Best TWAS P=8.62e-12 · Best GWAS P=6.98e-12 conditioned to 0.0193
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | C17orf103 | 0.16 | 0.06 | lasso | 5 | 0.06 | 2.1e-04 | 4.9 | -5.5 | 4.0e-08 | 0.35 | 0.20 | 0.38 | FALSE |
| 2 | GTEx | Lung | C17orf103 | 0.08 | 0.01 | enet | 11 | 0.04 | 6.6e-04 | -4.2 | -5.3 | 1.2e-07 | 0.53 | 0.18 | 0.40 | FALSE |
| 3 | GTEx | Testis | C17orf103 | 0.15 | 0.21 | enet | 4 | 0.19 | 7.1e-09 | 5.5 | -6.1 | 1.0e-09 | 0.35 | 0.87 | 0.11 | FALSE |
| 4 | GTEx | Thyroid | KCNJ12 | 0.36 | 0.23 | lasso | 5 | 0.25 | 2.9e-19 | 5.1 | 6.8 | 8.6e-12 | -0.80 | 0.67 | 0.33 | TRUE |
| 5 | NTR | Blood | C17orf103 | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.6e-07 | 5.4 | -5.8 | 5.5e-09 | 0.34 | 0.93 | 0.05 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C17orf103 | 0.03 | 0.04 | lasso | 1 | 0.04 | 7.9e-08 | 5.4 | -5.4 | 6.5e-08 | 0.32 | 0.00 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C17orf103 | 0.05 | 0.04 | lasso | 3 | 0.02 | 5.4e-03 | 5.4 | -5.4 | 7.2e-08 | 0.32 | 0.00 | 0.89 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C17orf103 | 0.13 | 0.14 | lasso | 1 | 0.11 | 2.9e-05 | 5.4 | -5.4 | 6.5e-08 | 0.32 | 0.00 | 0.97 | FALSE |