Best TWAS P=1.71e-10 · Best GWAS P=6.66e-10 conditioned to 2.15e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DIP2B | 0.11 | 0.10 | enet | 16 | 0.13 | 2.6e-15 | 6.1 | 6.4 | 1.7e-10 | 0.07 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Brain Putamen basal ganglia | CERS5 | 0.29 | 0.12 | enet | 36 | 0.21 | 1.2e-05 | 5.3 | 5.3 | 9.2e-08 | -0.01 | 0.35 | 0.32 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | CERS5 | 0.09 | 0.03 | lasso | 3 | 0.05 | 1.8e-02 | -3.8 | 6.2 | 6.1e-10 | -0.53 | 0.06 | 0.13 | TRUE |
| 4 | GTEx | Heart Atrial Appendage | CERS5 | 0.14 | 0.03 | lasso | 6 | 0.02 | 4.2e-02 | 5.4 | 5.3 | 1.1e-07 | -0.02 | 0.36 | 0.38 | FALSE |
| 5 | GTEx | Nerve Tibial | CERS5 | 0.31 | 0.28 | enet | 20 | 0.36 | 2.2e-26 | 5.4 | 5.4 | 5.4e-08 | 0.01 | 0.30 | 0.70 | FALSE |
| 6 | GTEx | Prostate | CERS5 | 0.19 | 0.08 | lasso | 4 | 0.02 | 1.2e-01 | 5.2 | 5.5 | 4.0e-08 | 0.01 | 0.07 | 0.25 | FALSE |
| 7 | GTEx | Testis | SMARCD1 | 0.22 | 0.10 | enet | 22 | 0.10 | 2.6e-05 | 5.4 | -5.3 | 1.1e-07 | 0.09 | 0.22 | 0.70 | FALSE |
| 8 | GTEx | Testis | CERS5 | 0.12 | 0.06 | lasso | 6 | 0.07 | 4.0e-04 | 5.4 | 5.6 | 1.9e-08 | 0.02 | 0.10 | 0.53 | FALSE |
| 9 | GTEx | Whole Blood | RP4-605O3.4 | 0.04 | 0.04 | lasso | 4 | 0.01 | 1.5e-02 | 5.2 | 5.3 | 1.1e-07 | 0.00 | 0.12 | 0.60 | FALSE |
| 10 | NTR | Blood | ATF1 | 0.06 | 0.07 | enet | 35 | 0.07 | 4.0e-21 | 6.0 | 5.2 | 1.9e-07 | 0.05 | 0.01 | 0.99 | FALSE |
| 11 | YFS | Blood | ATF1 | 0.05 | 0.07 | lasso | 9 | 0.07 | 2.0e-21 | 5.9 | 6.3 | 3.4e-10 | 0.04 | 0.02 | 0.98 | FALSE |
| 12 | YFS | Blood | DIP2B | 0.36 | 0.27 | bslmm | 385 | 0.28 | 2.8e-90 | -4.6 | 5.2 | 2.1e-07 | 0.01 | 0.97 | 0.03 | FALSE |
| 13 | YFS | Blood | LIMA1 | 0.04 | 0.06 | enet | 31 | 0.06 | 3.5e-19 | -4.1 | -5.6 | 2.3e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SMARCD1 | 0.02 | 0.03 | lasso | 1 | 0.03 | 3.7e-06 | 5.3 | -5.3 | 1.4e-07 | 0.02 | 0.02 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIMA1 | 0.08 | 0.10 | blup | 59 | 0.10 | 1.8e-11 | 5.5 | -5.6 | 1.8e-08 | -0.02 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ATF1 | 0.03 | 0.04 | lasso | 1 | 0.04 | 6.3e-05 | 5.9 | -5.9 | 4.5e-09 | -0.04 | 0.01 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | DIP2B | 0.09 | 0.02 | enet | 9 | 0.05 | 1.3e-06 | -4.7 | -5.5 | 4.3e-08 | -0.04 | 0.20 | 0.61 | FALSE |