TWAS hub - KCNJ12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.239	0.080	2.5e-03	0.027	NA	0.073	NA	-0.005	1.3e-02	NA	7.6e-05	NA	8.2e-01
2	GTEx	Skin Sun Exposed Lower leg	0.104	0.039	2.4e-03	0.008	NA	0.006	NA	0.018	6.3e-02	NA	8.8e-02	NA	1.2e-02
3	GTEx	Thyroid	0.361	0.061	1.5e-12	0.233	NA	0.216	NA	0.251	9.2e-18	NA	1.8e-16	NA	2.9e-19

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Leg fat percentage (right)	4.7	16.9	50.1	0.3	0.6	-7.1
Leg fat percentage (left)	4.7	17.1	50.7	0.5	0.5	-7.1
Body mass index (BMI)	4.5	19.0	56.1	0.6	0.7	-7.5
Taking other prescription medications	4.3	6.6	19.8	0.1	-0.3	-4.5
BMI	4.2	24.1	71.7	0.3	0.7	-8.5
Number of live births	4.2	5.9	16.6	1.0	0.3	-4.1
Exposure to tobacco smoke outside home	4.2	5.6	13.2	1.4	1.3	-3.6
Qualifications: nursing, teaching	4.1	6.4	8.0	2.4	2.4	2.8
Medication: Lansoprazole	3.9	4.4	11.2	0.8	1.2	-3.3
Cholesterol lowering medication	3.6	5.3	12.9	-1.3	-1.1	-3.6
Qualifications: O levels/GCSEs or equivalent	3.5	5.6	7.1	2.2	2.7	2.2
Medication: Aspirin	3.5	4.6	8.0	1.6	1.8	-2.8
Medication: Simvastatin	3.4	5.0	14.8	-0.4	-0.0	-3.9
Standing height	3.4	34.1	100.0	-1.1	-1.0	10.0
Qualifications: None of the above	3.3	7.1	8.2	-2.2	-2.9	-2.9
Impedance of arm (right)	3.3	15.6	46.6	-0.1	0.3	6.8
Chronic bronchitis/emphysema (mother)	3.3	3.8	6.6	2.6	2.1	-0.6
Body Mass Index (BMI) (2010)	3.2	4.3	12.7	-0.6	0.1	-3.6
Impedance of arm (left)	3.2	14.6	43.7	-0.5	-0.0	6.6
Height	3.1	59.5	174.2	-1.4	-1.5	13.2
Neuroticism score	3.1	6.4	9.4	-3.0	-3.1	1.0
Sensitivity / hurt feelings	3.0	5.2	6.8	-2.6	-2.4	1.8
Medication: Ramipril	3.0	3.9	4.4	2.0	2.1	-1.8
Medication: Aspirin	3.0	4.0	8.9	1.2	1.2	-3.0
Age at first live birth	2.8	5.0	11.8	-1.2	-1.4	3.4
Hearing aid user	2.8	3.2	9.2	0.5	0.3	-3.0
Leg fat mass (left)	2.8	10.9	32.7	0.2	0.2	-5.7
Number of treatments/medications taken	2.7	4.9	11.9	-1.3	-1.1	-3.5
Leg fat mass (right)	2.7	10.6	31.6	0.0	0.3	-5.6
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	7.7	0.4	0.9	-2.8
Medication for hormone replacement therapy	2.6	2.9	5.8	1.2	1.2	2.4
Pulse wave Arterial Stiffness index	2.6	3.1	4.2	2.0	1.9	1.2
High cholesterol (Self-reported)	2.6	4.6	13.4	-0.5	-0.2	-3.7
Neuroticism	2.5	6.1	9.3	-3.0	-3.0	0.3
Waist circumference	2.5	9.1	25.1	1.0	1.1	-5.0
Body fat percentage	2.5	9.9	29.1	0.3	0.7	-5.4
Pulse wave peak to peak time	2.5	3.0	4.6	-2.1	-2.0	-0.6
Overall health rating	2.5	5.3	14.0	1.1	0.9	-3.7
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.4	15.6	-0.5	-0.7	-3.9
Exposure to tobacco smoke at home	2.4	2.7	8.2	-0.0	-0.1	-2.9
Worry too long after embarrassment	2.4	4.0	8.6	-1.3	-1.3	2.9
Pain type(s) experienced in last month: Hip pain	2.4	3.0	7.9	-0.9	-0.5	-2.8
HDL Cholesterol	2.3	3.9	5.6	-1.9	-1.6	2.4
Severe depression (siblings)	2.3	2.6	5.2	1.2	1.0	2.3
Medication: Allopurinol	2.3	3.1	5.9	-1.7	-2.4	-0.7
Number of full sisters	2.3	2.9	8.3	-0.4	-0.3	-2.9
Diabetes diagnosed by doctor	2.3	3.8	9.8	0.4	1.2	-3.1
Number of self-reported non-cancer illnesses	2.3	3.9	8.9	1.5	0.7	-3.0
Medication: Atorvastatin	2.3	2.8	3.4	-1.8	-1.9	-1.4
Average weekly spirits intake	2.2	2.7	3.7	-1.8	-1.1	-1.9
Arm fat percentage (left)	2.2	8.9	25.9	0.3	0.8	-5.1
Bipolar Disorder or Schizophrenia	2.1	5.1	7.9	2.8	2.3	-1.4
Triglycerides	2.1	3.4	7.5	1.3	1.0	-2.7
Type 2 Diabetes (T2D) (2018)	2.1	3.9	11.1	-0.7	0.3	-3.3
Angina	2.1	2.7	6.8	-0.5	-1.1	-2.6
Townsend deprivation index at recruitment	2.1	3.0	8.0	0.6	-0.8	-2.8
Average weekly fortified wine intake	2.1	2.4	5.0	0.9	1.2	2.2
Age when periods started (menarche)	2.1	5.2	9.4	-1.8	-1.7	3.1
Arm fat percentage (right)	2.1	8.2	24.0	0.3	0.8	-4.9
Qualifications: A levels/AS levels or equivalent	2.1	4.6	9.8	1.4	1.4	3.1
Schizophrenia (2018)	2.0	4.1	5.1	2.0	2.3	-1.8
Diabetes (self-reported)	2.0	3.1	8.5	0.0	0.9	-2.9
Illnesses of mother	2.0	2.5	4.3	-1.8	-2.1	0.1
Qualifications: College or University degree	2.0	6.2	10.9	2.0	1.9	3.3
Illnesses of siblings: Diabetes	2.0	2.5	3.7	-1.6	-1.1	-1.9
Breast cancer (self-reported)	2.0	2.4	7.0	-0.4	-0.0	-2.6
Impedance of whole body	2.0	10.0	29.8	-0.3	0.1	5.5
Hair/balding pattern: Pattern 3	1.9	2.8	4.7	1.9	2.2	-0.4
Angina (self-reported)	1.9	2.5	4.9	-0.8	-1.4	-2.2
Schizophrenia (2014)	1.8	3.9	5.5	2.3	2.1	-1.3
Sitting height	1.8	12.5	32.1	-1.8	-1.5	5.7
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	3.4	1.7	1.8	1.0
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	8.2	-0.6	-0.6	2.9
Mood swings	1.8	3.2	5.9	-1.3	-1.4	-2.4
Ever taken oral contraceptive pill	1.8	2.0	3.1	1.2	1.2	1.8
Unable to work because of sickness or disability	1.8	2.3	6.7	0.4	0.4	-2.6
Fed-up feelings	1.7	3.1	4.4	-1.7	-2.1	1.5
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.2	-1.8	-1.3	1.0
Multivitamins +/- minerals	1.7	2.2	3.9	1.0	2.0	1.3
High blood pressure (mother)	1.7	2.3	4.1	1.1	2.0	-1.3
Illnesses of siblings	1.7	2.4	7.1	0.3	0.0	2.7
Hair/balding pattern: Pattern 4	1.7	4.1	5.5	-2.2	-1.4	2.4
High blood pressure (siblings)	1.7	2.4	4.0	1.1	1.4	-2.0
Arm fat mass (left)	1.7	7.0	20.2	0.4	0.7	-4.5
Miserableness	1.7	2.9	5.2	-1.8	-2.3	-0.7
LDL Cholesterol	1.6	2.6	6.0	-1.0	-0.9	-2.5
Vitamin and mineral supplements	1.6	2.1	4.3	-0.8	-2.1	-1.2
Arm fat mass (right)	1.6	6.6	18.8	0.5	0.8	-4.3
Myopia	1.6	2.3	6.7	0.1	0.4	2.6
Heart disease (siblings)	1.6	2.0	2.9	-0.9	-1.5	-1.7
Coronary Artery Disease (CAD)	1.5	1.8	3.5	1.3	1.9	-0.5
Cardiovascular Disease	1.5	4.9	8.0	1.6	2.0	-2.8
Trunk fat percentage	1.5	5.8	16.6	0.5	0.8	-4.1
Medication: Levothyroxine sodium	1.5	2.5	3.5	-0.9	-1.9	-1.8
Alcohol usually taken with meals	1.5	2.5	2.8	1.5	1.7	1.5
Whole body fat mass	1.5	6.4	19.2	0.0	0.3	-4.4
Hypertension (Self-reported)	1.5	4.2	6.7	2.6	2.2	-0.9
Long-standing illness, disability or infirmity	1.5	2.2	6.7	0.0	0.1	-2.6
Medication: Gliclazide	1.5	1.7	4.3	0.3	0.9	-2.1
Commuting to job workplace: Public transport	1.5	1.8	2.8	-1.0	-1.3	1.7
Depressed Affect (Nagel 2018)	1.4	2.9	4.0	-2.0	-1.9	-1.1
HbA1C	1.4	1.5	2.3	1.5	1.5	-0.4
Neuroticism (2016)	1.4	2.0	2.4	-1.4	-1.2	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.1	-1.6	-1.8	-0.1
High blood pressure	1.4	3.8	6.4	2.5	2.0	-1.0
Pulse rate	1.4	2.4	3.3	1.4	1.8	-1.4
Medication: Cholesterol lowering	1.4	2.2	6.4	0.0	0.3	-2.5
Lung cancer (father)	1.4	1.6	2.6	-1.6	-1.2	-0.8
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	3.6	-1.2	-1.8	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	8.8	0.3	0.1	3.0
Wears glasses or contact lenses	1.4	1.6	4.7	0.2	-0.2	2.2
Irritability	1.4	2.4	3.8	-2.0	-1.8	-0.2
Commuting to job workplace: Cycle	1.4	1.7	3.0	1.7	0.5	-1.4
Prostate Cancer	1.3	1.9	5.2	0.3	-0.6	-2.3
Lupus	1.3	2.0	5.2	0.2	0.9	2.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.3	-1.2	-1.2	-1.5
Chronic bronchitis/emphysema (father)	1.3	1.5	1.8	-1.2	-1.1	-1.4
Had menopause	1.3	1.6	3.2	-0.8	-1.0	1.8
Medication for pain relief, constipation, heartburn	1.3	2.3	5.6	1.0	0.4	2.4
Pulse rate, automated reading	1.3	4.3	4.8	2.2	2.1	-2.0
Illnesses of father: None of the above (group 1)	1.3	1.6	3.5	1.2	0.1	1.9
Guilty feelings	1.3	1.9	5.6	0.2	0.4	2.4
Vascular/heart problems diagnosed by doctor	1.3	3.6	5.6	-2.4	-1.8	1.4
Age at First Birth	1.2	1.7	2.2	1.5	1.3	1.1
Hypothyroidism (self reported)	1.2	2.8	5.0	-1.0	-1.6	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	7.5	-0.6	-0.8	-2.7
Qualifications: CSEs or equivalent	1.2	1.6	2.8	1.2	1.7	-0.7
Gout (self-reported)	1.2	1.7	2.9	-0.8	-1.7	-1.3
Smoking status: Current	1.2	1.8	5.2	0.3	0.5	-2.3
Relative age of first facial hair	1.1	2.2	6.1	0.5	0.6	-2.5
Medication: Metformin	1.1	1.6	3.8	0.4	0.9	-2.0
Diabetes (mother)	1.1	1.4	3.6	-0.6	0.3	-1.9
Mouth/teeth dental problems: Dentures	1.1	1.8	2.4	-1.5	-1.5	-1.0
Length of working week for main job	1.1	1.2	1.8	-0.7	-1.1	1.3
Pulse wave reflection index	1.1	1.4	1.6	1.3	1.1	1.1
Suffer from ‘nerves’	1.1	1.8	3.9	0.9	0.8	2.0
Supplements: Vitamin C	1.1	1.3	1.8	0.6	1.4	1.3
Ever smoked	1.1	1.9	5.1	-0.4	-0.7	2.2
Supplements: Calcium	1.1	1.2	2.2	-1.2	-1.5	0.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.5	0.9	-0.1	-1.9
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.5	1.0	1.2	0.9
Hand grip strength (left)	1.0	2.7	3.4	1.5	1.8	1.6
Serious illness, injury or assault to yourself	1.0	1.2	2.2	-1.0	-0.6	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.9	-1.4	-1.7	-0.2
Alcohol intake versus 10 years previously	1.0	1.5	2.0	-1.2	-1.0	-1.4
Worrier / anxious feelings	1.0	1.9	2.3	-1.5	-1.5	1.0
Falls in the last year	1.0	1.4	2.2	-1.2	-1.5	-0.7
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.4	-1.2	-1.6	-0.3
Number of full brothers	1.0	1.3	3.9	-0.2	-0.2	-2.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.9	-0.9	-1.7	-0.2
Medication: Blood pressure	1.0	1.8	4.2	0.9	0.6	-2.1
Medication: Omeprazole	1.0	1.2	3.1	0.4	-0.7	-1.8
Mean time to correctly identify matches	1.0	1.8	3.4	-0.8	-1.9	1.2
Smoking status: Previous	1.0	1.5	2.4	-0.7	-1.3	1.5
Medication: Bendroflumethiazide	1.0	1.6	2.6	1.6	1.4	0.3
Average weekly beer plus cider intake	1.0	1.4	3.4	-0.5	-0.7	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	3.1	0.0	-0.9	-1.8
Alcohol drinker status: Previous	1.0	1.2	2.7	-0.9	-1.6	-0.1
Bipolar Disorder (2018)	0.9	1.5	3.6	1.9	0.9	-0.0
Depression (Nagel 2018)	0.9	1.3	2.3	-1.3	-1.5	0.0
Rheumatoid Arthritis	0.9	1.2	2.7	0.6	0.8	1.7
Blood Platelet Count	0.9	10.5	22.0	2.0	2.4	-4.7
Lung FVC	0.9	4.5	12.0	1.2	0.2	-3.5
Diabetes (father)	0.9	1.1	3.2	0.4	0.1	-1.8
Hand grip strength (right)	0.9	2.6	3.9	1.5	2.0	1.2
Trunk fat mass	0.9	3.8	11.2	0.2	0.5	-3.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.8	-0.6	0.0	1.7
Number of children fathered	0.9	1.1	1.6	-0.8	-1.0	-1.3
Neck or shoulder pain in last month	0.9	1.3	3.2	-0.7	-0.5	-1.8
Knee pain experienced in last month	0.9	1.4	2.9	-0.8	-0.7	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.5	-1.0	-0.9	-1.2
Medication: Blood pressure	0.9	1.8	2.9	1.7	1.5	-0.3
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.3	1.0	1.1	-1.0
Reaction Time	0.8	1.5	2.3	-0.9	-1.2	1.5
Waist Hip Ratio (WHR)	0.8	3.4	4.2	1.7	1.8	-2.1
Forced vital capacity (FVC)	0.8	2.9	5.9	1.3	1.1	2.4
Blood clot in the leg (DVT)	0.8	1.0	2.5	0.6	-0.4	-1.6
Had major operations	0.8	0.9	2.6	-0.2	0.2	-1.6
Crohns Disease (2017)	0.7	1.6	2.6	-0.5	-1.6	-1.4
Chronotype (morning person)	0.7	1.6	3.6	-1.9	-0.9	-0.7
Impedance of leg (right)	0.7	3.3	9.8	-0.4	0.2	3.1
Current tobacco smoking	0.7	1.1	3.3	-0.0	0.0	-1.8
Maternal smoking around birth	0.7	0.9	2.5	-0.1	-0.6	-1.6
Impedance of leg (left)	0.7	3.4	10.3	-0.2	0.1	3.2
Past tobacco smoking	0.7	1.2	1.8	0.8	1.2	-1.3
Hip circumference	0.7	3.0	7.6	0.6	1.0	-2.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	3.9	1.1	1.2	2.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	-1.2	-0.8	0.8
Medication: Ibuprofen	0.7	0.8	1.2	-1.1	-1.0	0.4
Ever had bowel cancer screening	0.7	0.9	1.7	0.7	1.3	0.6
Eye problems/disorders: Cataract	0.7	0.8	1.3	0.9	0.3	-1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.3	0.6	1.0	1.1
Medication: Lisinopril	0.7	0.9	2.2	0.3	0.7	-1.5
Neuroticism (Nagel 2018)	0.6	1.4	2.2	-1.5	-1.4	0.2
Irritable Bowel Disease (IBD)	0.6	1.4	3.4	-0.4	-1.9	-0.7
Pack years adult smoking proportion	0.6	0.9	2.3	0.6	0.2	-1.5
Stomach or abdominal pain in last month	0.6	0.8	1.5	-0.3	-1.2	-0.9
Time employed in main current job	0.6	0.6	1.9	0.1	0.1	-1.4
Breastfed as a baby	0.6	0.7	2.0	-1.4	-0.4	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	-0.2	0.1	1.4
Shortness of breath walking on level ground	0.6	0.7	1.1	-0.9	-0.2	-1.1
Migraine (self-reported)	0.6	0.7	1.2	-1.0	-1.1	0.3
Alcohol intake frequency.	0.6	1.5	3.1	-0.1	-1.1	-1.8
Comparative height size at age 10	0.6	3.5	10.4	-0.0	0.2	3.2
Loneliness, isolation	0.6	0.8	1.7	-1.3	-0.2	-0.8
Mineral and other dietary supplements	0.6	0.8	1.7	-0.8	-1.3	-0.1
Osteoarthritis (self-reported)	0.6	0.8	1.7	0.8	0.3	-1.3
Average weekly champagne plus white wine intake	0.6	0.9	1.6	0.8	0.5	1.3
Illnesses of father: High blood pressure	0.6	0.8	1.3	1.1	1.0	-0.3
Ulcerative Colitis	0.5	0.7	1.2	-0.7	-1.1	0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	-1.1	-0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.8	-0.0	0.0	-1.3
Medication: Atenolol	0.5	0.6	0.8	-0.4	-0.9	-0.8
Fluid intelligence score	0.5	1.0	2.8	-0.1	-0.3	1.7
Weight	0.5	2.4	7.2	0.1	0.2	-2.7
Depression (self-reported)	0.5	0.6	1.0	1.0	0.7	0.4
Forced vital capacity (FVC), Best measure	0.5	1.9	4.7	0.8	0.6	2.2
Health satisfaction	0.5	0.6	1.3	0.5	0.6	-1.2
Eye problems/disorders: None of the above	0.5	0.6	0.9	-1.0	-0.6	0.7
Osteoporosis (self-reported)	0.5	0.7	1.1	-0.7	-1.1	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.2	1.8	1.0	-0.1
Alzheimer’s Disease (in mother)	0.4	0.4	0.7	-0.4	-0.8	-0.7
Alzheimer’s Disease (in father)	0.4	0.5	0.7	-0.8	0.3	0.8
Blood White Count	0.4	2.8	8.3	-0.2	0.3	-2.9
Ever had hysterectomy (womb removed)	0.4	0.4	0.6	-0.8	-0.8	-0.3
Systolic blood pressure, automated reading	0.4	1.3	3.8	0.2	0.1	-2.0
Supplements: Zinc	0.4	0.4	1.1	-0.3	0.1	1.1
Mouth/teeth dental problems	0.4	0.6	1.3	0.6	0.4	1.1
Heart attack	0.4	0.6	0.7	-0.7	-0.9	-0.7
Happiness	0.4	0.5	0.9	0.4	0.7	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	1.0	0.5	-0.6
Prospective memory result	0.4	0.4	0.9	0.2	0.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.3	0.4	0.6	1.8
Headache pain in last month	0.4	0.7	1.0	-1.0	-0.6	0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	-1.0	-0.7	0.2
Illnesses of father: Heart disease	0.4	0.5	0.8	0.5	0.9	-0.8
Risk taking	0.4	0.6	1.0	0.3	1.0	-0.9
Age started oral contraceptive pill	0.4	0.5	0.9	0.8	-0.0	1.0
Pack years of smoking	0.4	0.6	1.7	0.3	-0.2	-1.3
Worry (Nagel 2018)	0.3	0.7	1.1	-0.9	-1.1	-0.0
Mean Putamen Volume	0.3	0.4	0.8	0.1	-0.6	-0.9
Blood Red Count	0.3	3.1	8.7	-0.7	-0.3	3.0
Heel T-Score	0.3	2.0	4.8	1.0	0.5	-2.2
Smoking Status	0.3	0.6	1.4	0.7	0.1	-1.2
Tanning	0.3	3.2	4.5	-1.6	-1.6	2.1
Medication: Co-codamol	0.3	0.4	0.8	0.6	-0.0	-0.9
Relative age voice broke	0.3	0.5	0.9	0.5	0.6	-1.0
Number of incorrect matches in round	0.3	0.5	1.2	-0.4	-1.1	-0.3
Noisy workplace	0.3	0.4	0.6	0.6	0.4	-0.8
Tense / ‘highly strung’	0.3	0.4	0.8	-0.6	-0.9	-0.3
Peak expiratory flow (PEF)	0.3	0.6	1.2	0.7	1.1	0.5
Medication: Amlodipine	0.3	0.4	0.9	-0.7	-0.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.6	0.6	0.2	-0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.8	-0.1	0.1	-1.4
Heart disease (mother)	0.3	0.4	0.6	0.8	0.4	-0.7
Age at last live birth	0.3	0.4	1.2	0.3	0.1	1.1
Average weekly red wine intake	0.3	0.4	0.6	0.1	0.8	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	0.9	0.2	-0.4
Mother’s age at death	0.3	0.3	0.7	-0.5	-0.9	0.0
Diastolic blood pressure, automated reading	0.3	0.8	2.2	0.2	0.4	-1.5
Ever depressed for a whole week	0.3	0.4	1.0	-0.0	1.0	0.4
Pain experienced in last month	0.3	0.4	1.0	0.5	0.2	1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.4	-0.6	-0.6	-0.6
Systolic Blood Pressure	0.2	1.0	1.5	1.2	1.0	0.8
Lung FEV1/FVC ratio	0.2	1.1	2.5	0.7	1.6	0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.1	0.2	0.8
Nervous feelings	0.2	0.3	0.5	-0.5	-0.5	0.7
Financial difficulties in last 2 years	0.2	0.2	0.6	0.1	-0.1	0.8
Pain all over the body in last month	0.2	0.2	0.5	-0.2	-0.7	0.5
Trunk fat-free mass	0.2	1.3	3.8	-0.0	-0.1	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	-0.6	-0.6	-0.4
Asthma	0.2	0.3	0.7	-0.4	-0.4	0.8
Trunk predicted mass	0.2	1.3	3.8	-0.1	-0.1	1.9
Birth weight of first child	0.2	0.3	0.8	0.0	0.0	-0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.7	-0.4	0.1
Medication: Paracetamol	0.2	0.3	0.4	-0.7	0.2	-0.5
Glaucoma (self-reported)	0.2	0.3	0.5	-0.5	-0.2	-0.7
Comparative body size at age 10	0.2	0.7	1.6	0.6	1.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	-0.5	-0.4	-0.7
Chest pain or discomfort	0.2	0.3	0.5	-0.0	-0.7	-0.7
Family relationship satisfaction	0.2	0.3	0.4	0.6	0.7	-0.0
Leg pain on walking	0.2	0.3	0.6	-0.2	-0.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.5	0.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	0.2	-0.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.1	0.2	-1.0
Asthma (self-reported)	0.2	0.3	0.6	-0.4	-0.5	0.8
Alcohol drinker status: Never	0.2	0.2	0.5	-0.3	-0.7	-0.1
Number of operations (self-reported)	0.2	0.2	0.4	-0.6	0.1	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.2	-0.6	0.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	0.0	0.0	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.7	-0.2	0.0
Ulcerative Colitis (UC)	0.1	0.2	0.7	0.1	-0.8	0.1
Major Depression (MDD)	0.1	0.1	0.3	-0.6	0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.9	0.2	0.3	1.0
Breast Cancer	0.1	0.3	0.4	-0.4	-0.7	0.6
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.0	0.0	-0.6
Blood Eosinophil Count	0.1	1.1	1.7	1.3	1.3	-0.2
Allergy or Eczema	0.1	0.2	0.4	-0.5	-0.1	0.6
Respiratory disease	0.1	0.2	0.3	0.4	0.0	0.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.2	-0.5	0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.3	0.1	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	-0.1	0.3	0.9
Supplements: Glucosamine	0.1	0.1	0.2	-0.1	0.4	0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.5	0.5	0.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	-0.3	0.0
Had other major operations	0.1	0.2	0.3	-0.6	0.0	0.4
Father’s age at death	0.1	0.1	0.3	0.0	-0.1	0.6
Loud music exposure frequency	0.1	0.1	0.2	-0.0	-0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.2	0.0	0.7
Birth weight	0.1	0.3	0.5	0.4	0.5	-0.7
Arm fat-free mass (right)	0.1	0.4	1.1	0.0	-0.0	-1.1
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.2	0.0	0.5
Arm predicted mass (right)	0.1	0.4	1.2	-0.1	-0.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.1	-0.4	-0.3
Friendships satisfaction	0.1	0.1	0.2	0.0	0.1	0.4
Medication for cholesterol	0.1	0.2	0.4	-0.2	-0.5	0.6
Back pain experienced in last month	0.1	0.2	0.5	-0.4	0.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	0.6	0.0	-0.2
Financial situation satisfaction	0.1	0.1	0.4	0.1	-0.0	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.0	0.6	0.4
Medication: Paracetamol	0.1	0.1	0.1	0.0	0.4	-0.3
Arm fat-free mass (left)	0.1	0.4	1.2	0.2	0.2	-1.1
Fractured/broken bones in last 5 years	0.1	0.1	0.4	-0.2	-0.1	-0.6
Arm predicted mass (left)	0.1	0.4	1.1	-0.0	-0.0	-1.0
Ovarian Cancer	0.0	0.0	0.1	0.2	0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.1	0.0	0.0	0.4
Fasting Glucose	0.0	0.0	0.0	0.2	0.1	0.2
Hair Pigment	0.0	1.0	2.7	-0.0	0.7	-1.6
Leg fat-free mass (left)	0.0	0.1	0.2	0.4	0.4	-0.2
Leg predicted mass (left)	0.0	0.1	0.1	0.3	0.3	-0.1
Allergy	0.0	0.1	0.1	0.3	0.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.0	0.0	0.3
Emphysema/chronic bronchitis	0.0	0.0	0.1	-0.2	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.1	0.1	-0.3	-0.1	0.2
Whole body fat-free mass	0.0	0.3	0.8	0.1	0.0	0.9
Leg fat-free mass (right)	0.0	0.1	0.3	0.5	0.4	0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	0.0	-0.0	0.3
Whole body water mass	0.0	0.2	0.6	0.2	0.2	0.7
Leg predicted mass (right)	0.0	0.2	0.3	0.5	0.3	0.2
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.3	-0.2	-0.2
Basal metabolic rate	0.0	0.1	0.1	0.3	0.3	0.0

Hub : Genes

KCNJ12

Models

Trait associations