Best TWAS P=9.31e-16 · Best GWAS P=5.06e-12 conditioned to 0.0777
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAMTS17 | 0.14 | 0.00 | enet | 19 | 0.02 | 5.0e-03 | 6.1 | -5.6 | 2.1e-08 | -0.08 | 0.11 | 0.55 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | ADAMTS17 | 0.20 | 0.00 | enet | 20 | 0.05 | 2.2e-03 | -5.6 | -8.0 | 9.3e-16 | 0.00 | 0.10 | 0.25 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | CTD-3076O17.1 | 0.21 | 0.00 | lasso | 6 | 0.00 | 6.2e-01 | -6.4 | -7.9 | 2.6e-15 | -0.71 | 0.08 | 0.38 | TRUE |
| 4 | GTEx | Esophagus Mucosa | CTD-3076O17.1 | 0.28 | 0.10 | lasso | 6 | 0.11 | 4.7e-08 | -6.4 | -5.6 | 2.5e-08 | -0.59 | 0.11 | 0.89 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | CTD-3076O17.1 | 0.25 | 0.11 | enet | 24 | 0.17 | 3.8e-08 | -5.2 | -5.2 | 1.8e-07 | -0.44 | 0.13 | 0.83 | FALSE |
| 6 | GTEx | Lung | CTD-3076O17.1 | 0.15 | 0.09 | enet | 13 | 0.09 | 2.8e-07 | -6.4 | -6.3 | 3.4e-10 | -0.57 | 0.10 | 0.90 | FALSE |
| 7 | GTEx | Pancreas | CTD-3076O17.1 | 0.24 | 0.11 | enet | 6 | 0.11 | 2.7e-05 | -6.2 | -7.0 | 2.8e-12 | -0.58 | 0.11 | 0.80 | FALSE |
| 8 | GTEx | Testis | ADAMTS17 | 0.30 | 0.24 | lasso | 2 | 0.22 | 6.7e-10 | -6.2 | -6.2 | 5.2e-10 | -0.62 | 0.14 | 0.86 | FALSE |
| 9 | GTEx | Testis | CTD-3076O17.1 | 0.45 | 0.17 | enet | 19 | 0.14 | 1.0e-06 | -6.2 | -6.8 | 8.3e-12 | -0.66 | 0.13 | 0.86 | FALSE |