TWAS
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Genes
Traits
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Traits
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Impedance of arm (right)
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chr4:57,080,198-58,593,295
Best TWAS P=6.72e-14 · Best GWAS P=2.99e-12 conditioned to 2.11e-05
57M
57.2M
57.4M
57.6M
57.8M
58M
58.2M
58.4M
58.6M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
POLR2B
0.09
0.05
bslmm
572
0.02
4.7e-04
-6.8
-7.5
6.7e-14
0.41
0.01
0.99
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
C4orf14
0.07
0.05
blup
57
0.06
3.2e-06
-3.2
6.0
2.5e-09
-0.80
0.02
0.97
FALSE
2
GTEx
Artery Tibial
NOA1
0.22
0.08
lasso
5
0.12
1.6e-09
-6.8
5.9
4.5e-09
-0.77
0.02
0.98
FALSE
3
ROSMAP
Brain Pre-frontal Cortex
REST
0.04
0.02
bslmm
536
0.02
3.4e-03
4.4
5.8
8.7e-09
-0.38
0.08
0.80
FALSE