Best TWAS P=4.44e-09 · Best GWAS P=2.33e-09 conditioned to 0.651
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | GTEx | Thyroid | HEY2 | 0.22 | 0.24 | lasso | 6 | 0.23 | 1.0e-17 | 5.7 | 5.9 | 4.4e-09 | 0.17 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Skin Sun Exposed Lower leg | HINT3 | 0.08 | 0.01 | lasso | 4 | 0.03 | 2.0e-03 | 5.0 | 5.5 | 5.0e-08 | 0.05 | 0.18 | 0.28 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | CENPW | 0.04 | 0.06 | lasso | 10 | 0.06 | 2.4e-07 | -5.6 | 5.4 | 5.3e-08 | 0.06 | 0.03 | 0.97 | TRUE |
| 3 | GTEx | Colon Transverse | ECHDC1 | 0.18 | 0.11 | lasso | 3 | 0.15 | 2.0e-07 | 4.1 | 5.4 | 6.8e-08 | 0.90 | 0.01 | 0.98 | TRUE |
| 5 | GTEx | Testis | HEY2 | 0.31 | 0.17 | lasso | 5 | 0.19 | 7.4e-09 | 5.7 | 5.8 | 8.8e-09 | 0.17 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | HEY2 | 0.15 | 0.20 | lasso | 10 | 0.21 | 6.7e-25 | 5.5 | 5.6 | 2.7e-08 | 0.16 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPW | 0.04 | 0.06 | blup | 35 | 0.05 | 9.2e-07 | -5.3 | 5.4 | 5.5e-08 | 0.05 | 0.03 | 0.97 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | HEY2 | 0.10 | 0.12 | enet | 15 | 0.13 | 9.8e-17 | -5.5 | 5.3 | 9.6e-08 | 0.15 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | HEY2 | 0.03 | 0.04 | lasso | 3 | 0.02 | 3.8e-03 | -5.1 | 5.2 | 1.7e-07 | 0.16 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPW | 0.04 | 0.05 | lasso | 5 | 0.05 | 2.6e-06 | -5.5 | 5.1 | 2.8e-07 | 0.06 | 0.02 | 0.98 | FALSE |