Best TWAS P=1.94e-13 · Best GWAS P=1.74e-30 conditioned to 9.88e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 0.00041 | -6.0 | -6.0 | 2.0e-09 | -0.26 | 0.86 | 0.00 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | BDNF-AS | 0.22 | 0.17 | lasso | 4 | 0.13 | 0.00055 | 5.2 | -5.7 | 1.2e-08 | -0.65 | 0.04 | 0.81 | TRUE |
| 3 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 0.00060 | -6.0 | -5.3 | 1.1e-07 | -0.14 | 0.81 | 0.01 | TRUE |
| 4 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 0.00218 | -6.1 | 5.5 | 4.3e-08 | 0.17 | 0.52 | 0.01 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BDNFOS | 0.03 | 0.01 | blup | 83 | 0.02 | 0.00143 | 2.3 | -7.4 | 1.9e-13 | -0.76 | 0.01 | 0.96 | TRUE |