Best TWAS P=3.26e-12 · Best GWAS P=7.43e-14 conditioned to 0.0295
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WDR20 | 0.14 | 0.18 | lasso | 3 | 0.18 | 9.0e-21 | -6.8 | -6.6 | 3.9e-11 | 0.90 | 0.16 | 0.84 | FALSE |
| 2 | GTEx | Brain Cerebellum | ZNF839 | 0.22 | 0.04 | lasso | 4 | 0.07 | 5.2e-03 | -5.3 | -6.5 | 8.3e-11 | 0.54 | 0.10 | 0.17 | TRUE |
| 3 | GTEx | Esophagus Muscularis | MOK | 0.13 | 0.02 | lasso | 5 | 0.01 | 4.1e-02 | -6.9 | 5.4 | 5.2e-08 | -0.76 | 0.07 | 0.56 | FALSE |
| 4 | GTEx | Pituitary | ZNF839 | 0.38 | 0.20 | lasso | 7 | 0.18 | 3.6e-05 | -6.4 | -5.2 | 2.5e-07 | 0.50 | 0.12 | 0.21 | FALSE |
| 5 | GTEx | Thyroid | ZNF839 | 0.10 | 0.08 | enet | 9 | 0.13 | 5.6e-10 | -6.4 | -6.8 | 1.2e-11 | 0.64 | 0.76 | 0.24 | FALSE |
| 6 | METSIM | Adipose | WDR20 | 0.03 | 0.04 | lasso | 8 | 0.04 | 1.6e-06 | -7.2 | 7.0 | 3.3e-12 | -0.92 | 0.02 | 0.98 | TRUE |
| 7 | YFS | Blood | HSP90AA1 | 0.02 | 0.02 | lasso | 2 | 0.02 | 3.2e-07 | -6.2 | 6.1 | 8.4e-10 | -0.67 | 0.72 | 0.27 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | RAGE | 0.08 | 0.09 | blup | 60 | 0.09 | 7.3e-06 | -6.8 | 6.4 | 1.2e-10 | -0.82 | 0.02 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HSP90AA1 | 0.03 | 0.00 | blup | 49 | 0.01 | 1.4e-02 | -6.6 | 5.9 | 3.1e-09 | -0.60 | 0.04 | 0.27 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAGE | 0.04 | 0.01 | blup | 60 | 0.03 | 2.5e-04 | -6.8 | 5.8 | 6.3e-09 | -0.75 | 0.03 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RAGE | 0.09 | 0.00 | blup | 58 | 0.03 | 3.0e-02 | -2.7 | 5.2 | 2.3e-07 | -0.76 | 0.02 | 0.65 | FALSE |