Best TWAS P=6.62e-18 · Best GWAS P=1.9e-13 conditioned to 0.0595
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | YFS | Blood | CBX5 | 0.02 | 0.01 | lasso | 3 | 0.02 | 2.0e-07 | 6.2 | 5.9 | 4.9e-09 | 0.15 | 0.86 | 0.12 | TRUE |
2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | HOTAIR | 0.07 | 0.06 | enet | 4 | 0.05 | 8.9e-05 | -5.3 | -5.4 | 6.8e-08 | -0.22 | 0.02 | 0.97 | FALSE |
3 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HOXC5 | 0.02 | 0.00 | blup | 51 | 0.01 | 2.4e-02 | 7.2 | 8.6 | 6.6e-18 | 0.77 | 0.01 | 0.73 | TRUE |
4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LOC400043 | 0.05 | 0.02 | blup | 31 | 0.03 | 4.6e-04 | 5.3 | 5.1 | 3.0e-07 | 0.23 | 0.00 | 0.94 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOTAIR | 0.08 | 0.13 | enet | 12 | 0.13 | 1.1e-14 | -5.4 | -5.3 | 1.4e-07 | -0.23 | 0.02 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC6 | 0.03 | 0.02 | blup | 50 | 0.03 | 3.9e-04 | 7.2 | -8.1 | 5.1e-16 | -0.81 | 0.01 | 0.97 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC8 | 0.03 | 0.05 | enet | 5 | 0.04 | 2.4e-05 | 7.2 | -7.8 | 8.9e-15 | -0.92 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | LOC400043 | 0.19 | 0.02 | blup | 31 | 0.04 | 8.6e-03 | -1.4 | 5.3 | 1.5e-07 | 0.19 | 0.01 | 0.19 | TRUE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HOTAIR | 0.10 | 0.12 | lasso | 3 | 0.11 | 1.8e-11 | -5.3 | -5.3 | 1.4e-07 | -0.21 | 0.02 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Rectum Adenocarcinoma | CBX5 | 0.16 | 0.10 | lasso | 4 | 0.11 | 1.5e-03 | 6.2 | 5.3 | 1.3e-07 | 0.03 | 0.01 | 0.70 | FALSE |
11 | The Cancer Genome Atlas | Rectum Adenocarcinoma | LOC400043 | 0.26 | 0.07 | blup | 31 | 0.13 | 4.9e-04 | 5.3 | 5.7 | 1.5e-08 | 0.27 | 0.00 | 0.69 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC400043 | 0.15 | 0.00 | enet | 9 | 0.07 | 4.7e-07 | 3.6 | 5.2 | 2.1e-07 | 0.20 | 0.01 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FLJ12825 | 0.15 | 0.02 | lasso | 5 | 0.06 | 8.9e-03 | 7.3 | 6.7 | 2.2e-11 | 0.79 | 0.01 | 0.75 | FALSE |