TWAS hub - ELP4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0700	0.0290	0.00110	0.044	NA	0.030	NA	0.036	1.7e-04	NA	1.5e-03	NA	5.8e-04
2	GTEx	Adipose Visceral Omentum	0.0980	0.0370	0.00029	0.117	NA	0.120	NA	0.113	1.2e-06	NA	8.8e-07	NA	1.7e-06
3	GTEx	Breast Mammary Tissue	0.0920	0.0460	0.00950	0.036	NA	0.031	NA	0.048	5.8e-03	NA	9.9e-03	NA	1.8e-03
4	GTEx	Breast Mammary Tissue (Female)	0.2626	0.0997	0.00110	0.117	NA	0.055	NA	0.066	2.3e-04	NA	1.0e-02	NA	5.2e-03
5	TCGA	Breast Invasive Carcinoma	0.0703	0.0518	0.00400	0.017	0.007	0.006	NA	0.011	1.3e-04	0.0110	1.4e-02	NA	1.6e-03
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0465	0.0292	0.00720	0.003	0.016	0.002	NA	0.002	1.4e-01	0.0056	1.6e-01	NA	1.7e-01
7	TCGA	Prostate Adenocarcinoma	0.0318	0.0195	0.00550	0.031	0.016	0.025	NA	0.023	2.8e-04	0.0067	9.7e-04	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	6.2	7.2	10.2	-2.8	-2.6	-2.6	-3.0	-2.2	-3.2	-2.3
Mouth/teeth dental problems: Loose teeth	6.1	7.3	11.2	-3.3	-3.4	-3.0	-2.3	-2.8	-2.5	-0.1
Mean time to correctly identify matches	5.6	10.7	18.3	-2.9	-2.9	-4.3	-4.1	-3.0	-2.1	-3.1
Blood Red Count	5.5	53.2	104.0	6.7	6.7	9.6	10.2	4.5	5.5	6.0
Reaction Time	5.4	10.3	17.3	-3.2	-3.1	-4.2	-3.9	-2.9	-2.0	-2.8
Impedance of arm (left)	5.2	24.0	49.2	-2.6	-3.2	-5.0	-5.8	-3.1	-5.8	-7.0
Diastolic blood pressure, automated reading	5.0	15.5	21.1	-4.3	-4.2	-4.6	-4.2	-3.7	-4.1	-1.6
Exposure to tobacco smoke outside home	4.9	6.5	9.8	-2.9	-2.8	-3.1	-3.1	-1.8	-2.1	-1.3
Impedance of arm (right)	4.8	22.5	42.8	-2.6	-3.1	-4.9	-5.6	-3.1	-5.7	-6.5
Pain type(s) experienced in last month: Hip pain	4.8	6.0	10.2	-3.2	-2.7	-2.9	-2.8	-2.2	-1.9	-0.3
Medication: Co-codamol	4.3	5.0	9.9	-2.7	-2.5	-3.1	-2.5	-2.1	-1.0	0.1
Illness, injury, bereavement, stress in last 2 years	4.3	5.3	12.4	-1.3	-1.8	-2.4	-2.8	-1.5	-1.9	-3.5
Average weekly spirits intake	4.2	5.3	8.2	2.8	2.7	2.9	2.0	2.7	1.5	0.3
Sensitivity / hurt feelings	4.1	6.9	12.6	3.5	3.4	3.1	2.0	3.1	-0.9	0.8
Hair/balding pattern: Pattern 2	4.0	5.1	7.3	-2.1	-2.3	-2.6	-2.7	-2.3	-1.8	-1.9
Falls in the last year	4.0	5.4	7.7	-2.8	-2.7	-2.5	-1.9	-2.2	-2.8	-0.1
Bipolar Disorder (2011)	3.7	3.6	7.3	1.3	1.7	1.8	2.0	0.6	2.4	2.7
Breastfed as a baby	3.7	4.7	11.2	-1.2	-1.0	-2.7	-3.4	-0.5	-1.6	-3.0
Past tobacco smoking	3.5	6.4	10.3	3.0	2.9	3.2	2.6	2.0	2.5	-0.3
Irritability	3.5	6.0	19.3	-0.7	-0.7	-2.1	-2.6	-0.8	-4.4	-3.1
Commuting to job workplace: Cycle	3.5	4.2	9.1	-1.9	-2.0	-1.7	-1.8	-1.4	-2.2	-3.0
Impedance of whole body	3.3	16.7	31.7	-1.8	-2.3	-4.0	-4.9	-2.1	-5.6	-5.6
Worrier / anxious feelings	3.2	6.1	18.9	1.6	1.3	-0.4	-2.0	0.6	-4.3	-3.8
Fasting Glucose	3.1	3.7	7.1	1.2	1.8	2.5	2.7	1.6	1.1	2.0
High blood pressure (mother)	3.1	4.3	10.8	-0.6	-0.9	-2.0	-2.8	0.4	-3.3	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.6	5.3	-2.3	-2.1	-2.0	-2.1	-2.1	-1.6	-0.5
Ever depressed for a whole week	3.1	3.8	7.4	-1.1	-1.2	-2.3	-2.6	-1.0	-1.9	-2.7
Unable to work because of sickness or disability	3.1	4.0	7.3	-2.7	-2.6	-2.2	-1.8	-1.4	-1.3	1.5
Medication: Blood pressure	3.0	5.7	16.3	-1.6	-1.6	-3.3	-4.0	0.1	-1.4	-2.3
Alcohol usually taken with meals	2.9	4.6	8.6	2.6	2.4	2.9	2.4	2.1	0.6	0.6
Ever unenthusiastic/disinterested for a whole week	2.9	3.6	6.3	-1.1	-1.1	-1.6	-2.4	-1.4	-2.4	-2.5
Hair/balding pattern: Pattern 3	2.9	4.3	6.5	2.4	2.4	2.3	2.5	2.3	0.8	0.8
Osteoporosis (self-reported)	2.9	3.5	6.3	1.6	1.6	2.3	2.5	0.1	2.0	2.0
Alcohol drinker status: Previous	2.9	3.4	8.5	-1.3	-1.3	-2.2	-2.9	-0.6	-1.9	-1.7
Osteoarthritis (self-reported)	2.8	3.6	8.5	-1.8	-1.8	-2.9	-2.7	-1.0	-1.3	-0.8
Medication: Amlodipine	2.7	3.8	11.5	-0.5	-0.6	-1.2	-2.6	-1.4	-2.0	-3.4
Medication: Omeprazole	2.7	3.2	8.8	-1.5	-1.3	-2.4	-3.0	-1.5	-0.8	-0.8
Worry (Nagel 2018)	2.6	5.4	18.1	0.6	0.4	-0.8	-2.0	0.0	-4.3	-3.8
Systolic Blood Pressure	2.6	12.8	31.8	-3.1	-3.1	-3.5	-3.4	-2.5	-5.6	-3.0
Ever had bowel cancer screening	2.6	3.0	5.9	-2.1	-2.2	-1.4	-1.6	-2.4	-1.0	-0.2
Pulse rate	2.4	4.1	8.9	0.9	1.2	3.0	2.7	0.8	0.8	2.9
Systolic blood pressure, automated reading	2.3	6.8	13.0	-2.5	-2.5	-2.8	-2.0	-3.0	-3.6	-1.1
High blood pressure	2.3	6.5	19.4	-1.1	-1.2	-2.9	-4.4	0.0	-2.6	-2.8
Financial difficulties in last 2 years	2.3	3.1	12.3	-0.4	-0.1	1.2	2.1	0.5	1.8	3.5
Medication: Atorvastatin	2.3	2.9	4.3	1.7	1.8	1.9	1.6	2.1	1.6	1.2
Neuroticism	2.2	5.4	20.8	1.1	1.0	-0.2	-1.4	1.2	-4.6	-3.3
Asthma	2.2	4.3	7.3	2.7	2.7	2.0	1.1	1.3	2.5	1.8
Leg pain on walking	2.2	2.8	4.8	-1.7	-1.5	-2.2	-2.2	-1.3	-1.7	0.1
Hypertension (Self-reported)	2.2	6.0	19.7	-1.3	-1.3	-3.0	-4.4	-0.0	-2.2	-2.3
Ever smoked	2.2	3.9	6.2	-2.3	-2.3	-2.0	-2.2	-1.0	-2.5	-0.5
Schizophrenia vs Biploar Disorder	2.1	2.8	4.9	-1.9	-2.2	-1.6	-1.4	-2.1	-1.2	-0.9
Smoking Status	2.1	4.9	8.0	-2.8	-2.6	-2.5	-2.8	-1.1	-2.0	-0.6
Neuroticism score	2.1	4.4	20.4	0.4	0.3	-0.6	-1.5	0.4	-4.5	-2.7
Major Depression (MDD)	2.0	2.5	4.6	-1.2	-1.1	-1.4	-2.1	-0.3	-2.1	-1.9
Ever highly irritable/argumentative for 2 days	2.0	2.4	4.2	-1.5	-1.4	-1.7	-2.1	-1.4	-1.4	-1.2
Smoking status: Previous	2.0	3.0	6.4	-1.6	-1.4	-2.5	-1.9	-1.8	-1.7	0.5
Average weekly champagne plus white wine intake	2.0	2.8	3.9	1.8	1.7	2.0	1.9	1.7	1.6	0.6
Taking other prescription medications	1.9	2.9	4.8	-1.9	-1.8	-2.1	-2.2	-1.4	-1.4	0.3
Birth weight	1.9	4.2	7.5	-1.8	-2.1	-2.0	-2.7	-1.4	-2.4	-1.7
High blood pressure (siblings)	1.9	2.7	6.5	-1.0	-1.2	-2.1	-2.1	-0.5	-2.5	-1.1
Pulse rate, automated reading	1.9	6.1	12.5	2.4	2.7	3.5	2.7	1.7	1.1	2.3
Medication: Bendroflumethiazide	1.9	2.9	8.7	-1.4	-1.4	-1.9	-3.0	-0.1	-1.1	-1.7
Medication: Lisinopril	1.9	2.5	6.4	-1.2	-1.1	-2.0	-2.5	-0.9	-1.6	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.9	-1.5	-1.3	-1.8	-2.4	-1.6	-0.9	-0.4
Neuroticism (Nagel 2018)	1.8	4.3	15.7	1.6	1.6	0.0	-1.4	1.0	-4.0	-2.6
Had major operations	1.8	2.1	3.3	1.8	1.8	1.8	0.8	1.6	1.4	0.0
Asthma (self-reported)	1.8	3.6	6.2	2.5	2.5	1.7	0.9	1.3	2.3	1.6
Tinnitus: Yes, now most or all of the time	1.8	2.0	4.1	-1.4	-1.5	-2.0	-1.7	-1.5	-0.9	0.2
LDL Cholesterol	1.7	2.7	5.9	1.3	1.4	2.4	2.4	0.9	0.7	1.6
Supplements: Zinc	1.7	1.9	6.3	0.1	0.1	0.1	1.7	-0.7	1.8	2.5
Nervous feelings	1.7	3.2	10.6	0.9	0.6	0.6	0.1	0.7	-3.2	-3.1
Heel bone mineral density (BMD) T-score, automated (right)	1.7	4.0	11.8	-1.2	-1.1	-2.6	-3.4	-0.1	-1.2	-2.2
Medication: Ramipril	1.7	2.2	5.2	2.3	2.0	1.7	0.8	1.7	0.1	0.2
Loneliness, isolation	1.7	2.4	4.0	1.2	1.3	1.7	1.9	1.7	-0.1	2.0
Commuting to job workplace: Public transport	1.7	2.1	8.7	0.4	0.4	-1.0	-1.9	-0.2	-0.8	-3.0
Schizophrenia (2018)	1.6	3.3	9.9	-2.1	-2.2	-1.5	-0.4	-3.1	-0.9	0.8
Alzheimer’s Disease (in father)	1.6	1.7	4.0	-0.5	-0.6	1.3	1.7	-1.5	0.9	2.0
Number of incorrect matches in round	1.6	2.6	10.2	0.9	1.2	0.7	1.7	0.5	1.5	3.2
Illnesses of siblings	1.6	2.3	6.2	0.4	0.6	1.9	2.1	0.8	2.5	0.8
Supplements: Vitamin C	1.6	1.9	4.9	1.5	1.4	0.5	0.1	1.7	2.2	0.7
Mood swings	1.6	2.8	11.9	-0.5	-0.4	-1.4	-1.8	-0.9	-3.5	-1.2
Mean Putamen Volume	1.5	1.7	6.3	-0.1	-0.3	-0.4	-1.0	-0.4	-2.0	-2.5
Impedance of leg (right)	1.5	7.2	23.9	-0.8	-1.3	-2.3	-3.0	-1.2	-4.9	-2.8
Current tobacco smoking	1.5	2.4	5.0	-2.2	-2.2	-1.2	-1.6	-0.8	-1.2	-0.9
Multivitamins +/- minerals	1.5	2.0	4.2	1.3	1.3	1.1	1.4	0.8	2.0	1.4
Alcohol intake versus 10 years previously	1.5	2.3	4.1	-2.0	-1.7	-2.0	-1.8	-0.9	-0.7	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	5.8	-0.4	-0.4	-1.9	-2.4	-0.2	-2.1	-1.4
Loud music exposure frequency	1.5	1.6	2.9	-1.7	-1.5	-1.7	-0.5	-1.5	-0.7	0.3
Health satisfaction	1.5	1.9	5.6	-1.1	-1.0	-1.9	-2.4	-0.7	-1.2	-0.3
Alcohol drinker status: Never	1.5	1.8	2.9	1.3	1.4	1.7	1.4	0.7	1.6	1.2
Vascular/heart problems diagnosed by doctor	1.5	4.1	13.3	0.9	0.9	2.4	3.6	-0.1	2.1	1.9
Cholesterol lowering medication	1.5	2.2	5.2	-0.7	-0.7	-1.9	-2.3	-0.4	-1.1	-2.1
Ulcerative Colitis (UC)	1.4	2.6	4.2	1.7	1.9	1.2	1.1	2.0	2.1	0.8
Ulcerative Colitis	1.4	2.1	3.6	1.9	1.9	1.2	1.2	1.6	1.4	0.4
Diabetes (father)	1.4	1.7	4.2	0.5	0.7	1.2	2.0	0.6	1.7	1.5
Impedance of leg (left)	1.4	6.8	21.7	-0.7	-1.2	-2.2	-3.1	-1.0	-4.7	-3.0
Illnesses of father: Heart disease	1.4	2.0	4.0	-1.8	-1.7	-2.0	-1.2	-1.3	-0.8	-0.0
Long-standing illness, disability or infirmity	1.4	2.2	4.8	-1.6	-1.4	-1.8	-2.2	-1.5	-0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	3.6	1.7	1.8	1.9	1.5	1.3	0.3	1.4
Myopia	1.4	2.0	3.6	-1.0	-1.2	-1.5	-1.3	-0.5	-1.8	-1.9
Alzheimer’s Disease (in mother)	1.3	1.5	4.2	-1.0	-0.9	-2.0	-1.4	-1.3	-0.6	-0.6
Respiratory disease	1.3	2.8	4.9	2.0	2.0	1.7	1.0	1.4	2.2	1.0
Relative age of first facial hair	1.3	2.7	6.0	-1.7	-1.7	-2.5	-1.7	-0.7	-1.6	-1.0
Average weekly fortified wine intake	1.3	1.5	2.8	1.0	0.9	1.4	1.7	1.0	0.8	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	5.7	-1.6	-1.3	-0.8	-0.7	-1.1	-2.4	0.1
Arm fat-free mass (right)	1.3	6.5	19.3	0.2	0.7	1.7	2.3	1.6	3.9	4.4
Worry too long after embarrassment	1.3	2.1	7.4	1.0	0.8	0.5	-0.3	0.5	-2.7	-2.2
Friendships satisfaction	1.3	1.6	3.2	-0.9	-1.0	-0.9	-0.7	-1.8	-1.8	-1.5
Arm predicted mass (left)	1.3	6.4	21.4	-0.2	0.4	1.6	2.5	1.3	3.6	4.6
Height	1.2	23.6	43.2	-5.2	-5.4	-6.0	-6.6	-3.5	-3.2	-2.6
Vitamin and mineral supplements	1.2	1.7	3.7	-1.6	-1.5	-0.8	-0.7	-0.9	-1.9	-1.0
Townsend deprivation index at recruitment	1.2	1.7	4.5	-1.4	-0.9	-2.1	-1.4	-0.3	-1.3	0.9
Fed-up feelings	1.2	2.1	7.9	-1.0	-0.9	-0.5	-0.7	-2.0	-2.8	-0.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.9	1.7	1.7	1.5	0.4	1.4	0.7	-1.0
Time employed in main current job	1.2	1.4	2.9	-1.4	-1.1	-1.7	-1.0	-1.5	-0.1	0.5
Depression (self-reported)	1.2	1.5	4.9	0.5	0.5	-0.8	-1.7	0.1	-2.2	-1.2
Pulse wave Arterial Stiffness index	1.2	1.4	2.4	-1.0	-0.9	-1.0	-1.5	-1.2	-1.5	-1.1
Medication: Aspirin	1.2	1.6	1.9	1.3	1.4	1.4	0.7	1.1	1.4	1.3
Smoking status: Current	1.2	1.8	4.7	-2.2	-2.2	-0.9	-1.3	-0.5	-0.8	-0.4
Irritable Bowel Disease (IBD)	1.1	2.5	3.8	1.5	1.8	1.3	1.3	1.8	2.0	1.3
Severe depression (siblings)	1.1	1.2	3.4	1.0	1.1	0.9	0.7	1.8	0.7	1.0
Medication: Simvastatin	1.1	1.6	3.7	-0.9	-0.9	-1.5	-1.9	-1.1	-1.2	-1.3
Medication: Lansoprazole	1.1	1.3	3.2	-1.6	-1.5	-0.5	-0.6	-0.8	-1.8	0.1
Length of working week for main job	1.1	1.3	2.1	-1.3	-1.3	-1.0	-0.4	-1.1	-0.9	1.4
Tense / ‘highly strung’	1.1	1.8	7.3	-0.4	-0.5	-1.0	-1.3	0.4	-2.7	-1.5
Guilty feelings	1.1	1.7	3.3	1.7	1.8	0.7	0.6	1.7	-1.0	-0.9
Schizophrenia (2014)	1.0	2.2	5.6	-1.8	-1.7	-1.4	-0.3	-2.4	-0.5	1.1
Cardiovascular Disease	1.0	3.3	10.4	-1.4	-1.2	-2.2	-3.2	0.4	-1.3	-1.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.5	1.1	0.9	1.6	1.4	0.5	0.7	0.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.0	0.4	0.6	1.3	1.4	0.3	1.1	1.2
Allergy	1.0	2.2	4.4	-1.7	-1.9	-1.8	-0.8	-0.6	-2.1	-0.9
Pain all over the body in last month	1.0	1.1	3.0	-1.0	-1.0	-1.5	-1.7	0.0	-0.6	-0.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.6	-0.2	0.1	0.5	0.5	-0.6	1.9	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	3.8	-0.7	-0.8	-1.0	-0.9	-2.0	-1.1	0.3
Arm predicted mass (right)	1.0	4.9	15.2	-0.1	0.4	1.3	1.9	1.4	3.5	3.9
Diabetes diagnosed by doctor	1.0	1.6	3.5	1.1	1.1	1.1	1.0	1.0	1.9	1.4
Medication: Aspirin	1.0	1.3	1.9	1.3	1.4	1.1	0.6	1.0	1.3	1.2
Illnesses of father: None of the above (group 1)	1.0	1.2	2.9	1.4	1.2	1.1	0.7	1.7	0.4	-0.5
Arm fat-free mass (left)	1.0	5.2	18.4	-0.3	0.3	1.3	2.1	1.1	3.3	4.3
Neuroticism (2016)	0.9	1.3	2.5	1.5	1.6	0.7	-0.4	0.7	-1.5	-0.9
Primary Biliary Cirrhosis	0.9	1.4	2.9	1.1	1.2	0.5	0.9	1.1	1.7	1.2
Blood Eosinophil Count	0.9	6.8	10.3	-2.7	-2.7	-2.9	-3.2	-1.5	-2.5	-2.3
Lung FEV1/FVC ratio	0.9	4.5	6.8	-2.6	-2.6	-2.6	-1.6	-1.5	-2.4	-0.7
Pack years adult smoking proportion	0.9	1.3	2.2	-1.5	-1.4	-1.1	-0.9	-0.8	-1.0	-1.3
Medication: Atenolol	0.9	1.1	2.6	0.9	0.9	-0.7	-1.6	-0.3	0.0	-1.6
Mouth/teeth dental problems	0.9	1.4	3.1	-1.6	-1.8	-1.5	-1.0	0.1	0.2	-1.0
Fluid intelligence score	0.9	1.9	9.7	-0.6	-0.6	-0.5	-1.3	-0.6	-0.7	-3.1
Happiness	0.9	1.2	3.2	1.4	1.4	1.8	0.5	0.4	0.7	0.2
Exposure to tobacco smoke at home	0.9	1.0	2.7	0.2	0.3	1.4	1.2	0.2	0.6	1.6
Headache pain in last month	0.9	1.6	4.8	1.7	1.7	0.8	0.3	2.2	-0.1	-0.4
Suffer from ‘nerves’	0.9	1.3	3.8	0.3	0.4	-0.2	-1.3	0.4	-1.9	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.0	1.0	1.0	1.4	1.2	0.3	0.7	0.8
Medication for cholesterol	0.9	1.3	4.9	0.5	0.4	1.8	2.2	-0.3	-0.2	0.7
Age started oral contraceptive pill	0.9	1.1	2.9	-0.0	-0.2	-1.7	-1.2	-0.8	-0.1	-1.7
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.7	-0.1	0.3	0.5	1.4	0.3	0.4	1.9
Forced vital capacity (FVC)	0.8	2.9	6.3	-2.5	-2.4	-1.8	-1.2	-0.9	-1.6	-0.4
Noisy workplace	0.8	0.9	4.5	-0.5	-0.3	-1.0	-0.1	-0.9	-0.1	2.1
Lung cancer (father)	0.8	0.9	1.6	1.3	1.1	0.4	-0.7	1.2	0.2	-1.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.1	0.9	1.1	1.4	1.4	0.6	-0.3	1.1
Comparative body size at age 10	0.8	2.2	9.7	1.1	1.1	0.9	0.5	1.4	3.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.6	-0.2	-0.3	-0.8	-1.4	0.5	-1.9	-1.0
Pulse wave peak to peak time	0.8	1.0	1.7	0.8	0.7	0.8	1.2	1.1	1.3	0.7
Migraine (self-reported)	0.8	0.9	2.2	1.5	1.1	0.7	0.2	1.3	0.3	0.9
Medication: Seretide 50 evohaler	0.8	1.0	2.8	-0.8	-0.6	-1.7	-1.2	-0.7	0.4	0.8
Number of self-reported non-cancer illnesses	0.8	1.3	5.7	-0.1	-0.1	-1.3	-2.4	0.6	-0.9	-0.8
Ever taken oral contraceptive pill	0.8	0.9	2.1	0.1	0.2	-1.1	-1.4	-0.7	-1.1	-1.0
Medication: Paracetamol	0.8	1.2	2.5	1.5	1.4	0.8	0.5	1.6	-0.4	-0.8
Bipolar Disorder (2018)	0.7	1.0	2.4	0.7	0.9	1.2	1.6	0.4	0.5	1.2
Body Mass Index (BMI) (2010)	0.7	0.9	4.2	-0.2	0.1	0.4	0.8	0.2	1.1	2.1
HDL Cholesterol	0.7	1.1	2.4	-1.2	-1.6	-0.1	-0.2	-0.8	-1.3	-1.3
Lupus	0.7	1.0	1.7	0.6	0.8	1.2	1.0	-0.2	1.3	1.3
Heel T-Score	0.7	5.9	13.5	-2.3	-2.2	-2.7	-3.7	-2.1	-1.9	-1.4
Allergy or Eczema	0.7	1.7	3.2	1.6	1.7	1.7	0.4	0.5	1.8	0.2
Number of treatments/medications taken	0.7	1.3	5.2	0.4	0.4	-1.3	-2.3	-0.4	-0.4	-1.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.4	-0.6	-0.5	-1.1	-1.3	-0.6	-1.8	-0.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.5	1.3	1.4	1.9	0.7	0.5	1.5	0.6
Body mass index (BMI)	0.7	3.2	11.0	-0.5	0.2	0.2	1.4	0.3	2.9	3.3
Waist circumference	0.7	2.5	8.2	-0.4	0.2	0.5	1.3	0.6	2.6	2.9
Hearing difficulty/problems with background noise	0.7	1.1	3.4	0.7	0.9	0.5	0.7	-0.6	1.3	1.9
Trunk fat-free mass	0.7	4.2	12.8	0.0	0.4	1.5	1.8	1.0	3.2	3.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.3	-2.3	-2.2	-1.8	-1.1	-0.1	-1.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.1	0.6	0.5	0.1	0.3	-0.9	-1.8	-1.0
Prospective memory result	0.7	0.9	2.5	-0.4	-0.2	-1.1	-1.6	-0.7	-0.8	-0.9
Trunk predicted mass	0.7	4.2	12.4	0.1	0.5	1.5	1.8	0.9	3.2	3.5
Blood clot in the leg (DVT)	0.7	0.9	2.4	0.6	0.9	0.7	1.0	0.4	1.5	1.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.1	-1.4	-1.3	-1.5	-1.0	-1.4	-0.6	0.6
Number of full brothers	0.7	0.9	1.8	-1.3	-1.2	-1.0	-0.9	-0.9	-0.5	-0.3
Emphysema/chronic bronchitis	0.7	0.8	2.0	-0.8	-0.8	-0.9	-1.4	-1.0	-0.8	-0.2
Medication: Ibuprofen	0.7	0.9	2.4	0.9	0.7	0.0	0.2	-1.1	-1.6	-1.2
Alcohol intake frequency.	0.7	1.5	2.8	-1.7	-1.5	-1.4	-1.3	-1.3	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	0.7	0.5	1.3	0.9	0.7	-0.7	1.1
Whole body water mass	0.7	3.9	11.8	-0.6	-0.1	0.9	1.6	0.9	3.3	3.4
Fractured/broken bones in last 5 years	0.7	1.0	2.6	0.2	0.1	0.6	1.6	-0.1	1.2	1.5
Supplements: Calcium	0.7	0.8	1.5	-0.7	-0.5	-0.8	0.4	-1.2	0.9	1.2
Heart disease (siblings)	0.7	0.9	1.8	-1.0	-1.0	-1.0	-1.0	-0.2	-1.3	0.4
Pack years of smoking	0.7	1.1	1.8	-1.2	-1.0	-1.1	-1.1	-0.7	-0.8	-1.4
Bipolar Disorder or Schizophrenia	0.6	1.4	4.8	-1.2	-1.1	-0.4	0.6	-2.2	-0.4	1.4
Depressed Affect (Nagel 2018)	0.6	1.3	7.2	0.3	0.4	-0.4	-1.0	-0.0	-2.7	-0.4
Depression (Nagel 2018)	0.6	0.8	2.2	-0.9	-0.7	-0.7	-0.8	-1.1	-1.5	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	7.8	-0.1	-0.3	-0.2	-1.5	-0.5	-0.6	-2.8
HbA1C	0.6	0.7	2.1	0.3	0.4	1.1	1.1	-0.0	1.4	0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	0.4	0.4	1.2	1.0	0.9	1.4	1.5
Chronotype (morning person)	0.6	1.3	3.9	0.4	0.3	0.1	-1.4	2.0	-1.4	-1.3
Medication: Metformin	0.6	0.8	2.3	-0.1	-0.1	0.6	1.2	0.3	1.1	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.8	-0.3	-0.2	-1.7	-2.2	-0.2	-0.2	-1.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	-0.8	-0.7	-1.0	-1.1	-1.3	-0.4	-0.2
Illnesses of mother	0.6	0.8	2.0	0.6	0.7	1.4	1.4	0.2	0.6	0.3
Pulse wave reflection index	0.6	0.8	2.2	-0.3	-0.5	-1.2	-1.5	-0.4	-0.8	-0.9
Medication: Paracetamol	0.6	1.0	2.8	1.0	1.0	0.1	-0.2	1.7	-0.8	-1.2
Shortness of breath walking on level ground	0.6	0.7	1.2	-0.9	-1.0	-0.1	-0.4	-1.0	-0.7	1.1
Overall health rating	0.6	1.3	5.2	-1.3	-1.1	-0.9	-0.5	-0.0	0.2	2.3
Age at last live birth	0.6	0.9	2.7	-0.6	-1.0	-0.5	0.2	0.4	-1.7	-1.3
Family relationship satisfaction	0.6	0.8	2.2	-0.8	-0.6	-0.3	-0.4	-1.3	-1.5	0.6
Whole body fat-free mass	0.6	3.7	11.0	-0.5	-0.0	0.9	1.5	0.9	3.2	3.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-1.1	-0.8	-0.4	-1.1	0.9	0.5	0.9
Mineral and other dietary supplements	0.6	0.8	2.5	-0.8	-0.7	0.5	0.3	0.7	-1.6	-1.1
Miserableness	0.6	1.1	4.9	-0.3	-0.0	-0.6	-1.4	0.2	-2.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.5	1.6	1.4	-0.1	-0.8	-0.2	0.8	-0.3
Basal metabolic rate	0.6	3.3	10.8	-0.9	-0.3	0.5	1.3	0.6	3.0	3.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.2	0.5	0.8	0.6	0.9	0.5	1.5	0.9
Intelligence (Savage-Jansen 2018)	0.5	1.7	7.2	-0.1	-0.2	-0.6	-1.6	-0.9	-0.8	-2.7
Blood White Count	0.5	3.6	9.7	1.9	1.9	3.1	2.5	1.1	0.4	0.6
BMI	0.5	2.9	10.0	-1.1	-0.4	-0.2	1.4	0.4	3.2	2.6
Angina	0.5	0.6	3.0	0.4	0.4	-0.0	0.6	0.1	0.8	1.7
Diabetes (mother)	0.5	0.6	1.4	-1.2	-0.8	-0.9	0.0	0.1	0.6	1.0
Leg fat-free mass (left)	0.5	2.4	7.5	-1.4	-0.9	-0.2	0.8	0.3	2.7	2.4
Trunk fat percentage	0.5	1.9	5.0	-1.8	-1.3	-2.2	-1.4	-1.0	-0.0	0.3
Relative age voice broke	0.5	0.7	1.8	-0.8	-0.7	-1.0	-1.3	-0.2	-0.3	-0.9
Qualifications: CSEs or equivalent	0.5	0.7	2.4	-0.3	-0.1	0.5	0.9	1.3	-1.5	0.0
Serious illness, injury or assault to yourself	0.5	0.6	1.1	-0.8	-0.7	-0.1	0.8	-0.7	-0.9	1.1
Stomach or abdominal pain in last month	0.5	0.6	1.4	0.9	1.0	-0.2	-0.5	0.6	-1.2	0.7
Medication: Levothyroxine sodium	0.5	0.8	1.4	-0.6	-0.7	-1.2	-1.1	-0.3	-1.2	-0.9
Leg predicted mass (left)	0.5	2.6	8.1	-1.4	-0.9	-0.1	0.9	0.4	2.8	2.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	4.8	-0.1	0.0	0.1	-0.4	0.3	-2.2	0.4
Glaucoma (self-reported)	0.5	0.6	1.7	-1.3	-1.0	0.3	0.5	-0.9	0.5	0.1
Qualifications: College or University degree	0.5	1.7	5.7	-0.3	-0.6	-1.1	-2.4	-1.3	-0.4	-1.6
Medication: Blood pressure	0.5	0.8	2.2	0.5	0.3	-0.4	-1.5	-0.1	-1.3	-1.1
Angina (self-reported)	0.5	0.7	2.9	0.5	0.5	0.1	0.6	0.2	0.9	1.7
Leg fat mass (right)	0.5	1.8	7.2	-1.4	-0.7	-0.8	0.2	-0.2	1.6	2.7
Leg fat-free mass (right)	0.5	2.4	8.5	-1.3	-0.8	-0.1	0.8	0.5	2.9	2.3
Eye problems/disorders: Cataract	0.5	0.5	2.6	-0.3	-0.4	-0.2	-0.2	-0.7	-0.5	-1.6
Leg predicted mass (right)	0.5	2.4	8.4	-1.3	-0.8	-0.1	0.8	0.5	2.9	2.3
Financial situation satisfaction	0.5	0.6	1.3	-1.0	-0.9	-0.2	0.1	-0.8	-0.5	1.1
High cholesterol (Self-reported)	0.5	0.9	1.7	-1.3	-1.2	-1.2	-1.0	-0.6	-0.5	-0.2
Leg fat mass (left)	0.5	2.0	7.6	-1.4	-0.7	-0.7	0.3	-0.2	1.9	2.8
Age at First Birth	0.4	0.6	1.9	0.8	0.8	0.4	0.3	1.4	0.6	0.3
Rheumatoid Arthritis	0.4	0.6	2.8	-0.4	-0.2	-0.9	-1.7	0.3	0.5	0.0
Triglycerides	0.4	0.7	1.1	0.7	0.9	0.8	0.9	0.7	0.9	1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-1.1	-1.0	-0.3	-0.5	-0.6	-0.3	0.5
Medication for hormone replacement therapy	0.4	0.5	1.1	-0.9	-1.0	-0.3	0.3	-0.5	0.8	0.7
Maternal smoking around birth	0.4	0.6	2.0	-0.1	0.4	-0.9	-0.4	0.9	0.2	1.4
Trunk fat mass	0.4	1.7	3.3	-1.8	-1.2	-1.8	-0.9	-0.7	1.0	1.4
Had other major operations	0.4	0.5	1.5	-0.6	-0.4	-1.2	-0.8	-0.2	-0.7	0.3
Weight	0.4	2.2	7.1	-1.3	-0.7	-0.6	0.1	0.0	2.4	2.7
Arm fat percentage (right)	0.4	1.5	3.1	-1.7	-1.2	-1.8	-0.7	-1.4	0.6	0.7
Arm fat mass (right)	0.4	1.6	3.7	-1.6	-0.9	-1.1	-0.0	-0.7	1.5	1.9
Wheeze or whistling in the chest in last year	0.4	0.8	3.7	-0.7	-0.5	-0.3	-0.8	0.1	0.2	1.9
Heart disease (mother)	0.4	0.5	1.7	-0.3	-0.3	0.0	0.2	-0.7	0.9	1.3
Whole body fat mass	0.4	1.5	4.0	-1.4	-0.8	-1.2	-0.2	-0.3	1.6	2.0
Knee pain experienced in last month	0.4	0.7	1.2	-0.8	-0.7	-0.8	-1.1	-0.5	-1.1	0.5
Arm fat percentage (left)	0.4	1.7	4.1	-1.8	-1.3	-2.0	-1.1	-1.3	0.5	0.3
Average weekly red wine intake	0.4	0.6	1.7	0.0	-0.2	-0.7	-0.7	-0.7	-1.3	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-0.6	-0.6	-1.0	-0.6	-1.1	-0.3	0.6
Commuting to job workplace: Walk	0.4	0.4	0.5	-0.7	-0.7	-0.7	-0.5	-0.7	0.1	-0.7
Breast cancer (self-reported)	0.4	0.5	1.5	-0.4	-0.2	-1.1	-1.2	-0.2	0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.3	-1.2	-1.1	-0.3	0.8	0.1	0.5	1.5
Arm fat mass (left)	0.4	1.5	3.4	-1.5	-0.9	-1.2	-0.2	-0.6	1.6	1.8
Wears glasses or contact lenses	0.4	0.5	1.2	-0.7	-0.7	-0.8	-0.5	-1.1	-0.6	0.2
Mother’s age at death	0.4	0.5	2.3	-0.2	-0.3	0.2	-0.1	-1.5	0.1	-1.0
Illnesses of father: High blood pressure	0.4	0.5	1.2	-0.4	-0.4	-0.8	-0.7	1.1	-0.0	-0.7
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	0.8	0.7	0.6	0.1	0.8	0.5	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.5	-0.6	-0.7	-0.1	0.2	-1.2	0.1	0.8
Crohns Disease (2017)	0.3	0.7	2.0	0.1	0.6	0.6	0.7	0.5	1.2	1.4
Coronary Artery Disease (CAD)	0.3	0.4	0.9	0.8	0.9	0.2	0.0	0.7	-0.5	0.5
Crohns Disease (2012)	0.3	0.4	1.2	0.4	0.6	-0.0	0.1	0.3	1.1	1.0
Waist Hip Ratio (WHR)	0.3	1.4	3.4	1.0	1.0	1.8	1.6	0.9	0.3	1.0
Hypothyroidism (self reported)	0.3	0.7	2.4	-0.9	-0.8	-0.8	-0.5	-0.8	0.0	1.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	-0.7	-0.7	0.4	0.3	0.0	1.0	0.2
Supplements: Glucosamine	0.3	0.4	1.3	-0.2	-0.2	-0.3	-0.4	-0.4	0.9	1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	-0.3	-0.3	0.3	0.9	-0.3	0.9	0.8
Sitting height	0.3	1.8	4.3	-1.4	-1.6	-1.7	-2.1	-1.0	-0.2	0.3
Heart attack	0.3	0.4	0.8	0.4	0.4	0.7	0.7	0.2	0.9	0.7
Hip circumference	0.3	1.3	3.9	-1.1	-0.5	-0.7	-0.1	-0.1	2.0	1.9
Father’s age at death	0.3	0.3	1.2	0.5	0.3	0.3	0.7	0.0	1.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.6	-1.6	-1.5	-1.2	-0.2	0.5	-0.5	0.8
Standing height	0.3	3.2	8.2	-1.7	-2.0	-2.1	-2.9	-0.7	-0.9	-1.2
Birth weight of first child	0.3	0.6	1.6	0.9	0.8	0.4	0.0	1.3	0.9	0.2
Gout (self-reported)	0.3	0.4	2.2	-0.5	-0.3	-0.5	-0.2	-0.1	0.2	1.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.6	-0.7	-0.4	0.3	-0.4	-0.8	0.7
Forced vital capacity (FVC), Best measure	0.3	1.2	3.0	-1.7	-1.6	-1.3	-0.9	-0.3	-0.5	0.2
Body fat percentage	0.3	1.3	3.5	-1.5	-1.0	-1.9	-0.9	-0.8	0.3	0.8
Leg fat percentage (right)	0.3	1.1	4.5	-1.1	-0.5	-1.0	0.1	-0.6	0.8	2.1
Number of children fathered	0.3	0.3	0.9	-0.0	-0.3	-0.4	-0.9	-0.4	-0.5	-0.8
Eye problems/disorders: None of the above	0.3	0.4	1.3	0.3	0.4	-0.4	-0.8	0.5	-1.1	-0.1
Medication: Allopurinol	0.3	0.4	1.3	-0.4	-0.4	0.4	0.6	-0.7	0.4	1.1
Chest pain or discomfort	0.3	0.5	0.9	-1.0	-0.8	-0.6	-0.8	-0.3	-0.5	0.5
Illnesses of siblings: Diabetes	0.3	0.3	0.9	0.9	0.9	0.3	0.5	0.3	-0.3	0.0
Qualifications: nursing, teaching	0.3	0.4	1.0	0.5	0.4	-0.1	-0.7	0.8	1.0	-0.7
Medication: Gliclazide	0.3	0.4	1.0	-0.2	-0.5	0.7	1.0	0.2	0.2	0.8
Hearing aid user	0.3	0.4	0.9	0.5	0.7	0.3	0.1	0.3	0.9	0.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.7	-0.4	0.6	0.7	-0.7	0.5	-0.2
Leg fat percentage (left)	0.3	1.2	4.6	-1.1	-0.5	-0.9	0.1	-0.5	1.1	2.1
Number of operations (self-reported)	0.3	0.5	1.0	0.7	1.0	0.8	-0.1	1.0	0.1	0.3
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.7	-0.5	-0.6	-0.7	0.3	0.6	0.8
Risk taking	0.3	0.5	1.5	-0.3	-0.2	-0.9	-0.6	-0.5	0.4	1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	0.4	0.4	0.7	0.7	0.3	0.9	0.8
Breast Cancer	0.2	0.4	1.4	-0.5	-0.5	-0.0	-0.6	0.3	0.4	-1.2
Ovarian Cancer	0.2	0.2	0.8	0.5	0.4	0.1	-0.4	-0.4	-0.2	-0.9
Lung FVC	0.2	0.8	2.2	-1.5	-1.3	-0.7	0.2	-0.5	-0.8	0.8
Tanning	0.2	1.9	4.2	1.3	1.4	1.0	0.5	2.1	2.0	0.2
Hearing difficulty/problems: Yes	0.2	0.4	1.1	0.4	0.5	-0.1	0.5	-0.8	0.5	1.1
Hand grip strength (right)	0.2	0.6	1.1	-0.9	-1.1	0.4	1.0	-0.9	-0.1	0.6
Qualifications: None of the above	0.2	0.4	2.0	-0.5	-0.3	-0.3	0.5	-0.5	-0.1	1.4
Diabetes (self-reported)	0.2	0.3	1.6	0.2	0.2	-0.1	-0.0	0.4	1.3	0.6
Number of live births	0.2	0.4	0.9	0.1	-0.0	0.8	0.4	-1.0	0.5	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	0.2	0.1	-0.3	-0.3	0.1	0.1	-1.0
Medication: Cholesterol lowering	0.2	0.3	0.4	0.6	0.6	0.6	-0.0	0.6	0.3	0.5
Peak expiratory flow (PEF)	0.2	0.4	0.8	-0.7	-0.6	-0.8	-0.3	0.5	0.4	0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.2	0.4	0.3	0.2	0.0	1.1	0.0	-1.0
Medication for pain relief, constipation, heartburn	0.2	0.4	1.4	-0.4	-0.4	0.1	0.8	-0.4	1.2	0.7
Neck or shoulder pain in last month	0.2	0.3	0.7	0.7	0.4	0.4	0.2	0.1	-0.8	0.8
Comparative height size at age 10	0.2	1.3	2.3	-1.1	-1.1	-1.2	-1.5	-0.4	1.5	0.2
Number of full sisters	0.2	0.3	1.0	-0.2	-0.3	-0.2	-0.3	-1.0	-0.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	0.1	0.1	0.5	0.6	0.1	-0.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.8	-0.9	-0.8	-0.0	-0.1	-0.5	0.2	1.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	0.7	0.8	-0.4	-0.6	-0.1	0.4	0.3
Pain experienced in last month	0.2	0.3	0.7	-0.7	-0.8	-0.2	0.2	-0.4	0.4	-0.8
Prostate Cancer	0.1	0.2	0.8	0.0	0.2	0.9	0.5	0.2	0.3	0.6
Blood Platelet Count	0.1	1.2	3.7	-0.0	-0.3	-0.8	-0.7	0.0	-1.8	-1.9
Hand grip strength (left)	0.1	0.4	1.0	-0.5	-0.6	0.1	1.0	-0.4	0.1	0.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	0.3	0.3	0.0	-0.4	-0.3	0.4	0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.5	-0.2	-0.2	0.2	-0.0	0.4	-0.3	-0.7
Age when periods started (menarche)	0.1	0.3	0.8	0.1	-0.1	-0.1	0.9	-0.1	-0.6	0.9
Had menopause	0.1	0.1	0.4	-0.3	-0.6	-0.0	0.1	-0.2	0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.5	-0.3	-0.4	-0.3	-0.5	-0.3	0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.5	0.4	0.7	0.6	0.3	0.6	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.7	0.8	-0.3	-0.1	-0.3	0.1	-0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	0.1	-0.0	-0.1	-0.1	-0.8	0.7	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.5	-0.0	-0.1	-0.0	0.7	-0.4	0.4	-0.2
Age at first live birth	0.1	0.2	0.5	0.0	-0.4	-0.3	0.1	0.7	-0.2	-0.7
Back pain experienced in last month	0.1	0.1	0.6	0.1	0.3	-0.1	-0.2	0.1	0.0	-0.7
Hair Pigment	0.0	0.7	1.2	1.0	1.1	0.8	0.6	0.7	0.8	0.6

Hub : Genes

ELP4

Models

Trait associations