TWAS
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Models
Genes
Traits
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Traits
:
Impedance of arm (left)
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chr11:26,818,083-28,416,646
Best TWAS P=1.94e-13 · Best GWAS P=1.74e-30 conditioned to 9.88e-07
26.8M
27M
27.2M
27.4M
27.6M
27.8M
28M
28.2M
28.4M
0
5
10
15
20
25
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
BDNFOS
0.03
0.01
blup
83
0.02
0.00143
2.3
-7.4
1.9e-13
-0.76
0.01
0.96
TRUE
2
GTEx
Brain Putamen basal ganglia
BDNF-AS
0.22
0.17
lasso
4
0.13
0.00055
5.2
-5.7
1.2e-08
-0.65
0.04
0.81
TRUE
3
GTEx
Thyroid
LIN7C
0.08
0.04
lasso
4
0.04
0.00060
-6.0
-5.3
1.1e-07
-0.14
0.81
0.01
TRUE
1
GTEx
Adipose Subcutaneous
LIN7C
0.08
0.06
lasso
1
0.04
0.00041
-6.0
-6.0
2.0e-09
-0.26
0.86
0.00
FALSE
4
NTR
Blood
LIN7C
0.01
0.00
lasso
3
0.01
0.00218
-6.1
5.5
4.3e-08
0.17
0.52
0.01
FALSE