Best TWAS P=9.67e-17 · Best GWAS P=2.37e-17 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | 5.51 | 6.4 | 1.6e-10 | -0.57 | 0.21 | 0.30 | FALSE |
2 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | -8.42 | 8.1 | 7.6e-16 | -0.98 | 0.01 | 0.99 | FALSE |
3 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | -8.42 | 8.0 | 1.9e-15 | -0.97 | 0.01 | 0.99 | FALSE |
4 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | -8.44 | 8.3 | 9.7e-17 | -0.97 | 0.01 | 0.99 | TRUE |
5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SHISA4 | 0.03 | 0.01 | enet | 5 | 0.00 | 2.5e-01 | 6.86 | 5.8 | 7.9e-09 | -0.55 | 0.04 | 0.16 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LMOD1 | 0.02 | 0.01 | blup | 59 | 0.02 | 1.2e-04 | -8.47 | 6.8 | 7.8e-12 | -0.86 | 0.01 | 0.97 | FALSE |
7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | -8.42 | 7.7 | 1.1e-14 | -0.90 | 0.01 | 0.87 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | 6.86 | 7.6 | 2.2e-14 | -0.75 | 0.23 | 0.76 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | -8.30 | 7.3 | 3.1e-13 | -0.84 | 0.01 | 0.83 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LMOD1 | 0.08 | -0.01 | blup | 59 | 0.01 | 1.3e-01 | 0.27 | 6.0 | 1.7e-09 | -0.78 | 0.01 | 0.47 | FALSE |