Best TWAS P=4.73e-25 · Best GWAS P=5.72e-25 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CENPP | 0.43 | 0.52 | bslmm | 525 | 0.51 | 2.3e-72 | -5.7 | -5.8 | 7.6e-09 | 0.65 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | LOC100128361 | 0.10 | 0.08 | lasso | 4 | 0.09 | 2.2e-11 | -5.7 | -5.8 | 5.0e-09 | 0.71 | 0.99 | 0.01 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | OGN | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.3e-05 | -5.2 | -6.9 | 7.2e-12 | 0.68 | 0.49 | 0.42 | FALSE |
4 | GTEx | Adipose Subcutaneous | ECM2 | 0.05 | 0.00 | lasso | 4 | 0.00 | 1.2e-01 | 3.7 | -5.5 | 2.9e-08 | 0.64 | 0.15 | 0.27 | FALSE |
5 | GTEx | Adipose Subcutaneous | ANKRD19P | 0.06 | 0.03 | enet | 16 | 0.04 | 2.2e-04 | -2.6 | 5.7 | 1.5e-08 | -0.70 | 0.28 | 0.68 | FALSE |
6 | GTEx | Adipose Visceral Omentum | CENPP | 0.28 | 0.29 | enet | 14 | 0.30 | 5.1e-16 | -5.4 | -5.4 | 6.4e-08 | 0.63 | 1.00 | 0.00 | FALSE |
7 | GTEx | Adrenal Gland | CENPP | 0.45 | 0.32 | enet | 21 | 0.31 | 7.5e-12 | -5.7 | -5.6 | 2.3e-08 | 0.63 | 1.00 | 0.00 | FALSE |
8 | GTEx | Artery Aorta | NOL8 | 0.09 | 0.04 | lasso | 9 | 0.02 | 2.3e-02 | -9.6 | 9.0 | 2.0e-19 | -0.89 | 0.05 | 0.93 | FALSE |
9 | GTEx | Artery Coronary | CENPP | 0.16 | 0.22 | lasso | 1 | 0.18 | 1.6e-06 | -5.3 | -5.3 | 9.1e-08 | 0.63 | 0.62 | 0.33 | FALSE |
10 | GTEx | Artery Tibial | CENPP | 0.44 | 0.40 | enet | 35 | 0.42 | 7.5e-36 | -5.4 | -5.2 | 2.1e-07 | 0.61 | 1.00 | 0.00 | FALSE |
11 | GTEx | Artery Tibial | NOL8 | 0.04 | 0.03 | lasso | 4 | 0.03 | 3.5e-03 | -10.3 | 10.0 | 1.5e-23 | -0.99 | 0.02 | 0.96 | FALSE |
12 | GTEx | Brain Caudate basal ganglia | CENPP | 0.37 | 0.30 | enet | 10 | 0.31 | 1.3e-09 | -5.4 | -5.4 | 6.3e-08 | 0.62 | 0.93 | 0.04 | FALSE |
13 | GTEx | Brain Cerebellar Hemisphere | IPPK | 0.17 | 0.22 | lasso | 13 | 0.16 | 6.8e-05 | -9.6 | -9.4 | 4.4e-21 | 0.93 | 0.10 | 0.86 | FALSE |
14 | GTEx | Brain Cerebellar Hemisphere | CENPP | 0.27 | 0.23 | lasso | 1 | 0.20 | 7.0e-06 | -5.3 | -5.3 | 9.1e-08 | 0.63 | 0.42 | 0.08 | FALSE |
15 | GTEx | Brain Cerebellum | IPPK | 0.12 | 0.01 | enet | 17 | 0.01 | 1.6e-01 | -8.3 | -6.8 | 1.3e-11 | 0.81 | 0.07 | 0.54 | FALSE |
16 | GTEx | Brain Cerebellum | CENPP | 0.41 | 0.34 | lasso | 6 | 0.32 | 2.5e-10 | -5.4 | -5.6 | 2.5e-08 | 0.64 | 0.98 | 0.01 | FALSE |
17 | GTEx | Brain Cortex | CENPP | 0.24 | 0.29 | lasso | 9 | 0.28 | 2.1e-08 | -5.3 | -5.5 | 3.2e-08 | 0.65 | 0.28 | 0.71 | FALSE |
18 | GTEx | Brain Frontal Cortex BA9 | CENPP | 0.47 | 0.30 | lasso | 9 | 0.29 | 1.8e-08 | -5.4 | -5.6 | 2.3e-08 | 0.61 | 0.77 | 0.10 | FALSE |
19 | GTEx | Brain Hypothalamus | CENPP | 0.35 | 0.22 | lasso | 6 | 0.14 | 4.0e-04 | -5.4 | -5.7 | 1.1e-08 | 0.64 | 0.32 | 0.31 | FALSE |
20 | GTEx | Brain Putamen basal ganglia | CENPP | 0.37 | 0.18 | lasso | 5 | 0.11 | 1.5e-03 | -5.4 | -5.1 | 3.0e-07 | 0.58 | 0.15 | 0.11 | FALSE |
21 | GTEx | Breast Mammary Tissue (Female) | CENPP | 0.10 | 0.12 | enet | 7 | 0.07 | 4.0e-03 | -5.0 | -5.4 | 5.9e-08 | 0.65 | 0.22 | 0.21 | FALSE |
22 | GTEx | Cells Transformed fibroblasts | OGN | 0.03 | 0.03 | lasso | 2 | 0.01 | 3.2e-02 | -9.2 | -9.2 | 5.0e-20 | 0.84 | 0.11 | 0.83 | FALSE |
23 | GTEx | Cells Transformed fibroblasts | CENPP | 0.27 | 0.16 | lasso | 8 | 0.15 | 1.4e-11 | -5.4 | -5.5 | 4.1e-08 | 0.63 | 1.00 | 0.00 | FALSE |
24 | GTEx | Cells Transformed fibroblasts | PHF2 | 0.07 | 0.06 | lasso | 5 | 0.04 | 5.5e-04 | -7.8 | -7.7 | 1.1e-14 | 0.07 | 0.01 | 0.99 | TRUE |
25 | GTEx | Colon Sigmoid | CENPP | 0.55 | 0.40 | lasso | 5 | 0.39 | 8.8e-15 | -5.7 | -5.7 | 1.3e-08 | 0.63 | 1.00 | 0.00 | FALSE |
26 | GTEx | Colon Transverse | CENPP | 0.25 | 0.26 | lasso | 2 | 0.24 | 1.5e-11 | -5.7 | -5.7 | 1.1e-08 | 0.64 | 1.00 | 0.00 | FALSE |
27 | GTEx | Esophagus Gastroesophageal Junction | CENPP | 0.22 | 0.19 | lasso | 8 | 0.15 | 6.2e-06 | -5.7 | -6.3 | 2.3e-10 | 0.71 | 0.52 | 0.46 | FALSE |
28 | GTEx | Esophagus Muscularis | OGN | 0.07 | 0.03 | enet | 13 | 0.02 | 2.0e-02 | -2.2 | -5.9 | 4.3e-09 | 0.60 | 0.07 | 0.86 | FALSE |
29 | GTEx | Esophagus Muscularis | CENPP | 0.40 | 0.40 | lasso | 5 | 0.41 | 2.7e-26 | -5.7 | -5.6 | 2.0e-08 | 0.64 | 1.00 | 0.00 | FALSE |
30 | GTEx | Heart Atrial Appendage | CENPP | 0.41 | 0.40 | lasso | 7 | 0.40 | 1.7e-19 | -5.4 | -5.5 | 3.3e-08 | 0.61 | 1.00 | 0.00 | FALSE |
31 | GTEx | Heart Left Ventricle | CENPP | 0.12 | 0.15 | lasso | 3 | 0.13 | 2.4e-07 | -5.1 | -5.1 | 2.7e-07 | 0.63 | 0.93 | 0.05 | FALSE |
32 | GTEx | Liver | OGN | 0.13 | 0.03 | lasso | 4 | 0.04 | 3.5e-02 | -5.3 | -7.6 | 4.3e-14 | 0.63 | 0.05 | 0.74 | FALSE |
33 | GTEx | Liver | ECM2 | 0.16 | 0.18 | enet | 8 | 0.18 | 7.4e-06 | -9.0 | 9.0 | 2.2e-19 | -0.85 | 0.17 | 0.80 | FALSE |
34 | GTEx | Liver | CENPP | 0.44 | 0.21 | lasso | 9 | 0.21 | 2.0e-06 | -6.2 | -6.2 | 6.8e-10 | 0.72 | 0.75 | 0.08 | FALSE |
35 | GTEx | Lung | CENPP | 0.30 | 0.24 | lasso | 8 | 0.27 | 1.1e-20 | -5.7 | -5.9 | 4.5e-09 | 0.63 | 1.00 | 0.00 | FALSE |
36 | GTEx | Lung | NOL8 | 0.08 | 0.03 | enet | 15 | 0.04 | 2.3e-04 | -8.3 | 7.9 | 4.1e-15 | -0.88 | 0.03 | 0.97 | FALSE |
37 | GTEx | Muscle Skeletal | OGN | 0.03 | 0.02 | enet | 9 | 0.03 | 3.0e-04 | -9.2 | -9.5 | 2.9e-21 | 0.90 | 0.05 | 0.92 | FALSE |
38 | GTEx | Muscle Skeletal | CENPP | 0.30 | 0.29 | lasso | 6 | 0.30 | 1.0e-29 | -5.7 | -5.6 | 1.7e-08 | 0.65 | 1.00 | 0.00 | FALSE |
39 | GTEx | Nerve Tibial | OGN | 0.08 | 0.14 | lasso | 9 | 0.12 | 6.3e-09 | -9.9 | -9.9 | 4.3e-23 | 0.93 | 0.10 | 0.90 | FALSE |
40 | GTEx | Nerve Tibial | CENPP | 0.47 | 0.36 | enet | 45 | 0.39 | 7.6e-29 | -5.4 | -5.7 | 1.0e-08 | 0.61 | 1.00 | 0.00 | FALSE |
41 | GTEx | Nerve Tibial | NOL8 | 0.10 | 0.02 | enet | 7 | 0.03 | 4.7e-03 | -9.2 | 9.4 | 3.5e-21 | -0.89 | 0.12 | 0.83 | FALSE |
42 | GTEx | Pituitary | IPPK | 0.16 | 0.07 | lasso | 4 | 0.07 | 8.5e-03 | -8.2 | -9.0 | 2.6e-19 | 0.85 | 0.10 | 0.55 | FALSE |
43 | GTEx | Pituitary | CENPP | 0.38 | 0.31 | lasso | 8 | 0.34 | 2.9e-09 | -5.4 | -5.6 | 2.0e-08 | 0.66 | 0.32 | 0.66 | FALSE |
44 | GTEx | Skin Sun Exposed Lower leg | CENPP | 0.20 | 0.06 | lasso | 9 | 0.14 | 2.9e-11 | 3.2 | -6.0 | 1.9e-09 | 0.56 | 0.96 | 0.04 | FALSE |
45 | GTEx | Small Intestine Terminal Ileum | CENPP | 0.29 | 0.11 | enet | 11 | 0.10 | 2.9e-03 | -8.6 | -7.3 | 2.2e-13 | 0.71 | 0.17 | 0.46 | FALSE |
46 | GTEx | Spleen | NOL8 | 0.29 | 0.24 | lasso | 2 | 0.19 | 1.1e-05 | -7.7 | 7.7 | 1.6e-14 | -0.74 | 0.17 | 0.76 | FALSE |
47 | GTEx | Stomach | CENPP | 0.28 | 0.24 | lasso | 6 | 0.22 | 5.0e-11 | -5.7 | -5.5 | 3.8e-08 | 0.61 | 0.98 | 0.02 | FALSE |
48 | GTEx | Testis | NFIL3 | 0.47 | 0.33 | enet | 8 | 0.29 | 3.8e-13 | 4.9 | -5.1 | 2.6e-07 | 0.06 | 1.00 | 0.00 | TRUE |
49 | GTEx | Testis | NOL8 | 0.19 | 0.24 | lasso | 11 | 0.23 | 1.3e-10 | -10.3 | 10.3 | 4.7e-25 | -1.00 | 0.02 | 0.98 | TRUE |
50 | GTEx | Thyroid | OGN | 0.09 | 0.08 | lasso | 4 | 0.05 | 9.9e-05 | -7.0 | -7.7 | 1.3e-14 | 0.65 | 0.22 | 0.77 | FALSE |
51 | GTEx | Whole Blood | NOL8 | 0.05 | 0.01 | enet | 21 | 0.01 | 3.5e-02 | -9.8 | 7.4 | 2.0e-13 | -0.69 | 0.04 | 0.88 | FALSE |
52 | METSIM | Adipose | NOL8 | 0.06 | 0.03 | blup | 418 | 0.04 | 4.1e-07 | -6.2 | 8.6 | 8.3e-18 | -0.82 | 0.03 | 0.97 | FALSE |
53 | METSIM | Adipose | ROR2 | 0.12 | 0.04 | bslmm | 639 | 0.05 | 3.2e-08 | 3.2 | 6.0 | 2.0e-09 | -0.28 | 1.00 | 0.00 | FALSE |
54 | NTR | Blood | ASPN | 0.03 | 0.04 | lasso | 8 | 0.03 | 3.4e-11 | -5.7 | -6.2 | 7.3e-10 | 0.66 | 1.00 | 0.00 | FALSE |
55 | NTR | Blood | CENPP | 0.02 | 0.02 | lasso | 4 | 0.02 | 2.0e-07 | -5.7 | -8.2 | 2.8e-16 | 0.82 | 0.42 | 0.58 | FALSE |
56 | NTR | Blood | ECM2 | 0.03 | 0.01 | lasso | 4 | 0.01 | 1.4e-04 | -5.7 | -5.4 | 5.5e-08 | 0.64 | 0.94 | 0.00 | FALSE |
57 | NTR | Blood | IPPK | 0.02 | 0.01 | bslmm | 416 | 0.01 | 9.9e-06 | -9.2 | -8.7 | 2.2e-18 | 0.79 | 0.40 | 0.60 | FALSE |
58 | NTR | Blood | OGN | 0.10 | 0.11 | lasso | 3 | 0.11 | 5.1e-33 | -5.7 | -5.7 | 1.1e-08 | 0.64 | 1.00 | 0.00 | FALSE |
59 | NTR | Blood | OMD | 0.08 | 0.06 | lasso | 19 | 0.05 | 4.5e-17 | -5.4 | -5.5 | 3.7e-08 | 0.64 | 1.00 | 0.00 | FALSE |
60 | ROSMAP | Brain Pre-frontal Cortex | CENPP | 0.51 | 0.53 | bslmm | 500 | 0.53 | 1.8e-80 | -5.7 | -5.5 | 3.5e-08 | 0.62 | 1.00 | 0.00 | FALSE |
61 | YFS | Blood | NOL8 | 0.06 | 0.09 | lasso | 17 | 0.10 | 1.5e-29 | -10.1 | 9.2 | 4.8e-20 | -0.94 | 0.01 | 0.99 | FALSE |
62 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C9orf44 | 0.11 | 0.06 | blup | 45 | 0.08 | 1.2e-15 | -3.7 | 5.4 | 5.8e-08 | -0.38 | 1.00 | 0.00 | FALSE |
63 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CENPP | 0.07 | 0.03 | lasso | 5 | 0.06 | 2.1e-11 | 3.2 | -7.0 | 3.5e-12 | 0.58 | 1.00 | 0.00 | FALSE |
64 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ECM2 | 0.03 | 0.02 | lasso | 5 | 0.02 | 3.9e-05 | 5.3 | -7.4 | 9.5e-14 | 0.81 | 0.03 | 0.96 | FALSE |
65 | The Cancer Genome Atlas | Breast Invasive Carcinoma | OGN | 0.02 | 0.02 | lasso | 1 | 0.02 | 2.7e-04 | -9.9 | -9.9 | 3.1e-23 | 0.94 | 0.10 | 0.86 | FALSE |
66 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHF2 | 0.02 | 0.01 | blup | 104 | 0.01 | 4.6e-03 | -8.0 | -7.0 | 3.0e-12 | 0.09 | 0.00 | 0.98 | FALSE |
67 | The Cancer Genome Atlas | Esophageal Carcinoma | PHF2 | 0.29 | 0.14 | blup | 103 | 0.16 | 1.0e-05 | -7.4 | -7.4 | 1.8e-13 | 0.04 | 0.04 | 0.92 | FALSE |
68 | The Cancer Genome Atlas | Glioblastoma Multiforme | CENPP | 0.27 | 0.03 | lasso | 6 | 0.08 | 2.6e-03 | -8.0 | -5.3 | 1.5e-07 | 0.54 | 0.16 | 0.07 | FALSE |
69 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CENPP | 0.06 | 0.02 | blup | 160 | 0.04 | 6.3e-05 | 3.1 | -6.3 | 3.1e-10 | 0.51 | 0.54 | 0.04 | FALSE |
70 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | OGN | 0.02 | 0.01 | blup | 51 | 0.01 | 3.4e-02 | -7.9 | -9.1 | 9.4e-20 | 0.85 | 0.06 | 0.23 | FALSE |
71 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPP | 0.23 | 0.16 | lasso | 8 | 0.16 | 1.3e-17 | -5.7 | -6.1 | 1.2e-09 | 0.65 | 1.00 | 0.00 | FALSE |
72 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CENPP | 0.23 | 0.16 | lasso | 6 | 0.16 | 1.9e-09 | -5.7 | -5.7 | 1.3e-08 | 0.64 | 0.99 | 0.00 | FALSE |
73 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOC100128076 | 0.12 | 0.00 | enet | 8 | 0.04 | 4.0e-03 | -3.7 | -5.3 | 1.1e-07 | 0.40 | 0.01 | 0.71 | FALSE |
74 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPP | 0.33 | 0.28 | lasso | 8 | 0.28 | 1.6e-31 | -5.7 | -5.7 | 9.4e-09 | 0.66 | 1.00 | 0.00 | FALSE |
75 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | OGN | 0.07 | 0.08 | lasso | 1 | 0.06 | 8.0e-04 | -9.7 | -9.7 | 4.1e-22 | 0.90 | 0.04 | 0.86 | FALSE |
76 | The Cancer Genome Atlas | Lung Adenocarcinoma | CENPP | 0.14 | 0.08 | lasso | 5 | 0.07 | 2.9e-08 | -5.7 | -5.8 | 7.3e-09 | 0.60 | 1.00 | 0.00 | FALSE |
77 | The Cancer Genome Atlas | Lung Adenocarcinoma | OGN | 0.07 | 0.12 | blup | 52 | 0.14 | 1.2e-15 | -9.7 | -9.9 | 4.4e-23 | 0.94 | 0.12 | 0.88 | FALSE |
78 | The Cancer Genome Atlas | Lung Adenocarcinoma | OMD | 0.04 | 0.06 | lasso | 3 | 0.05 | 1.1e-06 | -9.7 | -9.6 | 5.5e-22 | 0.90 | 0.13 | 0.86 | FALSE |
79 | The Cancer Genome Atlas | Lung Adenocarcinoma | PHF2 | 0.07 | 0.03 | blup | 104 | 0.05 | 1.9e-06 | -7.4 | -6.5 | 9.9e-11 | -0.02 | 0.07 | 0.91 | FALSE |
80 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CENPP | 0.06 | 0.04 | blup | 160 | 0.05 | 5.6e-06 | 3.1 | -7.3 | 3.0e-13 | 0.62 | 0.73 | 0.10 | FALSE |
81 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | OGN | 0.02 | 0.02 | blup | 52 | 0.02 | 2.8e-03 | 7.7 | -9.8 | 7.1e-23 | 0.92 | 0.10 | 0.72 | FALSE |
82 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CENPP | 0.10 | 0.01 | blup | 161 | 0.04 | 6.3e-04 | -2.1 | -6.1 | 7.9e-10 | 0.51 | 0.26 | 0.12 | FALSE |
83 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C9orf44 | 0.27 | 0.05 | lasso | 6 | 0.10 | 7.4e-05 | -6.1 | 5.8 | 7.6e-09 | -0.49 | 0.13 | 0.16 | FALSE |
84 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | OGN | 0.05 | 0.02 | blup | 52 | 0.03 | 2.4e-02 | 7.7 | -9.9 | 6.5e-23 | 0.92 | 0.03 | 0.63 | FALSE |
85 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CENPP | 0.14 | 0.04 | lasso | 12 | 0.03 | 1.9e-02 | -5.7 | -6.0 | 2.3e-09 | 0.69 | 0.11 | 0.39 | FALSE |
86 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CENPP | 0.29 | 0.19 | lasso | 13 | 0.19 | 4.5e-19 | -5.4 | -6.6 | 3.0e-11 | 0.72 | 1.00 | 0.00 | FALSE |
87 | The Cancer Genome Atlas | Prostate Adenocarcinoma | OGN | 0.16 | 0.01 | enet | 16 | 0.05 | 5.8e-06 | -9.6 | -5.5 | 3.2e-08 | 0.52 | 0.06 | 0.34 | FALSE |
88 | The Cancer Genome Atlas | Thyroid Carcinoma | CENPP | 0.22 | 0.15 | blup | 158 | 0.19 | 3.3e-18 | -5.0 | -6.0 | 1.8e-09 | 0.62 | 1.00 | 0.00 | FALSE |
89 | The Cancer Genome Atlas | Thyroid Carcinoma | IPPK | 0.03 | 0.04 | blup | 50 | 0.04 | 6.7e-05 | 4.6 | -6.0 | 1.8e-09 | 0.51 | 0.69 | 0.04 | FALSE |
90 | The Cancer Genome Atlas | Thyroid Carcinoma | NOL8 | 0.02 | 0.01 | blup | 38 | 0.02 | 7.3e-03 | -8.0 | 10.1 | 9.2e-24 | -0.94 | 0.02 | 0.74 | FALSE |