Best TWAS P=2.42e-09 · Best GWAS P=3.61e-09 conditioned to 0.00579
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CD79B | 0.15 | 0.16 | enet | 9 | 0.17 | 3.5e-14 | 5.7 | -5.5 | 3.1e-08 | -0.98 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Visceral Omentum | CD79B | 0.15 | 0.00 | lasso | 6 | 0.02 | 4.1e-02 | 5.7 | -5.3 | 1.5e-07 | -0.89 | 0.02 | 0.88 | FALSE |
3 | GTEx | Esophagus Mucosa | PSMC5 | 0.11 | 0.09 | lasso | 4 | 0.14 | 1.1e-09 | -4.7 | 5.6 | 2.3e-08 | 0.58 | 0.22 | 0.78 | FALSE |
4 | GTEx | Esophagus Mucosa | STRADA | 0.05 | 0.07 | lasso | 2 | 0.05 | 1.9e-04 | 5.2 | 5.2 | 2.1e-07 | 0.74 | 0.05 | 0.85 | FALSE |
5 | GTEx | Esophagus Muscularis | PSMC5 | 0.12 | 0.08 | lasso | 3 | 0.07 | 3.8e-05 | 5.7 | 5.3 | 1.1e-07 | 0.74 | 0.02 | 0.96 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CD79B | 0.02 | 0.02 | lasso | 2 | 0.01 | 3.0e-03 | 5.9 | -5.6 | 1.7e-08 | -0.99 | 0.01 | 0.75 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TCAM1P | 0.04 | 0.07 | blup | 26 | 0.07 | 4.9e-15 | -4.7 | -5.5 | 4.9e-08 | -0.51 | 0.56 | 0.43 | FALSE |
8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CSH2 | 0.09 | 0.01 | blup | 37 | 0.08 | 5.7e-05 | -4.7 | -5.8 | 7.7e-09 | -0.66 | 0.15 | 0.73 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | TCAM1P | 0.05 | 0.03 | blup | 26 | 0.05 | 6.0e-04 | -4.8 | -6.0 | 2.4e-09 | -0.63 | 0.03 | 0.77 | TRUE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STRADA | 0.05 | 0.03 | lasso | 1 | 0.02 | 1.7e-03 | 5.2 | 5.2 | 1.5e-07 | 0.75 | 0.00 | 0.86 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STRADA | 0.07 | 0.01 | blup | 57 | 0.03 | 5.5e-04 | -3.5 | -5.3 | 9.5e-08 | -0.70 | 0.01 | 0.82 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | STRADA | 0.03 | 0.00 | blup | 57 | 0.01 | 5.2e-02 | 5.2 | -5.5 | 3.0e-08 | -0.73 | 0.00 | 0.74 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TCAM1P | 0.02 | 0.03 | blup | 26 | 0.02 | 9.4e-04 | -4.8 | -5.9 | 3.1e-09 | -0.62 | 0.03 | 0.59 | FALSE |
14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FTSJ3 | 0.30 | 0.12 | enet | 10 | 0.18 | 6.7e-08 | -4.7 | 5.4 | 5.9e-08 | 0.53 | 0.18 | 0.81 | FALSE |
15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TCAM1P | 0.13 | 0.14 | blup | 26 | 0.13 | 5.1e-06 | -4.8 | -5.2 | 2.1e-07 | -0.46 | 0.44 | 0.51 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMC5 | 0.04 | 0.03 | lasso | 1 | 0.03 | 5.6e-04 | 5.6 | 5.6 | 2.0e-08 | 0.76 | 0.01 | 0.95 | FALSE |
17 | The Cancer Genome Atlas | Thyroid Carcinoma | TCAM1P | 0.07 | 0.07 | blup | 26 | 0.08 | 2.8e-08 | -4.8 | -5.8 | 7.2e-09 | -0.61 | 0.07 | 0.93 | FALSE |