Hub : Genes

NUMB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.1430 0.0590 2.8e-03 -0.004 NA -0.008 NA -0.008 4.4e-01 NA 7.9e-01 NA 8.3e-01
2 GTEx Spleen 0.4650 0.0980 3.1e-05 -0.010 NA 0.086 NA 0.021 7.3e-01 NA 3.2e-03 NA 9.5e-02
3 GTEx Testis 0.3680 0.0850 9.9e-06 0.050 NA 0.272 NA 0.106 3.0e-03 NA 1.7e-12 NA 1.9e-05
4 YFS Blood 0.0400 0.0120 2.0e-07 0.022 0.026 0.022 0.026 0.021 9.8e-08 3.9e-09 9.4e-08 6.2e-09 1.3e-07
5 TCGA Breast Invasive Carcinoma 0.0439 0.0248 9.1e-04 0.017 0.013 0.010 NA 0.014 1.5e-04 7.2e-04 3.1e-03 NA 5.3e-04
6 TCGA Testicular Germ Cell Tumors 0.1170 0.0590 9.0e-03 0.004 0.029 -0.008 NA -0.007 2.3e-01 3.4e-02 9.1e-01 NA 7.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.5 1.9 0.8 0.1 -0.6 -0.3 -0.4 1.4
Bipolar Disorder or Schizophrenia 0.7 1.8 8.7 -0.6 -0.5 -0.8 -0.2 -3.0 -1.0
Depressed Affect (Nagel 2018) 0.4 0.9 2.8 -0.1 0.8 -1.7 1.0 -0.9 -0.3
Depression (Nagel 2018) 0.5 0.8 1.8 -0.1 1.4 -0.8 1.1 -1.0 -0.4
Intelligence (Savage-Jansen 2018) 1.8 5.6 14.6 0.3 -3.8 0.6 -3.3 -1.0 2.5
Neuroticism (Nagel 2018) 0.1 0.3 0.6 -0.7 -0.4 -0.7 -0.2 -0.8 -0.2
Schizophrenia (2018) 1.6 3.4 12.1 -1.4 -0.7 -0.7 0.0 -3.5 -2.3
Schizophrenia vs Biploar Disorder 1.0 1.3 3.3 -0.9 1.2 -0.2 1.8 -0.4 -1.5
Worry (Nagel 2018) 0.3 0.6 2.6 -1.6 -0.4 0.0 -0.3 -0.6 -0.3
Alzheimer’s Disease (in mother) 3.3 3.9 11.3 1.4 0.8 1.9 -1.0 3.4 2.2
Alzheimer’s Disease (in father) 0.9 0.9 2.5 -0.6 0.4 1.3 -0.3 1.6 -0.9
Alzheimer’s Disease (including proxy) 1.4 2.1 7.2 -0.3 0.7 1.9 -0.6 2.7 0.8
Crohns Disease (2017) 0.3 0.6 1.3 -0.9 -0.7 -0.8 0.5 -1.1 -0.1
Irritable Bowel Disease (IBD) 0.3 0.7 2.9 -0.5 -0.5 -0.6 0.4 -1.7 0.4
Ulcerative Colitis (UC) 0.4 0.7 2.5 0.4 0.2 -0.8 0.6 -1.6 0.8
Major Depression (MDD) 0.3 0.3 1.0 -0.1 -1.0 0.5 0.4 -0.1 -0.7
Reaction Time 0.6 1.2 2.8 1.7 -0.4 -0.9 0.5 1.5 1.0
Verbal and Numeric Reasoning (VNR) 2.0 4.9 19.0 0.5 -2.8 0.8 -4.4 -0.3 1.2
Breast Cancer 0.2 0.6 1.4 -0.7 0.6 -1.2 -0.9 0.4 0.6
Ovarian Cancer 1.3 1.7 4.7 1.7 2.2 -0.1 0.7 1.5 -0.3
Prostate Cancer 1.3 1.8 5.8 2.4 1.6 1.0 -0.7 0.8 0.9
Age at First Birth 1.0 1.5 4.4 -1.0 -1.2 0.2 -2.1 -1.3 0.6
Bipolar Disorder (2011) 1.6 1.5 5.1 -1.0 -0.5 -1.6 0.1 -2.3 0.3
Body Mass Index (BMI) (2010) 1.4 1.9 4.3 0.9 1.9 -1.1 2.1 -0.7 -1.1
Coronary Artery Disease (CAD) 0.5 0.6 2.0 -0.9 -1.4 -0.9 0.1 -0.2 0.4
Crohns Disease (2012) 0.5 0.9 3.3 0.1 0.6 -0.3 1.8 -0.6 1.0
Mean Putamen Volume 0.2 0.2 0.8 0.2 0.9 0.0 -0.7 -0.1 -0.1
Fasting Glucose 0.6 0.8 1.7 1.1 -0.9 -0.6 -0.7 -1.3 -0.1
HbA1C 2.4 2.6 6.7 -0.4 1.8 0.5 2.6 -2.0 1.2
HDL Cholesterol 1.1 1.8 5.6 -0.2 2.4 -1.4 0.3 1.7 0.2
LDL Cholesterol 1.2 2.0 7.8 -0.3 -2.8 0.9 -1.6 -0.8 0.2
Lupus 0.6 0.9 2.9 -0.0 -1.0 1.7 -0.6 0.8 -0.3
Neuroticism (2016) 0.7 1.1 2.4 -0.2 1.2 -1.5 1.5 0.5 -0.0
Primary Biliary Cirrhosis 0.4 0.5 1.2 -0.8 0.9 0.2 1.1 -0.8 -0.2
Rheumatoid Arthritis 0.9 1.3 6.2 2.5 -0.7 0.0 0.2 -0.5 -0.7
Schizophrenia (2014) 1.4 3.0 10.7 -0.7 -0.3 -1.0 0.9 -3.3 -2.2
Triglycerides 0.7 1.2 3.7 0.8 0.1 0.9 0.7 1.9 -1.3
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.9 -0.3 2.0 1.4 0.9 0.9 0.0
Ulcerative Colitis 0.7 1.0 1.8 0.5 1.2 -0.4 1.3 -0.9 1.3
Blood Eosinophil Count 0.5 3.9 16.2 4.0 2.5 -0.2 -0.3 0.9 0.5
Blood Platelet Count 1.3 14.7 34.2 -5.8 0.4 -3.6 3.2 -4.9 -2.5
Blood Red Count 2.6 25.0 71.7 1.1 8.0 -1.4 8.5 -0.2 -3.4
Blood White Count 0.4 3.2 12.3 3.5 0.3 0.0 0.2 2.5 0.5
Heel T-Score 0.0 0.3 1.0 0.0 0.4 0.1 -0.9 1.0 -0.4
BMI 2.8 16.5 42.8 2.3 5.8 -4.0 6.5 0.5 1.0
Height 0.6 11.2 30.6 -2.3 1.1 2.2 -4.7 1.8 5.5
Waist Hip Ratio (WHR) 0.5 2.0 4.6 -1.4 -1.3 0.9 -2.1 -1.1 -1.4
Systolic Blood Pressure 1.2 6.1 11.9 -1.3 3.5 -3.3 3.4 0.3 0.6
Smoking Status 0.2 0.4 1.2 -0.5 0.5 1.1 -0.6 -0.6 0.4
Allergy or Eczema 0.7 1.9 5.7 -0.8 1.2 -2.4 1.7 -0.7 0.7
Cardiovascular Disease 0.7 2.4 3.3 0.9 -1.8 -1.7 1.8 -0.9 1.8
Hypothyroidism (self reported) 0.9 2.0 6.4 1.3 -2.5 0.6 -1.3 -1.0 -1.0
Respiratory disease 1.1 2.4 4.9 -0.8 2.2 -2.1 1.4 1.5 0.5
Type 2 Diabetes (T2D) (2018) 0.8 1.4 3.6 1.9 0.9 -1.0 -0.2 1.8 -0.1
Lung FEV1/FVC ratio 1.3 6.4 18.7 0.7 -3.5 -0.0 1.6 -4.3 -2.0
Lung FVC 0.8 3.9 8.4 2.8 2.2 0.5 -0.7 2.9 1.5
Neuroticism 0.5 1.2 3.1 -0.1 1.8 -1.6 1.2 0.6 -0.1
Chronotype (morning person) 0.6 1.3 3.5 -0.6 1.3 0.4 0.5 -1.4 1.9
Hair Pigment 0.1 1.7 4.0 -0.9 2.0 -1.5 1.4 0.5 0.8
Tanning 0.1 1.1 5.2 -0.3 -0.7 -0.1 -0.7 -2.3 0.6
Hand grip strength (left) 1.3 3.3 6.8 -1.2 2.5 0.1 2.3 -0.7 2.6
Number of treatments/medications taken 0.4 0.8 3.5 0.4 0.0 -1.9 0.7 0.5 0.3
Average weekly spirits intake 1.5 1.9 7.0 -1.3 1.3 -0.5 2.6 0.3 0.6
Sensitivity / hurt feelings 0.3 0.6 1.5 -0.4 -1.2 0.0 -0.2 -0.6 -1.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.2 0.5 0.3 -0.0 -0.2 1.1 -0.9
Hearing difficulty/problems: Yes 2.4 3.6 9.1 -0.3 -2.2 2.5 0.0 1.1 3.0
Relative age of first facial hair 1.5 3.2 10.7 0.4 -3.3 0.6 -1.6 -1.8 -1.4
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 4.0 -1.3 -1.6 -0.4 -0.6 0.3 -2.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.5 -0.2 -0.2 -0.5 0.9 -0.6 -1.2
Ever had hysterectomy (womb removed) 1.5 1.7 7.2 1.4 0.7 0.4 -0.1 2.7 -0.8
Systolic blood pressure, automated reading 2.5 7.4 24.5 -0.5 5.0 -2.5 3.6 0.6 0.3
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 4.0 1.1 1.7 -0.2 0.9 2.0 1.2
Angina 0.8 1.1 5.1 -1.0 -2.3 -0.2 0.2 -0.4 0.2
Medication for hormone replacement therapy 1.0 1.1 3.0 1.7 0.4 -0.9 0.8 -0.0 1.4
Vitamin and mineral supplements 1.0 1.3 5.3 0.7 0.8 0.5 2.3 -0.4 -0.9
Supplements: Zinc 0.7 0.8 2.9 -0.1 0.4 0.7 0.3 -1.7 1.1
Medication: Co-codamol 1.2 1.4 3.2 1.2 1.8 -0.3 1.2 1.4 0.5
Medication: Metformin 1.5 2.1 3.8 1.8 2.0 -1.4 0.7 1.2 1.2
Diabetes (father) 0.5 0.6 1.4 -0.6 0.7 -1.1 0.5 0.4 -1.2
Diabetes (mother) 0.8 1.0 2.6 -0.1 -0.8 -1.5 0.8 -1.6 -0.3
Severe depression (siblings) 0.9 1.1 2.9 0.5 -1.7 0.3 -0.4 1.6 0.6
Pack years adult smoking proportion 0.7 1.1 4.3 0.6 2.1 0.6 0.9 0.7 0.3
Impedance of leg (right) 1.7 8.4 23.1 -2.7 -4.8 2.2 -3.9 -0.6 0.2
Leg fat-free mass (left) 1.3 6.8 22.3 1.8 4.7 -1.4 3.0 0.8 1.9
Trunk fat percentage 0.5 2.2 5.8 0.6 1.7 -1.7 2.4 0.4 0.8
Hand grip strength (right) 1.2 3.3 8.3 -0.8 1.8 0.3 2.0 -2.0 2.9
Townsend deprivation index at recruitment 2.0 2.8 11.1 1.6 1.2 -1.0 -0.1 3.3 -1.1
Current tobacco smoking 0.7 1.2 2.1 1.0 0.2 1.2 -0.7 1.3 -1.4
Average weekly fortified wine intake 1.6 1.9 8.4 -2.9 -1.2 -0.7 0.0 -0.9 0.3
Maternal smoking around birth 1.2 1.8 8.1 0.2 0.4 0.0 0.2 2.8 1.5
Fed-up feelings 1.1 2.0 6.2 0.3 2.5 -1.8 1.3 0.3 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.7 1.1 1.3 -0.8 1.1 -0.2 -0.2
Relative age voice broke 0.9 1.4 3.9 -0.0 -1.5 0.5 -0.2 -2.0 -1.5
Taking other prescription medications 0.6 0.9 2.5 0.4 0.8 -1.2 0.5 1.6 0.4
Age when periods started (menarche) 2.7 6.4 22.0 0.6 -4.7 2.7 -2.5 -1.3 -0.9
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 4.0 1.0 0.7 -1.2 1.2 2.0 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.9 0.0 0.9 0.5 -0.9 1.0 -0.4
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.8 -0.3 0.4 -1.7 1.1 0.3 -1.3
Qualifications: CSEs or equivalent 1.2 1.6 4.3 -0.7 0.9 -0.9 2.1 -1.8 0.1
Serious illness, injury or assault to yourself 0.7 0.9 2.7 1.2 -0.4 0.4 -1.6 0.2 -0.9
High blood pressure 0.5 1.5 5.1 1.0 0.1 -2.3 0.9 0.2 1.4
Hayfever, allergic rhinitis or eczema 0.4 0.8 3.3 0.2 -0.1 -1.8 1.0 -0.0 0.6
Multivitamins +/- minerals 0.9 1.1 3.5 -0.5 -1.0 -0.4 -1.9 0.5 1.2
Stomach or abdominal pain in last month 0.2 0.2 0.7 -0.1 0.3 -0.2 0.8 -0.4 -0.5
Supplements: Glucosamine 0.6 0.8 2.8 0.7 1.0 0.7 -0.5 0.1 1.7
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.0 -1.4 0.3 0.1 0.8 0.4 1.4
Medication: Atenolol 1.7 2.2 6.0 0.6 0.1 -1.4 2.0 -0.9 2.4
Medication: Levothyroxine sodium 0.9 1.6 5.4 -0.7 -2.3 0.8 -0.6 -1.1 -1.1
Sitting height 0.7 4.7 21.9 -0.3 1.7 -0.3 0.9 1.5 4.7
Chronic bronchitis/emphysema (father) 0.5 0.6 2.2 0.1 0.6 -0.3 0.8 0.7 1.5
High blood pressure (mother) 0.4 0.5 1.7 -0.1 -0.7 -1.3 0.7 -0.7 -0.2
Body mass index (BMI) 1.9 8.3 23.2 1.7 4.1 -2.6 4.8 0.1 0.0
Impedance of leg (left) 1.5 7.4 20.1 -2.3 -4.5 2.0 -3.8 -0.7 0.1
Leg predicted mass (left) 1.3 7.1 22.9 1.7 4.8 -1.4 3.1 0.8 2.0
Trunk fat mass 0.9 4.0 9.3 0.8 3.1 -1.9 2.9 0.5 1.4
Waist circumference 0.9 3.5 8.9 0.6 3.0 -1.8 2.9 -0.1 -0.1
Number of incorrect matches in round 0.9 1.5 3.9 0.6 1.4 1.2 -0.7 2.0 0.9
Past tobacco smoking 0.6 1.1 2.0 1.0 -1.3 0.6 -0.2 1.3 -1.4
Alcohol usually taken with meals 0.9 1.4 3.6 0.6 0.7 -1.4 1.9 -1.2 0.7
Nervous feelings 0.2 0.4 0.7 0.8 -0.1 0.8 -0.6 -0.6 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.0 1.3 0.5 -0.1 0.9 0.8 1.4
Hearing difficulty/problems with background noise 2.3 3.6 11.0 1.2 -1.3 2.1 -0.1 1.8 3.3
Hair/balding pattern: Pattern 2 0.9 1.1 3.6 -1.1 -1.9 0.0 -0.6 -0.2 -1.2
Had menopause 1.2 1.5 5.0 -2.2 -1.4 -0.2 0.2 -1.0 -1.0
Had other major operations 1.4 1.7 3.8 1.9 1.3 0.3 0.8 2.0 -0.7
Forced vital capacity (FVC) 1.3 5.1 11.5 1.8 1.8 1.2 -2.1 2.6 3.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.3 0.9 1.1 -0.1 -0.1 0.9 -0.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.8 0.3 0.0 -0.6 1.7 1.0 -0.5
Qualifications: None of the above 0.9 2.0 5.4 -0.9 1.9 -0.2 2.3 -0.2 -1.5
Financial difficulties in last 2 years 1.2 1.7 9.3 -0.1 0.1 -0.4 0.7 0.3 -3.0
Mouth/teeth dental problems 0.5 0.7 1.8 0.2 -1.3 -0.8 -0.4 -1.3 0.2
Heart attack 0.2 0.3 0.6 0.5 -0.7 -0.1 0.8 0.3 0.2
Allergy 0.5 1.1 3.0 0.4 -1.0 1.7 -0.9 -1.2 0.3
Pain all over the body in last month 0.8 0.9 2.1 -0.4 1.4 -1.3 0.9 0.5 0.5
Diabetes (self-reported) 1.9 2.9 7.6 2.8 2.1 -1.0 0.3 1.9 0.8
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.7 -1.0 -0.6 1.6 -0.3 -1.0 -0.3
Medication: Ramipril 0.8 1.0 3.3 -0.4 0.7 -0.6 1.8 -1.0 0.8
Medication: Simvastatin 0.7 1.1 2.9 1.7 -1.7 0.1 0.8 -0.2 0.2
Fluid intelligence score 2.1 4.3 11.8 0.9 -2.8 -0.5 -3.4 0.1 2.3
Illnesses of siblings 0.5 0.7 1.2 0.7 0.6 0.9 -0.9 0.6 -1.1
Neuroticism score 0.2 0.4 1.3 0.5 1.1 -0.5 0.2 0.8 0.3
Weight 1.2 6.1 17.9 1.0 4.2 -1.9 3.4 0.3 1.4
Impedance of arm (right) 3.3 15.5 45.3 -2.6 -6.7 2.9 -5.7 -0.1 0.4
Arm fat percentage (right) 0.5 2.0 5.6 0.8 1.6 -1.7 2.4 0.5 -0.0
Trunk fat-free mass 0.9 5.2 21.1 0.8 4.6 -0.8 2.5 0.6 1.6
Hip circumference 0.9 4.1 11.9 0.8 2.8 -1.7 3.4 0.5 0.7
Time employed in main current job 1.3 1.5 5.7 0.4 1.0 0.5 1.1 -0.7 2.4
Alcohol intake versus 10 years previously 1.3 2.0 5.2 1.1 1.4 -0.2 1.5 1.0 -2.3
Father’s age at death 1.0 1.3 4.0 0.0 -1.7 0.2 -2.0 -0.3 -0.8
Worrier / anxious feelings 0.2 0.3 0.8 0.4 -0.1 -0.9 0.7 -0.3 0.6
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 4.1 1.7 0.4 -0.4 1.7 2.0 -0.5
Falls in the last year 0.2 0.2 0.8 0.2 0.5 -0.1 0.9 0.6 0.2
Hair/balding pattern: Pattern 3 0.2 0.4 1.4 -0.5 -0.2 -0.4 0.2 -1.2 -0.4
Number of live births 0.6 0.8 3.2 1.8 0.9 -0.5 0.5 0.5 -0.5
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 4.6 1.4 1.1 0.6 -1.0 1.0 2.1
Pulse rate 1.0 1.6 6.0 -0.2 -0.2 -1.5 2.4 -1.1 0.4
Happiness 1.0 1.2 4.2 0.1 0.3 1.2 0.7 0.9 2.0
Noisy workplace 1.2 1.5 4.0 -0.4 1.0 -0.3 2.0 1.9 -0.1
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.1 -0.2 -1.4 -0.2 -1.2 -1.1 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 1.9 0.8 0.6 -0.2 1.4 0.8 -0.3
Mouth/teeth dental problems: Dentures 1.5 2.5 9.1 1.6 1.6 3.0 -0.6 0.5 0.2
Asthma 0.6 1.1 2.4 -1.0 1.3 -1.2 -0.3 1.6 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 1.0 1.0 -0.7 -1.0 0.3 0.1 -0.9
Medication: Cholesterol lowering 1.5 2.3 6.0 2.4 -0.0 -0.6 0.6 1.0 2.4
Depression (self-reported) 0.4 0.5 2.5 0.2 -0.1 0.3 -0.6 1.6 0.0
Medication: Lansoprazole 1.5 1.7 3.6 -0.0 1.7 1.3 0.6 1.9 1.2
Prospective memory result 1.0 1.2 5.1 0.9 1.0 0.0 -0.6 0.3 -2.2
Lung cancer (father) 0.7 0.9 4.4 -0.1 0.5 0.7 0.0 2.1 0.3
Illnesses of mother 0.7 0.8 4.0 -0.1 2.0 0.4 0.7 -0.1 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 6.4 2.4 0.4 1.7 -1.4 0.9 2.5
Pulse wave Arterial Stiffness index 0.6 0.7 2.0 -1.4 0.4 -0.8 -0.6 -0.1 0.9
Impedance of arm (left) 2.6 12.1 33.4 -2.1 -5.8 2.2 -5.5 -0.1 0.2
Arm fat mass (right) 1.2 4.8 11.4 1.1 3.3 -2.0 3.4 0.8 0.6
Trunk predicted mass 0.9 5.3 21.3 0.8 4.6 -0.8 2.5 0.6 1.6
Standing height 0.4 3.6 10.9 -1.2 0.9 1.2 -2.6 0.5 3.3
Length of working week for main job 1.0 1.1 4.9 0.4 1.1 0.0 -0.3 2.2 0.3
Exposure to tobacco smoke at home 1.4 1.6 4.1 1.0 2.0 -0.5 1.9 -0.5 -0.6
Breastfed as a baby 1.7 2.2 7.5 -0.6 -2.7 0.1 -2.3 -0.2 -0.1
Tense / ‘highly strung’ 0.5 0.8 2.5 -1.2 0.2 0.6 0.2 0.5 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 4.1 -0.5 -2.0 -0.5 -1.4 0.6 0.8
Hair/balding pattern: Pattern 4 0.7 1.7 5.0 0.9 0.7 -2.2 1.7 -1.0 0.4
Birth weight of first child 1.0 1.8 4.8 1.2 0.2 2.0 -2.2 -0.3 0.6
Peak expiratory flow (PEF) 1.0 2.3 5.5 2.0 1.9 0.1 0.4 0.4 2.3
Pulse wave reflection index 1.4 1.7 3.9 -2.0 -1.0 -0.2 -1.8 -1.2 0.4
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.4 0.6 -0.3 0.6 -0.7 0.4 0.5
Loud music exposure frequency 0.8 0.9 1.5 1.2 -0.1 1.2 -0.9 -0.9 1.0
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 5.0 0.5 -0.9 0.7 -1.7 -2.2 0.5
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 4.8 -1.2 -0.6 -2.2 1.7 -0.7 -1.0
Blood clot in the leg (DVT) 0.9 1.2 5.2 0.8 -0.3 -0.0 -0.9 0.6 -2.3
Medication: Paracetamol 0.3 0.5 1.7 1.3 -0.3 0.4 0.9 -0.6 0.3
Headache pain in last month 0.6 1.0 4.6 0.3 0.1 -2.1 0.9 -0.1 0.8
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.1 -1.8 0.1 0.4 -0.3 0.1 -1.7
Glaucoma (self-reported) 1.2 1.4 3.2 1.8 0.0 -0.7 0.1 1.7 1.4
Gout (self-reported) 0.8 1.1 2.7 0.7 -0.7 -0.6 -1.6 1.6 -0.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.8 0.7 -1.7 0.4 -0.4 -1.2 -0.6
Medication: Amlodipine 1.0 1.3 4.3 0.6 1.2 -0.1 2.1 0.4 1.3
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.1 -1.1 1.1 0.6 -0.6 1.2 -1.4
Birth weight 1.4 3.1 14.4 3.8 0.2 0.0 -1.0 -1.7 -0.5
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.7 -0.6 0.0 -1.3 0.5 -0.1 -0.4
High blood pressure (siblings) 0.9 1.2 5.0 -0.7 -1.0 -1.0 0.1 -0.0 2.2
Forced vital capacity (FVC), Best measure 1.4 5.2 12.7 2.5 1.0 1.6 -2.1 2.0 3.6
Body fat percentage 0.7 2.8 8.5 0.6 2.1 -1.8 2.9 0.2 0.6
Leg fat percentage (right) 1.1 4.1 13.6 0.7 2.5 -1.7 3.7 -0.1 1.0
Arm fat-free mass (right) 1.6 8.0 28.3 1.4 5.3 -1.7 3.6 0.4 1.4
Exposure to tobacco smoke outside home 0.6 0.8 2.9 -0.1 -0.6 -0.8 1.7 0.2 -1.0
Comparative body size at age 10 1.3 3.7 11.7 -0.1 3.4 0.5 2.1 1.5 1.8
Number of full brothers 0.8 1.0 2.0 1.2 1.4 0.4 -0.1 1.3 0.9
Worry too long after embarrassment 0.3 0.5 1.5 1.2 -0.6 0.1 -0.3 0.9 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.4 -0.7 -0.1 -0.3 -0.8 0.9 -1.2
Wheeze or whistling in the chest in last year 0.7 1.3 3.8 -1.4 0.7 -2.0 0.9 0.5 0.8
Number of children fathered 3.1 3.5 7.8 2.8 1.8 -0.4 2.8 0.0 1.5
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.6 -1.6 -0.8 -1.3 -0.3 -1.2 0.7
Age at first live birth 0.7 1.3 2.9 -0.7 -1.3 1.3 -1.7 -1.0 0.1
Pulse wave peak to peak time 0.6 0.6 1.6 1.3 -0.4 1.2 0.1 0.2 -0.8
Health satisfaction 2.2 2.9 10.5 0.7 1.4 -1.9 3.2 -0.3 -0.8
Shortness of breath walking on level ground 0.3 0.4 0.9 1.0 -0.2 0.8 0.3 -0.5 -0.5
Qualifications: College or University degree 1.1 3.4 8.5 1.2 -1.5 0.6 -2.7 0.9 2.9
Eye problems/disorders: None of the above 1.6 1.9 4.6 -1.4 -2.1 1.3 -1.3 -0.0 -1.1
Mouth/teeth dental problems: Loose teeth 0.8 1.0 3.2 -1.8 -0.9 -1.2 0.3 0.4 -0.5
Emphysema/chronic bronchitis 1.5 1.7 3.0 -0.1 1.6 -1.7 1.5 0.8 -1.3
Medication for pain relief, constipation, heartburn 0.6 1.1 4.4 -1.3 -0.3 0.6 -2.1 -0.3 0.2
Neck or shoulder pain in last month 0.5 0.8 1.4 0.8 0.9 -0.6 0.9 0.6 -1.2
Medication: Blood pressure 0.5 0.8 1.9 1.4 1.2 -0.2 0.5 0.3 1.0
Angina (self-reported) 0.7 0.9 4.1 -0.9 -2.0 -0.0 0.4 -0.2 0.3
Migraine (self-reported) 0.9 1.2 5.8 0.6 -2.4 -0.4 -0.7 -0.3 0.2
Medication: Ibuprofen 0.5 0.6 1.1 0.9 -0.8 -1.1 0.0 -0.3 -1.0
Medication: Allopurinol 0.8 1.0 2.7 1.2 0.6 -0.7 -0.8 1.6 -0.5
Medication: Omeprazole 2.1 2.6 6.0 2.3 1.8 -0.8 2.5 -0.2 0.3
Medication: Seretide 50 evohaler 0.7 0.8 3.3 0.2 -0.2 -0.7 0.6 0.9 1.8
Mean time to correctly identify matches 0.5 1.0 2.0 1.4 -1.2 -0.8 0.2 1.0 0.7
Heart disease (mother) 1.8 2.2 8.8 -0.0 -3.0 1.3 -1.1 0.9 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 3.6 -0.8 0.8 0.3 0.7 -0.9 1.9
Whole body fat mass 1.3 5.5 13.6 1.1 3.7 -2.1 3.5 0.3 1.1
Leg fat mass (right) 1.5 5.8 14.3 1.1 3.6 -2.0 3.8 -0.2 1.4
Arm predicted mass (right) 1.6 8.3 30.2 1.6 5.5 -1.4 3.6 0.5 1.4
Pulse rate, automated reading 0.6 2.0 6.6 1.7 0.6 -1.3 2.6 -0.2 0.5
Alcohol intake frequency. 1.8 4.2 16.5 1.8 1.1 0.5 2.0 -0.2 -4.1
Comparative height size at age 10 0.6 3.2 6.8 -2.1 1.7 1.5 -2.6 1.4 1.0
Number of full sisters 0.7 0.9 3.0 0.9 -1.7 0.7 -0.9 0.4 0.3
Suffer from ‘nerves’ 0.5 0.8 2.5 -0.6 -0.9 0.6 -1.6 -0.6 0.3
Overall health rating 1.1 2.3 9.8 3.1 1.1 -0.6 1.6 0.1 0.3
Chest pain or discomfort 0.8 1.1 5.2 -0.0 0.5 -1.1 2.3 -0.1 0.4
Had major operations 0.7 0.8 2.8 1.7 0.1 0.7 -0.6 0.9 -0.4
Age at last live birth 0.7 1.0 2.4 -0.3 -1.0 1.1 -1.5 -0.3 -1.0
Family relationship satisfaction 0.4 0.5 1.6 0.5 -1.3 0.1 -0.2 0.2 1.1
Leg pain on walking 0.4 0.5 1.3 0.4 0.8 -0.5 0.6 0.2 -1.2
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 4.9 -1.4 0.4 -0.5 -0.0 -2.2 -1.7
Commuting to job workplace: Car/motor vehicle 0.0 0.1 0.1 -0.0 -0.2 0.0 0.3 -0.3 0.3
Illness, injury, bereavement, stress in last 2 years 2.3 2.8 10.1 -0.7 1.2 -1.8 0.9 -0.8 3.2
Medication: Aspirin 0.5 0.7 3.0 -0.2 -0.7 -0.4 1.7 0.4 0.5
Supplements: Vitamin C 0.2 0.2 0.6 -0.8 -0.1 -0.8 -0.4 -0.0 0.1
Knee pain experienced in last month 0.6 0.9 2.8 -0.4 1.7 -1.0 1.0 -0.1 0.7
Hypertension (Self-reported) 0.5 1.3 3.4 1.0 0.0 -1.8 0.9 0.2 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.6 0.3 1.6 0.6 1.4 -0.6 -0.5
Illnesses of father: Heart disease 0.9 1.3 5.6 -0.1 -2.4 0.0 0.1 -1.1 0.9
Illnesses of siblings: Diabetes 1.0 1.3 3.6 1.2 0.9 0.6 0.4 1.1 -1.9
Smoking status: Previous 0.9 1.4 4.0 -0.7 1.1 -0.6 -0.1 -2.0 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.4 0.3 0.2 1.3 -1.8 1.1 1.4
Whole body fat-free mass 1.2 6.7 25.0 1.4 5.0 -1.1 3.0 0.6 1.6
Leg fat-free mass (right) 1.4 7.3 24.5 1.9 5.0 -1.5 3.1 0.9 1.7
Arm fat percentage (left) 0.7 2.7 7.4 1.2 2.0 -1.8 2.7 0.4 -0.0
Average weekly red wine intake 1.0 1.5 6.4 -1.4 0.0 -0.4 0.3 0.7 2.5
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.4 0.8 -1.1 0.4 -1.6 -0.2 0.8
Mood swings 0.2 0.3 0.9 0.9 -0.1 -0.4 0.3 0.8 0.5
Loneliness, isolation 0.1 0.1 0.3 -0.5 0.0 -0.4 -0.5 -0.2 -0.4
Long-standing illness, disability or infirmity 1.0 1.5 3.2 0.6 0.8 -1.1 1.8 1.1 -1.7
Ever had bowel cancer screening 0.3 0.3 1.0 -0.4 0.2 -1.0 -0.5 0.5 -0.7
Diabetes diagnosed by doctor 1.2 1.9 5.1 2.2 1.6 -0.9 0.0 1.7 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.3 0.8 0.4 -0.5 1.1 0.0 -0.2
Friendships satisfaction 1.8 2.2 4.9 0.4 -2.2 1.8 -1.4 -1.0 1.4
Qualifications: nursing, teaching 1.4 2.2 4.5 2.1 -1.9 1.1 -1.3 0.1 1.3
Commuting to job workplace: Walk 0.4 0.4 1.4 -1.2 -0.1 0.1 0.6 -0.5 0.5
Eye problems/disorders: Cataract 1.1 1.3 3.1 0.4 -1.0 -0.8 -1.0 -1.8 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.1 -0.3 0.1 -0.7 -0.0 1.1 -0.1
Medication for cholesterol 1.1 1.7 4.2 -1.8 0.2 0.8 -1.4 -0.5 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 2.9 -0.2 0.6 0.5 -0.6 1.6 1.7
Back pain experienced in last month 0.5 0.7 1.4 -0.2 0.9 -0.3 1.2 0.9 -1.1
Mineral and other dietary supplements 1.0 1.4 4.0 -0.1 -2.0 -0.3 0.4 -0.2 -2.0
Breast cancer (self-reported) 1.1 1.4 4.4 -0.0 2.1 0.7 0.4 1.8 -0.2
Asthma (self-reported) 0.5 1.1 2.1 -1.1 1.4 -1.0 -0.2 1.5 -0.2
Osteoporosis (self-reported) 1.5 1.8 4.3 -1.4 -1.0 2.1 -1.3 -0.5 -1.4
Osteoarthritis (self-reported) 2.1 2.8 9.1 1.2 3.0 0.1 0.8 2.1 0.9
Medication: Aspirin 0.5 0.7 1.9 0.0 -1.1 -0.1 1.4 0.6 0.7
Medication: Gliclazide 1.6 1.8 5.0 2.2 0.8 -0.8 -0.1 1.7 1.4
Illnesses of father: None of the above (group 1) 0.6 0.7 2.9 0.5 1.7 0.4 0.2 0.8 -0.4
Smoking status: Current 0.5 0.8 1.8 0.6 0.5 0.9 -0.4 1.1 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 5.1 2.3 0.9 1.3 0.4 0.0 2.1
Whole body water mass 1.2 7.1 26.0 1.4 5.1 -1.3 3.2 0.7 1.6
Leg predicted mass (right) 1.4 7.6 25.1 2.0 5.0 -1.5 3.2 0.9 1.8
Arm fat mass (left) 1.3 5.3 12.7 1.3 3.5 -2.0 3.6 0.3 0.8
Number of self-reported non-cancer illnesses 0.7 1.2 2.3 1.5 -1.5 -1.1 -0.1 0.8 -1.0
Average weekly champagne plus white wine intake 2.3 3.1 7.7 2.7 1.5 -0.8 2.8 0.6 0.5
Miserableness 0.6 1.0 4.7 2.2 0.5 -0.9 0.4 -0.0 -0.2
Guilty feelings 0.5 0.8 2.6 -0.7 1.6 0.1 0.8 0.4 0.9
Wears glasses or contact lenses 2.4 2.8 9.5 0.1 1.7 -3.1 2.0 0.5 0.3
Ever taken oral contraceptive pill 0.1 0.1 0.3 -0.5 -0.1 -0.5 -0.1 0.5 0.2
Hearing aid user 1.1 1.3 3.5 1.2 -1.1 0.7 -0.7 1.9 -0.8
Mother’s age at death 1.3 1.6 6.8 -0.8 -1.2 0.8 -2.6 -0.3 -0.2
Financial situation satisfaction 1.6 2.0 7.0 -1.0 0.6 -0.9 2.6 0.5 -1.6
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.5 -0.1 -1.2 1.0 -0.0 0.3 -0.0
Commuting to job workplace: Public transport 0.3 0.4 0.7 0.5 0.5 -0.8 -0.8 0.3 -0.5
Eye problems/disorders: Glaucoma 2.0 2.3 7.8 2.8 1.0 -0.3 0.4 1.3 1.8
Medication: Blood pressure 0.8 1.5 4.8 0.5 0.3 -0.5 1.8 -0.2 2.2
Pain type(s) experienced in last month: Hip pain 2.9 3.6 8.3 2.9 1.7 1.7 1.7 0.9 1.9
Supplements: Fish oil (including cod liver oil) 1.3 1.7 4.2 0.8 1.6 -1.1 -0.4 1.1 2.0
High cholesterol (Self-reported) 0.5 0.9 4.5 0.0 -2.1 -0.3 -0.1 -0.9 0.3
Medication: Bendroflumethiazide 0.6 0.9 2.8 -0.2 0.4 -1.3 0.6 -0.5 1.7
Medication: Paracetamol 0.4 0.6 1.4 0.9 -0.3 -0.4 1.0 -1.2 0.3
Medication: Lisinopril 0.6 0.7 2.6 0.2 1.1 0.3 0.6 1.6 -0.5
Medication: Atorvastatin 0.2 0.2 0.5 0.7 -0.5 0.2 -0.4 0.6 0.4
Illnesses of father: High blood pressure 0.4 0.5 1.8 0.4 -0.3 -0.7 -1.4 -0.6 -0.1
Alcohol drinker status: Never 1.8 2.2 10.7 1.1 -0.4 -0.3 0.9 0.1 -3.3
Ever smoked 0.2 0.4 1.1 -0.4 0.7 0.5 0.1 -0.2 1.1
Basal metabolic rate 1.3 7.0 24.5 1.4 4.9 -1.4 3.2 0.8 1.6
Leg fat percentage (left) 1.3 4.9 15.3 0.9 2.8 -2.1 3.9 -0.2 0.9
Arm fat-free mass (left) 1.5 7.7 27.1 1.0 5.2 -1.4 3.8 0.5 1.4
Number of operations (self-reported) 2.7 3.9 10.3 3.2 1.8 0.2 0.3 2.9 -1.2
Average weekly beer plus cider intake 1.3 1.8 8.5 0.6 1.0 -0.5 0.9 -0.0 2.9
Irritability 0.7 1.1 2.6 1.6 0.5 -0.4 -1.5 0.9 0.7
Risk taking 0.8 1.2 2.7 -1.3 0.7 -1.0 -0.5 1.7 1.1
Ever had prostate specific antigen (PSA) test 0.7 0.8 3.7 -0.3 0.4 -1.9 0.6 0.5 0.4
Fractured/broken bones in last 5 years 1.3 1.7 3.2 0.7 -1.5 1.4 -0.8 -1.8 -1.4
Age started oral contraceptive pill 1.1 1.4 4.2 -0.8 -1.4 0.1 0.2 -1.3 -2.0
Diastolic blood pressure, automated reading 0.5 1.4 5.3 -2.3 0.5 0.2 1.4 -0.1 0.9
Ever depressed for a whole week 0.7 0.8 4.7 -0.0 -2.2 0.4 -0.4 0.1 -0.4
Unable to work because of sickness or disability 1.8 2.3 5.7 1.6 1.7 1.4 0.2 2.4 0.7
Commuting to job workplace: Cycle 0.9 1.1 4.1 -0.5 -1.2 0.8 0.3 -0.1 2.0
Myopia 1.0 1.4 4.3 -1.5 -0.2 -2.1 -1.1 -0.4 -1.0
Vascular/heart problems diagnosed by doctor 0.5 1.4 5.5 -0.8 0.2 2.3 -1.1 -0.4 -1.0
Cholesterol lowering medication 0.6 0.9 4.0 0.2 -2.0 0.2 0.2 0.2 -1.1
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 3.3 1.7 1.7 -1.0 1.8 0.5 0.5
Pain experienced in last month 1.4 2.3 5.5 0.3 -1.7 2.1 -2.4 0.2 -1.0
Supplements: Calcium 0.4 0.4 1.9 -1.4 -0.1 0.4 0.3 -0.7 -0.1
Basal cell carcinoma (self-reported) 0.3 0.4 0.9 0.9 0.8 0.1 -0.4 0.4 0.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 0.4 -0.7 -0.3 0.9 0.5 0.7
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 4.8 0.9 -0.2 -0.2 -0.6 0.5 -2.2
Heart disease (siblings) 1.1 1.3 3.3 0.7 -1.4 -1.3 1.8 -0.6 0.3
Alcohol drinker status: Previous 1.3 1.4 4.4 1.6 2.1 -1.1 0.7 -0.3 0.2
Pack years of smoking 0.6 0.8 2.9 0.5 1.7 0.6 1.1 0.7 0.1
Impedance of whole body 2.1 10.5 30.7 -2.4 -5.5 1.9 -4.8 -0.4 0.2
Leg fat mass (left) 1.6 6.3 15.0 1.2 3.9 -2.2 3.9 -0.2 1.4
Arm predicted mass (left) 1.8 9.2 30.9 1.3 5.6 -1.7 4.0 0.3 1.8