Best TWAS P=3.16e-14 · Best GWAS P=1.2e-27 conditioned to 5.29e-15
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | SAE1 | 0.21 | 0.09 | lasso | 3 | 0.07 | 2.0e-03 | 6.1 | 7.6 | 3.2e-14 | 0.77 | 0.06 | 0.67 | TRUE |
| 2 | GTEx | Small Intestine Terminal Ileum | PNMAL1 | 0.40 | 0.00 | enet | 11 | 0.15 | 2.7e-04 | -4.9 | -6.0 | 1.4e-09 | -0.01 | 0.01 | 0.56 | TRUE |
| 3 | METSIM | Adipose | PNMAL1 | 0.24 | 0.27 | bslmm | 380 | 0.28 | 2.9e-41 | -4.9 | -5.2 | 1.6e-07 | -0.01 | 0.00 | 0.99 | FALSE |
| 4 | METSIM | Adipose | SAE1 | 0.12 | 0.04 | lasso | 5 | 0.07 | 1.7e-10 | 5.4 | 7.4 | 1.4e-13 | 0.61 | 0.61 | 0.39 | FALSE |
| 5 | YFS | Blood | SAE1 | 0.07 | 0.02 | enet | 18 | 0.05 | 3.6e-16 | 7.7 | 6.9 | 3.9e-12 | 0.56 | 0.99 | 0.01 | FALSE |