Best TWAS P=2.35e-12 · Best GWAS P=2.22e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ELP4 | 0.03 | 0.03 | enet | 3 | 0.03 | 9.7e-04 | 6.9 | -7.0 | 2.3e-12 | -1.00 | 0.01 | 0.97 | TRUE |
| 3 | GTEx | Lung | ARL14EP | 0.10 | 0.06 | lasso | 8 | 0.11 | 1.1e-08 | 3.8 | 5.3 | 1.0e-07 | -0.04 | 0.85 | 0.12 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | Z83001.1 | 0.07 | 0.03 | bslmm | 375 | 0.03 | 5.1e-05 | 6.8 | -6.0 | 1.5e-09 | -0.77 | 0.01 | 0.98 | FALSE |
| 1 | GTEx | Breast Mammary Tissue | IMMP1L | 0.08 | 0.01 | enet | 18 | 0.00 | 2.1e-01 | 6.2 | -6.0 | 1.6e-09 | -0.59 | 0.10 | 0.39 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | ELP4 | 0.26 | 0.12 | lasso | 5 | 0.07 | 5.2e-03 | 5.1 | -5.8 | 6.3e-09 | -0.69 | 0.12 | 0.38 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ELP4 | 0.05 | 0.00 | blup | 106 | 0.02 | 5.6e-03 | 4.4 | -5.8 | 7.4e-09 | -0.64 | 0.02 | 0.37 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IMMP1L | 0.05 | 0.01 | blup | 40 | 0.00 | 1.8e-01 | 6.1 | -5.6 | 1.9e-08 | -0.69 | 0.02 | 0.22 | FALSE |