Best TWAS P=1.54e-09 · Best GWAS P=1.92e-10 conditioned to 0.0325
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | ASCC3 | 0.10 | 0.08 | lasso | 3 | 0.06 | 3.8e-05 | -4.9 | -5.1 | 3.1e-07 | 0.72 | 0.65 | 0.21 | FALSE |
| 2 | GTEx | Prostate | ASCC3 | 0.32 | 0.03 | lasso | 6 | 0.06 | 1.1e-02 | -2.3 | -5.8 | 8.3e-09 | 0.55 | 0.07 | 0.24 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | RP3-467N11.1 | 0.02 | 0.00 | blup | 287 | 0.01 | 2.3e-02 | 5.1 | -5.7 | 1.6e-08 | 0.81 | 0.07 | 0.44 | FALSE |
| 4 | The Cancer Genome Atlas | Esophageal Carcinoma | ASCC3 | 0.11 | 0.07 | blup | 131 | 0.07 | 2.4e-03 | 4.7 | 5.8 | 6.1e-09 | -0.87 | 0.09 | 0.66 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | ASCC3 | 0.06 | 0.05 | lasso | 1 | 0.04 | 2.0e-04 | -6.0 | 6.0 | 1.5e-09 | -0.90 | 0.08 | 0.89 | TRUE |