Best TWAS P=8.62e-11 · Best GWAS P=6.92e-10 conditioned to 0.293
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PNKP | 0.15 | 0.16 | enet | 23 | 0.16 | 7.0e-19 | 5.5 | 5.2 | 1.9e-07 | 0.89 | 0.07 | 0.93 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | CTB-33G10.6 | 0.21 | 0.02 | enet | 7 | -0.01 | 4.5e-01 | 5.8 | 5.3 | 1.0e-07 | 0.90 | 0.03 | 0.48 | FALSE |
| 3 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | 4.6 | 6.1 | 1.1e-09 | 0.75 | 0.10 | 0.90 | FALSE |
| 4 | GTEx | Muscle Skeletal | AKT1S1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.9e-08 | 5.8 | -5.8 | 6.2e-09 | -0.98 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | 5.1 | 6.5 | 8.6e-11 | 0.82 | 0.07 | 0.91 | TRUE |
| 6 | GTEx | Spleen | PPFIA3 | 0.25 | 0.23 | lasso | 4 | 0.21 | 3.9e-06 | -4.5 | 5.4 | 5.9e-08 | 0.03 | 0.05 | 0.88 | FALSE |
| 7 | GTEx | Stomach | VRK3 | 0.10 | -0.01 | enet | 10 | -0.01 | 7.3e-01 | -4.7 | -6.2 | 4.2e-10 | -0.57 | 0.04 | 0.55 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNRNP70 | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.9e-02 | -5.3 | 5.7 | 9.9e-09 | 0.04 | 0.00 | 0.82 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUP62 | 0.05 | 0.05 | blup | 54 | 0.05 | 9.5e-06 | -4.2 | 5.3 | 9.5e-08 | 0.61 | 0.27 | 0.27 | FALSE |