Best TWAS P=9.9e-16 · Best GWAS P=3.66e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Muscle Skeletal | SMAD3 | 0.13 | 0.10 | enet | 8 | 0.10 | 4.2e-10 | 7.7 | 8.0 | 9.9e-16 | 0.97 | 0.00 | 1.00 | TRUE |
| 6 | GTEx | Nerve Tibial | PIAS1 | 0.20 | 0.10 | lasso | 8 | 0.14 | 3.0e-10 | 5.6 | -6.3 | 3.6e-10 | -0.07 | 0.11 | 0.89 | TRUE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LBXCOR1 | 0.07 | 0.03 | blup | 57 | 0.03 | 6.3e-03 | 5.6 | -5.7 | 1.5e-08 | 0.02 | 0.02 | 0.53 | TRUE |
| 3 | GTEx | Brain Putamen basal ganglia | DIS3L | 0.37 | 0.01 | lasso | 4 | 0.02 | 1.4e-01 | -4.7 | -5.6 | 1.8e-08 | -0.01 | 0.05 | 0.11 | TRUE |
| 2 | GTEx | Artery Tibial | PIAS1 | 0.14 | 0.02 | enet | 26 | 0.08 | 1.6e-06 | 3.9 | -6.1 | 9.3e-10 | -0.03 | 0.30 | 0.65 | FALSE |
| 4 | GTEx | Colon Transverse | IQCH-AS1 | 0.24 | 0.01 | enet | 31 | 0.08 | 1.5e-04 | 6.1 | 5.9 | 3.2e-09 | 0.19 | 0.40 | 0.06 | FALSE |
| 1 | GTEx | Artery Aorta | PIAS1 | 0.26 | 0.12 | enet | 22 | 0.10 | 3.4e-06 | 5.6 | -5.5 | 3.7e-08 | -0.02 | 0.12 | 0.87 | FALSE |