Best TWAS P=6.54e-10 · Best GWAS P=2.76e-09 conditioned to 0.277
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | TRIM13 | 0.12 | 0.10 | lasso | 4 | 0.08 | 3.3e-06 | -5.0 | -5.3 | 1.1e-07 | 0.88 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | DLEU1 | 0.11 | 0.12 | lasso | 4 | 0.10 | 7.1e-09 | -5.7 | 6.1 | 1.1e-09 | -0.96 | 0.00 | 1.00 | FALSE |
| 3 | YFS | Blood | DLEU1 | 0.13 | 0.12 | lasso | 10 | 0.16 | 7.4e-49 | -5.7 | 6.2 | 6.5e-10 | -0.88 | 0.00 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DLEU1 | 0.13 | 0.04 | lasso | 3 | 0.04 | 2.6e-03 | -5.6 | 5.8 | 6.0e-09 | -0.56 | 0.02 | 0.90 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KCNRG | 0.03 | 0.04 | blup | 26 | 0.05 | 3.5e-06 | -4.8 | -5.4 | 6.8e-08 | 0.90 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIM13 | 0.04 | 0.00 | blup | 26 | 0.02 | 8.5e-03 | -1.5 | 5.3 | 9.9e-08 | -0.48 | 0.01 | 0.07 | FALSE |