Hub : Genes

POPDC3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.057	0.023	0.0037	0.030	0.014	0.016	0.022	0.017	0.00012	0.00750	3.8e-03	0.001	0.00340
2	TCGA	Colon Adenocarcinoma	0.055	0.033	0.0039	0.041	0.034	0.029	NA	0.033	0.00200	0.00460	8.3e-03	NA	0.00530
3	TCGA	Pancreatic Adenocarcinoma	0.211	0.096	0.0010	0.042	0.104	0.100	NA	0.069	0.00760	0.00004	5.5e-05	NA	0.00079

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	1.8	0.8	-0.6	-1.4
Bipolar Disorder or Schizophrenia	0.3	0.8	2.3	-0.1	0.1	-1.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.7	0.2	-1.3	0.5
Depression (Nagel 2018)	0.7	1.0	1.8	1.3	-0.9	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	-0.3	-0.0	0.7
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.3	-0.9	0.2
Schizophrenia (2018)	0.3	0.6	0.9	-0.7	0.6	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	-0.1	0.6	-0.6
Worry (Nagel 2018)	0.0	0.1	0.2	0.0	-0.0	0.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	-0.6	1.1	-0.8
Alzheimer’s Disease (in father)	2.7	3.0	4.6	-1.9	2.1	0.9
Alzheimer’s Disease (including proxy)	1.7	2.4	4.5	-1.6	2.1	0.1
Crohns Disease (2017)	0.2	0.3	0.4	0.5	-0.6	-0.6
Irritable Bowel Disease (IBD)	0.3	0.7	1.0	0.5	-1.0	-0.9
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.2	-0.3	-0.7
Major Depression (MDD)	0.9	1.1	2.4	1.0	0.3	1.6
Reaction Time	2.8	5.3	10.3	-3.2	2.3	0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.6	-0.8	0.6	0.7
Breast Cancer	0.2	0.6	1.5	-1.2	-0.2	0.4
Ovarian Cancer	3.0	4.0	7.7	-2.0	-0.4	2.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.1	3.1	3.8	-1.8	2.0	1.5
Bipolar Disorder (2011)	1.4	1.3	2.2	0.1	-1.5	-1.3
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	-0.6	0.7	0.3
Coronary Artery Disease (CAD)	0.3	0.4	1.1	1.0	0.1	0.0
Crohns Disease (2012)	1.1	1.7	3.3	1.4	-1.8	-0.2
Mean Putamen Volume	1.2	1.4	2.3	1.2	-1.5	0.5
Fasting Glucose	0.5	0.6	1.3	-1.1	0.6	0.2
HbA1C	0.1	0.1	0.2	-0.5	0.1	0.2
HDL Cholesterol	0.6	0.9	2.5	0.6	0.1	1.6
LDL Cholesterol	0.7	1.1	2.3	-1.0	-0.1	1.5
Lupus	0.7	1.1	1.6	1.0	-1.3	-0.7
Neuroticism (2016)	1.3	1.9	3.8	1.0	-2.0	1.0
Primary Biliary Cirrhosis	2.5	3.6	4.6	2.1	1.8	-1.7
Rheumatoid Arthritis	0.6	0.8	1.5	-0.8	0.6	1.2
Schizophrenia (2014)	0.3	0.8	1.7	-1.3	0.5	-0.6
Triglycerides	0.8	1.4	3.8	1.9	-0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	0.4	0.1	1.0
Ulcerative Colitis	0.1	0.2	0.4	0.0	0.7	-0.4
Blood Eosinophil Count	0.5	3.6	4.9	1.4	-1.9	2.2
Blood Platelet Count	0.2	2.9	5.0	-2.2	1.5	1.1
Blood Red Count	0.1	0.8	1.4	1.2	0.9	0.4
Blood White Count	0.8	6.3	8.3	-2.6	1.9	2.9
Heel T-Score	0.8	6.0	12.8	3.6	-2.2	0.5
BMI	0.1	0.6	0.9	0.9	-0.9	0.2
Height	2.7	51.9	146.4	-12.1	2.8	-1.1
Waist Hip Ratio (WHR)	0.2	0.8	2.2	-1.5	-0.1	0.5
Systolic Blood Pressure	0.6	3.2	5.3	-2.1	2.3	0.2
Smoking Status	0.4	1.0	2.6	-1.6	-0.3	0.6
Allergy or Eczema	0.4	1.1	2.2	-0.4	0.9	1.5
Cardiovascular Disease	0.8	2.6	7.3	0.5	0.5	2.7
Hypothyroidism (self reported)	0.1	0.2	0.5	0.1	0.7	-0.2
Respiratory disease	0.3	0.6	1.2	0.4	0.7	1.1
Type 2 Diabetes (T2D) (2018)	1.6	3.1	8.2	1.0	0.0	2.9
Lung FEV1/FVC ratio	0.9	4.7	11.2	-3.4	-0.8	-1.4
Lung FVC	0.0	0.2	0.3	0.4	0.5	-0.3
Neuroticism	0.0	0.1	0.1	0.1	-0.3	0.3
Chronotype (morning person)	3.1	7.1	11.0	3.3	-2.4	-2.2
Hair Pigment	0.0	1.2	1.8	0.8	-1.0	-1.3
Tanning	0.1	1.6	4.5	-0.1	-0.6	-2.1
Hand grip strength (left)	0.4	0.9	2.7	-1.6	-0.4	-0.0
Number of treatments/medications taken	1.1	1.9	4.4	2.1	0.2	1.2
Average weekly spirits intake	1.6	2.0	3.8	-1.3	2.0	0.7
Sensitivity / hurt feelings	0.3	0.6	1.2	0.3	-0.6	-1.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.1	1.4	-1.2	0.5
Hearing difficulty/problems: Yes	0.9	1.3	3.6	-0.5	1.9	0.3
Relative age of first facial hair	1.1	2.2	4.2	-2.0	-0.4	1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.6	0.9	0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.7	1.3	0.1	-0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.0	-0.2	0.7
Systolic blood pressure, automated reading	0.8	2.2	4.9	-1.1	2.2	0.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.2	1.2	0.2	1.5
Angina	0.4	0.5	1.4	0.3	0.1	-1.2
Medication for hormone replacement therapy	0.5	0.5	0.6	0.8	0.7	0.7
Vitamin and mineral supplements	1.1	1.4	2.5	-1.3	1.6	0.4
Supplements: Zinc	0.1	0.1	0.3	0.3	-0.1	0.5
Medication: Co-codamol	1.5	1.8	2.9	1.7	0.9	-1.3
Medication: Metformin	1.0	1.4	2.7	1.2	-0.4	1.6
Diabetes (father)	0.5	0.7	1.5	1.2	-0.7	0.1
Diabetes (mother)	0.4	0.5	0.8	-0.9	0.3	0.7
Severe depression (siblings)	0.8	0.9	1.0	-0.9	-0.8	1.0
Pack years adult smoking proportion	0.3	0.5	1.3	-0.5	-0.1	-1.1
Impedance of leg (right)	0.7	3.5	6.0	-2.5	1.9	-0.9
Leg fat-free mass (left)	0.8	4.0	10.8	-3.3	-0.7	0.8
Trunk fat percentage	0.7	2.8	7.3	-2.7	0.7	0.6
Hand grip strength (right)	0.7	2.0	6.0	-2.5	0.1	-0.1
Townsend deprivation index at recruitment	1.3	1.8	3.5	-1.9	0.5	1.3
Current tobacco smoking	0.9	1.5	4.2	-2.1	0.6	-0.1
Average weekly fortified wine intake	0.9	1.1	2.9	-0.5	-0.2	-1.7
Maternal smoking around birth	0.9	1.3	2.7	-0.5	-0.9	-1.6
Fed-up feelings	0.8	1.4	3.4	1.8	-0.7	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.1	-0.2	-0.9
Relative age voice broke	2.1	3.2	8.6	-2.9	0.8	-0.6
Taking other prescription medications	0.6	0.9	1.7	1.3	0.5	0.9
Age when periods started (menarche)	12.3	29.5	85.9	-9.3	1.0	-1.2
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	8.6	2.9	1.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.7	0.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.9	-0.6	-1.4	0.4
Qualifications: CSEs or equivalent	0.5	0.7	2.0	-0.1	1.4	0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.3	-0.2	-0.5
High blood pressure	0.4	1.0	2.4	1.5	0.1	0.8
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.7	-1.6	1.0	0.9
Multivitamins +/- minerals	0.8	1.0	2.3	0.7	-1.5	-0.4
Stomach or abdominal pain in last month	0.4	0.5	0.6	-0.6	0.8	0.7
Supplements: Glucosamine	3.1	4.0	9.4	1.6	-3.1	-0.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.3	0.9	0.9	1.5
Medication: Atenolol	1.1	1.3	3.1	-0.4	0.9	1.8
Medication: Levothyroxine sodium	0.3	0.5	1.5	0.0	0.2	-1.2
Sitting height	0.7	4.7	13.7	-3.7	-0.7	0.1
Chronic bronchitis/emphysema (father)	1.3	1.5	2.1	-1.5	1.3	-0.8
High blood pressure (mother)	1.0	1.4	2.6	1.6	-0.8	-1.0
Body mass index (BMI)	0.2	0.9	2.1	1.4	-0.4	0.7
Impedance of leg (left)	0.7	3.5	7.9	-2.8	1.4	-0.8
Leg predicted mass (left)	0.8	4.2	11.7	-3.4	-0.7	0.7
Trunk fat mass	0.8	3.4	9.4	-3.1	0.6	0.7
Waist circumference	0.0	0.2	0.4	-0.6	0.1	0.4
Number of incorrect matches in round	0.3	0.5	1.2	0.5	-0.0	-1.1
Past tobacco smoking	0.4	0.7	1.6	0.5	1.3	-0.5
Alcohol usually taken with meals	0.6	1.0	1.9	1.4	1.0	-0.2
Nervous feelings	0.1	0.2	0.2	-0.3	0.4	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.8	-0.3	0.9	0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.5	0.5	0.4
Hair/balding pattern: Pattern 2	0.9	1.2	1.9	-0.9	1.4	-0.9
Had menopause	0.1	0.1	0.2	0.3	0.5	0.0
Had other major operations	0.2	0.3	0.7	0.2	-0.9	-0.0
Forced vital capacity (FVC)	2.2	8.7	24.7	-5.0	1.0	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.7	0.4	0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	0.3	-1.2	0.2
Qualifications: None of the above	0.6	1.2	2.5	1.6	-0.8	0.7
Financial difficulties in last 2 years	0.1	0.1	0.2	0.1	-0.3	-0.5
Mouth/teeth dental problems	1.2	1.8	3.0	-0.6	1.4	1.7
Heart attack	0.7	1.0	2.9	1.7	-0.0	-0.0
Allergy	0.3	0.7	0.9	1.0	-0.8	-0.8
Pain all over the body in last month	0.3	0.3	0.6	0.5	0.8	0.2
Diabetes (self-reported)	1.6	2.4	4.8	1.5	-0.3	2.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	0.3	0.4	0.2
Medication: Ramipril	1.6	2.0	5.7	2.4	-0.3	-0.6
Medication: Simvastatin	2.0	3.0	8.2	0.7	-0.3	2.9
Fluid intelligence score	0.2	0.5	0.8	-0.9	0.1	0.8
Illnesses of siblings	0.9	1.3	1.5	-1.2	-1.1	1.1
Neuroticism score	0.1	0.2	0.3	0.3	-0.6	-0.3
Weight	0.5	2.5	7.1	-2.7	-0.0	0.7
Impedance of arm (right)	2.9	13.7	32.7	-5.7	2.9	0.2
Arm fat percentage (right)	0.3	1.4	1.5	-1.2	1.2	1.1
Trunk fat-free mass	0.7	3.8	11.2	-3.4	-0.2	0.2
Hip circumference	0.2	1.0	1.6	-1.2	1.2	0.1
Time employed in main current job	0.6	0.7	1.3	0.3	1.1	-0.9
Alcohol intake versus 10 years previously	0.2	0.3	0.7	-0.8	-0.0	0.3
Father’s age at death	1.1	1.5	2.3	-1.0	-1.1	1.5
Worrier / anxious feelings	0.1	0.2	0.6	0.1	0.8	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-0.2	0.7	1.0
Falls in the last year	0.5	0.6	1.4	1.2	-0.5	0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.7	0.8	-0.3
Number of live births	1.0	1.4	3.2	1.8	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1)	2.7	9.0	25.5	-5.0	1.2	-0.0
Pulse rate	0.6	1.0	2.0	-1.0	1.4	0.2
Happiness	0.3	0.3	0.6	-0.8	0.2	0.6
Noisy workplace	0.3	0.4	0.6	0.8	-0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	-0.6	-0.3	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.4	-0.5	1.6	-0.8
Mouth/teeth dental problems: Dentures	1.2	2.1	5.2	0.9	-0.4	-2.3
Asthma	0.2	0.4	0.6	0.7	0.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	4.4	2.1	-0.6	-1.1
Medication: Cholesterol lowering	1.2	1.9	4.0	1.3	0.2	2.0
Depression (self-reported)	2.0	2.3	5.4	1.2	-0.4	-2.3
Medication: Lansoprazole	0.1	0.2	0.2	0.3	0.5	0.4
Prospective memory result	1.0	1.2	2.8	0.7	0.6	-1.7
Lung cancer (father)	3.1	3.6	5.8	-2.4	2.3	0.3
Illnesses of mother	0.5	0.6	1.3	-0.3	-0.6	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	19.5	-4.4	0.4	0.1
Pulse wave Arterial Stiffness index	1.1	1.3	3.7	-0.3	-1.9	-0.4
Impedance of arm (left)	2.3	10.4	24.7	-5.0	2.6	-0.0
Arm fat mass (right)	0.3	1.1	2.7	-1.6	0.4	0.7
Trunk predicted mass	0.7	3.9	11.6	-3.4	-0.2	0.3
Standing height	2.9	28.6	85.2	-9.2	0.8	-0.4
Length of working week for main job	0.6	0.6	1.0	-0.7	1.0	-0.7
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.0	0.1	0.2
Breastfed as a baby	0.3	0.4	0.8	0.9	-0.2	-0.5
Tense / ‘highly strung’	0.3	0.5	0.7	-0.1	0.9	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	5.3	0.4	-2.3	-1.5
Hair/balding pattern: Pattern 4	1.2	2.8	7.5	-2.7	-0.6	-0.8
Birth weight of first child	0.2	0.4	0.7	-0.9	-0.1	-0.7
Peak expiratory flow (PEF)	0.8	1.9	4.9	-2.2	0.9	-0.2
Pulse wave reflection index	1.7	2.1	3.6	1.6	-1.9	0.2
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.4	1.6	-2.1	0.2
Loud music exposure frequency	2.3	2.5	3.8	-1.8	-0.7	2.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.2	-1.5	-0.5	-0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.4	0.6	-1.2	-0.3
Blood clot in the leg (DVT)	1.1	1.4	3.5	0.0	1.9	-0.8
Medication: Paracetamol	0.1	0.1	0.1	0.3	-0.3	0.3
Headache pain in last month	0.2	0.3	0.5	-0.3	-0.7	0.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.4	-1.8	-0.2	-1.7
Glaucoma (self-reported)	0.2	0.2	0.4	-0.5	0.3	0.6
Gout (self-reported)	0.2	0.3	0.7	0.4	0.8	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	0.8	0.5	-0.2
Medication: Amlodipine	0.2	0.3	0.6	0.8	0.1	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	0.6	0.2	0.8
Birth weight	0.6	1.3	3.0	-1.7	0.6	-0.7
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.1	0.0	1.4	1.2
High blood pressure (siblings)	0.9	1.3	4.0	2.0	-0.1	-0.2
Forced vital capacity (FVC), Best measure	2.4	8.6	24.4	-4.9	1.0	0.7
Body fat percentage	0.4	1.4	3.0	-1.7	0.8	0.8
Leg fat percentage (right)	0.1	0.3	0.4	0.6	0.5	0.6
Arm fat-free mass (right)	0.3	1.8	4.3	-2.1	-1.0	-0.1
Exposure to tobacco smoke outside home	0.7	0.9	1.5	-1.2	1.0	0.5
Comparative body size at age 10	0.8	2.1	3.7	1.9	-1.3	-1.0
Number of full brothers	1.2	1.5	2.2	0.9	1.5	-1.3
Worry too long after embarrassment	0.2	0.3	0.7	-0.4	0.8	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.3	-0.5	0.8
Wheeze or whistling in the chest in last year	1.3	2.3	3.0	-1.6	1.7	1.1
Number of children fathered	2.5	2.8	8.0	2.8	0.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	4.0	-1.8	2.0	0.6
Age at first live birth	0.9	1.6	3.4	-0.3	1.1	1.8
Pulse wave peak to peak time	1.3	1.5	4.2	-0.3	2.0	0.5
Health satisfaction	1.6	2.0	4.5	-2.1	0.2	1.2
Shortness of breath walking on level ground	1.3	1.6	3.2	-1.2	-0.1	1.8
Qualifications: College or University degree	0.3	0.8	1.5	-1.2	-0.6	-0.8
Eye problems/disorders: None of the above	0.4	0.5	0.8	0.7	-0.9	0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.3	1.1	-1.1	-0.5
Emphysema/chronic bronchitis	0.4	0.4	0.6	-0.8	0.6	-0.6
Medication for pain relief, constipation, heartburn	1.2	2.1	6.0	-2.4	0.3	0.4
Neck or shoulder pain in last month	0.1	0.1	0.1	0.3	0.4	-0.1
Medication: Blood pressure	1.2	2.1	4.1	2.0	0.1	1.5
Angina (self-reported)	0.5	0.7	1.7	0.3	0.4	-1.3
Migraine (self-reported)	0.0	0.0	0.1	-0.2	-0.1	-0.3
Medication: Ibuprofen	2.0	2.4	4.6	2.2	-1.1	-1.1
Medication: Allopurinol	0.4	0.5	0.9	0.9	0.3	-0.8
Medication: Omeprazole	1.5	1.8	5.1	2.3	0.3	0.5
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.1	0.2	0.3
Mean time to correctly identify matches	2.5	4.7	7.3	-2.6	2.7	0.4
Heart disease (mother)	3.4	4.1	9.9	3.1	-0.9	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.6	1.6	-0.2	-1.5
Whole body fat mass	0.5	2.0	5.2	-2.3	0.5	0.8
Leg fat mass (right)	0.1	0.4	0.8	-0.6	0.2	0.9
Arm predicted mass (right)	0.3	1.7	4.2	-2.1	-0.9	0.1
Pulse rate, automated reading	1.5	4.9	7.8	-1.6	2.1	-2.8
Alcohol intake frequency.	0.7	1.5	2.9	1.7	0.1	-1.3
Comparative height size at age 10	0.1	0.6	1.0	-1.0	0.8	0.2
Number of full sisters	0.4	0.5	1.1	1.0	-0.1	-0.5
Suffer from ‘nerves’	1.1	1.7	3.9	-0.6	-2.0	-0.9
Overall health rating	0.2	0.4	1.2	-0.2	1.1	0.2
Chest pain or discomfort	1.4	2.0	3.7	-1.9	0.7	1.3
Had major operations	1.1	1.3	3.5	1.9	-0.7	0.0
Age at last live birth	0.6	0.8	1.5	-0.5	0.9	1.2
Family relationship satisfaction	0.0	0.0	0.1	-0.3	0.0	0.2
Leg pain on walking	0.6	0.8	1.9	0.6	-1.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.0	1.0	-0.6
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.2	0.5	1.2	-2.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	-0.3	0.0	1.1
Medication: Aspirin	0.6	0.7	1.2	0.6	-0.8	1.1
Supplements: Vitamin C	0.3	0.3	0.5	-0.4	-0.5	-0.7
Knee pain experienced in last month	0.4	0.6	0.8	0.7	0.7	0.9
Hypertension (Self-reported)	0.5	1.5	3.8	1.9	-0.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.4	0.2	-0.2
Illnesses of father: Heart disease	0.0	0.0	0.0	0.1	-0.2	0.1
Illnesses of siblings: Diabetes	0.6	0.8	1.9	0.4	1.4	-0.5
Smoking status: Previous	0.7	1.1	2.1	0.7	-1.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.5	15.8	-4.0	0.1	-0.9
Whole body fat-free mass	0.7	4.1	11.7	-3.4	-0.5	0.5
Leg fat-free mass (right)	0.8	4.4	11.4	-3.4	-1.1	0.7
Arm fat percentage (left)	0.3	1.0	1.1	-1.0	1.0	1.1
Average weekly red wine intake	0.5	0.8	1.1	0.5	-1.0	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.6	-0.6	-0.9
Mood swings	0.5	0.9	2.7	-0.1	-1.6	-0.2
Loneliness, isolation	0.8	1.1	2.5	-0.6	-0.8	1.6
Long-standing illness, disability or infirmity	2.0	3.0	8.7	2.9	0.5	-0.3
Ever had bowel cancer screening	0.3	0.4	1.1	1.0	0.2	-0.2
Diabetes diagnosed by doctor	1.7	2.8	5.1	1.6	-0.8	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.5	-0.2	0.9	1.6
Friendships satisfaction	0.2	0.3	0.7	-0.1	0.4	0.8
Qualifications: nursing, teaching	0.8	1.2	2.2	-0.5	-1.1	-1.5
Commuting to job workplace: Walk	1.2	1.3	3.1	-0.9	-1.8	0.1
Eye problems/disorders: Cataract	0.5	0.6	1.5	0.2	-1.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.0	-1.0	-1.4	0.2
Medication for cholesterol	0.4	0.6	1.8	0.0	-0.0	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	-0.0	0.7	-0.9
Back pain experienced in last month	1.4	2.1	2.2	1.4	-1.5	-1.4
Mineral and other dietary supplements	4.4	5.9	10.0	-3.2	2.5	1.2
Breast cancer (self-reported)	0.2	0.2	0.5	0.1	0.3	-0.7
Asthma (self-reported)	0.2	0.4	0.5	0.7	0.6	0.6
Osteoporosis (self-reported)	0.5	0.6	1.3	0.4	1.1	0.5
Osteoarthritis (self-reported)	0.4	0.5	1.2	-1.1	0.1	-0.5
Medication: Aspirin	0.4	0.5	0.8	0.9	-0.3	0.8
Medication: Gliclazide	0.5	0.6	0.9	0.1	0.9	0.9
Illnesses of father: None of the above (group 1)	0.7	0.8	1.3	1.1	-0.4	-1.0
Smoking status: Current	1.0	1.6	4.4	-2.1	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.8	-0.9	0.5	0.1
Whole body water mass	0.6	3.6	10.4	-3.2	-0.5	0.4
Leg predicted mass (right)	0.8	4.3	11.3	-3.4	-1.1	0.7
Arm fat mass (left)	0.2	1.0	2.0	-1.4	0.3	0.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.4	-0.1	0.7
Average weekly champagne plus white wine intake	0.8	1.1	2.7	0.6	-0.3	-1.7
Miserableness	1.1	1.8	4.2	0.8	-2.1	-0.8
Guilty feelings	1.8	2.6	6.8	2.6	-0.7	-0.8
Wears glasses or contact lenses	1.7	1.9	3.5	1.9	-1.5	-0.3
Ever taken oral contraceptive pill	0.1	0.1	0.4	-0.2	-0.6	0.0
Hearing aid user	2.4	2.7	4.2	-2.1	2.0	0.2
Mother’s age at death	1.3	1.7	4.7	-0.4	2.2	0.4
Financial situation satisfaction	0.1	0.1	0.3	-0.0	0.5	0.1
Tinnitus: Yes, now most or all of the time	1.9	2.2	4.8	1.2	2.2	0.7
Commuting to job workplace: Public transport	0.6	0.7	1.9	-1.4	0.4	0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.7	0.3	0.0
Medication: Blood pressure	0.1	0.2	0.4	0.6	-0.3	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	0.2	-0.5	-0.5
Supplements: Fish oil (including cod liver oil)	2.9	3.7	6.2	2.5	-2.2	-0.5
High cholesterol (Self-reported)	0.9	1.6	3.1	1.3	-0.1	1.8
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.7	0.5	0.1
Medication: Paracetamol	0.1	0.1	0.3	0.6	-0.1	0.0
Medication: Lisinopril	0.3	0.4	1.0	0.3	-0.3	1.0
Medication: Atorvastatin	0.3	0.3	1.0	0.2	1.0	-0.2
Illnesses of father: High blood pressure	0.3	0.4	1.1	-0.1	-1.0	0.3
Alcohol drinker status: Never	1.2	1.4	2.6	1.6	1.3	-0.0
Ever smoked	1.4	2.5	7.3	-2.7	-0.4	-0.2
Basal metabolic rate	0.8	4.2	12.0	-3.5	-0.4	0.5
Leg fat percentage (left)	0.1	0.2	0.4	0.3	0.3	0.6
Arm fat-free mass (left)	0.5	2.5	7.0	-2.6	-0.5	0.4
Number of operations (self-reported)	1.2	1.7	4.4	2.1	-0.8	-0.2
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.8	-0.3	-0.5
Irritability	0.6	0.9	2.0	-0.5	-1.4	0.7
Risk taking	0.5	0.7	1.1	-1.0	-1.1	0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.0	1.7	0.9	1.6
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.6	0.5	-0.2
Age started oral contraceptive pill	0.3	0.4	1.2	-0.1	0.1	-1.1
Diastolic blood pressure, automated reading	0.3	1.0	2.3	-0.4	1.5	0.8
Ever depressed for a whole week	1.2	1.5	2.9	0.2	-1.7	1.3
Unable to work because of sickness or disability	0.2	0.2	0.6	0.3	-0.8	0.1
Commuting to job workplace: Cycle	0.7	0.9	1.9	1.4	-0.9	-0.2
Myopia	0.1	0.1	0.3	-0.2	0.2	-0.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.2	-1.5	-0.2	-0.5
Cholesterol lowering medication	0.6	0.9	2.0	0.6	-0.6	1.4
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	5.5	2.3	-0.1	0.2
Pain experienced in last month	0.1	0.2	0.6	-0.8	0.1	-0.3
Supplements: Calcium	0.3	0.4	0.8	0.9	0.5	-0.2
Basal cell carcinoma (self-reported)	1.0	1.2	2.9	-1.7	-0.8	0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.8	1.7	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	5.2	0.1	2.3	-1.1
Heart disease (siblings)	1.4	1.7	3.8	1.2	-0.0	-2.0
Alcohol drinker status: Previous	1.0	1.2	3.0	1.7	-0.6	0.4
Pack years of smoking	0.2	0.4	0.9	-0.4	0.0	-0.9
Impedance of whole body	1.7	8.5	21.1	-4.6	2.1	-0.2
Leg fat mass (left)	0.1	0.5	0.8	-0.8	0.0	0.9
Arm predicted mass (left)	0.5	2.4	6.5	-2.5	-0.8	0.4