Hub : Genes

NUMB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.1430	0.0590	2.8e-03	-0.004	NA	-0.008	NA	-0.008	4.4e-01	NA	7.9e-01	NA	8.3e-01
2	GTEx	Spleen	0.4650	0.0980	3.1e-05	-0.010	NA	0.086	NA	0.021	7.3e-01	NA	3.2e-03	NA	9.5e-02
3	GTEx	Testis	0.3680	0.0850	9.9e-06	0.050	NA	0.272	NA	0.106	3.0e-03	NA	1.7e-12	NA	1.9e-05
4	YFS	Blood	0.0400	0.0120	2.0e-07	0.022	0.026	0.022	0.026	0.021	9.8e-08	3.9e-09	9.4e-08	6.2e-09	1.3e-07
5	TCGA	Breast Invasive Carcinoma	0.0439	0.0248	9.1e-04	0.017	0.013	0.010	NA	0.014	1.5e-04	7.2e-04	3.1e-03	NA	5.3e-04
6	TCGA	Testicular Germ Cell Tumors	0.1170	0.0590	9.0e-03	0.004	0.029	-0.008	NA	-0.007	2.3e-01	3.4e-02	9.1e-01	NA	7.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.9	0.8	0.1	-0.6	-0.3	-0.4	1.4
Bipolar Disorder or Schizophrenia	0.7	1.8	8.7	-0.6	-0.5	-0.8	-0.2	-3.0	-1.0
Depressed Affect (Nagel 2018)	0.4	0.9	2.8	-0.1	0.8	-1.7	1.0	-0.9	-0.3
Depression (Nagel 2018)	0.5	0.8	1.8	-0.1	1.4	-0.8	1.1	-1.0	-0.4
Intelligence (Savage-Jansen 2018)	1.8	5.6	14.6	0.3	-3.8	0.6	-3.3	-1.0	2.5
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.7	-0.4	-0.7	-0.2	-0.8	-0.2
Schizophrenia (2018)	1.6	3.4	12.1	-1.4	-0.7	-0.7	0.0	-3.5	-2.3
Schizophrenia vs Biploar Disorder	1.0	1.3	3.3	-0.9	1.2	-0.2	1.8	-0.4	-1.5
Worry (Nagel 2018)	0.3	0.6	2.6	-1.6	-0.4	0.0	-0.3	-0.6	-0.3
Alzheimer’s Disease (in mother)	3.3	3.9	11.3	1.4	0.8	1.9	-1.0	3.4	2.2
Alzheimer’s Disease (in father)	0.9	0.9	2.5	-0.6	0.4	1.3	-0.3	1.6	-0.9
Alzheimer’s Disease (including proxy)	1.4	2.1	7.2	-0.3	0.7	1.9	-0.6	2.7	0.8
Crohns Disease (2017)	0.3	0.6	1.3	-0.9	-0.7	-0.8	0.5	-1.1	-0.1
Irritable Bowel Disease (IBD)	0.3	0.7	2.9	-0.5	-0.5	-0.6	0.4	-1.7	0.4
Ulcerative Colitis (UC)	0.4	0.7	2.5	0.4	0.2	-0.8	0.6	-1.6	0.8
Major Depression (MDD)	0.3	0.3	1.0	-0.1	-1.0	0.5	0.4	-0.1	-0.7
Reaction Time	0.6	1.2	2.8	1.7	-0.4	-0.9	0.5	1.5	1.0
Verbal and Numeric Reasoning (VNR)	2.0	4.9	19.0	0.5	-2.8	0.8	-4.4	-0.3	1.2
Breast Cancer	0.2	0.6	1.4	-0.7	0.6	-1.2	-0.9	0.4	0.6
Ovarian Cancer	1.3	1.7	4.7	1.7	2.2	-0.1	0.7	1.5	-0.3
Prostate Cancer	1.3	1.8	5.8	2.4	1.6	1.0	-0.7	0.8	0.9
Age at First Birth	1.0	1.5	4.4	-1.0	-1.2	0.2	-2.1	-1.3	0.6
Bipolar Disorder (2011)	1.6	1.5	5.1	-1.0	-0.5	-1.6	0.1	-2.3	0.3
Body Mass Index (BMI) (2010)	1.4	1.9	4.3	0.9	1.9	-1.1	2.1	-0.7	-1.1
Coronary Artery Disease (CAD)	0.5	0.6	2.0	-0.9	-1.4	-0.9	0.1	-0.2	0.4
Crohns Disease (2012)	0.5	0.9	3.3	0.1	0.6	-0.3	1.8	-0.6	1.0
Mean Putamen Volume	0.2	0.2	0.8	0.2	0.9	0.0	-0.7	-0.1	-0.1
Fasting Glucose	0.6	0.8	1.7	1.1	-0.9	-0.6	-0.7	-1.3	-0.1
HbA1C	2.4	2.6	6.7	-0.4	1.8	0.5	2.6	-2.0	1.2
HDL Cholesterol	1.1	1.8	5.6	-0.2	2.4	-1.4	0.3	1.7	0.2
LDL Cholesterol	1.2	2.0	7.8	-0.3	-2.8	0.9	-1.6	-0.8	0.2
Lupus	0.6	0.9	2.9	-0.0	-1.0	1.7	-0.6	0.8	-0.3
Neuroticism (2016)	0.7	1.1	2.4	-0.2	1.2	-1.5	1.5	0.5	-0.0
Primary Biliary Cirrhosis	0.4	0.5	1.2	-0.8	0.9	0.2	1.1	-0.8	-0.2
Rheumatoid Arthritis	0.9	1.3	6.2	2.5	-0.7	0.0	0.2	-0.5	-0.7
Schizophrenia (2014)	1.4	3.0	10.7	-0.7	-0.3	-1.0	0.9	-3.3	-2.2
Triglycerides	0.7	1.2	3.7	0.8	0.1	0.9	0.7	1.9	-1.3
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.9	-0.3	2.0	1.4	0.9	0.9	0.0
Ulcerative Colitis	0.7	1.0	1.8	0.5	1.2	-0.4	1.3	-0.9	1.3
Blood Eosinophil Count	0.5	3.9	16.2	4.0	2.5	-0.2	-0.3	0.9	0.5
Blood Platelet Count	1.3	14.7	34.2	-5.8	0.4	-3.6	3.2	-4.9	-2.5
Blood Red Count	2.6	25.0	71.7	1.1	8.0	-1.4	8.5	-0.2	-3.4
Blood White Count	0.4	3.2	12.3	3.5	0.3	0.0	0.2	2.5	0.5
Heel T-Score	0.0	0.3	1.0	0.0	0.4	0.1	-0.9	1.0	-0.4
BMI	2.8	16.5	42.8	2.3	5.8	-4.0	6.5	0.5	1.0
Height	0.6	11.2	30.6	-2.3	1.1	2.2	-4.7	1.8	5.5
Waist Hip Ratio (WHR)	0.5	2.0	4.6	-1.4	-1.3	0.9	-2.1	-1.1	-1.4
Systolic Blood Pressure	1.2	6.1	11.9	-1.3	3.5	-3.3	3.4	0.3	0.6
Smoking Status	0.2	0.4	1.2	-0.5	0.5	1.1	-0.6	-0.6	0.4
Allergy or Eczema	0.7	1.9	5.7	-0.8	1.2	-2.4	1.7	-0.7	0.7
Cardiovascular Disease	0.7	2.4	3.3	0.9	-1.8	-1.7	1.8	-0.9	1.8
Hypothyroidism (self reported)	0.9	2.0	6.4	1.3	-2.5	0.6	-1.3	-1.0	-1.0
Respiratory disease	1.1	2.4	4.9	-0.8	2.2	-2.1	1.4	1.5	0.5
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.6	1.9	0.9	-1.0	-0.2	1.8	-0.1
Lung FEV1/FVC ratio	1.3	6.4	18.7	0.7	-3.5	-0.0	1.6	-4.3	-2.0
Lung FVC	0.8	3.9	8.4	2.8	2.2	0.5	-0.7	2.9	1.5
Neuroticism	0.5	1.2	3.1	-0.1	1.8	-1.6	1.2	0.6	-0.1
Chronotype (morning person)	0.6	1.3	3.5	-0.6	1.3	0.4	0.5	-1.4	1.9
Hair Pigment	0.1	1.7	4.0	-0.9	2.0	-1.5	1.4	0.5	0.8
Tanning	0.1	1.1	5.2	-0.3	-0.7	-0.1	-0.7	-2.3	0.6
Hand grip strength (left)	1.3	3.3	6.8	-1.2	2.5	0.1	2.3	-0.7	2.6
Number of treatments/medications taken	0.4	0.8	3.5	0.4	0.0	-1.9	0.7	0.5	0.3
Average weekly spirits intake	1.5	1.9	7.0	-1.3	1.3	-0.5	2.6	0.3	0.6
Sensitivity / hurt feelings	0.3	0.6	1.5	-0.4	-1.2	0.0	-0.2	-0.6	-1.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	0.5	0.3	-0.0	-0.2	1.1	-0.9
Hearing difficulty/problems: Yes	2.4	3.6	9.1	-0.3	-2.2	2.5	0.0	1.1	3.0
Relative age of first facial hair	1.5	3.2	10.7	0.4	-3.3	0.6	-1.6	-1.8	-1.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	4.0	-1.3	-1.6	-0.4	-0.6	0.3	-2.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	-0.2	-0.2	-0.5	0.9	-0.6	-1.2
Ever had hysterectomy (womb removed)	1.5	1.7	7.2	1.4	0.7	0.4	-0.1	2.7	-0.8
Systolic blood pressure, automated reading	2.5	7.4	24.5	-0.5	5.0	-2.5	3.6	0.6	0.3
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.0	1.1	1.7	-0.2	0.9	2.0	1.2
Angina	0.8	1.1	5.1	-1.0	-2.3	-0.2	0.2	-0.4	0.2
Medication for hormone replacement therapy	1.0	1.1	3.0	1.7	0.4	-0.9	0.8	-0.0	1.4
Vitamin and mineral supplements	1.0	1.3	5.3	0.7	0.8	0.5	2.3	-0.4	-0.9
Supplements: Zinc	0.7	0.8	2.9	-0.1	0.4	0.7	0.3	-1.7	1.1
Medication: Co-codamol	1.2	1.4	3.2	1.2	1.8	-0.3	1.2	1.4	0.5
Medication: Metformin	1.5	2.1	3.8	1.8	2.0	-1.4	0.7	1.2	1.2
Diabetes (father)	0.5	0.6	1.4	-0.6	0.7	-1.1	0.5	0.4	-1.2
Diabetes (mother)	0.8	1.0	2.6	-0.1	-0.8	-1.5	0.8	-1.6	-0.3
Severe depression (siblings)	0.9	1.1	2.9	0.5	-1.7	0.3	-0.4	1.6	0.6
Pack years adult smoking proportion	0.7	1.1	4.3	0.6	2.1	0.6	0.9	0.7	0.3
Impedance of leg (right)	1.7	8.4	23.1	-2.7	-4.8	2.2	-3.9	-0.6	0.2
Leg fat-free mass (left)	1.3	6.8	22.3	1.8	4.7	-1.4	3.0	0.8	1.9
Trunk fat percentage	0.5	2.2	5.8	0.6	1.7	-1.7	2.4	0.4	0.8
Hand grip strength (right)	1.2	3.3	8.3	-0.8	1.8	0.3	2.0	-2.0	2.9
Townsend deprivation index at recruitment	2.0	2.8	11.1	1.6	1.2	-1.0	-0.1	3.3	-1.1
Current tobacco smoking	0.7	1.2	2.1	1.0	0.2	1.2	-0.7	1.3	-1.4
Average weekly fortified wine intake	1.6	1.9	8.4	-2.9	-1.2	-0.7	0.0	-0.9	0.3
Maternal smoking around birth	1.2	1.8	8.1	0.2	0.4	0.0	0.2	2.8	1.5
Fed-up feelings	1.1	2.0	6.2	0.3	2.5	-1.8	1.3	0.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.7	1.1	1.3	-0.8	1.1	-0.2	-0.2
Relative age voice broke	0.9	1.4	3.9	-0.0	-1.5	0.5	-0.2	-2.0	-1.5
Taking other prescription medications	0.6	0.9	2.5	0.4	0.8	-1.2	0.5	1.6	0.4
Age when periods started (menarche)	2.7	6.4	22.0	0.6	-4.7	2.7	-2.5	-1.3	-0.9
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.0	1.0	0.7	-1.2	1.2	2.0	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	0.0	0.9	0.5	-0.9	1.0	-0.4
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.8	-0.3	0.4	-1.7	1.1	0.3	-1.3
Qualifications: CSEs or equivalent	1.2	1.6	4.3	-0.7	0.9	-0.9	2.1	-1.8	0.1
Serious illness, injury or assault to yourself	0.7	0.9	2.7	1.2	-0.4	0.4	-1.6	0.2	-0.9
High blood pressure	0.5	1.5	5.1	1.0	0.1	-2.3	0.9	0.2	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.3	0.2	-0.1	-1.8	1.0	-0.0	0.6
Multivitamins +/- minerals	0.9	1.1	3.5	-0.5	-1.0	-0.4	-1.9	0.5	1.2
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.1	0.3	-0.2	0.8	-0.4	-0.5
Supplements: Glucosamine	0.6	0.8	2.8	0.7	1.0	0.7	-0.5	0.1	1.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	-1.4	0.3	0.1	0.8	0.4	1.4
Medication: Atenolol	1.7	2.2	6.0	0.6	0.1	-1.4	2.0	-0.9	2.4
Medication: Levothyroxine sodium	0.9	1.6	5.4	-0.7	-2.3	0.8	-0.6	-1.1	-1.1
Sitting height	0.7	4.7	21.9	-0.3	1.7	-0.3	0.9	1.5	4.7
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.1	0.6	-0.3	0.8	0.7	1.5
High blood pressure (mother)	0.4	0.5	1.7	-0.1	-0.7	-1.3	0.7	-0.7	-0.2
Body mass index (BMI)	1.9	8.3	23.2	1.7	4.1	-2.6	4.8	0.1	0.0
Impedance of leg (left)	1.5	7.4	20.1	-2.3	-4.5	2.0	-3.8	-0.7	0.1
Leg predicted mass (left)	1.3	7.1	22.9	1.7	4.8	-1.4	3.1	0.8	2.0
Trunk fat mass	0.9	4.0	9.3	0.8	3.1	-1.9	2.9	0.5	1.4
Waist circumference	0.9	3.5	8.9	0.6	3.0	-1.8	2.9	-0.1	-0.1
Number of incorrect matches in round	0.9	1.5	3.9	0.6	1.4	1.2	-0.7	2.0	0.9
Past tobacco smoking	0.6	1.1	2.0	1.0	-1.3	0.6	-0.2	1.3	-1.4
Alcohol usually taken with meals	0.9	1.4	3.6	0.6	0.7	-1.4	1.9	-1.2	0.7
Nervous feelings	0.2	0.4	0.7	0.8	-0.1	0.8	-0.6	-0.6	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.0	1.3	0.5	-0.1	0.9	0.8	1.4
Hearing difficulty/problems with background noise	2.3	3.6	11.0	1.2	-1.3	2.1	-0.1	1.8	3.3
Hair/balding pattern: Pattern 2	0.9	1.1	3.6	-1.1	-1.9	0.0	-0.6	-0.2	-1.2
Had menopause	1.2	1.5	5.0	-2.2	-1.4	-0.2	0.2	-1.0	-1.0
Had other major operations	1.4	1.7	3.8	1.9	1.3	0.3	0.8	2.0	-0.7
Forced vital capacity (FVC)	1.3	5.1	11.5	1.8	1.8	1.2	-2.1	2.6	3.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	0.9	1.1	-0.1	-0.1	0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.8	0.3	0.0	-0.6	1.7	1.0	-0.5
Qualifications: None of the above	0.9	2.0	5.4	-0.9	1.9	-0.2	2.3	-0.2	-1.5
Financial difficulties in last 2 years	1.2	1.7	9.3	-0.1	0.1	-0.4	0.7	0.3	-3.0
Mouth/teeth dental problems	0.5	0.7	1.8	0.2	-1.3	-0.8	-0.4	-1.3	0.2
Heart attack	0.2	0.3	0.6	0.5	-0.7	-0.1	0.8	0.3	0.2
Allergy	0.5	1.1	3.0	0.4	-1.0	1.7	-0.9	-1.2	0.3
Pain all over the body in last month	0.8	0.9	2.1	-0.4	1.4	-1.3	0.9	0.5	0.5
Diabetes (self-reported)	1.9	2.9	7.6	2.8	2.1	-1.0	0.3	1.9	0.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.7	-1.0	-0.6	1.6	-0.3	-1.0	-0.3
Medication: Ramipril	0.8	1.0	3.3	-0.4	0.7	-0.6	1.8	-1.0	0.8
Medication: Simvastatin	0.7	1.1	2.9	1.7	-1.7	0.1	0.8	-0.2	0.2
Fluid intelligence score	2.1	4.3	11.8	0.9	-2.8	-0.5	-3.4	0.1	2.3
Illnesses of siblings	0.5	0.7	1.2	0.7	0.6	0.9	-0.9	0.6	-1.1
Neuroticism score	0.2	0.4	1.3	0.5	1.1	-0.5	0.2	0.8	0.3
Weight	1.2	6.1	17.9	1.0	4.2	-1.9	3.4	0.3	1.4
Impedance of arm (right)	3.3	15.5	45.3	-2.6	-6.7	2.9	-5.7	-0.1	0.4
Arm fat percentage (right)	0.5	2.0	5.6	0.8	1.6	-1.7	2.4	0.5	-0.0
Trunk fat-free mass	0.9	5.2	21.1	0.8	4.6	-0.8	2.5	0.6	1.6
Hip circumference	0.9	4.1	11.9	0.8	2.8	-1.7	3.4	0.5	0.7
Time employed in main current job	1.3	1.5	5.7	0.4	1.0	0.5	1.1	-0.7	2.4
Alcohol intake versus 10 years previously	1.3	2.0	5.2	1.1	1.4	-0.2	1.5	1.0	-2.3
Father’s age at death	1.0	1.3	4.0	0.0	-1.7	0.2	-2.0	-0.3	-0.8
Worrier / anxious feelings	0.2	0.3	0.8	0.4	-0.1	-0.9	0.7	-0.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	4.1	1.7	0.4	-0.4	1.7	2.0	-0.5
Falls in the last year	0.2	0.2	0.8	0.2	0.5	-0.1	0.9	0.6	0.2
Hair/balding pattern: Pattern 3	0.2	0.4	1.4	-0.5	-0.2	-0.4	0.2	-1.2	-0.4
Number of live births	0.6	0.8	3.2	1.8	0.9	-0.5	0.5	0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.6	1.4	1.1	0.6	-1.0	1.0	2.1
Pulse rate	1.0	1.6	6.0	-0.2	-0.2	-1.5	2.4	-1.1	0.4
Happiness	1.0	1.2	4.2	0.1	0.3	1.2	0.7	0.9	2.0
Noisy workplace	1.2	1.5	4.0	-0.4	1.0	-0.3	2.0	1.9	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.1	-0.2	-1.4	-0.2	-1.2	-1.1	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.9	0.8	0.6	-0.2	1.4	0.8	-0.3
Mouth/teeth dental problems: Dentures	1.5	2.5	9.1	1.6	1.6	3.0	-0.6	0.5	0.2
Asthma	0.6	1.1	2.4	-1.0	1.3	-1.2	-0.3	1.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.0	1.0	-0.7	-1.0	0.3	0.1	-0.9
Medication: Cholesterol lowering	1.5	2.3	6.0	2.4	-0.0	-0.6	0.6	1.0	2.4
Depression (self-reported)	0.4	0.5	2.5	0.2	-0.1	0.3	-0.6	1.6	0.0
Medication: Lansoprazole	1.5	1.7	3.6	-0.0	1.7	1.3	0.6	1.9	1.2
Prospective memory result	1.0	1.2	5.1	0.9	1.0	0.0	-0.6	0.3	-2.2
Lung cancer (father)	0.7	0.9	4.4	-0.1	0.5	0.7	0.0	2.1	0.3
Illnesses of mother	0.7	0.8	4.0	-0.1	2.0	0.4	0.7	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	6.4	2.4	0.4	1.7	-1.4	0.9	2.5
Pulse wave Arterial Stiffness index	0.6	0.7	2.0	-1.4	0.4	-0.8	-0.6	-0.1	0.9
Impedance of arm (left)	2.6	12.1	33.4	-2.1	-5.8	2.2	-5.5	-0.1	0.2
Arm fat mass (right)	1.2	4.8	11.4	1.1	3.3	-2.0	3.4	0.8	0.6
Trunk predicted mass	0.9	5.3	21.3	0.8	4.6	-0.8	2.5	0.6	1.6
Standing height	0.4	3.6	10.9	-1.2	0.9	1.2	-2.6	0.5	3.3
Length of working week for main job	1.0	1.1	4.9	0.4	1.1	0.0	-0.3	2.2	0.3
Exposure to tobacco smoke at home	1.4	1.6	4.1	1.0	2.0	-0.5	1.9	-0.5	-0.6
Breastfed as a baby	1.7	2.2	7.5	-0.6	-2.7	0.1	-2.3	-0.2	-0.1
Tense / ‘highly strung’	0.5	0.8	2.5	-1.2	0.2	0.6	0.2	0.5	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.1	-0.5	-2.0	-0.5	-1.4	0.6	0.8
Hair/balding pattern: Pattern 4	0.7	1.7	5.0	0.9	0.7	-2.2	1.7	-1.0	0.4
Birth weight of first child	1.0	1.8	4.8	1.2	0.2	2.0	-2.2	-0.3	0.6
Peak expiratory flow (PEF)	1.0	2.3	5.5	2.0	1.9	0.1	0.4	0.4	2.3
Pulse wave reflection index	1.4	1.7	3.9	-2.0	-1.0	-0.2	-1.8	-1.2	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.4	0.6	-0.3	0.6	-0.7	0.4	0.5
Loud music exposure frequency	0.8	0.9	1.5	1.2	-0.1	1.2	-0.9	-0.9	1.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.0	0.5	-0.9	0.7	-1.7	-2.2	0.5
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	4.8	-1.2	-0.6	-2.2	1.7	-0.7	-1.0
Blood clot in the leg (DVT)	0.9	1.2	5.2	0.8	-0.3	-0.0	-0.9	0.6	-2.3
Medication: Paracetamol	0.3	0.5	1.7	1.3	-0.3	0.4	0.9	-0.6	0.3
Headache pain in last month	0.6	1.0	4.6	0.3	0.1	-2.1	0.9	-0.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.1	-1.8	0.1	0.4	-0.3	0.1	-1.7
Glaucoma (self-reported)	1.2	1.4	3.2	1.8	0.0	-0.7	0.1	1.7	1.4
Gout (self-reported)	0.8	1.1	2.7	0.7	-0.7	-0.6	-1.6	1.6	-0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.8	0.7	-1.7	0.4	-0.4	-1.2	-0.6
Medication: Amlodipine	1.0	1.3	4.3	0.6	1.2	-0.1	2.1	0.4	1.3
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.1	-1.1	1.1	0.6	-0.6	1.2	-1.4
Birth weight	1.4	3.1	14.4	3.8	0.2	0.0	-1.0	-1.7	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.7	-0.6	0.0	-1.3	0.5	-0.1	-0.4
High blood pressure (siblings)	0.9	1.2	5.0	-0.7	-1.0	-1.0	0.1	-0.0	2.2
Forced vital capacity (FVC), Best measure	1.4	5.2	12.7	2.5	1.0	1.6	-2.1	2.0	3.6
Body fat percentage	0.7	2.8	8.5	0.6	2.1	-1.8	2.9	0.2	0.6
Leg fat percentage (right)	1.1	4.1	13.6	0.7	2.5	-1.7	3.7	-0.1	1.0
Arm fat-free mass (right)	1.6	8.0	28.3	1.4	5.3	-1.7	3.6	0.4	1.4
Exposure to tobacco smoke outside home	0.6	0.8	2.9	-0.1	-0.6	-0.8	1.7	0.2	-1.0
Comparative body size at age 10	1.3	3.7	11.7	-0.1	3.4	0.5	2.1	1.5	1.8
Number of full brothers	0.8	1.0	2.0	1.2	1.4	0.4	-0.1	1.3	0.9
Worry too long after embarrassment	0.3	0.5	1.5	1.2	-0.6	0.1	-0.3	0.9	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.4	-0.7	-0.1	-0.3	-0.8	0.9	-1.2
Wheeze or whistling in the chest in last year	0.7	1.3	3.8	-1.4	0.7	-2.0	0.9	0.5	0.8
Number of children fathered	3.1	3.5	7.8	2.8	1.8	-0.4	2.8	0.0	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.6	-1.6	-0.8	-1.3	-0.3	-1.2	0.7
Age at first live birth	0.7	1.3	2.9	-0.7	-1.3	1.3	-1.7	-1.0	0.1
Pulse wave peak to peak time	0.6	0.6	1.6	1.3	-0.4	1.2	0.1	0.2	-0.8
Health satisfaction	2.2	2.9	10.5	0.7	1.4	-1.9	3.2	-0.3	-0.8
Shortness of breath walking on level ground	0.3	0.4	0.9	1.0	-0.2	0.8	0.3	-0.5	-0.5
Qualifications: College or University degree	1.1	3.4	8.5	1.2	-1.5	0.6	-2.7	0.9	2.9
Eye problems/disorders: None of the above	1.6	1.9	4.6	-1.4	-2.1	1.3	-1.3	-0.0	-1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.2	-1.8	-0.9	-1.2	0.3	0.4	-0.5
Emphysema/chronic bronchitis	1.5	1.7	3.0	-0.1	1.6	-1.7	1.5	0.8	-1.3
Medication for pain relief, constipation, heartburn	0.6	1.1	4.4	-1.3	-0.3	0.6	-2.1	-0.3	0.2
Neck or shoulder pain in last month	0.5	0.8	1.4	0.8	0.9	-0.6	0.9	0.6	-1.2
Medication: Blood pressure	0.5	0.8	1.9	1.4	1.2	-0.2	0.5	0.3	1.0
Angina (self-reported)	0.7	0.9	4.1	-0.9	-2.0	-0.0	0.4	-0.2	0.3
Migraine (self-reported)	0.9	1.2	5.8	0.6	-2.4	-0.4	-0.7	-0.3	0.2
Medication: Ibuprofen	0.5	0.6	1.1	0.9	-0.8	-1.1	0.0	-0.3	-1.0
Medication: Allopurinol	0.8	1.0	2.7	1.2	0.6	-0.7	-0.8	1.6	-0.5
Medication: Omeprazole	2.1	2.6	6.0	2.3	1.8	-0.8	2.5	-0.2	0.3
Medication: Seretide 50 evohaler	0.7	0.8	3.3	0.2	-0.2	-0.7	0.6	0.9	1.8
Mean time to correctly identify matches	0.5	1.0	2.0	1.4	-1.2	-0.8	0.2	1.0	0.7
Heart disease (mother)	1.8	2.2	8.8	-0.0	-3.0	1.3	-1.1	0.9	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.6	-0.8	0.8	0.3	0.7	-0.9	1.9
Whole body fat mass	1.3	5.5	13.6	1.1	3.7	-2.1	3.5	0.3	1.1
Leg fat mass (right)	1.5	5.8	14.3	1.1	3.6	-2.0	3.8	-0.2	1.4
Arm predicted mass (right)	1.6	8.3	30.2	1.6	5.5	-1.4	3.6	0.5	1.4
Pulse rate, automated reading	0.6	2.0	6.6	1.7	0.6	-1.3	2.6	-0.2	0.5
Alcohol intake frequency.	1.8	4.2	16.5	1.8	1.1	0.5	2.0	-0.2	-4.1
Comparative height size at age 10	0.6	3.2	6.8	-2.1	1.7	1.5	-2.6	1.4	1.0
Number of full sisters	0.7	0.9	3.0	0.9	-1.7	0.7	-0.9	0.4	0.3
Suffer from ‘nerves’	0.5	0.8	2.5	-0.6	-0.9	0.6	-1.6	-0.6	0.3
Overall health rating	1.1	2.3	9.8	3.1	1.1	-0.6	1.6	0.1	0.3
Chest pain or discomfort	0.8	1.1	5.2	-0.0	0.5	-1.1	2.3	-0.1	0.4
Had major operations	0.7	0.8	2.8	1.7	0.1	0.7	-0.6	0.9	-0.4
Age at last live birth	0.7	1.0	2.4	-0.3	-1.0	1.1	-1.5	-0.3	-1.0
Family relationship satisfaction	0.4	0.5	1.6	0.5	-1.3	0.1	-0.2	0.2	1.1
Leg pain on walking	0.4	0.5	1.3	0.4	0.8	-0.5	0.6	0.2	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.9	-1.4	0.4	-0.5	-0.0	-2.2	-1.7
Commuting to job workplace: Car/motor vehicle	0.0	0.1	0.1	-0.0	-0.2	0.0	0.3	-0.3	0.3
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	10.1	-0.7	1.2	-1.8	0.9	-0.8	3.2
Medication: Aspirin	0.5	0.7	3.0	-0.2	-0.7	-0.4	1.7	0.4	0.5
Supplements: Vitamin C	0.2	0.2	0.6	-0.8	-0.1	-0.8	-0.4	-0.0	0.1
Knee pain experienced in last month	0.6	0.9	2.8	-0.4	1.7	-1.0	1.0	-0.1	0.7
Hypertension (Self-reported)	0.5	1.3	3.4	1.0	0.0	-1.8	0.9	0.2	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.6	0.3	1.6	0.6	1.4	-0.6	-0.5
Illnesses of father: Heart disease	0.9	1.3	5.6	-0.1	-2.4	0.0	0.1	-1.1	0.9
Illnesses of siblings: Diabetes	1.0	1.3	3.6	1.2	0.9	0.6	0.4	1.1	-1.9
Smoking status: Previous	0.9	1.4	4.0	-0.7	1.1	-0.6	-0.1	-2.0	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.4	0.3	0.2	1.3	-1.8	1.1	1.4
Whole body fat-free mass	1.2	6.7	25.0	1.4	5.0	-1.1	3.0	0.6	1.6
Leg fat-free mass (right)	1.4	7.3	24.5	1.9	5.0	-1.5	3.1	0.9	1.7
Arm fat percentage (left)	0.7	2.7	7.4	1.2	2.0	-1.8	2.7	0.4	-0.0
Average weekly red wine intake	1.0	1.5	6.4	-1.4	0.0	-0.4	0.3	0.7	2.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.4	0.8	-1.1	0.4	-1.6	-0.2	0.8
Mood swings	0.2	0.3	0.9	0.9	-0.1	-0.4	0.3	0.8	0.5
Loneliness, isolation	0.1	0.1	0.3	-0.5	0.0	-0.4	-0.5	-0.2	-0.4
Long-standing illness, disability or infirmity	1.0	1.5	3.2	0.6	0.8	-1.1	1.8	1.1	-1.7
Ever had bowel cancer screening	0.3	0.3	1.0	-0.4	0.2	-1.0	-0.5	0.5	-0.7
Diabetes diagnosed by doctor	1.2	1.9	5.1	2.2	1.6	-0.9	0.0	1.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	0.8	0.4	-0.5	1.1	0.0	-0.2
Friendships satisfaction	1.8	2.2	4.9	0.4	-2.2	1.8	-1.4	-1.0	1.4
Qualifications: nursing, teaching	1.4	2.2	4.5	2.1	-1.9	1.1	-1.3	0.1	1.3
Commuting to job workplace: Walk	0.4	0.4	1.4	-1.2	-0.1	0.1	0.6	-0.5	0.5
Eye problems/disorders: Cataract	1.1	1.3	3.1	0.4	-1.0	-0.8	-1.0	-1.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	-0.3	0.1	-0.7	-0.0	1.1	-0.1
Medication for cholesterol	1.1	1.7	4.2	-1.8	0.2	0.8	-1.4	-0.5	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.9	-0.2	0.6	0.5	-0.6	1.6	1.7
Back pain experienced in last month	0.5	0.7	1.4	-0.2	0.9	-0.3	1.2	0.9	-1.1
Mineral and other dietary supplements	1.0	1.4	4.0	-0.1	-2.0	-0.3	0.4	-0.2	-2.0
Breast cancer (self-reported)	1.1	1.4	4.4	-0.0	2.1	0.7	0.4	1.8	-0.2
Asthma (self-reported)	0.5	1.1	2.1	-1.1	1.4	-1.0	-0.2	1.5	-0.2
Osteoporosis (self-reported)	1.5	1.8	4.3	-1.4	-1.0	2.1	-1.3	-0.5	-1.4
Osteoarthritis (self-reported)	2.1	2.8	9.1	1.2	3.0	0.1	0.8	2.1	0.9
Medication: Aspirin	0.5	0.7	1.9	0.0	-1.1	-0.1	1.4	0.6	0.7
Medication: Gliclazide	1.6	1.8	5.0	2.2	0.8	-0.8	-0.1	1.7	1.4
Illnesses of father: None of the above (group 1)	0.6	0.7	2.9	0.5	1.7	0.4	0.2	0.8	-0.4
Smoking status: Current	0.5	0.8	1.8	0.6	0.5	0.9	-0.4	1.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	5.1	2.3	0.9	1.3	0.4	0.0	2.1
Whole body water mass	1.2	7.1	26.0	1.4	5.1	-1.3	3.2	0.7	1.6
Leg predicted mass (right)	1.4	7.6	25.1	2.0	5.0	-1.5	3.2	0.9	1.8
Arm fat mass (left)	1.3	5.3	12.7	1.3	3.5	-2.0	3.6	0.3	0.8
Number of self-reported non-cancer illnesses	0.7	1.2	2.3	1.5	-1.5	-1.1	-0.1	0.8	-1.0
Average weekly champagne plus white wine intake	2.3	3.1	7.7	2.7	1.5	-0.8	2.8	0.6	0.5
Miserableness	0.6	1.0	4.7	2.2	0.5	-0.9	0.4	-0.0	-0.2
Guilty feelings	0.5	0.8	2.6	-0.7	1.6	0.1	0.8	0.4	0.9
Wears glasses or contact lenses	2.4	2.8	9.5	0.1	1.7	-3.1	2.0	0.5	0.3
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.5	-0.1	-0.5	-0.1	0.5	0.2
Hearing aid user	1.1	1.3	3.5	1.2	-1.1	0.7	-0.7	1.9	-0.8
Mother’s age at death	1.3	1.6	6.8	-0.8	-1.2	0.8	-2.6	-0.3	-0.2
Financial situation satisfaction	1.6	2.0	7.0	-1.0	0.6	-0.9	2.6	0.5	-1.6
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	-0.1	-1.2	1.0	-0.0	0.3	-0.0
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.5	0.5	-0.8	-0.8	0.3	-0.5
Eye problems/disorders: Glaucoma	2.0	2.3	7.8	2.8	1.0	-0.3	0.4	1.3	1.8
Medication: Blood pressure	0.8	1.5	4.8	0.5	0.3	-0.5	1.8	-0.2	2.2
Pain type(s) experienced in last month: Hip pain	2.9	3.6	8.3	2.9	1.7	1.7	1.7	0.9	1.9
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.2	0.8	1.6	-1.1	-0.4	1.1	2.0
High cholesterol (Self-reported)	0.5	0.9	4.5	0.0	-2.1	-0.3	-0.1	-0.9	0.3
Medication: Bendroflumethiazide	0.6	0.9	2.8	-0.2	0.4	-1.3	0.6	-0.5	1.7
Medication: Paracetamol	0.4	0.6	1.4	0.9	-0.3	-0.4	1.0	-1.2	0.3
Medication: Lisinopril	0.6	0.7	2.6	0.2	1.1	0.3	0.6	1.6	-0.5
Medication: Atorvastatin	0.2	0.2	0.5	0.7	-0.5	0.2	-0.4	0.6	0.4
Illnesses of father: High blood pressure	0.4	0.5	1.8	0.4	-0.3	-0.7	-1.4	-0.6	-0.1
Alcohol drinker status: Never	1.8	2.2	10.7	1.1	-0.4	-0.3	0.9	0.1	-3.3
Ever smoked	0.2	0.4	1.1	-0.4	0.7	0.5	0.1	-0.2	1.1
Basal metabolic rate	1.3	7.0	24.5	1.4	4.9	-1.4	3.2	0.8	1.6
Leg fat percentage (left)	1.3	4.9	15.3	0.9	2.8	-2.1	3.9	-0.2	0.9
Arm fat-free mass (left)	1.5	7.7	27.1	1.0	5.2	-1.4	3.8	0.5	1.4
Number of operations (self-reported)	2.7	3.9	10.3	3.2	1.8	0.2	0.3	2.9	-1.2
Average weekly beer plus cider intake	1.3	1.8	8.5	0.6	1.0	-0.5	0.9	-0.0	2.9
Irritability	0.7	1.1	2.6	1.6	0.5	-0.4	-1.5	0.9	0.7
Risk taking	0.8	1.2	2.7	-1.3	0.7	-1.0	-0.5	1.7	1.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.7	-0.3	0.4	-1.9	0.6	0.5	0.4
Fractured/broken bones in last 5 years	1.3	1.7	3.2	0.7	-1.5	1.4	-0.8	-1.8	-1.4
Age started oral contraceptive pill	1.1	1.4	4.2	-0.8	-1.4	0.1	0.2	-1.3	-2.0
Diastolic blood pressure, automated reading	0.5	1.4	5.3	-2.3	0.5	0.2	1.4	-0.1	0.9
Ever depressed for a whole week	0.7	0.8	4.7	-0.0	-2.2	0.4	-0.4	0.1	-0.4
Unable to work because of sickness or disability	1.8	2.3	5.7	1.6	1.7	1.4	0.2	2.4	0.7
Commuting to job workplace: Cycle	0.9	1.1	4.1	-0.5	-1.2	0.8	0.3	-0.1	2.0
Myopia	1.0	1.4	4.3	-1.5	-0.2	-2.1	-1.1	-0.4	-1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	5.5	-0.8	0.2	2.3	-1.1	-0.4	-1.0
Cholesterol lowering medication	0.6	0.9	4.0	0.2	-2.0	0.2	0.2	0.2	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.3	1.7	1.7	-1.0	1.8	0.5	0.5
Pain experienced in last month	1.4	2.3	5.5	0.3	-1.7	2.1	-2.4	0.2	-1.0
Supplements: Calcium	0.4	0.4	1.9	-1.4	-0.1	0.4	0.3	-0.7	-0.1
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.9	0.8	0.1	-0.4	0.4	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.4	-0.7	-0.3	0.9	0.5	0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	4.8	0.9	-0.2	-0.2	-0.6	0.5	-2.2
Heart disease (siblings)	1.1	1.3	3.3	0.7	-1.4	-1.3	1.8	-0.6	0.3
Alcohol drinker status: Previous	1.3	1.4	4.4	1.6	2.1	-1.1	0.7	-0.3	0.2
Pack years of smoking	0.6	0.8	2.9	0.5	1.7	0.6	1.1	0.7	0.1
Impedance of whole body	2.1	10.5	30.7	-2.4	-5.5	1.9	-4.8	-0.4	0.2
Leg fat mass (left)	1.6	6.3	15.0	1.2	3.9	-2.2	3.9	-0.2	1.4
Arm predicted mass (left)	1.8	9.2	30.9	1.3	5.6	-1.7	4.0	0.3	1.8