Best TWAS P=5.41e-13 · Best GWAS P=3.59e-13 conditioned to 0.000151
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DCAF4 | 0.23 | 0.07 | enet | 30 | 0.13 | 4.3e-07 | -4.7 | -5.7 | 1.2e-08 | 0.53 | 0.32 | 0.64 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | DCAF4 | 0.24 | 0.10 | lasso | 6 | 0.18 | 1.2e-09 | -5.0 | -6.8 | 1.2e-11 | 0.53 | 0.87 | 0.06 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | DCAF4 | 0.16 | 0.07 | lasso | 4 | 0.03 | 4.4e-02 | 5.3 | -5.8 | 5.1e-09 | 0.35 | 0.10 | 0.11 | FALSE |
| 4 | GTEx | Colon Sigmoid | DCAF4 | 0.30 | 0.10 | lasso | 9 | 0.11 | 1.3e-04 | -5.5 | -6.9 | 7.0e-12 | 0.58 | 0.12 | 0.31 | FALSE |
| 5 | GTEx | Colon Transverse | DCAF4 | 0.26 | 0.27 | lasso | 10 | 0.27 | 2.7e-13 | -5.0 | -5.7 | 1.1e-08 | 0.61 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | DCAF4 | 0.18 | 0.01 | enet | 10 | 0.06 | 3.0e-03 | -5.5 | -6.5 | 6.1e-11 | 0.52 | 0.09 | 0.37 | FALSE |
| 7 | GTEx | Esophagus Mucosa | DCAF4 | 0.30 | 0.19 | enet | 35 | 0.23 | 1.3e-15 | -5.5 | -5.3 | 1.4e-07 | 0.51 | 0.99 | 0.01 | FALSE |
| 8 | GTEx | Esophagus Mucosa | ZFYVE1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 2.0e-01 | -5.5 | -7.1 | 1.2e-12 | 0.66 | 0.23 | 0.25 | FALSE |
| 9 | GTEx | Pancreas | DCAF4 | 0.20 | 0.15 | lasso | 4 | 0.14 | 2.4e-06 | -5.5 | -5.3 | 1.3e-07 | 0.51 | 0.51 | 0.04 | FALSE |
| 10 | GTEx | Spleen | DCAF4 | 0.47 | 0.12 | enet | 10 | 0.19 | 1.5e-05 | -5.0 | -7.2 | 5.4e-13 | 0.58 | 0.13 | 0.82 | TRUE |
| 11 | GTEx | Spleen | NUMB | 0.46 | -0.01 | enet | 28 | 0.09 | 3.2e-03 | -2.4 | -6.7 | 1.7e-11 | 0.51 | 0.06 | 0.49 | FALSE |
| 12 | NTR | Blood | DCAF4 | 0.04 | 0.03 | lasso | 6 | 0.03 | 6.5e-09 | -5.5 | -5.8 | 5.0e-09 | 0.58 | 0.96 | 0.04 | FALSE |
| 13 | YFS | Blood | NUMB | 0.04 | 0.02 | blup | 461 | 0.03 | 3.9e-09 | 4.5 | -5.7 | 1.1e-08 | 0.07 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DCAF4 | 0.04 | 0.02 | blup | 83 | 0.03 | 1.2e-04 | -4.5 | -6.2 | 7.3e-10 | 0.75 | 0.15 | 0.70 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPF3 | 0.18 | 0.18 | lasso | 7 | 0.22 | 1.6e-24 | -6.1 | -6.9 | 4.6e-12 | 0.48 | 0.52 | 0.48 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DPF3 | 0.05 | 0.04 | lasso | 3 | 0.03 | 2.0e-04 | -5.9 | -5.8 | 5.1e-09 | 0.36 | 0.45 | 0.47 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | DPF3 | 0.10 | 0.02 | blup | 210 | 0.07 | 1.9e-07 | 4.2 | 7.0 | 3.1e-12 | -0.50 | 0.82 | 0.12 | FALSE |