Hub : Genes

POPDC3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.057 0.023 0.0037 0.030 0.014 0.016 0.022 0.017 0.00012 0.00750 3.8e-03 0.001 0.00340
2 TCGA Colon Adenocarcinoma 0.055 0.033 0.0039 0.041 0.034 0.029 NA 0.033 0.00200 0.00460 8.3e-03 NA 0.00530
3 TCGA Pancreatic Adenocarcinoma 0.211 0.096 0.0010 0.042 0.104 0.100 NA 0.069 0.00760 0.00004 5.5e-05 NA 0.00079

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 1.0 1.8 0.8 -0.6 -1.4
Bipolar Disorder or Schizophrenia 0.3 0.8 2.3 -0.1 0.1 -1.5
Depressed Affect (Nagel 2018) 0.3 0.6 1.7 0.2 -1.3 0.5
Depression (Nagel 2018) 0.7 1.0 1.8 1.3 -0.9 0.6
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.5 -0.3 -0.0 0.7
Neuroticism (Nagel 2018) 0.1 0.3 0.8 0.3 -0.9 0.2
Schizophrenia (2018) 0.3 0.6 0.9 -0.7 0.6 -0.9
Schizophrenia vs Biploar Disorder 0.2 0.3 0.4 -0.1 0.6 -0.6
Worry (Nagel 2018) 0.0 0.1 0.2 0.0 -0.0 0.4
Alzheimer’s Disease (in mother) 0.7 0.8 1.3 -0.6 1.1 -0.8
Alzheimer’s Disease (in father) 2.7 3.0 4.6 -1.9 2.1 0.9
Alzheimer’s Disease (including proxy) 1.7 2.4 4.5 -1.6 2.1 0.1
Crohns Disease (2017) 0.2 0.3 0.4 0.5 -0.6 -0.6
Irritable Bowel Disease (IBD) 0.3 0.7 1.0 0.5 -1.0 -0.9
Ulcerative Colitis (UC) 0.1 0.2 0.5 0.2 -0.3 -0.7
Major Depression (MDD) 0.9 1.1 2.4 1.0 0.3 1.6
Reaction Time 2.8 5.3 10.3 -3.2 2.3 0.0
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.6 -0.8 0.6 0.7
Breast Cancer 0.2 0.6 1.5 -1.2 -0.2 0.4
Ovarian Cancer 3.0 4.0 7.7 -2.0 -0.4 2.8
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.1 3.1 3.8 -1.8 2.0 1.5
Bipolar Disorder (2011) 1.4 1.3 2.2 0.1 -1.5 -1.3
Body Mass Index (BMI) (2010) 0.2 0.3 0.4 -0.6 0.7 0.3
Coronary Artery Disease (CAD) 0.3 0.4 1.1 1.0 0.1 0.0
Crohns Disease (2012) 1.1 1.7 3.3 1.4 -1.8 -0.2
Mean Putamen Volume 1.2 1.4 2.3 1.2 -1.5 0.5
Fasting Glucose 0.5 0.6 1.3 -1.1 0.6 0.2
HbA1C 0.1 0.1 0.2 -0.5 0.1 0.2
HDL Cholesterol 0.6 0.9 2.5 0.6 0.1 1.6
LDL Cholesterol 0.7 1.1 2.3 -1.0 -0.1 1.5
Lupus 0.7 1.1 1.6 1.0 -1.3 -0.7
Neuroticism (2016) 1.3 1.9 3.8 1.0 -2.0 1.0
Primary Biliary Cirrhosis 2.5 3.6 4.6 2.1 1.8 -1.7
Rheumatoid Arthritis 0.6 0.8 1.5 -0.8 0.6 1.2
Schizophrenia (2014) 0.3 0.8 1.7 -1.3 0.5 -0.6
Triglycerides 0.8 1.4 3.8 1.9 -0.3 -0.5
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.9 0.4 0.1 1.0
Ulcerative Colitis 0.1 0.2 0.4 0.0 0.7 -0.4
Blood Eosinophil Count 0.5 3.6 4.9 1.4 -1.9 2.2
Blood Platelet Count 0.2 2.9 5.0 -2.2 1.5 1.1
Blood Red Count 0.1 0.8 1.4 1.2 0.9 0.4
Blood White Count 0.8 6.3 8.3 -2.6 1.9 2.9
Heel T-Score 0.8 6.0 12.8 3.6 -2.2 0.5
BMI 0.1 0.6 0.9 0.9 -0.9 0.2
Height 2.7 51.9 146.4 -12.1 2.8 -1.1
Waist Hip Ratio (WHR) 0.2 0.8 2.2 -1.5 -0.1 0.5
Systolic Blood Pressure 0.6 3.2 5.3 -2.1 2.3 0.2
Smoking Status 0.4 1.0 2.6 -1.6 -0.3 0.6
Allergy or Eczema 0.4 1.1 2.2 -0.4 0.9 1.5
Cardiovascular Disease 0.8 2.6 7.3 0.5 0.5 2.7
Hypothyroidism (self reported) 0.1 0.2 0.5 0.1 0.7 -0.2
Respiratory disease 0.3 0.6 1.2 0.4 0.7 1.1
Type 2 Diabetes (T2D) (2018) 1.6 3.1 8.2 1.0 0.0 2.9
Lung FEV1/FVC ratio 0.9 4.7 11.2 -3.4 -0.8 -1.4
Lung FVC 0.0 0.2 0.3 0.4 0.5 -0.3
Neuroticism 0.0 0.1 0.1 0.1 -0.3 0.3
Chronotype (morning person) 3.1 7.1 11.0 3.3 -2.4 -2.2
Hair Pigment 0.0 1.2 1.8 0.8 -1.0 -1.3
Tanning 0.1 1.6 4.5 -0.1 -0.6 -2.1
Hand grip strength (left) 0.4 0.9 2.7 -1.6 -0.4 -0.0
Number of treatments/medications taken 1.1 1.9 4.4 2.1 0.2 1.2
Average weekly spirits intake 1.6 2.0 3.8 -1.3 2.0 0.7
Sensitivity / hurt feelings 0.3 0.6 1.2 0.3 -0.6 -1.1
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.1 1.4 -1.2 0.5
Hearing difficulty/problems: Yes 0.9 1.3 3.6 -0.5 1.9 0.3
Relative age of first facial hair 1.1 2.2 4.2 -2.0 -0.4 1.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 0.6 0.9 0.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.7 1.3 0.1 -0.5
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 0.0 -0.2 0.7
Systolic blood pressure, automated reading 0.8 2.2 4.9 -1.1 2.2 0.7
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.2 1.2 0.2 1.5
Angina 0.4 0.5 1.4 0.3 0.1 -1.2
Medication for hormone replacement therapy 0.5 0.5 0.6 0.8 0.7 0.7
Vitamin and mineral supplements 1.1 1.4 2.5 -1.3 1.6 0.4
Supplements: Zinc 0.1 0.1 0.3 0.3 -0.1 0.5
Medication: Co-codamol 1.5 1.8 2.9 1.7 0.9 -1.3
Medication: Metformin 1.0 1.4 2.7 1.2 -0.4 1.6
Diabetes (father) 0.5 0.7 1.5 1.2 -0.7 0.1
Diabetes (mother) 0.4 0.5 0.8 -0.9 0.3 0.7
Severe depression (siblings) 0.8 0.9 1.0 -0.9 -0.8 1.0
Pack years adult smoking proportion 0.3 0.5 1.3 -0.5 -0.1 -1.1
Impedance of leg (right) 0.7 3.5 6.0 -2.5 1.9 -0.9
Leg fat-free mass (left) 0.8 4.0 10.8 -3.3 -0.7 0.8
Trunk fat percentage 0.7 2.8 7.3 -2.7 0.7 0.6
Hand grip strength (right) 0.7 2.0 6.0 -2.5 0.1 -0.1
Townsend deprivation index at recruitment 1.3 1.8 3.5 -1.9 0.5 1.3
Current tobacco smoking 0.9 1.5 4.2 -2.1 0.6 -0.1
Average weekly fortified wine intake 0.9 1.1 2.9 -0.5 -0.2 -1.7
Maternal smoking around birth 0.9 1.3 2.7 -0.5 -0.9 -1.6
Fed-up feelings 0.8 1.4 3.4 1.8 -0.7 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.8 -0.1 -0.2 -0.9
Relative age voice broke 2.1 3.2 8.6 -2.9 0.8 -0.6
Taking other prescription medications 0.6 0.9 1.7 1.3 0.5 0.9
Age when periods started (menarche) 12.3 29.5 85.9 -9.3 1.0 -1.2
Bilateral oophorectomy (both ovaries removed) 2.8 3.2 8.6 2.9 1.1 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.5 -0.7 0.3 0.1
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.9 -0.6 -1.4 0.4
Qualifications: CSEs or equivalent 0.5 0.7 2.0 -0.1 1.4 0.2
Serious illness, injury or assault to yourself 0.1 0.1 0.2 0.3 -0.2 -0.5
High blood pressure 0.4 1.0 2.4 1.5 0.1 0.8
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.7 -1.6 1.0 0.9
Multivitamins +/- minerals 0.8 1.0 2.3 0.7 -1.5 -0.4
Stomach or abdominal pain in last month 0.4 0.5 0.6 -0.6 0.8 0.7
Supplements: Glucosamine 3.1 4.0 9.4 1.6 -3.1 -0.0
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.3 0.9 0.9 1.5
Medication: Atenolol 1.1 1.3 3.1 -0.4 0.9 1.8
Medication: Levothyroxine sodium 0.3 0.5 1.5 0.0 0.2 -1.2
Sitting height 0.7 4.7 13.7 -3.7 -0.7 0.1
Chronic bronchitis/emphysema (father) 1.3 1.5 2.1 -1.5 1.3 -0.8
High blood pressure (mother) 1.0 1.4 2.6 1.6 -0.8 -1.0
Body mass index (BMI) 0.2 0.9 2.1 1.4 -0.4 0.7
Impedance of leg (left) 0.7 3.5 7.9 -2.8 1.4 -0.8
Leg predicted mass (left) 0.8 4.2 11.7 -3.4 -0.7 0.7
Trunk fat mass 0.8 3.4 9.4 -3.1 0.6 0.7
Waist circumference 0.0 0.2 0.4 -0.6 0.1 0.4
Number of incorrect matches in round 0.3 0.5 1.2 0.5 -0.0 -1.1
Past tobacco smoking 0.4 0.7 1.6 0.5 1.3 -0.5
Alcohol usually taken with meals 0.6 1.0 1.9 1.4 1.0 -0.2
Nervous feelings 0.1 0.2 0.2 -0.3 0.4 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.8 -0.3 0.9 0.8
Hearing difficulty/problems with background noise 0.1 0.2 0.3 0.5 0.5 0.4
Hair/balding pattern: Pattern 2 0.9 1.2 1.9 -0.9 1.4 -0.9
Had menopause 0.1 0.1 0.2 0.3 0.5 0.0
Had other major operations 0.2 0.3 0.7 0.2 -0.9 -0.0
Forced vital capacity (FVC) 2.2 8.7 24.7 -5.0 1.0 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.5 -0.7 0.4 0.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.4 0.3 -1.2 0.2
Qualifications: None of the above 0.6 1.2 2.5 1.6 -0.8 0.7
Financial difficulties in last 2 years 0.1 0.1 0.2 0.1 -0.3 -0.5
Mouth/teeth dental problems 1.2 1.8 3.0 -0.6 1.4 1.7
Heart attack 0.7 1.0 2.9 1.7 -0.0 -0.0
Allergy 0.3 0.7 0.9 1.0 -0.8 -0.8
Pain all over the body in last month 0.3 0.3 0.6 0.5 0.8 0.2
Diabetes (self-reported) 1.6 2.4 4.8 1.5 -0.3 2.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 0.3 0.4 0.2
Medication: Ramipril 1.6 2.0 5.7 2.4 -0.3 -0.6
Medication: Simvastatin 2.0 3.0 8.2 0.7 -0.3 2.9
Fluid intelligence score 0.2 0.5 0.8 -0.9 0.1 0.8
Illnesses of siblings 0.9 1.3 1.5 -1.2 -1.1 1.1
Neuroticism score 0.1 0.2 0.3 0.3 -0.6 -0.3
Weight 0.5 2.5 7.1 -2.7 -0.0 0.7
Impedance of arm (right) 2.9 13.7 32.7 -5.7 2.9 0.2
Arm fat percentage (right) 0.3 1.4 1.5 -1.2 1.2 1.1
Trunk fat-free mass 0.7 3.8 11.2 -3.4 -0.2 0.2
Hip circumference 0.2 1.0 1.6 -1.2 1.2 0.1
Time employed in main current job 0.6 0.7 1.3 0.3 1.1 -0.9
Alcohol intake versus 10 years previously 0.2 0.3 0.7 -0.8 -0.0 0.3
Father’s age at death 1.1 1.5 2.3 -1.0 -1.1 1.5
Worrier / anxious feelings 0.1 0.2 0.6 0.1 0.8 -0.0
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.0 -0.2 0.7 1.0
Falls in the last year 0.5 0.6 1.4 1.2 -0.5 0.5
Hair/balding pattern: Pattern 3 0.3 0.4 0.7 -0.7 0.8 -0.3
Number of live births 1.0 1.4 3.2 1.8 -0.2 -1.0
Forced expiratory volume in 1-second (FEV1) 2.7 9.0 25.5 -5.0 1.2 -0.0
Pulse rate 0.6 1.0 2.0 -1.0 1.4 0.2
Happiness 0.3 0.3 0.6 -0.8 0.2 0.6
Noisy workplace 0.3 0.4 0.6 0.8 -0.2 -0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.4 -0.6 -0.3 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.4 -0.5 1.6 -0.8
Mouth/teeth dental problems: Dentures 1.2 2.1 5.2 0.9 -0.4 -2.3
Asthma 0.2 0.4 0.6 0.7 0.4 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 4.4 2.1 -0.6 -1.1
Medication: Cholesterol lowering 1.2 1.9 4.0 1.3 0.2 2.0
Depression (self-reported) 2.0 2.3 5.4 1.2 -0.4 -2.3
Medication: Lansoprazole 0.1 0.2 0.2 0.3 0.5 0.4
Prospective memory result 1.0 1.2 2.8 0.7 0.6 -1.7
Lung cancer (father) 3.1 3.6 5.8 -2.4 2.3 0.3
Illnesses of mother 0.5 0.6 1.3 -0.3 -0.6 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.6 19.5 -4.4 0.4 0.1
Pulse wave Arterial Stiffness index 1.1 1.3 3.7 -0.3 -1.9 -0.4
Impedance of arm (left) 2.3 10.4 24.7 -5.0 2.6 -0.0
Arm fat mass (right) 0.3 1.1 2.7 -1.6 0.4 0.7
Trunk predicted mass 0.7 3.9 11.6 -3.4 -0.2 0.3
Standing height 2.9 28.6 85.2 -9.2 0.8 -0.4
Length of working week for main job 0.6 0.6 1.0 -0.7 1.0 -0.7
Exposure to tobacco smoke at home 0.0 0.0 0.0 0.0 0.1 0.2
Breastfed as a baby 0.3 0.4 0.8 0.9 -0.2 -0.5
Tense / ‘highly strung’ 0.3 0.5 0.7 -0.1 0.9 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 5.3 0.4 -2.3 -1.5
Hair/balding pattern: Pattern 4 1.2 2.8 7.5 -2.7 -0.6 -0.8
Birth weight of first child 0.2 0.4 0.7 -0.9 -0.1 -0.7
Peak expiratory flow (PEF) 0.8 1.9 4.9 -2.2 0.9 -0.2
Pulse wave reflection index 1.7 2.1 3.6 1.6 -1.9 0.2
Ever highly irritable/argumentative for 2 days 1.9 2.3 4.4 1.6 -2.1 0.2
Loud music exposure frequency 2.3 2.5 3.8 -1.8 -0.7 2.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.2 -1.5 -0.5 -0.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.4 0.6 -1.2 -0.3
Blood clot in the leg (DVT) 1.1 1.4 3.5 0.0 1.9 -0.8
Medication: Paracetamol 0.1 0.1 0.1 0.3 -0.3 0.3
Headache pain in last month 0.2 0.3 0.5 -0.3 -0.7 0.6
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 3.4 -1.8 -0.2 -1.7
Glaucoma (self-reported) 0.2 0.2 0.4 -0.5 0.3 0.6
Gout (self-reported) 0.2 0.3 0.7 0.4 0.8 -0.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.7 0.8 0.5 -0.2
Medication: Amlodipine 0.2 0.3 0.6 0.8 0.1 0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 0.6 0.2 0.8
Birth weight 0.6 1.3 3.0 -1.7 0.6 -0.7
Chronic bronchitis/emphysema (mother) 1.0 1.1 2.1 0.0 1.4 1.2
High blood pressure (siblings) 0.9 1.3 4.0 2.0 -0.1 -0.2
Forced vital capacity (FVC), Best measure 2.4 8.6 24.4 -4.9 1.0 0.7
Body fat percentage 0.4 1.4 3.0 -1.7 0.8 0.8
Leg fat percentage (right) 0.1 0.3 0.4 0.6 0.5 0.6
Arm fat-free mass (right) 0.3 1.8 4.3 -2.1 -1.0 -0.1
Exposure to tobacco smoke outside home 0.7 0.9 1.5 -1.2 1.0 0.5
Comparative body size at age 10 0.8 2.1 3.7 1.9 -1.3 -1.0
Number of full brothers 1.2 1.5 2.2 0.9 1.5 -1.3
Worry too long after embarrassment 0.2 0.3 0.7 -0.4 0.8 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 -0.3 -0.5 0.8
Wheeze or whistling in the chest in last year 1.3 2.3 3.0 -1.6 1.7 1.1
Number of children fathered 2.5 2.8 8.0 2.8 0.1 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.5 4.0 -1.8 2.0 0.6
Age at first live birth 0.9 1.6 3.4 -0.3 1.1 1.8
Pulse wave peak to peak time 1.3 1.5 4.2 -0.3 2.0 0.5
Health satisfaction 1.6 2.0 4.5 -2.1 0.2 1.2
Shortness of breath walking on level ground 1.3 1.6 3.2 -1.2 -0.1 1.8
Qualifications: College or University degree 0.3 0.8 1.5 -1.2 -0.6 -0.8
Eye problems/disorders: None of the above 0.4 0.5 0.8 0.7 -0.9 0.4
Mouth/teeth dental problems: Loose teeth 0.7 0.9 1.3 1.1 -1.1 -0.5
Emphysema/chronic bronchitis 0.4 0.4 0.6 -0.8 0.6 -0.6
Medication for pain relief, constipation, heartburn 1.2 2.1 6.0 -2.4 0.3 0.4
Neck or shoulder pain in last month 0.1 0.1 0.1 0.3 0.4 -0.1
Medication: Blood pressure 1.2 2.1 4.1 2.0 0.1 1.5
Angina (self-reported) 0.5 0.7 1.7 0.3 0.4 -1.3
Migraine (self-reported) 0.0 0.0 0.1 -0.2 -0.1 -0.3
Medication: Ibuprofen 2.0 2.4 4.6 2.2 -1.1 -1.1
Medication: Allopurinol 0.4 0.5 0.9 0.9 0.3 -0.8
Medication: Omeprazole 1.5 1.8 5.1 2.3 0.3 0.5
Medication: Seretide 50 evohaler 0.0 0.0 0.1 -0.1 0.2 0.3
Mean time to correctly identify matches 2.5 4.7 7.3 -2.6 2.7 0.4
Heart disease (mother) 3.4 4.1 9.9 3.1 -0.9 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 2.6 1.6 -0.2 -1.5
Whole body fat mass 0.5 2.0 5.2 -2.3 0.5 0.8
Leg fat mass (right) 0.1 0.4 0.8 -0.6 0.2 0.9
Arm predicted mass (right) 0.3 1.7 4.2 -2.1 -0.9 0.1
Pulse rate, automated reading 1.5 4.9 7.8 -1.6 2.1 -2.8
Alcohol intake frequency. 0.7 1.5 2.9 1.7 0.1 -1.3
Comparative height size at age 10 0.1 0.6 1.0 -1.0 0.8 0.2
Number of full sisters 0.4 0.5 1.1 1.0 -0.1 -0.5
Suffer from ‘nerves’ 1.1 1.7 3.9 -0.6 -2.0 -0.9
Overall health rating 0.2 0.4 1.2 -0.2 1.1 0.2
Chest pain or discomfort 1.4 2.0 3.7 -1.9 0.7 1.3
Had major operations 1.1 1.3 3.5 1.9 -0.7 0.0
Age at last live birth 0.6 0.8 1.5 -0.5 0.9 1.2
Family relationship satisfaction 0.0 0.0 0.1 -0.3 0.0 0.2
Leg pain on walking 0.6 0.8 1.9 0.6 -1.4 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.1 0.0 1.0 -0.6
Commuting to job workplace: Car/motor vehicle 1.7 1.9 4.2 0.5 1.2 -2.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.3 -0.3 0.0 1.1
Medication: Aspirin 0.6 0.7 1.2 0.6 -0.8 1.1
Supplements: Vitamin C 0.3 0.3 0.5 -0.4 -0.5 -0.7
Knee pain experienced in last month 0.4 0.6 0.8 0.7 0.7 0.9
Hypertension (Self-reported) 0.5 1.5 3.8 1.9 -0.1 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.4 0.2 -0.2
Illnesses of father: Heart disease 0.0 0.0 0.0 0.1 -0.2 0.1
Illnesses of siblings: Diabetes 0.6 0.8 1.9 0.4 1.4 -0.5
Smoking status: Previous 0.7 1.1 2.1 0.7 -1.5 0.8
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.5 15.8 -4.0 0.1 -0.9
Whole body fat-free mass 0.7 4.1 11.7 -3.4 -0.5 0.5
Leg fat-free mass (right) 0.8 4.4 11.4 -3.4 -1.1 0.7
Arm fat percentage (left) 0.3 1.0 1.1 -1.0 1.0 1.1
Average weekly red wine intake 0.5 0.8 1.1 0.5 -1.0 1.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.8 0.6 -0.6 -0.9
Mood swings 0.5 0.9 2.7 -0.1 -1.6 -0.2
Loneliness, isolation 0.8 1.1 2.5 -0.6 -0.8 1.6
Long-standing illness, disability or infirmity 2.0 3.0 8.7 2.9 0.5 -0.3
Ever had bowel cancer screening 0.3 0.4 1.1 1.0 0.2 -0.2
Diabetes diagnosed by doctor 1.7 2.8 5.1 1.6 -0.8 2.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.5 -0.2 0.9 1.6
Friendships satisfaction 0.2 0.3 0.7 -0.1 0.4 0.8
Qualifications: nursing, teaching 0.8 1.2 2.2 -0.5 -1.1 -1.5
Commuting to job workplace: Walk 1.2 1.3 3.1 -0.9 -1.8 0.1
Eye problems/disorders: Cataract 0.5 0.6 1.5 0.2 -1.2 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.7 1.0 2.0 -1.0 -1.4 0.2
Medication for cholesterol 0.4 0.6 1.8 0.0 -0.0 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.9 -0.0 0.7 -0.9
Back pain experienced in last month 1.4 2.1 2.2 1.4 -1.5 -1.4
Mineral and other dietary supplements 4.4 5.9 10.0 -3.2 2.5 1.2
Breast cancer (self-reported) 0.2 0.2 0.5 0.1 0.3 -0.7
Asthma (self-reported) 0.2 0.4 0.5 0.7 0.6 0.6
Osteoporosis (self-reported) 0.5 0.6 1.3 0.4 1.1 0.5
Osteoarthritis (self-reported) 0.4 0.5 1.2 -1.1 0.1 -0.5
Medication: Aspirin 0.4 0.5 0.8 0.9 -0.3 0.8
Medication: Gliclazide 0.5 0.6 0.9 0.1 0.9 0.9
Illnesses of father: None of the above (group 1) 0.7 0.8 1.3 1.1 -0.4 -1.0
Smoking status: Current 1.0 1.6 4.4 -2.1 0.6 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.8 -0.9 0.5 0.1
Whole body water mass 0.6 3.6 10.4 -3.2 -0.5 0.4
Leg predicted mass (right) 0.8 4.3 11.3 -3.4 -1.1 0.7
Arm fat mass (left) 0.2 1.0 2.0 -1.4 0.3 0.9
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.4 -0.1 0.7
Average weekly champagne plus white wine intake 0.8 1.1 2.7 0.6 -0.3 -1.7
Miserableness 1.1 1.8 4.2 0.8 -2.1 -0.8
Guilty feelings 1.8 2.6 6.8 2.6 -0.7 -0.8
Wears glasses or contact lenses 1.7 1.9 3.5 1.9 -1.5 -0.3
Ever taken oral contraceptive pill 0.1 0.1 0.4 -0.2 -0.6 0.0
Hearing aid user 2.4 2.7 4.2 -2.1 2.0 0.2
Mother’s age at death 1.3 1.7 4.7 -0.4 2.2 0.4
Financial situation satisfaction 0.1 0.1 0.3 -0.0 0.5 0.1
Tinnitus: Yes, now most or all of the time 1.9 2.2 4.8 1.2 2.2 0.7
Commuting to job workplace: Public transport 0.6 0.7 1.9 -1.4 0.4 0.4
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 -0.7 0.3 0.0
Medication: Blood pressure 0.1 0.2 0.4 0.6 -0.3 -0.1
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.3 0.2 -0.5 -0.5
Supplements: Fish oil (including cod liver oil) 2.9 3.7 6.2 2.5 -2.2 -0.5
High cholesterol (Self-reported) 0.9 1.6 3.1 1.3 -0.1 1.8
Medication: Bendroflumethiazide 0.2 0.3 0.5 -0.7 0.5 0.1
Medication: Paracetamol 0.1 0.1 0.3 0.6 -0.1 0.0
Medication: Lisinopril 0.3 0.4 1.0 0.3 -0.3 1.0
Medication: Atorvastatin 0.3 0.3 1.0 0.2 1.0 -0.2
Illnesses of father: High blood pressure 0.3 0.4 1.1 -0.1 -1.0 0.3
Alcohol drinker status: Never 1.2 1.4 2.6 1.6 1.3 -0.0
Ever smoked 1.4 2.5 7.3 -2.7 -0.4 -0.2
Basal metabolic rate 0.8 4.2 12.0 -3.5 -0.4 0.5
Leg fat percentage (left) 0.1 0.2 0.4 0.3 0.3 0.6
Arm fat-free mass (left) 0.5 2.5 7.0 -2.6 -0.5 0.4
Number of operations (self-reported) 1.2 1.7 4.4 2.1 -0.8 -0.2
Average weekly beer plus cider intake 0.2 0.3 0.6 -0.8 -0.3 -0.5
Irritability 0.6 0.9 2.0 -0.5 -1.4 0.7
Risk taking 0.5 0.7 1.1 -1.0 -1.1 0.2
Ever had prostate specific antigen (PSA) test 1.9 2.2 3.0 1.7 0.9 1.6
Fractured/broken bones in last 5 years 0.1 0.2 0.3 -0.6 0.5 -0.2
Age started oral contraceptive pill 0.3 0.4 1.2 -0.1 0.1 -1.1
Diastolic blood pressure, automated reading 0.3 1.0 2.3 -0.4 1.5 0.8
Ever depressed for a whole week 1.2 1.5 2.9 0.2 -1.7 1.3
Unable to work because of sickness or disability 0.2 0.2 0.6 0.3 -0.8 0.1
Commuting to job workplace: Cycle 0.7 0.9 1.9 1.4 -0.9 -0.2
Myopia 0.1 0.1 0.3 -0.2 0.2 -0.5
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.2 -1.5 -0.2 -0.5
Cholesterol lowering medication 0.6 0.9 2.0 0.6 -0.6 1.4
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 5.5 2.3 -0.1 0.2
Pain experienced in last month 0.1 0.2 0.6 -0.8 0.1 -0.3
Supplements: Calcium 0.3 0.4 0.8 0.9 0.5 -0.2
Basal cell carcinoma (self-reported) 1.0 1.2 2.9 -1.7 -0.8 0.2
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.8 1.7 -0.2 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 5.2 0.1 2.3 -1.1
Heart disease (siblings) 1.4 1.7 3.8 1.2 -0.0 -2.0
Alcohol drinker status: Previous 1.0 1.2 3.0 1.7 -0.6 0.4
Pack years of smoking 0.2 0.4 0.9 -0.4 0.0 -0.9
Impedance of whole body 1.7 8.5 21.1 -4.6 2.1 -0.2
Leg fat mass (left) 0.1 0.5 0.8 -0.8 0.0 0.9
Arm predicted mass (left) 0.5 2.4 6.5 -2.5 -0.8 0.4