Best TWAS P=4.59e-19 · Best GWAS P=1.24e-29 conditioned to 9.21e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HACE1 | 0.14 | 0.10 | enet | 28 | 0.11 | 8.9e-14 | 4.1 | -6.1 | 9.9e-10 | -0.42 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LIN28B | 0.04 | 0.04 | lasso | 9 | 0.03 | 3.9e-05 | 8.9 | 8.9 | 4.6e-19 | 0.74 | 0.20 | 0.79 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | POPDC3 | 0.06 | 0.03 | bslmm | 386 | 0.02 | 1.0e-03 | 2.6 | -5.7 | 1.1e-08 | -0.31 | 0.19 | 0.10 | TRUE |
| 4 | GTEx | Breast Mammary Tissue (Female) | BVES | 0.07 | 0.01 | lasso | 3 | 0.01 | 1.4e-01 | 3.8 | 5.2 | 2.5e-07 | 0.26 | 0.04 | 0.14 | FALSE |
| 5 | GTEx | Lung | HACE1 | 0.09 | 0.00 | lasso | 4 | 0.00 | 6.2e-01 | 1.4 | -5.3 | 1.2e-07 | -0.56 | 0.05 | 0.30 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | BVES | 0.08 | 0.00 | enet | 26 | 0.05 | 7.3e-07 | 1.4 | 5.7 | 1.6e-08 | 0.26 | 0.15 | 0.12 | FALSE |