Best TWAS P=6.76e-17 · Best GWAS P=2.93e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PSMB7 | 0.05 | 0.01 | lasso | 3 | 0.03 | 3.1e-04 | -7.1 | 6.6 | 4.1e-11 | -0.62 | 0.24 | 0.18 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | -5.8 | 7.7 | 1.9e-14 | -0.85 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | 6.1 | 6.7 | 2.1e-11 | -0.55 | 0.12 | 0.44 | FALSE |
| 4 | GTEx | Artery Tibial | PSMB7 | 0.07 | 0.04 | enet | 7 | 0.03 | 4.1e-03 | -5.8 | 6.1 | 1.0e-09 | -0.66 | 0.49 | 0.15 | FALSE |
| 5 | GTEx | Artery Tibial | GAPVD1 | 0.11 | 0.16 | enet | 19 | 0.16 | 6.4e-13 | 4.6 | 5.3 | 9.9e-08 | -0.05 | 0.06 | 0.94 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | PSMB7 | 0.11 | 0.03 | lasso | 7 | 0.04 | 4.7e-03 | -8.7 | 8.4 | 6.8e-17 | -0.99 | 0.00 | 0.98 | TRUE |
| 7 | GTEx | Cells Transformed fibroblasts | PSMB7 | 0.09 | 0.07 | enet | 11 | 0.06 | 2.1e-05 | 6.1 | 6.5 | 1.1e-10 | -0.78 | 0.30 | 0.68 | FALSE |
| 8 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | -6.8 | 7.1 | 1.6e-12 | -0.76 | 0.12 | 0.76 | FALSE |
| 9 | GTEx | Colon Transverse | PSMB7 | 0.13 | 0.02 | lasso | 3 | 0.03 | 1.8e-02 | -8.7 | 7.5 | 4.7e-14 | -0.91 | 0.00 | 0.97 | FALSE |
| 10 | GTEx | Nerve Tibial | NEK6 | 0.11 | 0.02 | enet | 40 | 0.03 | 3.9e-03 | -6.7 | 5.9 | 2.8e-09 | -0.37 | 0.09 | 0.40 | FALSE |
| 11 | GTEx | Nerve Tibial | GAPVD1 | 0.17 | 0.08 | lasso | 10 | 0.10 | 9.3e-08 | -4.9 | 5.6 | 2.0e-08 | -0.05 | 0.04 | 0.96 | TRUE |
| 12 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | -6.7 | 7.1 | 1.2e-12 | -0.79 | 0.77 | 0.23 | FALSE |
| 13 | GTEx | Thyroid | PSMB7 | 0.06 | 0.04 | lasso | 2 | 0.06 | 4.1e-05 | -5.8 | 6.9 | 3.9e-12 | -0.77 | 0.03 | 0.96 | FALSE |
| 14 | GTEx | Thyroid | GAPVD1 | 0.05 | 0.05 | enet | 13 | 0.01 | 6.6e-02 | 4.8 | 5.2 | 2.3e-07 | -0.06 | 0.05 | 0.94 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK6 | 0.04 | 0.02 | blup | 87 | 0.02 | 2.5e-05 | 6.6 | 5.7 | 1.6e-08 | -0.37 | 0.88 | 0.03 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | LOC100129034 | 0.12 | 0.00 | lasso | 4 | 0.04 | 1.7e-03 | -7.5 | -5.9 | 4.5e-09 | 0.60 | 0.02 | 0.24 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NEK6 | 0.06 | 0.01 | blup | 87 | 0.04 | 1.0e-04 | 6.6 | 6.7 | 1.8e-11 | -0.51 | 0.18 | 0.45 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB7 | 0.03 | 0.04 | lasso | 4 | 0.04 | 1.2e-04 | -7.1 | 7.2 | 6.4e-13 | -0.79 | 0.08 | 0.84 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB7 | 0.06 | 0.06 | lasso | 4 | 0.04 | 3.7e-05 | -7.1 | 7.2 | 8.4e-13 | -0.85 | 0.44 | 0.55 | FALSE |