Best TWAS P=8.5e-12 · Best GWAS P=7.7e-12 conditioned to 3.97e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BTBD7 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.8e-04 | 5.7 | -5.8 | 5.2e-09 | 0.05 | 0.07 | 0.92 | TRUE |
2 | GTEx | Cells Transformed fibroblasts | BTBD7 | 0.16 | 0.01 | lasso | 8 | 0.04 | 3.6e-04 | 5.7 | -5.6 | 2.6e-08 | -0.01 | 0.08 | 0.91 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | 6.7 | -6.8 | 8.5e-12 | 0.03 | 0.01 | 0.99 | TRUE |
4 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | -6.7 | 6.8 | 1.0e-11 | 0.28 | 0.02 | 0.96 | TRUE |
5 | GTEx | Colon Sigmoid | RPS6KA5 | 0.16 | 0.09 | lasso | 5 | 0.08 | 7.1e-04 | 6.1 | 6.2 | 6.8e-10 | -0.01 | 0.06 | 0.85 | FALSE |
6 | GTEx | Esophagus Muscularis | RIN3 | 0.17 | 0.05 | lasso | 6 | 0.06 | 1.6e-04 | -5.6 | 6.0 | 1.5e-09 | 0.39 | 0.09 | 0.65 | FALSE |
7 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | 5.3 | -6.0 | 1.9e-09 | 0.01 | 0.08 | 0.36 | FALSE |
8 | NTR | Blood | BTBD7 | 0.02 | 0.03 | lasso | 2 | 0.02 | 6.1e-08 | 5.7 | -5.8 | 5.2e-09 | 0.05 | 0.08 | 0.92 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | RIN3 | 0.05 | 0.00 | blup | 163 | 0.01 | 6.0e-02 | 3.0 | 5.8 | 8.0e-09 | 0.33 | 0.02 | 0.18 | TRUE |
10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | BTBD7 | 0.02 | 0.01 | blup | 72 | 0.02 | 6.8e-03 | 5.8 | -5.8 | 8.1e-09 | -0.08 | 0.01 | 0.87 | FALSE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BTBD7 | 0.11 | 0.03 | blup | 72 | 0.02 | 8.0e-02 | 5.7 | -5.6 | 1.6e-08 | -0.05 | 0.02 | 0.72 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIP11 | 0.08 | 0.04 | blup | 70 | 0.06 | 3.6e-06 | -3.7 | -5.2 | 2.2e-07 | 0.04 | 0.12 | 0.81 | TRUE |