Best TWAS P=1.84e-12 · Best GWAS P=2.18e-19 conditioned to 4.79e-13
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | NLN | 0.09 | 0.11 | enet | 12 | 0.10 | 1.6e-08 | 5.2 | 5.4 | 5.8e-08 | 0.21 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | RNF180 | 0.04 | 0.02 | lasso | 5 | 0.01 | 1.0e-01 | 5.5 | -5.6 | 2.3e-08 | -0.09 | 0.05 | 0.92 | FALSE |
3 | GTEx | Artery Aorta | RNF180 | 0.06 | 0.00 | lasso | 2 | -0.01 | 9.5e-01 | 5.5 | -5.5 | 3.4e-08 | -0.09 | 0.05 | 0.80 | FALSE |
4 | GTEx | Brain Cerebellum | TRIM23 | 0.16 | 0.09 | lasso | 6 | 0.07 | 4.7e-03 | 5.1 | -5.2 | 1.6e-07 | -0.18 | 0.18 | 0.06 | FALSE |
5 | GTEx | Brain Hippocampus | PPWD1 | 0.22 | 0.15 | enet | 19 | 0.19 | 3.7e-05 | 4.2 | -5.1 | 3.1e-07 | -0.21 | 0.22 | 0.05 | FALSE |
6 | GTEx | Breast Mammary Tissue | NLN | 0.17 | 0.04 | enet | 13 | 0.06 | 3.6e-04 | 5.1 | 5.5 | 3.6e-08 | 0.17 | 0.36 | 0.04 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | NLN | 0.17 | 0.03 | lasso | 9 | 0.06 | 2.3e-05 | 5.1 | 5.5 | 3.6e-08 | 0.10 | 0.95 | 0.00 | FALSE |
8 | GTEx | Esophagus Mucosa | NLN | 0.14 | 0.11 | lasso | 7 | 0.11 | 9.8e-08 | 5.1 | 5.3 | 1.3e-07 | 0.20 | 0.98 | 0.00 | FALSE |
9 | GTEx | Testis | RNF180 | 0.10 | 0.08 | lasso | 5 | 0.06 | 1.8e-03 | 5.7 | -6.1 | 1.3e-09 | -0.07 | 0.05 | 0.93 | TRUE |
10 | GTEx | Thyroid | RNF180 | 0.09 | 0.09 | lasso | 3 | 0.10 | 7.7e-08 | 5.6 | -5.6 | 2.3e-08 | -0.11 | 0.05 | 0.95 | FALSE |
11 | METSIM | Adipose | SGTB | 0.03 | 0.00 | bslmm | 384 | 0.01 | 4.7e-03 | -2.8 | 7.0 | 1.8e-12 | 0.22 | 0.22 | 0.06 | TRUE |
12 | NTR | Blood | NLN | 0.04 | 0.03 | lasso | 3 | 0.03 | 3.4e-09 | 5.0 | 5.2 | 1.6e-07 | 0.19 | 1.00 | 0.00 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | RNF180 | 0.06 | 0.06 | lasso | 5 | 0.07 | 2.7e-09 | 5.5 | -5.2 | 1.7e-07 | -0.10 | 0.07 | 0.93 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NLN | 0.04 | 0.02 | lasso | 7 | 0.02 | 3.2e-05 | 5.0 | 5.6 | 2.3e-08 | 0.14 | 0.00 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NLN | 0.06 | 0.00 | blup | 101 | 0.03 | 3.8e-04 | 4.2 | 5.1 | 2.6e-07 | 0.03 | 0.02 | 0.84 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RNF180 | 0.02 | 0.02 | blup | 58 | 0.02 | 2.0e-03 | 5.5 | -5.9 | 2.9e-09 | -0.10 | 0.03 | 0.68 | FALSE |