7	-1.1	-2.9	0.0	-2.9	-2.2
Blood Eosinophil Count	2.2	17.2	38.6	2.2	-3.4	-6.2	-5.2	-3.2	-3.4
Body mass index (BMI)	2.2	9.4	16.3	-0.2	2.8	3.8	2.6	4.0	3.3
Health satisfaction	2.2	2.9	6.3	1.4	-1.7	-1.3	-2.5	-1.3	-1.7
Basal cell carcinoma (self-reported)	2.2	2.6	4.1	2.0	-2.0	-1.7	-1.4	-0.7	-1.4
Alcohol drinker status: Previous	2.2	2.5	5.8	2.4	-2.0	-0.9	-1.9	-0.3	-1.0
Blood White Count	2.1	15.6	36.4	1.9	1.9	6.0	2.5	5.2	4.0
Chronotype (morning person)	2.1	4.8	10.8	0.4	-2.3	-2.2	-1.5	-2.4	-3.3
Average weekly fortified wine intake	2.1	2.4	4.8	0.4	-1.2	-2.2	-1.2	-1.8	-1.8
Exposure to tobacco smoke at home	2.1	2.4	5.3	-0.3	2.3	1.1	0.7	1.8	2.1
Primary Biliary Cirrhosis	2.0	2.9	6.3	1.7	1.0	0.9	-0.6	2.5	2.5
Sensitivity / hurt feelings	2.0	3.5	9.3	-0.5	-1.6	-1.4	-1.0	-2.4	-3.0
Eye problems/disorders: Diabetes related eye disease	2.0	2.3	4.8	1.8	-1.0	-2.2	-2.0	-0.6	-0.4
Medication: Levothyroxine sodium	2.0	3.4	9.7	-2.7	1.3	1.2	3.1	-0.3	-0.0
Hair/balding pattern: Pattern 2	2.0	2.6	5.3	0.5	-2.3	-1.1	-1.4	-1.7	-1.9
Father’s age at death	2.0	2.7	8.4	1.4	-1.1	-2.1	-2.9	-0.5	0.4
Average weekly beer plus cider intake	2.0	2.9	5.3	0.1	1.6	1.5	1.6	2.1	2.3
Alzheimer’s Disease (in mother)	1.9	2.2	5.1	-2.3	1.6	0.5	2.2	-0.4	0.7
High blood pressure (mother)	1.9	2.7	5.8	1.1	-2.3	-0.2	-1.6	-1.2	-2.4
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	4.9	-0.4	2.1	1.9	1.7	2.2	1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.5	6.8	-1.2	2.6	2.5	2.0	1.9	2.2
Leg pain on walking	1.9	2.3	5.0	-0.1	1.9	1.3	0.7	1.8	2.2
HDL Cholesterol	1.8	3.0	7.7	-0.3	-1.0	-2.8	-2.5	-1.5	-0.8
Mouth/teeth dental problems: Dentures	1.8	3.0	6.5	-2.5	1.5	1.6	2.4	0.4	0.7
Lung cancer (father)	1.8	2.1	7.1	0.8	-1.7	0.0	-0.4	-1.2	-2.7
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	8.7	-2.8	1.6	1.6	3.0	-0.0	-0.3
Number of full sisters	1.8	2.2	6.4	0.2	1.1	2.5	1.4	1.7	0.8
Cholesterol lowering medication	1.8	2.7	6.3	-1.4	2.5	0.1	0.8	1.3	2.3
Alzheimer’s Disease (including proxy)	1.7	2.4	5.6	-2.3	1.6	0.3	2.4	-0.9	0.1
Heel T-Score	1.7	13.2	19.3	-1.0	3.4	4.4	3.6	3.9	4.4
Qualifications: CSEs or equivalent	1.7	2.2	6.3	2.5	-0.0	0.0	-2.2	1.5	0.2
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	5.1	1.0	-2.3	-0.9	-1.7	-1.2	-2.2
Smoking status: Current	1.7	2.6	5.5	-1.3	2.0	0.5	1.4	1.5	2.3
Mother’s age at death	1.7	2.2	3.1	1.5	-1.7	-1.8	-1.7	-1.0	-1.1
BMI	1.6	9.0	13.8	-1.4	3.4	2.4	3.3	3.3	3.7
Length of working week for main job	1.6	1.8	4.7	-0.3	1.3	0.8	1.1	1.5	2.2
Pulse wave peak to peak time	1.6	1.9	5.3	0.2	-1.2	-2.3	-0.6	-1.6	-1.4
Fractured/broken bones in last 5 years	1.6	2.0	5.8	2.3	-0.5	-0.9	-2.4	0.5	-0.3
Depression (Nagel 2018)	1.5	2.2	3.3	-1.2	1.8	1.8	1.4	1.4	1.3
Age at First Birth	1.5	2.2	5.0	-0.2	-1.9	-1.0	-0.1	-1.8	-2.2
Falls in the last year	1.5	2.0	4.7	-2.2	1.1	0.1	2.0	-1.2	-0.8
Leg fat percentage (right)	1.5	5.3	13.5	-0.5	1.2	3.7	3.0	2.4	1.3
Hearing aid user	1.4	1.5	2.8	1.5	1.7	0.4	0.0	1.6	1.3
Schizophrenia vs Biploar Disorder	1.3	1.7	4.1	0.7	1.3	-0.1	-1.2	1.6	2.0
Reaction Time	1.3	2.4	7.5	-0.6	-1.0	-2.7	-0.4	-1.9	-1.4
Stomach or abdominal pain in last month	1.3	1.6	3.4	-1.2	1.2	1.8	1.7	0.7	0.1
Impedance of leg (left)	1.3	6.1	14.7	-0.1	-3.0	-1.1	-0.6	-3.4	-3.8
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.6	-1.0	1.6	1.3	1.2	0.9	1.3
Commuting to job workplace: Public transport	1.3	1.5	3.8	0.3	-1.1	-2.0	-1.4	-1.3	-0.6
Ulcerative Colitis	1.2	1.7	4.2	-0.3	1.0	2.1	1.1	1.6	1.1
Lung FVC	1.2	5.9	14.0	2.2	1.5	2.0	-2.0	3.7	2.6
Supplements: Zinc	1.2	1.3	2.1	1.1	-1.0	-1.3	-0.9	-1.0	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.7	-0.1	1.1	2.2	0.2	1.9	1.6
Hair/balding pattern: Pattern 4	1.2	2.8	6.7	-1.3	-0.6	-1.6	-0.3	-2.4	-2.6
Age at first live birth	1.2	2.1	3.7	0.7	-1.9	-1.6	-1.1	-1.6	-1.5
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.3	-1.8	0.7	0.9	1.8	0.3	0.9
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.4	-0.6	-1.1	-1.4	-0.0	-1.8	-1.4
Eye problems/disorders: Glaucoma	1.2	1.4	2.8	-1.5	1.1	1.1	1.7	0.8	0.6
Ever smoked	1.2	2.2	5.8	-1.1	1.6	1.1	2.4	1.0	1.2
Leg fat percentage (left)	1.2	4.5	11.6	-0.2	1.2	3.4	2.5	2.4	1.3
Supplements: Calcium	1.2	1.3	2.1	0.9	-1.4	-0.6	-1.4	-0.8	-1.4
Smoking Status	1.1	2.6	8.2	-0.9	1.3	1.2	2.9	1.3	1.4
Impedance of leg (right)	1.1	5.6	13.4	-0.6	-2.8	-0.9	0.0	-3.3	-3.7
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	4.6	-0.9	2.0	2.1	1.4	1.4	1.3
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.9	0.1	-1.1	-0.9	-1.7	-1.3	-1.4
Medication: Lansoprazole	1.1	1.3	4.4	2.1	-0.4	-0.3	-1.6	0.5	-0.4
Pulse wave reflection index	1.1	1.4	2.9	0.7	0.6	1.3	-0.6	1.7	1.6
Qualifications: College or University degree	1.1	3.4	8.0	1.9	-1.5	-2.4	-2.8	-0.4	0.9
Long-standing illness, disability or infirmity	1.1	1.6	4.5	-1.8	2.1	-0.0	1.2	-0.1	0.5
Financial situation satisfaction	1.1	1.3	2.8	0.2	1.0	1.6	-0.1	1.7	1.4
Diabetes (father)	1.0	1.3	2.9	1.1	-0.6	-1.7	-1.5	-0.6	-0.7
Alcohol intake versus 10 years previously	1.0	1.5	4.6	-0.8	2.1	1.0	0.7	0.9	1.2
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.6	-0.5	-1.0	-0.8	-0.4	-1.5	-1.6
Major Depression (MDD)	0.9	1.0	1.8	0.6	1.3	0.7	0.3	1.3	1.3
Triglycerides	0.9	1.4	2.7	-0.8	1.1	1.6	1.5	0.8	1.0
Medication: Co-codamol	0.9	1.0	3.4	-1.8	1.1	-0.4	0.6	-0.1	0.9
Taking other prescription medications	0.9	1.4	3.8	-1.9	1.5	0.5	1.5	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	6.7	0.9	-1.4	-2.2	-2.6	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	8.8	1.6	-0.8	-2.2	-3.0	-0.6	-0.8
Pulse wave Arterial Stiffness index	0.9	1.1	3.7	-0.1	0.8	1.9	0.4	1.1	0.9
Birth weight	0.9	2.0	4.3	1.1	-1.6	-0.8	-1.2	-1.3	-2.1
Emphysema/chronic bronchitis	0.9	1.0	2.0	-1.4	0.2	0.3	1.3	-1.0	-1.0
Comparative height size at age 10	0.9	5.1	10.7	-0.3	-1.4	-3.3	-0.6	-3.0	-2.9
Age at last live birth	0.9	1.3	2.5	0.3	-1.6	-1.3	-0.6	-1.3	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.4	1.0	0.5	-0.2	-1.3	1.1	1.5
Depressed Affect (Nagel 2018)	0.8	1.7	3.5	-0.6	1.6	1.9	0.9	1.4	0.9
Sitting height	0.8	5.5	12.2	0.9	-1.1	-3.5	-2.3	-2.7	-2.5
Past tobacco smoking	0.8	1.4	4.5	0.4	-1.4	-0.8	-2.1	-0.8	-0.8
Hearing difficulty/problems with background noise	0.8	1.4	3.0	0.4	1.0	1.6	-0.0	1.7	1.1
Had other major operations	0.8	0.9	1.8	-0.0	0.9	0.8	1.1	1.4	1.1
Qualifications: None of the above	0.8	1.7	4.4	-1.8	0.6	1.4	2.1	-0.1	-0.7
Medication: Ramipril	0.8	1.0	3.7	-0.3	-0.5	0.1	0.5	-1.2	-1.9
Medication: Simvastatin	0.8	1.2	3.0	-1.0	1.7	0.9	1.3	0.7	0.7
Illnesses of siblings	0.8	1.1	2.5	0.9	-1.4	-0.1	-1.6	-0.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.4	0.6	0.9	0.9	-0.3	1.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.7	1.9	-0.7	-0.0	-1.6	0.7	-0.5
Medication: Aspirin	0.8	1.1	3.7	-1.2	1.1	0.4	1.9	0.3	0.2
Illnesses of siblings: Diabetes	0.8	1.0	2.1	-1.2	1.3	0.8	1.4	0.2	0.4
Average weekly red wine intake	0.8	1.1	2.6	-1.6	0.1	-1.1	1.3	-1.0	0.3
Mood swings	0.8	1.4	2.8	-0.9	1.5	1.2	1.7	0.9	0.4
Back pain experienced in last month	0.8	1.2	3.1	0.8	0.9	1.4	-0.0	1.8	0.8
Medication: Aspirin	0.8	1.0	3.5	-1.2	0.9	0.5	1.9	-0.0	-0.3
Number of self-reported non-cancer illnesses	0.8	1.3	3.9	-0.7	-0.2	-1.1	-0.2	-1.6	-2.0
Guilty feelings	0.8	1.2	1.7	-0.7	1.3	1.3	1.0	1.2	0.9
Pain experienced in last month	0.8	1.4	2.6	-0.2	-1.6	-1.3	-0.4	-1.6	-1.0
Breast Cancer	0.7	1.6	3.9	1.3	0.7	0.5	-0.2	2.0	1.8
Lupus	0.7	1.0	2.1	1.4	-0.2	-0.7	-1.4	0.9	0.9
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	1.0	0.5	1.1	-0.4	1.3	0.5
Lung FEV1/FVC ratio	0.7	3.4	7.1	1.0	-2.6	-1.1	-0.6	-2.1	-2.7
High blood pressure	0.7	1.9	5.1	-0.6	-1.2	0.3	1.7	-1.3	-2.3
Waist circumference	0.7	2.4	4.8	-1.0	1.2	2.2	2.2	1.4	0.8
Mouth/teeth dental problems	0.7	1.0	1.8	1.4	0.8	-0.7	-0.7	1.0	1.2
Peak expiratory flow (PEF)	0.7	1.6	2.7	-0.4	-1.3	-1.6	-0.8	-1.6	-1.4
Arm fat-free mass (right)	0.7	3.6	7.6	0.7	2.2	1.7	0.5	2.8	2.3
Neck or shoulder pain in last month	0.7	1.0	2.6	0.7	0.3	1.6	0.7	1.4	0.8
Medication: Omeprazole	0.7	0.9	2.9	-1.7	0.9	-0.6	0.6	-1.0	-0.1
Arm predicted mass (right)	0.7	3.7	7.8	0.7	2.2	1.7	0.5	2.8	2.3
Loneliness, isolation	0.7	0.9	3.6	1.3	-0.3	0.1	-1.9	0.5	0.3
Ever had bowel cancer screening	0.7	0.9	1.6	-1.0	-0.5	-0.3	1.0	-1.2	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.3	-0.3	0.7	0.5	1.0	1.1	1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.5	0.7	-0.2	-1.6	-1.2	-0.2	0.6
Vascular/heart problems diagnosed by doctor	0.7	1.8	5.3	1.2	-0.1	-0.5	-2.3	1.0	1.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.2	-1.8	0.5	-0.5	0.7	-1.1	-0.2
Ulcerative Colitis (UC)	0.6	1.1	4.2	0.0	0.2	2.1	1.0	1.3	-0.1
Fasting Glucose	0.6	0.7	2.2	0.3	-0.1	-1.5	-0.9	-0.6	-0.7
Blood Red Count	0.6	5.4	10.6	2.2	-2.7	-2.4	-3.3	-1.5	-1.3
Vitamin and mineral supplements	0.6	0.8	2.0	-0.8	1.1	0.4	0.3	0.7	1.4
Trunk fat percentage	0.6	2.6	6.1	-1.2	-1.6	-0.3	1.1	-2.0	-2.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.5	0.3	-0.8	-1.2	-1.1	-0.6	-0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.4	-0.1	0.2	1.6	0.8	1.0	0.4
Chronic bronchitis/emphysema (father)	0.6	0.6	1.3	-0.5	1.1	1.2	0.9	0.5	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	1.3	-1.2	-0.2	-1.0	0.1	-0.3
Pain all over the body in last month	0.6	0.7	1.8	-1.1	0.1	-0.0	1.4	-0.8	-0.8
Happiness	0.6	0.7	2.5	0.8	0.3	1.6	-0.4	0.9	0.2
Tense / ‘highly strung’	0.6	1.0	2.5	1.1	-0.9	-0.2	-1.6	-0.1	-1.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.4	0.1	0.2	1.8	0.6	0.6	-0.1
Number of full brothers	0.6	0.8	3.0	-0.5	0.2	1.1	1.7	0.4	0.0
Leg fat mass (right)	0.6	2.4	6.6	-0.2	0.7	2.6	2.1	1.6	0.5
Suffer from ‘nerves’	0.6	0.9	2.2	0.9	-1.0	-0.3	-1.2	-0.5	-1.5
Hypertension (Self-reported)	0.6	1.8	5.2	-0.4	-1.3	0.2	1.5	-1.3	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.6	1.2	-0.5	0.8	1.1	0.6	0.9	0.8
Qualifications: nursing, teaching	0.6	0.9	3.3	0.7	0.8	0.5	-0.2	0.9	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.8	-1.0	0.3	-1.4	-0.4	-1.2	-0.3
Medication: Blood pressure	0.6	1.1	3.1	-0.3	-0.3	1.4	1.1	-0.1	-1.8
Medication: Bendroflumethiazide	0.6	0.8	1.4	-1.1	-0.4	-0.1	1.0	-1.1	-1.2
Arm fat-free mass (left)	0.6	3.0	6.1	0.3	2.1	1.8	0.8	2.5	1.9
Unable to work because of sickness or disability	0.6	0.7	2.9	-0.9	1.7	0.3	0.7	0.1	0.2
Commuting to job workplace: Cycle	0.6	0.7	2.0	-1.4	0.8	0.4	1.1	-0.2	0.4
Arm predicted mass (left)	0.6	2.8	5.8	0.3	2.1	1.7	0.8	2.4	1.8
Alzheimer’s Disease (in father)	0.5	0.6	1.5	-0.2	0.1	-1.0	0.1	-1.1	-1.2
Mean Putamen Volume	0.5	0.6	1.6	1.3	-0.1	-1.1	-0.5	-0.4	-0.5
Waist Hip Ratio (WHR)	0.5	2.3	4.1	-1.7	-0.6	1.2	2.0	-1.4	-1.7
Systolic Blood Pressure	0.5	2.5	5.5	0.6	-1.9	-1.3	-0.4	-1.9	-2.4
Neuroticism	0.5	1.3	4.9	0.3	-1.1	0.2	-0.6	-1.1	-2.2
Hand grip strength (left)	0.5	1.4	2.9	-0.1	1.0	1.7	1.0	1.5	1.3
Hand grip strength (right)	0.5	1.2	2.6	-0.5	0.8	1.6	1.1	1.2	1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.4	0.4	1.2	-0.3	-0.4	0.8	0.8
Medication: Atenolol	0.5	0.6	1.4	-0.7	-0.4	-0.4	0.4	-1.0	-1.2
Number of incorrect matches in round	0.5	0.8	2.1	-0.2	1.1	-0.5	-0.4	1.1	1.5
Forced vital capacity (FVC)	0.5	2.0	5.7	1.2	-0.8	-1.9	-2.4	-0.5	-0.8
Number of live births	0.5	0.6	1.2	1.1	0.4	-0.5	-0.9	0.8	0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.4	1.6	-0.3	-1.0	-1.4	0.3	1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.5	0.2	-1.0	-0.4	-0.8	-0.9	-1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.6	-0.5	-0.3	0.9	1.3	-0.4	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.8	6.2	1.6	-0.0	-1.5	-2.5	0.2	-0.1
Exposure to tobacco smoke outside home	0.5	0.6	1.3	-0.3	1.1	0.2	-0.8	1.0	0.9
Worry too long after embarrassment	0.5	0.9	2.9	-0.1	-1.2	0.3	0.4	-0.9	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.9	-0.1	1.0	-1.4	-0.8	0.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.7	0.5	0.6	-1.0	-1.3	-0.2	-0.0
Medication: Blood pressure	0.5	0.9	1.8	0.0	-0.6	-1.3	0.4	-1.3	-1.2
Migraine (self-reported)	0.5	0.6	1.1	1.1	-0.2	0.7	-1.0	1.0	0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-0.6	0.8	0.7	1.2	0.4	0.6
Heart disease (mother)	0.5	0.6	1.8	-0.6	0.3	1.2	1.4	0.0	0.0
Smoking status: Previous	0.5	0.7	2.5	0.0	0.7	1.0	1.6	0.6	0.3
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.4	-1.2	0.4	0.3	1.0	-0.5	-0.6
Miserableness	0.5	0.9	1.8	-1.2	0.8	1.3	1.1	0.4	0.5
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	0.2	-0.2	-1.5	-0.5	-1.0	-0.7
Medication: Atorvastatin	0.5	0.6	1.3	-1.0	1.1	-0.6	0.6	0.2	0.9
Risk taking	0.5	0.7	1.3	-0.6	0.9	0.2	0.8	1.0	1.1
Leg fat mass (left)	0.5	2.1	5.7	-0.1	0.7	2.4	1.9	1.6	0.6
Cardiovascular Disease	0.4	1.4	3.5	-1.4	0.5	0.0	1.9	-1.1	-1.2
Number of treatments/medications taken	0.4	0.8	2.0	-0.8	1.4	1.0	0.9	0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.7	-0.5	1.3	0.1	0.3	0.5	0.8
Pack years adult smoking proportion	0.4	0.6	1.0	-0.3	1.0	1.0	0.3	0.9	0.7
Multivitamins +/- minerals	0.4	0.5	1.6	0.3	-0.9	0.4	0.5	-0.6	-1.3
Trunk fat mass	0.4	1.6	4.3	-0.9	-1.2	-0.2	0.9	-1.5	-2.1
Nervous feelings	0.4	0.7	1.8	1.4	-0.3	0.6	-1.1	0.5	-0.6
Had menopause	0.4	0.5	1.6	-0.5	0.5	-1.3	-0.4	-0.7	0.2
Allergy	0.4	0.9	2.6	-0.7	1.0	0.4	1.6	0.3	0.9
Diabetes (self-reported)	0.4	0.5	1.6	-0.2	1.2	-0.2	-0.5	0.5	1.1
Arm fat percentage (right)	0.4	1.5	5.0	-1.2	-0.3	1.3	2.2	-0.1	-0.7
Hair/balding pattern: Pattern 3	0.4	0.7	1.5	0.6	0.5	0.5	-0.2	1.2	1.2
Prospective memory result	0.4	0.4	1.9	-1.4	0.8	-0.2	-0.0	-0.3	-0.2
Loud music exposure frequency	0.4	0.5	1.2	-0.2	0.7	1.1	0.5	0.9	0.4
Blood clot in the leg (DVT)	0.4	0.5	1.3	-1.1	0.7	-0.9	0.1	-0.2	0.5
Gout (self-reported)	0.4	0.6	1.4	-0.3	0.6	0.7	1.2	0.7	0.8
Medication: Amlodipine	0.4	0.6	1.3	0.1	0.8	0.9	0.9	1.1	0.2
Number of children fathered	0.4	0.4	1.6	-0.9	0.2	-0.1	1.3	-0.3	-0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.8	1.3	0.0	0.6	-0.3	1.2	0.7
Alcohol intake frequency.	0.4	1.0	2.6	1.6	-0.0	0.5	-1.6	1.0	0.1
Illnesses of father: Heart disease	0.4	0.5	1.8	-0.8	-0.2	0.3	1.4	-0.4	-0.5
Commuting to job workplace: Walk	0.4	0.5	1.3	-0.6	1.1	0.1	0.7	0.3	0.7
Mineral and other dietary supplements	0.4	0.5	1.0	-0.8	0.6	1.0	0.4	0.5	0.7
Medication: Gliclazide	0.4	0.4	0.8	-0.9	0.8	-0.7	0.6	-0.5	0.1
Average weekly champagne plus white wine intake	0.4	0.6	2.5	-0.2	0.4	-1.6	-0.3	-0.9	-0.2
Wears glasses or contact lenses	0.4	0.5	1.4	1.2	-1.1	-0.3	-0.2	-0.1	-0.3
Ever taken oral contraceptive pill	0.4	0.5	1.1	0.6	-1.0	1.0	0.6	0.1	-0.1
Irritability	0.4	0.6	1.5	-0.5	1.2	0.9	0.2	0.9	0.7
Diastolic blood pressure, automated reading	0.4	1.3	3.8	-0.4	1.1	2.0	1.3	0.9	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.8	0.7	0.4	0.1	0.1	0.9	1.9
Coronary Artery Disease (CAD)	0.3	0.4	1.3	-0.7	0.4	0.3	1.2	0.1	0.4
Crohns Disease (2012)	0.3	0.4	1.6	0.4	0.2	-1.2	-0.8	-0.3	0.2
HbA1C	0.3	0.4	1.0	0.6	-1.0	-0.2	-0.9	0.1	-0.2
Rheumatoid Arthritis	0.3	0.4	1.3	0.4	-0.5	-1.1	-0.4	-0.3	-0.3
Blood Platelet Count	0.3	3.5	8.0	-1.1	-0.9	-2.8	-0.8	-2.5	-2.0
Ever had hysterectomy (womb removed)	0.3	0.3	1.4	0.4	0.4	-0.2	-1.2	0.3	0.4
Diabetes (mother)	0.3	0.4	0.7	-0.0	0.8	0.7	0.3	0.5	0.8
Serious illness, injury or assault to yourself	0.3	0.3	1.0	0.5	0.4	-1.0	-0.6	-0.1	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.9	1.1	-0.4	0.6	-1.4	0.7	0.0
Fluid intelligence score	0.3	0.6	2.2	0.4	0.5	0.2	0.7	0.6	1.5
Time employed in main current job	0.3	0.4	1.1	-0.2	-0.7	-1.0	-0.4	-0.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.2	-0.9	0.6	-0.4	-0.7	-0.9
Depression (self-reported)	0.3	0.3	1.1	0.5	1.1	-0.1	-0.3	0.6	0.4
Arm fat mass (right)	0.3	1.3	3.6	-0.7	0.4	1.7	1.9	0.9	0.1
Breastfed as a baby	0.3	0.3	0.9	-0.1	0.7	-0.3	-0.2	0.6	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	-0.4	0.4	0.9	0.2	0.8	1.0
Body fat percentage	0.3	1.3	2.8	-1.0	-0.8	0.8	1.7	-0.7	-1.4
Comparative body size at age 10	0.3	0.7	3.2	0.7	-0.6	-1.8	-0.5	-0.0	0.3
Medication: Ibuprofen	0.3	0.4	0.9	0.2	-0.8	1.0	-0.4	-0.1	-0.7
Family relationship satisfaction	0.3	0.3	0.7	-0.6	0.8	0.5	-0.3	0.2	0.7
Arm fat percentage (left)	0.3	1.1	3.7	-1.1	-0.1	1.3	1.9	0.1	-0.3
Friendships satisfaction	0.3	0.4	1.7	0.1	-0.3	0.4	-1.3	-0.3	-0.4
Osteoporosis (self-reported)	0.3	0.3	1.2	-0.6	1.1	0.4	-0.1	0.3	0.5
High cholesterol (Self-reported)	0.3	0.5	1.4	-0.7	1.2	-0.2	0.0	0.3	0.8
Alcohol drinker status: Never	0.3	0.4	0.9	0.1	0.7	0.2	-0.2	0.8	1.0
Myopia	0.3	0.5	1.9	-0.4	0.0	-1.4	0.2	-0.8	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	-0.9	0.5	-1.0	0.0	-0.2	0.4
Pack years of smoking	0.3	0.4	0.7	-0.4	0.8	0.8	0.3	0.7	0.6
Bipolar Disorder (2018)	0.2	0.3	0.8	0.0	0.1	-0.3	0.9	-0.2	-0.9
Neuroticism (Nagel 2018)	0.2	0.4	1.8	0.1	-0.5	0.6	-0.3	-0.3	-1.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.5	0.6	0.2	0.2	0.6	0.4	1.2
Ovarian Cancer	0.2	0.2	0.7	0.1	0.6	-0.9	-0.0	0.2	0.3
Prostate Cancer	0.2	0.3	0.7	0.7	0.3	-0.6	-0.4	0.4	0.8
Neuroticism (2016)	0.2	0.3	0.8	0.9	-0.1	-0.6	-0.6	0.3	0.6
Schizophrenia (2014)	0.2	0.5	1.7	-0.7	1.3	-0.6	-0.0	0.3	0.6
Allergy or Eczema	0.2	0.6	1.2	0.7	0.4	1.1	-0.9	1.0	0.5
Respiratory disease	0.2	0.5	1.3	-1.2	0.3	-0.3	1.1	-0.4	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.2	0.5	0.6	-0.4	0.9	0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.4	0.6	0.5	0.0	-0.5	0.6	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.7	-0.5	-0.0	-0.5	0.7	0.4
Systolic blood pressure, automated reading	0.2	0.7	1.9	-0.6	0.4	1.2	1.4	0.3	0.3
Supplements: Glucosamine	0.2	0.3	0.7	0.8	0.5	-0.0	0.0	0.8	0.4
Neuroticism score	0.2	0.5	1.7	0.3	-0.4	0.8	-0.4	-0.3	-1.3
Trunk fat-free mass	0.2	1.1	2.4	0.5	1.5	0.4	0.0	1.5	1.3
Hip circumference	0.2	1.0	2.1	0.2	0.7	1.4	1.1	1.3	0.5
Trunk predicted mass	0.2	1.1	2.3	0.4	1.5	0.5	0.1	1.5	1.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	0.6	-0.2	-0.1	-1.1	-0.4	-0.3
Headache pain in last month	0.2	0.4	1.0	-0.0	1.0	0.7	0.5	0.7	0.4
Wheeze or whistling in the chest in last year	0.2	0.4	0.6	-0.5	0.6	0.6	0.8	0.4	-0.7
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.3	0.4	0.8	0.2	0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	0.4	-0.4	0.1	-0.6	-0.2	-0.9
Whole body fat mass	0.2	0.7	2.2	-0.7	-0.2	0.7	1.5	-0.3	-1.0
Pulse rate, automated reading	0.2	0.7	1.6	-0.8	0.3	0.2	0.3	-1.2	-1.2
Had major operations	0.2	0.3	0.8	0.5	0.9	-0.4	-0.0	0.5	0.3
Eye problems/disorders: Cataract	0.2	0.3	0.7	0.6	-0.5	0.2	-0.5	0.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.4	0.1	0.7	-0.3	-1.2	0.8	0.7
Arm fat mass (left)	0.2	1.0	2.5	-0.5	0.5	1.4	1.6	0.9	0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	-0.6	0.9	-0.2	0.0	-0.3	0.1
Medication: Paracetamol	0.2	0.3	1.2	-0.6	-0.0	1.1	0.6	0.2	0.0
Number of operations (self-reported)	0.2	0.3	0.6	0.7	0.8	-0.6	-0.5	0.3	0.1
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	-0.3	0.7	-0.5	0.0	0.1	-0.1
Schizophrenia (2018)	0.1	0.3	0.6	-0.4	0.7	-0.3	-0.7	0.3	0.5
Crohns Disease (2017)	0.1	0.1	0.2	-0.2	-0.1	-0.5	0.2	-0.4	-0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.0	-0.4	0.8	0.6	0.3	-0.8
LDL Cholesterol	0.1	0.2	0.6	0.4	-0.2	-0.3	-0.4	0.8	0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.6	-0.4	0.8	0.2	0.3	0.3	0.8
Tanning	0.1	0.8	2.9	0.1	-0.8	0.9	0.1	-0.3	-1.7
Medication: Metformin	0.1	0.2	0.6	0.7	-0.1	0.2	-0.7	0.2	-0.3
Weight	0.1	0.4	0.8	-0.0	0.6	0.9	0.9	0.8	0.1
Asthma	0.1	0.1	0.6	-0.3	-0.2	-0.2	-0.2	-0.3	-0.8
Medication: Cholesterol lowering	0.1	0.1	0.4	0.2	0.6	0.3	0.2	0.4	0.1
Medication: Paracetamol	0.1	0.1	0.5	-0.7	0.1	0.0	0.4	-0.2	0.2
Glaucoma (self-reported)	0.1	0.2	0.3	-0.4	-0.1	0.5	0.4	0.1	-0.5
Medication: Allopurinol	0.1	0.2	0.5	0.3	0.4	0.1	0.7	0.3	0.5
Overall health rating	0.1	0.2	0.9	-0.7	0.9	0.0	0.2	-0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.5	0.1	-0.6	0.2	-0.0	-0.2	-0.7
Knee pain experienced in last month	0.1	0.2	0.5	0.6	0.4	-0.2	-0.7	0.2	0.1
Whole body fat-free mass	0.1	0.7	1.8	0.2	1.3	0.3	0.1	1.2	1.0
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.1	0.7	-0.1	-0.7	0.0	0.3
Medication for cholesterol	0.1	0.2	1.0	-0.3	0.3	-0.2	0.2	0.0	1.0
Breast cancer (self-reported)	0.1	0.1	0.4	0.6	-0.2	0.1	-0.2	-0.1	-0.5
Asthma (self-reported)	0.1	0.2	0.7	-0.3	-0.4	-0.4	-0.4	-0.5	-0.9
Osteoarthritis (self-reported)	0.1	0.1	0.4	0.2	-0.2	0.7	-0.1	0.2	-0.2
Whole body water mass	0.1	0.8	2.1	0.0	1.4	0.3	0.3	1.2	1.1
Medication: Lisinopril	0.1	0.1	0.3	0.5	0.1	-0.6	-0.2	-0.1	0.1
Illnesses of father: High blood pressure	0.1	0.2	0.4	0.0	-0.0	-0.5	0.0	-0.5	-0.7
Basal metabolic rate	0.1	0.7	1.6	0.1	1.2	0.5	0.4	1.2	0.8
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	0.2	-0.3	-0.1	-0.2	-0.2	-0.3
Hair Pigment	0.0	0.2	0.5	-0.4	0.7	0.6	-0.2	0.4	0.2
Leg fat-free mass (left)	0.0	0.2	0.6	-0.1	0.8	-0.3	0.2	0.4	0.3
Leg predicted mass (left)	0.0	0.2	0.6	-0.2	0.8	-0.3	0.3	0.4	0.3
Pulse rate	0.0	0.1	0.3	0.1	0.3	0.5	0.3	-0.2	-0.2
Birth weight of first child	0.0	0.1	0.2	-0.4	0.3	-0.1	-0.4	-0.1	-0.2
High blood pressure (siblings)	0.0	0.1	0.1	0.2	0.2	-0.2	0.3	-0.0	-0.4
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.0	-0.2	0.1	-0.2	-0.3	0.1
Leg fat-free mass (right)	0.0	0.2	0.5	0.2	0.7	-0.6	-0.3	0.4	0.3
Leg predicted mass (right)	0.0	0.2	0.6	0.2	0.8	-0.5	-0.3	0.5	0.4

Hub : Genes

UBQLN1

Models

Trait associations