Hub : Genes

KCNJ12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Not Sun Exposed Suprapubic 0.239 0.080 2.5e-03 0.027 NA 0.073 NA -0.005 1.3e-02 NA 7.6e-05 NA 8.2e-01
2 GTEx Skin Sun Exposed Lower leg 0.104 0.039 2.4e-03 0.008 NA 0.006 NA 0.018 6.3e-02 NA 8.8e-02 NA 1.2e-02
3 GTEx Thyroid 0.361 0.061 1.5e-12 0.233 NA 0.216 NA 0.251 9.2e-18 NA 1.8e-16 NA 2.9e-19

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.5 3.6 1.9 0.9 -0.0
Bipolar Disorder or Schizophrenia 2.1 5.1 7.9 2.8 2.3 -1.4
Depressed Affect (Nagel 2018) 1.4 2.9 4.0 -2.0 -1.9 -1.1
Depression (Nagel 2018) 0.9 1.3 2.3 -1.3 -1.5 0.0
Intelligence (Savage-Jansen 2018) 0.4 1.4 3.2 1.8 1.0 -0.1
Neuroticism (Nagel 2018) 0.6 1.4 2.2 -1.5 -1.4 0.2
Schizophrenia (2018) 2.0 4.1 5.1 2.0 2.3 -1.8
Schizophrenia vs Biploar Disorder 0.1 0.2 0.6 0.0 0.0 -0.8
Worry (Nagel 2018) 0.3 0.7 1.1 -0.9 -1.1 -0.0
Alzheimer’s Disease (in mother) 0.4 0.4 0.7 -0.4 -0.8 -0.7
Alzheimer’s Disease (in father) 0.4 0.5 0.7 -0.8 0.3 0.8
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 -0.7 -0.2 0.0
Crohns Disease (2017) 0.7 1.6 2.6 -0.5 -1.6 -1.4
Irritable Bowel Disease (IBD) 0.6 1.4 3.4 -0.4 -1.9 -0.7
Ulcerative Colitis (UC) 0.1 0.2 0.7 0.1 -0.8 0.1
Major Depression (MDD) 0.1 0.1 0.3 -0.6 0.0 0.0
Reaction Time 0.8 1.5 2.3 -0.9 -1.2 1.5
Verbal and Numeric Reasoning (VNR) 0.1 0.4 0.9 0.2 0.3 1.0
Breast Cancer 0.1 0.3 0.4 -0.4 -0.7 0.6
Ovarian Cancer 0.0 0.0 0.1 0.2 0.1 0.1
Prostate Cancer 1.3 1.9 5.2 0.3 -0.6 -2.3
Age at First Birth 1.2 1.7 2.2 1.5 1.3 1.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 3.2 4.3 12.7 -0.6 0.1 -3.6
Coronary Artery Disease (CAD) 1.5 1.8 3.5 1.3 1.9 -0.5
Crohns Disease (2012) 0.0 0.0 0.1 0.0 0.0 0.4
Mean Putamen Volume 0.3 0.4 0.8 0.1 -0.6 -0.9
Fasting Glucose 0.0 0.0 0.0 0.2 0.1 0.2
HbA1C 1.4 1.5 2.3 1.5 1.5 -0.4
HDL Cholesterol 2.3 3.9 5.6 -1.9 -1.6 2.4
LDL Cholesterol 1.6 2.6 6.0 -1.0 -0.9 -2.5
Lupus 1.3 2.0 5.2 0.2 0.9 2.3
Neuroticism (2016) 1.4 2.0 2.4 -1.4 -1.2 -1.6
Primary Biliary Cirrhosis 0.1 0.1 0.4 0.0 0.0 -0.6
Rheumatoid Arthritis 0.9 1.2 2.7 0.6 0.8 1.7
Schizophrenia (2014) 1.8 3.9 5.5 2.3 2.1 -1.3
Triglycerides 2.1 3.4 7.5 1.3 1.0 -2.7
Type 2 Diabetes (T2D) (2012) 1.0 1.1 1.5 1.0 1.2 0.9
Ulcerative Colitis 0.5 0.7 1.2 -0.7 -1.1 0.6
Blood Eosinophil Count 0.1 1.1 1.7 1.3 1.3 -0.2
Blood Platelet Count 0.9 10.5 22.0 2.0 2.4 -4.7
Blood Red Count 0.3 3.1 8.7 -0.7 -0.3 3.0
Blood White Count 0.4 2.8 8.3 -0.2 0.3 -2.9
Heel T-Score 0.3 2.0 4.8 1.0 0.5 -2.2
BMI 4.2 24.1 71.7 0.3 0.7 -8.5
Height 3.1 59.5 174.2 -1.4 -1.5 13.2
Waist Hip Ratio (WHR) 0.8 3.4 4.2 1.7 1.8 -2.1
Systolic Blood Pressure 0.2 1.0 1.5 1.2 1.0 0.8
Smoking Status 0.3 0.6 1.4 0.7 0.1 -1.2
Allergy or Eczema 0.1 0.2 0.4 -0.5 -0.1 0.6
Cardiovascular Disease 1.5 4.9 8.0 1.6 2.0 -2.8
Hypothyroidism (self reported) 1.2 2.8 5.0 -1.0 -1.6 -2.2
Respiratory disease 0.1 0.2 0.3 0.4 0.0 0.6
Type 2 Diabetes (T2D) (2018) 2.1 3.9 11.1 -0.7 0.3 -3.3
Lung FEV1/FVC ratio 0.2 1.1 2.5 0.7 1.6 0.6
Lung FVC 0.9 4.5 12.0 1.2 0.2 -3.5
Neuroticism 2.5 6.1 9.3 -3.0 -3.0 0.3
Chronotype (morning person) 0.7 1.6 3.6 -1.9 -0.9 -0.7
Hair Pigment 0.0 1.0 2.7 -0.0 0.7 -1.6
Tanning 0.3 3.2 4.5 -1.6 -1.6 2.1
Hand grip strength (left) 1.0 2.7 3.4 1.5 1.8 1.6
Number of treatments/medications taken 2.7 4.9 11.9 -1.3 -1.1 -3.5
Average weekly spirits intake 2.2 2.7 3.7 -1.8 -1.1 -1.9
Sensitivity / hurt feelings 3.0 5.2 6.8 -2.6 -2.4 1.8
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 -0.2 -0.5 0.0
Hearing difficulty/problems: Yes 0.2 0.3 0.7 0.1 0.2 0.8
Relative age of first facial hair 1.1 2.2 6.1 0.5 0.6 -2.5
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 2.3 -1.2 -1.2 -1.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.1 -1.1 -0.3 0.8
Ever had hysterectomy (womb removed) 0.4 0.4 0.6 -0.8 -0.8 -0.3
Systolic blood pressure, automated reading 0.4 1.3 3.8 0.2 0.1 -2.0
Eye problems/disorders: Diabetes related eye disease 2.6 2.9 7.7 0.4 0.9 -2.8
Angina 2.1 2.7 6.8 -0.5 -1.1 -2.6
Medication for hormone replacement therapy 2.6 2.9 5.8 1.2 1.2 2.4
Vitamin and mineral supplements 1.6 2.1 4.3 -0.8 -2.1 -1.2
Supplements: Zinc 0.4 0.4 1.1 -0.3 0.1 1.1
Medication: Co-codamol 0.3 0.4 0.8 0.6 -0.0 -0.9
Medication: Metformin 1.1 1.6 3.8 0.4 0.9 -2.0
Diabetes (father) 0.9 1.1 3.2 0.4 0.1 -1.8
Diabetes (mother) 1.1 1.4 3.6 -0.6 0.3 -1.9
Severe depression (siblings) 2.3 2.6 5.2 1.2 1.0 2.3
Pack years adult smoking proportion 0.6 0.9 2.3 0.6 0.2 -1.5
Impedance of leg (right) 0.7 3.3 9.8 -0.4 0.2 3.1
Leg fat-free mass (left) 0.0 0.1 0.2 0.4 0.4 -0.2
Trunk fat percentage 1.5 5.8 16.6 0.5 0.8 -4.1
Hand grip strength (right) 0.9 2.6 3.9 1.5 2.0 1.2
Townsend deprivation index at recruitment 2.1 3.0 8.0 0.6 -0.8 -2.8
Current tobacco smoking 0.7 1.1 3.3 -0.0 0.0 -1.8
Average weekly fortified wine intake 2.1 2.4 5.0 0.9 1.2 2.2
Maternal smoking around birth 0.7 0.9 2.5 -0.1 -0.6 -1.6
Fed-up feelings 1.7 3.1 4.4 -1.7 -2.1 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 3.1 -1.6 -1.8 -0.1
Relative age voice broke 0.3 0.5 0.9 0.5 0.6 -1.0
Taking other prescription medications 4.3 6.6 19.8 0.1 -0.3 -4.5
Age when periods started (menarche) 2.1 5.2 9.4 -1.8 -1.7 3.1
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 3.2 -1.8 -1.3 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 7.5 -0.6 -0.8 -2.7
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 0.3 0.1 -0.6
Qualifications: CSEs or equivalent 1.2 1.6 2.8 1.2 1.7 -0.7
Serious illness, injury or assault to yourself 1.0 1.2 2.2 -1.0 -0.6 -1.5
High blood pressure 1.4 3.8 6.4 2.5 2.0 -1.0
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.7 -0.1 0.3 0.9
Multivitamins +/- minerals 1.7 2.2 3.9 1.0 2.0 1.3
Stomach or abdominal pain in last month 0.6 0.8 1.5 -0.3 -1.2 -0.9
Supplements: Glucosamine 0.1 0.1 0.2 -0.1 0.4 0.3
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.8 -0.0 0.0 -1.3
Medication: Atenolol 0.5 0.6 0.8 -0.4 -0.9 -0.8
Medication: Levothyroxine sodium 1.5 2.5 3.5 -0.9 -1.9 -1.8
Sitting height 1.8 12.5 32.1 -1.8 -1.5 5.7
Chronic bronchitis/emphysema (father) 1.3 1.5 1.8 -1.2 -1.1 -1.4
High blood pressure (mother) 1.7 2.3 4.1 1.1 2.0 -1.3
Body mass index (BMI) 4.5 19.0 56.1 0.6 0.7 -7.5
Impedance of leg (left) 0.7 3.4 10.3 -0.2 0.1 3.2
Leg predicted mass (left) 0.0 0.1 0.1 0.3 0.3 -0.1
Trunk fat mass 0.9 3.8 11.2 0.2 0.5 -3.3
Waist circumference 2.5 9.1 25.1 1.0 1.1 -5.0
Number of incorrect matches in round 0.3 0.5 1.2 -0.4 -1.1 -0.3
Past tobacco smoking 0.7 1.2 1.8 0.8 1.2 -1.3
Alcohol usually taken with meals 1.5 2.5 2.8 1.5 1.7 1.5
Nervous feelings 0.2 0.3 0.5 -0.5 -0.5 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 2.9 -1.4 -1.7 -0.2
Hearing difficulty/problems with background noise 0.1 0.2 0.3 0.5 0.5 0.1
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.4 -0.3 0.0
Had menopause 1.3 1.6 3.2 -0.8 -1.0 1.8
Had other major operations 0.1 0.2 0.3 -0.6 0.0 0.4
Forced vital capacity (FVC) 0.8 2.9 5.9 1.3 1.1 2.4
Heel bone mineral density (BMD) T-score, automated (right) 2.4 5.4 15.6 -0.5 -0.7 -3.9
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.8 -0.6 0.0 1.7
Qualifications: None of the above 3.3 7.1 8.2 -2.2 -2.9 -2.9
Financial difficulties in last 2 years 0.2 0.2 0.6 0.1 -0.1 0.8
Mouth/teeth dental problems 0.4 0.6 1.3 0.6 0.4 1.1
Heart attack 0.4 0.6 0.7 -0.7 -0.9 -0.7
Allergy 0.0 0.1 0.1 0.3 0.1 -0.3
Pain all over the body in last month 0.2 0.2 0.5 -0.2 -0.7 0.5
Diabetes (self-reported) 2.0 3.1 8.5 0.0 0.9 -2.9
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 3.4 1.7 1.8 1.0
Medication: Ramipril 3.0 3.9 4.4 2.0 2.1 -1.8
Medication: Simvastatin 3.4 5.0 14.8 -0.4 -0.0 -3.9
Fluid intelligence score 0.5 1.0 2.8 -0.1 -0.3 1.7
Illnesses of siblings 1.7 2.4 7.1 0.3 0.0 2.7
Neuroticism score 3.1 6.4 9.4 -3.0 -3.1 1.0
Weight 0.5 2.4 7.2 0.1 0.2 -2.7
Impedance of arm (right) 3.3 15.6 46.6 -0.1 0.3 6.8
Arm fat percentage (right) 2.1 8.2 24.0 0.3 0.8 -4.9
Trunk fat-free mass 0.2 1.3 3.8 -0.0 -0.1 1.9
Hip circumference 0.7 3.0 7.6 0.6 1.0 -2.8
Time employed in main current job 0.6 0.6 1.9 0.1 0.1 -1.4
Alcohol intake versus 10 years previously 1.0 1.5 2.0 -1.2 -1.0 -1.4
Father’s age at death 0.1 0.1 0.3 0.0 -0.1 0.6
Worrier / anxious feelings 1.0 1.9 2.3 -1.5 -1.5 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.4 -0.6 -0.6 -0.4
Falls in the last year 1.0 1.4 2.2 -1.2 -1.5 -0.7
Hair/balding pattern: Pattern 3 1.9 2.8 4.7 1.9 2.2 -0.4
Number of live births 4.2 5.9 16.6 1.0 0.3 -4.1
Forced expiratory volume in 1-second (FEV1) 0.7 2.2 3.9 1.1 1.2 2.0
Pulse rate 1.4 2.4 3.3 1.4 1.8 -1.4
Happiness 0.4 0.5 0.9 0.4 0.7 0.9
Noisy workplace 0.3 0.4 0.6 0.6 0.4 -0.8
Qualifications: A levels/AS levels or equivalent 2.1 4.6 9.8 1.4 1.4 3.1
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.9 1.0 0.5 -0.6
Mouth/teeth dental problems: Dentures 1.1 1.8 2.4 -1.5 -1.5 -1.0
Asthma 0.2 0.3 0.7 -0.4 -0.4 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.4 -1.2 -0.8 0.8
Medication: Cholesterol lowering 1.4 2.2 6.4 0.0 0.3 -2.5
Depression (self-reported) 0.5 0.6 1.0 1.0 0.7 0.4
Medication: Lansoprazole 3.9 4.4 11.2 0.8 1.2 -3.3
Prospective memory result 0.4 0.4 0.9 0.2 0.6 0.9
Lung cancer (father) 1.4 1.6 2.6 -1.6 -1.2 -0.8
Illnesses of mother 2.0 2.5 4.3 -1.8 -2.1 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 3.3 0.4 0.6 1.8
Pulse wave Arterial Stiffness index 2.6 3.1 4.2 2.0 1.9 1.2
Impedance of arm (left) 3.2 14.6 43.7 -0.5 -0.0 6.6
Arm fat mass (right) 1.6 6.6 18.8 0.5 0.8 -4.3
Trunk predicted mass 0.2 1.3 3.8 -0.1 -0.1 1.9
Standing height 3.4 34.1 100.0 -1.1 -1.0 10.0
Length of working week for main job 1.1 1.2 1.8 -0.7 -1.1 1.3
Exposure to tobacco smoke at home 2.4 2.7 8.2 -0.0 -0.1 -2.9
Breastfed as a baby 0.6 0.7 2.0 -1.4 -0.4 -0.0
Tense / ‘highly strung’ 0.3 0.4 0.8 -0.6 -0.9 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.0 0.0 0.3
Hair/balding pattern: Pattern 4 1.7 4.1 5.5 -2.2 -1.4 2.4
Birth weight of first child 0.2 0.3 0.8 0.0 0.0 -0.9
Peak expiratory flow (PEF) 0.3 0.6 1.2 0.7 1.1 0.5
Pulse wave reflection index 1.1 1.4 1.6 1.3 1.1 1.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 -0.7 -0.4 0.1
Loud music exposure frequency 0.1 0.1 0.2 -0.0 -0.4 -0.4
Qualifications: O levels/GCSEs or equivalent 3.5 5.6 7.1 2.2 2.7 2.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.4 0.2 0.0 0.7
Blood clot in the leg (DVT) 0.8 1.0 2.5 0.6 -0.4 -1.6
Medication: Paracetamol 0.2 0.3 0.4 -0.7 0.2 -0.5
Headache pain in last month 0.4 0.7 1.0 -1.0 -0.6 0.8
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 8.2 -0.6 -0.6 2.9
Glaucoma (self-reported) 0.2 0.3 0.5 -0.5 -0.2 -0.7
Gout (self-reported) 1.2 1.7 2.9 -0.8 -1.7 -1.3
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 3.6 -1.2 -1.8 -1.9
Medication: Amlodipine 0.3 0.4 0.9 -0.7 -0.0 -0.9
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.4 -1.2 -1.6 -0.3
Birth weight 0.1 0.3 0.5 0.4 0.5 -0.7
Chronic bronchitis/emphysema (mother) 3.3 3.8 6.6 2.6 2.1 -0.6
High blood pressure (siblings) 1.7 2.4 4.0 1.1 1.4 -2.0
Forced vital capacity (FVC), Best measure 0.5 1.9 4.7 0.8 0.6 2.2
Body fat percentage 2.5 9.9 29.1 0.3 0.7 -5.4
Leg fat percentage (right) 4.7 16.9 50.1 0.3 0.6 -7.1
Arm fat-free mass (right) 0.1 0.4 1.1 0.0 -0.0 -1.1
Exposure to tobacco smoke outside home 4.2 5.6 13.2 1.4 1.3 -3.6
Comparative body size at age 10 0.2 0.7 1.6 0.6 1.3 0.1
Number of full brothers 1.0 1.3 3.9 -0.2 -0.2 -2.0
Worry too long after embarrassment 2.4 4.0 8.6 -1.3 -1.3 2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.6 0.6 0.2 -0.8
Wheeze or whistling in the chest in last year 0.3 0.6 1.8 -0.1 0.1 -1.4
Number of children fathered 0.9 1.1 1.6 -0.8 -1.0 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.9 -0.2 0.1 1.4
Age at first live birth 2.8 5.0 11.8 -1.2 -1.4 3.4
Pulse wave peak to peak time 2.5 3.0 4.6 -2.1 -2.0 -0.6
Health satisfaction 0.5 0.6 1.3 0.5 0.6 -1.2
Shortness of breath walking on level ground 0.6 0.7 1.1 -0.9 -0.2 -1.1
Qualifications: College or University degree 2.0 6.2 10.9 2.0 1.9 3.3
Eye problems/disorders: None of the above 0.5 0.6 0.9 -1.0 -0.6 0.7
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.9 -0.9 -1.7 -0.2
Emphysema/chronic bronchitis 0.0 0.0 0.1 -0.2 -0.2 0.2
Medication for pain relief, constipation, heartburn 1.3 2.3 5.6 1.0 0.4 2.4
Neck or shoulder pain in last month 0.9 1.3 3.2 -0.7 -0.5 -1.8
Medication: Blood pressure 1.0 1.8 4.2 0.9 0.6 -2.1
Angina (self-reported) 1.9 2.5 4.9 -0.8 -1.4 -2.2
Migraine (self-reported) 0.6 0.7 1.2 -1.0 -1.1 0.3
Medication: Ibuprofen 0.7 0.8 1.2 -1.1 -1.0 0.4
Medication: Allopurinol 2.3 3.1 5.9 -1.7 -2.4 -0.7
Medication: Omeprazole 1.0 1.2 3.1 0.4 -0.7 -1.8
Medication: Seretide 50 evohaler 0.1 0.1 0.2 -0.2 0.0 0.5
Mean time to correctly identify matches 1.0 1.8 3.4 -0.8 -1.9 1.2
Heart disease (mother) 0.3 0.4 0.6 0.8 0.4 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.5 -0.5 -0.4 -0.7
Whole body fat mass 1.5 6.4 19.2 0.0 0.3 -4.4
Leg fat mass (right) 2.7 10.6 31.6 0.0 0.3 -5.6
Arm predicted mass (right) 0.1 0.4 1.2 -0.1 -0.0 -1.1
Pulse rate, automated reading 1.3 4.3 4.8 2.2 2.1 -2.0
Alcohol intake frequency. 0.6 1.5 3.1 -0.1 -1.1 -1.8
Comparative height size at age 10 0.6 3.5 10.4 -0.0 0.2 3.2
Number of full sisters 2.3 2.9 8.3 -0.4 -0.3 -2.9
Suffer from ‘nerves’ 1.1 1.8 3.9 0.9 0.8 2.0
Overall health rating 2.5 5.3 14.0 1.1 0.9 -3.7
Chest pain or discomfort 0.2 0.3 0.5 -0.0 -0.7 -0.7
Had major operations 0.8 0.9 2.6 -0.2 0.2 -1.6
Age at last live birth 0.3 0.4 1.2 0.3 0.1 1.1
Family relationship satisfaction 0.2 0.3 0.4 0.6 0.7 -0.0
Leg pain on walking 0.2 0.3 0.6 -0.2 -0.5 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.3 0.5 0.4 -0.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.0 -1.0 -0.7 0.2
Illness, injury, bereavement, stress in last 2 years 0.0 0.1 0.1 -0.3 -0.1 0.2
Medication: Aspirin 3.5 4.6 8.0 1.6 1.8 -2.8
Supplements: Vitamin C 1.1 1.3 1.8 0.6 1.4 1.3
Knee pain experienced in last month 0.9 1.4 2.9 -0.8 -0.7 -1.7
Hypertension (Self-reported) 1.5 4.2 6.7 2.6 2.2 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.7 0.2 -0.3 -0.8
Illnesses of father: Heart disease 0.4 0.5 0.8 0.5 0.9 -0.8
Illnesses of siblings: Diabetes 2.0 2.5 3.7 -1.6 -1.1 -1.9
Smoking status: Previous 1.0 1.5 2.4 -0.7 -1.3 1.5
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 8.8 0.3 0.1 3.0
Whole body fat-free mass 0.0 0.3 0.8 0.1 0.0 0.9
Leg fat-free mass (right) 0.0 0.1 0.3 0.5 0.4 0.2
Arm fat percentage (left) 2.2 8.9 25.9 0.3 0.8 -5.1
Average weekly red wine intake 0.3 0.4 0.6 0.1 0.8 0.7
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.8 0.9 0.2 -0.4
Mood swings 1.8 3.2 5.9 -1.3 -1.4 -2.4
Loneliness, isolation 0.6 0.8 1.7 -1.3 -0.2 -0.8
Long-standing illness, disability or infirmity 1.5 2.2 6.7 0.0 0.1 -2.6
Ever had bowel cancer screening 0.7 0.9 1.7 0.7 1.3 0.6
Diabetes diagnosed by doctor 2.3 3.8 9.8 0.4 1.2 -3.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 0.1 -0.4 -0.3
Friendships satisfaction 0.1 0.1 0.2 0.0 0.1 0.4
Qualifications: nursing, teaching 4.1 6.4 8.0 2.4 2.4 2.8
Commuting to job workplace: Walk 0.0 0.0 0.1 0.0 -0.0 0.3
Eye problems/disorders: Cataract 0.7 0.8 1.3 0.9 0.3 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 -0.1 0.2 -1.0
Medication for cholesterol 0.1 0.2 0.4 -0.2 -0.5 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 1.5 -1.0 -0.9 -1.2
Back pain experienced in last month 0.1 0.2 0.5 -0.4 0.0 -0.7
Mineral and other dietary supplements 0.6 0.8 1.7 -0.8 -1.3 -0.1
Breast cancer (self-reported) 2.0 2.4 7.0 -0.4 -0.0 -2.6
Asthma (self-reported) 0.2 0.3 0.6 -0.4 -0.5 0.8
Osteoporosis (self-reported) 0.5 0.7 1.1 -0.7 -1.1 0.6
Osteoarthritis (self-reported) 0.6 0.8 1.7 0.8 0.3 -1.3
Medication: Aspirin 3.0 4.0 8.9 1.2 1.2 -3.0
Medication: Gliclazide 1.5 1.7 4.3 0.3 0.9 -2.1
Illnesses of father: None of the above (group 1) 1.3 1.6 3.5 1.2 0.1 1.9
Smoking status: Current 1.2 1.8 5.2 0.3 0.5 -2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.3 0.6 0.0 -0.2
Whole body water mass 0.0 0.2 0.6 0.2 0.2 0.7
Leg predicted mass (right) 0.0 0.2 0.3 0.5 0.3 0.2
Arm fat mass (left) 1.7 7.0 20.2 0.4 0.7 -4.5
Number of self-reported non-cancer illnesses 2.3 3.9 8.9 1.5 0.7 -3.0
Average weekly champagne plus white wine intake 0.6 0.9 1.6 0.8 0.5 1.3
Miserableness 1.7 2.9 5.2 -1.8 -2.3 -0.7
Guilty feelings 1.3 1.9 5.6 0.2 0.4 2.4
Wears glasses or contact lenses 1.4 1.6 4.7 0.2 -0.2 2.2
Ever taken oral contraceptive pill 1.8 2.0 3.1 1.2 1.2 1.8
Hearing aid user 2.8 3.2 9.2 0.5 0.3 -3.0
Mother’s age at death 0.3 0.3 0.7 -0.5 -0.9 0.0
Financial situation satisfaction 0.1 0.1 0.4 0.1 -0.0 -0.6
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.3 0.0 0.6 0.4
Commuting to job workplace: Public transport 1.5 1.8 2.8 -1.0 -1.3 1.7
Eye problems/disorders: Glaucoma 0.0 0.0 0.1 -0.3 -0.2 -0.2
Medication: Blood pressure 0.9 1.8 2.9 1.7 1.5 -0.3
Pain type(s) experienced in last month: Hip pain 2.4 3.0 7.9 -0.9 -0.5 -2.8
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.3 0.6 1.0 1.1
High cholesterol (Self-reported) 2.6 4.6 13.4 -0.5 -0.2 -3.7
Medication: Bendroflumethiazide 1.0 1.6 2.6 1.6 1.4 0.3
Medication: Paracetamol 0.1 0.1 0.1 0.0 0.4 -0.3
Medication: Lisinopril 0.7 0.9 2.2 0.3 0.7 -1.5
Medication: Atorvastatin 2.3 2.8 3.4 -1.8 -1.9 -1.4
Illnesses of father: High blood pressure 0.6 0.8 1.3 1.1 1.0 -0.3
Alcohol drinker status: Never 0.2 0.2 0.5 -0.3 -0.7 -0.1
Ever smoked 1.1 1.9 5.1 -0.4 -0.7 2.2
Basal metabolic rate 0.0 0.1 0.1 0.3 0.3 0.0
Leg fat percentage (left) 4.7 17.1 50.7 0.5 0.5 -7.1
Arm fat-free mass (left) 0.1 0.4 1.2 0.2 0.2 -1.1
Number of operations (self-reported) 0.2 0.2 0.4 -0.6 0.1 -0.6
Average weekly beer plus cider intake 1.0 1.4 3.4 -0.5 -0.7 -1.8
Irritability 1.4 2.4 3.8 -2.0 -1.8 -0.2
Risk taking 0.4 0.6 1.0 0.3 1.0 -0.9
Ever had prostate specific antigen (PSA) test 0.9 1.1 1.3 1.0 1.1 -1.0
Fractured/broken bones in last 5 years 0.1 0.1 0.4 -0.2 -0.1 -0.6
Age started oral contraceptive pill 0.4 0.5 0.9 0.8 -0.0 1.0
Diastolic blood pressure, automated reading 0.3 0.8 2.2 0.2 0.4 -1.5
Ever depressed for a whole week 0.3 0.4 1.0 -0.0 1.0 0.4
Unable to work because of sickness or disability 1.8 2.3 6.7 0.4 0.4 -2.6
Commuting to job workplace: Cycle 1.4 1.7 3.0 1.7 0.5 -1.4
Myopia 1.6 2.3 6.7 0.1 0.4 2.6
Vascular/heart problems diagnosed by doctor 1.3 3.6 5.6 -2.4 -1.8 1.4
Cholesterol lowering medication 3.6 5.3 12.9 -1.3 -1.1 -3.6
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 3.1 0.0 -0.9 -1.8
Pain experienced in last month 0.3 0.4 1.0 0.5 0.2 1.0
Supplements: Calcium 1.1 1.2 2.2 -1.2 -1.5 0.4
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 0.2 -0.6 0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.4 -0.6 -0.6 -0.6
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 3.5 0.9 -0.1 -1.9
Heart disease (siblings) 1.6 2.0 2.9 -0.9 -1.5 -1.7
Alcohol drinker status: Previous 1.0 1.2 2.7 -0.9 -1.6 -0.1
Pack years of smoking 0.4 0.6 1.7 0.3 -0.2 -1.3
Impedance of whole body 2.0 10.0 29.8 -0.3 0.1 5.5
Leg fat mass (left) 2.8 10.9 32.7 0.2 0.2 -5.7
Arm predicted mass (left) 0.1 0.4 1.1 -0.0 -0.0 -1.0