Best TWAS P=4.5e-17 · Best GWAS P=6.33e-19 conditioned to 0.00024
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ISLR | 0.02 | 0.02 | lasso | 2 | 0.01 | 6.2e-04 | -8.3 | 8.4 | 4.5e-17 | -0.15 | 0.01 | 0.96 | TRUE |
| 5 | GTEx | Testis | LOXL1-AS1 | 0.36 | 0.15 | lasso | 10 | 0.13 | 2.4e-06 | -7.2 | -7.9 | 2.4e-15 | 0.60 | 0.51 | 0.08 | TRUE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | ISLR2 | 0.04 | 0.05 | lasso | 2 | 0.04 | 6.5e-05 | -8.2 | -8.2 | 3.4e-16 | 0.16 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ISLR2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 5.4e-04 | -8.2 | -8.2 | 3.5e-16 | 0.17 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC283731 | 0.02 | 0.03 | lasso | 2 | 0.02 | 7.7e-04 | -8.1 | -8.1 | 5.1e-16 | 0.17 | 0.00 | 0.97 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ISLR2 | 0.06 | 0.07 | lasso | 2 | 0.06 | 3.9e-07 | -8.1 | -8.1 | 5.1e-16 | 0.17 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC283731 | 0.02 | 0.03 | lasso | 3 | 0.02 | 1.5e-03 | -8.0 | -8.1 | 7.7e-16 | 0.17 | 0.00 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC283731 | 0.04 | 0.06 | lasso | 1 | 0.05 | 4.8e-06 | -8.0 | -8.0 | 1.2e-15 | 0.16 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC283731 | 0.02 | 0.01 | blup | 15 | 0.01 | 1.9e-03 | -8.1 | -7.4 | 1.5e-13 | 0.20 | 0.00 | 0.88 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STRA6 | 0.02 | 0.02 | lasso | 2 | 0.02 | 4.5e-05 | -7.4 | 7.3 | 3.7e-13 | -0.09 | 0.10 | 0.47 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | ISLR | 0.08 | 0.00 | enet | 14 | 0.03 | 2.8e-03 | 3.7 | 6.7 | 1.5e-11 | -0.12 | 0.15 | 0.07 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | LOXL1-AS1 | 0.28 | 0.09 | lasso | 6 | 0.17 | 1.7e-12 | 3.8 | 6.4 | 1.2e-10 | -0.64 | 0.99 | 0.01 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC33 | 0.05 | 0.02 | blup | 93 | 0.04 | 4.0e-05 | 1.9 | 6.4 | 2.1e-10 | -0.12 | 0.28 | 0.65 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CYP1A1 | 0.06 | 0.03 | enet | 12 | 0.03 | 1.9e-04 | -5.8 | -5.3 | 1.3e-07 | 0.12 | 0.00 | 0.94 | FALSE |
| 3 | GTEx | Lung | CYP11A1 | 0.10 | 0.01 | enet | 21 | 0.02 | 9.5e-03 | 4.2 | -5.2 | 2.6e-07 | -0.07 | 0.32 | 0.03 | FALSE |
| 1 | GTEx | Breast Mammary Tissue (Female) | STOML1 | 0.30 | 0.00 | lasso | 11 | 0.01 | 1.4e-01 | 1.2 | 5.1 | 3.1e-07 | 0.05 | 0.05 | 0.10 | FALSE |