Best TWAS P=1.19e-18 · Best GWAS P=4.46e-29 conditioned to 3.84e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HACE1 | 0.14 | 0.10 | enet | 28 | 0.11 | 8.9e-14 | 3.51 | -5.5 | 4.4e-08 | -0.44 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LIN28B | 0.04 | 0.04 | lasso | 9 | 0.03 | 3.9e-05 | 8.96 | 8.8 | 1.2e-18 | 0.74 | 0.22 | 0.78 | TRUE |
| 3 | GTEx | Lung | HACE1 | 0.09 | 0.00 | lasso | 4 | 0.00 | 6.2e-01 | 1.01 | -5.5 | 4.9e-08 | -0.58 | 0.05 | 0.32 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | BVES | 0.08 | 0.00 | enet | 26 | 0.05 | 7.3e-07 | 0.91 | 5.2 | 1.8e-07 | 0.26 | 0.15 | 0.12 | FALSE |