Best TWAS P=1.64e-15 · Best GWAS P=1.51e-14 conditioned to 0.0457
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-797A18.4 | 0.19 | 0.12 | lasso | 8 | 0.16 | 2.1e-13 | -4.5 | -6.5 | 6.6e-11 | -0.79 | 0.70 | 0.30 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP11-797A18.4 | 0.06 | 0.05 | lasso | 3 | 0.06 | 4.1e-04 | 6.9 | -6.4 | 1.5e-10 | -0.78 | 0.05 | 0.85 | FALSE |
3 | GTEx | Adrenal Gland | RP11-797A18.4 | 0.13 | 0.04 | enet | 18 | 0.11 | 1.1e-04 | -4.4 | -6.3 | 2.3e-10 | -0.75 | 0.04 | 0.80 | FALSE |
4 | GTEx | Artery Aorta | RP11-797A18.4 | 0.13 | 0.11 | enet | 17 | 0.12 | 2.3e-07 | -4.5 | -6.1 | 1.1e-09 | -0.76 | 0.17 | 0.82 | FALSE |
5 | GTEx | Artery Coronary | RP11-797A18.3 | 0.12 | 0.03 | lasso | 10 | 0.01 | 1.1e-01 | -4.4 | -6.9 | 5.5e-12 | -0.80 | 0.04 | 0.50 | FALSE |
6 | GTEx | Artery Tibial | TSPAN3 | 0.14 | 0.07 | lasso | 5 | 0.10 | 1.6e-08 | 7.4 | -8.0 | 1.6e-15 | -0.82 | 0.02 | 0.98 | TRUE |
7 | GTEx | Artery Tibial | RP11-797A18.4 | 0.14 | 0.03 | enet | 25 | 0.09 | 2.3e-07 | 6.9 | -6.6 | 5.0e-11 | -0.66 | 0.05 | 0.95 | FALSE |
8 | GTEx | Brain Caudate basal ganglia | PSTPIP1 | 0.22 | 0.12 | lasso | 9 | 0.13 | 1.4e-04 | 7.1 | 6.5 | 9.7e-11 | 0.80 | 0.03 | 0.92 | FALSE |
9 | GTEx | Brain Caudate basal ganglia | RP11-797A18.4 | 0.21 | 0.14 | lasso | 5 | 0.12 | 2.9e-04 | 6.9 | -7.0 | 2.0e-12 | -0.81 | 0.07 | 0.85 | FALSE |
10 | GTEx | Brain Cerebellar Hemisphere | RP11-797A18.3 | 0.14 | 0.03 | lasso | 6 | 0.02 | 7.9e-02 | -2.1 | -5.3 | 1.0e-07 | -0.66 | 0.06 | 0.33 | FALSE |
11 | GTEx | Brain Cerebellar Hemisphere | RP11-797A18.4 | 0.14 | 0.12 | enet | 10 | 0.12 | 6.4e-04 | 4.5 | -5.9 | 3.2e-09 | -0.75 | 0.06 | 0.67 | FALSE |
12 | GTEx | Brain Cerebellum | HMG20A | 0.14 | 0.03 | enet | 7 | 0.10 | 6.4e-04 | 7.1 | -6.6 | 3.3e-11 | -0.73 | 0.04 | 0.72 | FALSE |
13 | GTEx | Brain Cerebellum | RP11-797A18.4 | 0.29 | 0.20 | lasso | 9 | 0.25 | 4.0e-08 | 7.1 | -6.1 | 1.1e-09 | -0.78 | 0.06 | 0.91 | FALSE |
14 | GTEx | Brain Cortex | RP11-797A18.4 | 0.47 | 0.28 | enet | 14 | 0.34 | 3.3e-10 | 7.0 | -6.8 | 1.4e-11 | -0.81 | 0.03 | 0.97 | FALSE |
15 | GTEx | Brain Frontal Cortex BA9 | RP11-797A18.4 | 0.35 | 0.35 | lasso | 5 | 0.35 | 4.8e-10 | 6.9 | -6.8 | 1.5e-11 | -0.79 | 0.12 | 0.88 | FALSE |
16 | GTEx | Brain Hypothalamus | RP11-797A18.4 | 0.21 | 0.18 | lasso | 7 | 0.22 | 7.6e-06 | 7.1 | -7.6 | 2.7e-14 | -0.92 | 0.01 | 0.98 | FALSE |
17 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-797A18.4 | 0.12 | 0.22 | lasso | 1 | 0.17 | 3.1e-05 | 6.9 | -6.9 | 6.7e-12 | -0.80 | 0.06 | 0.72 | FALSE |
18 | GTEx | Brain Putamen basal ganglia | RP11-797A18.4 | 0.27 | 0.06 | lasso | 5 | 0.06 | 1.7e-02 | 6.9 | -6.2 | 4.0e-10 | -0.77 | 0.03 | 0.45 | FALSE |
19 | GTEx | Cells EBV-transformed lymphocytes | PSTPIP1 | 0.13 | 0.04 | enet | 13 | 0.10 | 4.0e-04 | 5.6 | -5.9 | 2.8e-09 | -0.73 | 0.07 | 0.76 | FALSE |
20 | GTEx | Cells EBV-transformed lymphocytes | TSPAN3 | 0.26 | 0.14 | lasso | 6 | 0.12 | 8.2e-05 | -5.6 | -6.0 | 2.2e-09 | -0.53 | 0.14 | 0.28 | FALSE |
21 | GTEx | Cells EBV-transformed lymphocytes | RP11-797A18.4 | 0.16 | 0.08 | lasso | 6 | 0.14 | 2.7e-05 | -4.5 | -6.3 | 2.2e-10 | -0.77 | 0.09 | 0.82 | FALSE |
22 | GTEx | Cells Transformed fibroblasts | TSPAN3 | 0.17 | 0.16 | lasso | 3 | 0.17 | 1.7e-12 | 7.4 | -6.8 | 1.5e-11 | -0.84 | 0.00 | 1.00 | FALSE |
23 | GTEx | Cells Transformed fibroblasts | RP11-797A18.4 | 0.12 | 0.11 | lasso | 8 | 0.12 | 4.0e-09 | 7.0 | -7.4 | 1.3e-13 | -0.86 | 0.02 | 0.98 | FALSE |
24 | GTEx | Cells Transformed fibroblasts | RP11-797A18.6 | 0.07 | 0.06 | lasso | 4 | 0.06 | 2.2e-05 | 7.4 | -6.3 | 2.6e-10 | -0.77 | 0.01 | 0.98 | FALSE |
25 | GTEx | Colon Transverse | RP11-797A18.4 | 0.15 | 0.03 | lasso | 5 | 0.05 | 3.1e-03 | -4.5 | -6.7 | 3.0e-11 | -0.77 | 0.04 | 0.89 | FALSE |
26 | GTEx | Esophagus Gastroesophageal Junction | RP11-797A18.4 | 0.14 | 0.11 | enet | 10 | 0.15 | 6.0e-06 | 4.5 | -6.5 | 7.1e-11 | -0.81 | 0.02 | 0.97 | FALSE |
27 | GTEx | Esophagus Muscularis | RP11-797A18.4 | 0.07 | 0.09 | lasso | 3 | 0.09 | 6.3e-06 | 7.4 | -7.4 | 1.8e-13 | -0.87 | 0.01 | 0.98 | FALSE |
28 | GTEx | Heart Atrial Appendage | RP11-797A18.4 | 0.16 | 0.06 | enet | 17 | 0.11 | 1.5e-05 | 6.9 | -6.0 | 2.5e-09 | -0.72 | 0.10 | 0.86 | FALSE |
29 | GTEx | Heart Left Ventricle | RP11-797A18.4 | 0.16 | 0.09 | enet | 12 | 0.08 | 3.3e-05 | 7.4 | -7.1 | 1.6e-12 | -0.84 | 0.02 | 0.98 | FALSE |
30 | GTEx | Lung | RP11-797A18.3 | 0.05 | 0.03 | enet | 8 | 0.04 | 3.4e-04 | -4.5 | -6.4 | 2.0e-10 | -0.79 | 0.08 | 0.82 | FALSE |
31 | GTEx | Lung | RP11-797A18.4 | 0.19 | 0.09 | enet | 21 | 0.17 | 3.5e-13 | 6.9 | -6.7 | 2.2e-11 | -0.68 | 0.09 | 0.91 | FALSE |
32 | GTEx | Muscle Skeletal | HMG20A | 0.04 | 0.00 | lasso | 4 | 0.01 | 7.2e-02 | 5.6 | -5.5 | 3.3e-08 | -0.55 | 0.03 | 0.75 | FALSE |
33 | GTEx | Muscle Skeletal | RP11-797A18.4 | 0.14 | 0.14 | lasso | 6 | 0.18 | 6.6e-17 | 7.0 | -6.6 | 4.0e-11 | -0.81 | 0.05 | 0.95 | FALSE |
34 | GTEx | Nerve Tibial | TSPAN3 | 0.13 | 0.08 | lasso | 2 | 0.07 | 9.0e-06 | 7.4 | -7.3 | 2.6e-13 | -0.85 | 0.01 | 0.99 | FALSE |
35 | GTEx | Ovary | RP11-797A18.6 | 0.21 | 0.04 | enet | 15 | 0.13 | 3.7e-04 | 7.4 | -5.6 | 2.6e-08 | -0.78 | 0.04 | 0.63 | FALSE |
36 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-797A18.3 | 0.15 | 0.08 | lasso | 3 | 0.09 | 1.2e-05 | -4.5 | -6.8 | 1.5e-11 | -0.78 | 0.13 | 0.82 | FALSE |
37 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-797A18.4 | 0.19 | 0.10 | enet | 31 | 0.15 | 8.0e-09 | 7.0 | -7.0 | 2.0e-12 | -0.72 | 0.11 | 0.89 | FALSE |
38 | GTEx | Skin Sun Exposed Lower leg | TSPAN3 | 0.11 | 0.03 | enet | 8 | 0.10 | 2.5e-08 | -5.6 | -6.2 | 6.1e-10 | -0.68 | 0.08 | 0.85 | FALSE |
39 | GTEx | Skin Sun Exposed Lower leg | RP11-797A18.4 | 0.16 | 0.08 | enet | 23 | 0.09 | 1.3e-07 | 6.9 | -7.4 | 1.6e-13 | -0.84 | 0.03 | 0.97 | FALSE |
40 | GTEx | Testis | PSTPIP1 | 0.10 | 0.03 | lasso | 3 | 0.02 | 4.1e-02 | 7.0 | -7.0 | 1.9e-12 | -0.81 | 0.04 | 0.82 | FALSE |
41 | GTEx | Testis | TSPAN3 | 0.19 | 0.05 | lasso | 7 | 0.06 | 1.6e-03 | 6.9 | -6.1 | 1.1e-09 | -0.72 | 0.04 | 0.86 | FALSE |
42 | GTEx | Uterus | RP11-797A18.4 | 0.26 | 0.11 | enet | 12 | 0.16 | 4.0e-04 | 7.6 | -5.8 | 6.4e-09 | -0.84 | 0.01 | 0.90 | FALSE |
43 | GTEx | Whole Blood | TSPAN3 | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.8e-03 | -5.6 | -5.9 | 4.5e-09 | -0.55 | 0.11 | 0.36 | FALSE |
44 | GTEx | Whole Blood | RP11-797A18.4 | 0.21 | 0.18 | enet | 26 | 0.19 | 1.6e-17 | -4.5 | -5.5 | 5.1e-08 | -0.64 | 1.00 | 0.00 | FALSE |
45 | GTEx | Whole Blood | RP11-797A18.6 | 0.04 | 0.02 | enet | 8 | 0.03 | 4.9e-04 | -4.4 | -5.5 | 3.3e-08 | -0.75 | 0.15 | 0.39 | FALSE |
46 | NTR | Blood | TSPAN3 | 0.07 | 0.08 | lasso | 9 | 0.09 | 5.1e-27 | 6.9 | -6.6 | 3.9e-11 | -0.79 | 0.31 | 0.69 | FALSE |
47 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TSPAN3 | 0.05 | 0.00 | enet | 7 | 0.02 | 9.7e-03 | 6.9 | -6.2 | 7.0e-10 | -0.71 | 0.01 | 0.74 | FALSE |
48 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSPAN3 | 0.03 | 0.01 | blup | 43 | 0.01 | 8.2e-03 | 3.9 | -5.8 | 4.9e-09 | -0.68 | 0.03 | 0.64 | FALSE |
49 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TSPAN3 | 0.05 | 0.01 | blup | 43 | 0.01 | 1.5e-02 | 7.0 | -7.3 | 3.5e-13 | -0.78 | 0.01 | 0.48 | FALSE |