Best TWAS P=6.12e-11 · Best GWAS P=3.38e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ELP4 | 0.03 | 0.03 | enet | 3 | 0.03 | 9.7e-04 | 6.5 | -6.5 | 6.1e-11 | -0.96 | 0.01 | 0.94 | TRUE |
| 4 | GTEx | Muscle Skeletal | MPPED2 | 0.09 | 0.07 | lasso | 3 | 0.06 | 2.4e-06 | 5.7 | -5.7 | 1.3e-08 | -0.24 | 0.04 | 0.96 | TRUE |
| 3 | GTEx | Lung | ARL14EP | 0.10 | 0.06 | lasso | 8 | 0.11 | 1.1e-08 | 3.8 | 5.2 | 1.8e-07 | -0.03 | 0.99 | 0.00 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | Z83001.1 | 0.07 | 0.03 | bslmm | 375 | 0.03 | 5.1e-05 | 6.6 | -5.9 | 4.7e-09 | -0.76 | 0.01 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ELP4 | 0.05 | 0.00 | blup | 106 | 0.02 | 5.6e-03 | 4.1 | -5.7 | 1.3e-08 | -0.65 | 0.02 | 0.40 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | ELP4 | 0.26 | 0.12 | lasso | 5 | 0.07 | 5.2e-03 | 4.8 | -5.6 | 1.7e-08 | -0.70 | 0.08 | 0.60 | FALSE |
| 1 | GTEx | Breast Mammary Tissue | IMMP1L | 0.08 | 0.01 | enet | 18 | 0.00 | 2.1e-01 | 6.1 | -5.6 | 1.9e-08 | -0.59 | 0.09 | 0.46 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IMMP1L | 0.05 | 0.01 | blup | 40 | 0.00 | 1.8e-01 | 6.0 | -5.4 | 5.6e-08 | -0.72 | 0.01 | 0.23 | FALSE |