Best TWAS P=3.93e-10 · Best GWAS P=1.14e-08 conditioned to 0.0198
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | NT5DC1 | 0.23 | 0.08 | lasso | 10 | 0.08 | 4.6e-05 | 5.1 | 5.5 | 3.0e-08 | 0.39 | 0.13 | 0.84 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | FRK | 0.12 | 0.07 | enet | 12 | 0.09 | 8.1e-04 | -4.6 | -5.6 | 2.3e-08 | -0.69 | 0.14 | 0.60 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | NT5DC1 | 0.07 | 0.03 | enet | 9 | 0.05 | 9.8e-05 | 5.3 | -6.0 | 2.1e-09 | -0.59 | 0.05 | 0.82 | FALSE |
| 4 | GTEx | Thyroid | TSPYL1 | 0.07 | 0.04 | lasso | 2 | 0.00 | 1.5e-01 | 5.2 | -5.1 | 3.0e-07 | -0.52 | 0.05 | 0.44 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | FRK | 0.10 | 0.10 | lasso | 7 | 0.09 | 4.2e-06 | 4.4 | -5.1 | 2.8e-07 | -0.62 | 0.07 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | FRK | 0.13 | 0.01 | blup | 94 | 0.05 | 1.5e-02 | -4.6 | -6.3 | 3.9e-10 | -0.62 | 0.02 | 0.38 | TRUE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FRK | 0.03 | 0.00 | blup | 94 | 0.03 | 4.6e-03 | 4.4 | -5.1 | 3.1e-07 | -0.50 | 0.05 | 0.40 | FALSE |