Hub : Genes

KCNRG

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0520 0.0220 1.4e-03 0.011 0.015 0.008 0.018 0.011 6.6e-03 2.2e-03 1.7e-02 0.00082 7.0e-03
2 TCGA Brain Lower Grade Glioma 0.0296 0.0152 9.1e-06 0.041 0.048 0.045 NA 0.043 1.8e-05 3.5e-06 7.2e-06 NA 1.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.4 0.7 -0.3 0.9
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 0.3 0.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.2 0.4 0.4
Depression (Nagel 2018) 0.5 0.8 0.9 -1.0 -0.7
Intelligence (Savage-Jansen 2018) 0.1 0.5 0.7 -0.8 0.5
Neuroticism (Nagel 2018) 0.1 0.1 0.2 0.2 0.5
Schizophrenia (2018) 0.1 0.2 0.3 0.5 -0.4
Schizophrenia vs Biploar Disorder 3.1 4.1 5.2 -1.7 -2.3
Worry (Nagel 2018) 1.0 2.2 3.8 0.8 1.9
Alzheimer’s Disease (in mother) 0.7 0.8 1.1 -1.1 -0.6
Alzheimer’s Disease (in father) 1.5 1.6 2.0 1.1 1.4
Alzheimer’s Disease (including proxy) 0.2 0.3 0.6 0.2 0.8
Crohns Disease (2017) 0.0 0.1 0.2 -0.4 0.2
Irritable Bowel Disease (IBD) 0.2 0.5 1.0 0.2 -1.0
Ulcerative Colitis (UC) 0.8 1.6 2.9 0.5 -1.7
Major Depression (MDD) 0.0 0.0 0.0 0.2 0.1
Reaction Time 0.7 1.3 2.6 -0.0 -1.6
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.1 -1.0 0.1
Breast Cancer 0.5 1.3 2.4 0.4 1.6
Ovarian Cancer 0.2 0.3 0.5 -0.2 -0.7
Prostate Cancer 0.2 0.3 0.6 0.1 0.8
Age at First Birth 0.1 0.1 0.2 -0.1 0.5
Bipolar Disorder (2011) 0.3 0.3 0.4 0.6 -0.4
Body Mass Index (BMI) (2010) 2.6 3.6 3.9 -2.0 -1.8
Coronary Artery Disease (CAD) 2.0 2.4 4.4 -2.1 -0.6
Crohns Disease (2012) 0.1 0.2 0.5 -0.0 -0.7
Mean Putamen Volume 0.4 0.4 0.5 -0.6 0.7
Fasting Glucose 0.8 0.9 1.7 0.3 1.3
HbA1C 0.1 0.1 0.2 0.4 -0.1
HDL Cholesterol 0.1 0.2 0.4 0.6 -0.3
LDL Cholesterol 0.3 0.5 0.9 0.2 0.9
Lupus 3.8 5.7 7.1 -2.1 -2.7
Neuroticism (2016) 2.1 3.0 3.3 -1.7 -1.8
Primary Biliary Cirrhosis 1.1 1.6 3.3 -0.1 -1.8
Rheumatoid Arthritis 0.6 0.8 1.1 1.1 0.7
Schizophrenia (2014) 0.6 1.4 2.2 -0.8 -1.5
Triglycerides 0.1 0.2 0.3 0.3 0.6
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.8 0.9 0.2
Ulcerative Colitis 0.9 1.4 2.3 0.7 -1.5
Blood Eosinophil Count 0.6 4.7 5.6 -2.4 -1.9
Blood Platelet Count 0.5 5.7 10.9 -0.7 -3.3
Blood Red Count 0.1 1.4 1.6 -1.1 -1.3
Blood White Count 0.1 0.5 0.6 -0.8 0.6
Heel T-Score 0.6 5.1 5.9 2.4 2.1
BMI 0.8 4.5 4.7 -2.2 -2.1
Height 0.2 3.4 3.5 -1.8 -1.9
Waist Hip Ratio (WHR) 0.1 0.3 0.6 0.1 -0.8
Systolic Blood Pressure 0.6 2.8 5.6 -0.2 2.4
Smoking Status 0.5 1.2 2.3 -0.3 1.5
Allergy or Eczema 1.1 2.8 4.2 -1.2 -2.1
Cardiovascular Disease 1.7 5.6 11.3 -0.0 3.4
Hypothyroidism (self reported) 1.3 3.1 4.6 1.3 -2.1
Respiratory disease 1.8 3.9 7.5 -0.6 -2.7
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 0.0 0.6
Lung FEV1/FVC ratio 0.6 3.2 5.8 0.8 2.4
Lung FVC 1.1 5.6 6.1 -2.5 -2.2
Neuroticism 0.0 0.1 0.2 0.3 0.4
Chronotype (morning person) 0.1 0.3 0.5 0.7 0.1
Hair Pigment 0.0 0.6 1.1 -0.4 -1.1
Tanning 0.1 0.8 1.0 0.7 1.0
Hand grip strength (left) 0.4 1.0 1.9 -0.1 1.4
Number of treatments/medications taken 0.1 0.1 0.2 -0.2 -0.5
Average weekly spirits intake 0.8 1.0 1.3 -1.2 0.7
Sensitivity / hurt feelings 0.3 0.5 0.6 -0.8 0.6
Frequency of depressed mood in last 2 weeks 0.8 1.1 1.2 -1.0 -1.1
Hearing difficulty/problems: Yes 0.2 0.2 0.4 -0.3 -0.7
Relative age of first facial hair 0.3 0.6 0.7 -0.8 -0.8
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.0 0.7 -1.0
Ever used hormone-replacement therapy (HRT) 0.7 0.8 1.0 1.0 0.8
Ever had hysterectomy (womb removed) 1.0 1.1 1.4 0.9 1.2
Systolic blood pressure, automated reading 0.6 1.8 3.1 -0.7 1.8
Eye problems/disorders: Diabetes related eye disease 1.6 1.8 2.3 -1.1 -1.5
Angina 1.7 2.2 2.7 1.6 1.3
Medication for hormone replacement therapy 0.1 0.1 0.1 -0.4 -0.0
Vitamin and mineral supplements 0.4 0.6 1.1 -0.3 1.0
Supplements: Zinc 1.5 1.7 2.5 -0.9 -1.6
Medication: Co-codamol 1.5 1.7 3.1 0.6 1.7
Medication: Metformin 0.7 1.0 1.7 -1.3 -0.6
Diabetes (father) 5.5 6.8 12.2 -1.1 -3.5
Diabetes (mother) 0.2 0.3 0.5 -0.7 -0.2
Severe depression (siblings) 0.4 0.4 0.5 0.6 0.7
Pack years adult smoking proportion 1.5 2.3 3.1 1.2 1.8
Impedance of leg (right) 2.8 13.6 21.4 -2.4 -4.6
Leg fat-free mass (left) 0.0 0.1 0.1 -0.3 -0.3
Trunk fat percentage 3.5 13.9 13.9 -3.7 -3.7
Hand grip strength (right) 0.3 0.8 1.5 0.3 1.2
Townsend deprivation index at recruitment 0.2 0.2 0.4 0.6 0.4
Current tobacco smoking 1.6 2.6 5.0 -0.3 2.2
Average weekly fortified wine intake 0.2 0.2 0.4 -0.6 -0.1
Maternal smoking around birth 0.2 0.2 0.5 0.7 -0.1
Fed-up feelings 0.2 0.4 0.6 0.8 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 0.2 -0.7
Relative age voice broke 0.2 0.3 0.5 0.3 0.7
Taking other prescription medications 1.0 1.6 2.5 -0.9 -1.6
Age when periods started (menarche) 1.1 2.7 3.6 1.3 1.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.4 -0.6 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 1.4 1.2 0.3
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 4.6 -2.1 -0.1
Qualifications: CSEs or equivalent 0.4 0.6 1.0 0.4 -1.0
Serious illness, injury or assault to yourself 0.6 0.8 1.5 -0.2 -1.2
High blood pressure 2.2 6.1 12.2 0.1 3.5
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.7 -0.4 -0.8
Multivitamins +/- minerals 0.5 0.6 1.2 1.1 0.2
Stomach or abdominal pain in last month 2.3 2.8 4.0 -2.0 -1.3
Supplements: Glucosamine 0.4 0.5 1.1 1.0 -0.1
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.7 0.8 -0.2
Medication: Atenolol 0.4 0.5 0.7 -0.5 0.8
Medication: Levothyroxine sodium 0.8 1.3 2.2 0.6 -1.5
Sitting height 0.2 1.1 2.0 0.5 1.4
Chronic bronchitis/emphysema (father) 1.4 1.6 2.2 1.0 -1.5
High blood pressure (mother) 0.0 0.0 0.0 0.0 0.1
Body mass index (BMI) 1.1 4.8 4.9 -2.1 -2.2
Impedance of leg (left) 1.8 8.9 12.8 -2.2 -3.6
Leg predicted mass (left) 0.0 0.1 0.1 -0.4 -0.3
Trunk fat mass 3.3 14.0 14.7 -3.6 -3.8
Waist circumference 1.6 6.0 6.9 -2.3 -2.6
Number of incorrect matches in round 3.6 6.1 8.8 -1.8 -3.0
Past tobacco smoking 0.1 0.2 0.5 0.7 0.0
Alcohol usually taken with meals 0.1 0.2 0.2 0.4 0.4
Nervous feelings 0.3 0.6 1.2 0.0 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 0.4 -0.7
Hearing difficulty/problems with background noise 1.1 1.8 1.8 -1.3 1.4
Hair/balding pattern: Pattern 2 0.2 0.2 0.5 -0.2 0.7
Had menopause 1.5 1.9 3.7 -0.0 1.9
Had other major operations 2.3 2.8 3.0 -1.7 -1.6
Forced vital capacity (FVC) 0.8 3.0 4.1 -1.4 -2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.4 1.2 0.3
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.0 0.2 1.4
Qualifications: None of the above 0.5 1.1 2.0 1.4 -0.4
Financial difficulties in last 2 years 1.9 2.6 2.9 -1.5 -1.7
Mouth/teeth dental problems 2.4 3.7 5.8 2.4 1.3
Heart attack 0.3 0.4 0.8 0.3 -0.9
Allergy 0.7 1.5 2.8 0.5 1.7
Pain all over the body in last month 0.3 0.4 0.6 -0.2 -0.8
Diabetes (self-reported) 0.0 0.1 0.1 0.2 0.3
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 1.9 0.2 -1.4
Medication: Ramipril 0.1 0.1 0.3 -0.5 0.1
Medication: Simvastatin 0.5 0.7 1.4 -0.0 1.2
Fluid intelligence score 1.1 2.4 4.6 -2.2 -0.3
Illnesses of siblings 2.4 3.4 6.7 2.6 0.4
Neuroticism score 0.5 1.1 1.7 0.8 1.3
Weight 1.4 7.0 7.9 -2.5 -2.8
Impedance of arm (right) 0.0 0.1 0.2 0.0 -0.5
Arm fat percentage (right) 2.2 8.5 9.8 -2.7 -3.1
Trunk fat-free mass 0.1 0.4 0.8 -0.3 -0.9
Hip circumference 1.4 6.0 6.3 -2.5 -2.4
Time employed in main current job 0.6 0.7 1.0 -1.0 -0.6
Alcohol intake versus 10 years previously 0.2 0.3 0.5 0.5 -0.7
Father’s age at death 2.3 3.1 3.4 -1.8 -1.7
Worrier / anxious feelings 0.7 1.4 1.8 1.0 1.3
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.1 -0.1 -0.3
Falls in the last year 0.5 0.6 1.2 0.0 -1.1
Hair/balding pattern: Pattern 3 0.8 1.3 1.6 1.2 -1.0
Number of live births 2.4 3.3 5.9 0.9 2.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.0 -0.9 -1.4
Pulse rate 0.8 1.3 2.6 -1.6 0.4
Happiness 0.3 0.3 0.5 0.7 -0.4
Noisy workplace 3.6 4.5 7.2 -1.3 -2.7
Qualifications: A levels/AS levels or equivalent 0.3 0.6 0.9 -1.0 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.1 1.1 -0.8
Mouth/teeth dental problems: Dentures 0.7 1.1 2.2 -1.5 -0.2
Asthma 0.6 1.2 2.4 -0.3 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.1 -1.0 -0.3
Medication: Cholesterol lowering 0.3 0.4 0.7 0.3 0.8
Depression (self-reported) 0.8 0.9 1.6 1.3 -0.4
Medication: Lansoprazole 1.8 2.0 3.3 -0.9 -1.8
Prospective memory result 0.3 0.4 0.6 -0.8 -0.3
Lung cancer (father) 1.1 1.3 2.5 -1.6 0.0
Illnesses of mother 1.8 2.2 2.9 1.7 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.0 5.4 -1.6 -2.3
Pulse wave Arterial Stiffness index 1.3 1.5 2.7 -1.7 0.6
Impedance of arm (left) 0.0 0.1 0.1 0.4 -0.2
Arm fat mass (right) 2.0 8.4 9.1 -2.8 -3.0
Trunk predicted mass 0.1 0.6 1.0 -0.4 -1.0
Standing height 0.1 1.5 2.1 -0.9 -1.5
Length of working week for main job 0.5 0.6 0.8 0.9 0.5
Exposure to tobacco smoke at home 0.9 1.1 1.3 -1.1 -0.9
Breastfed as a baby 0.0 0.0 0.0 0.0 -0.1
Tense / ‘highly strung’ 0.2 0.3 0.5 -0.3 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.7 -0.6 -0.8
Hair/balding pattern: Pattern 4 1.7 4.0 6.4 1.3 2.5
Birth weight of first child 0.2 0.5 0.8 -0.3 0.9
Peak expiratory flow (PEF) 0.6 1.4 2.5 1.6 0.5
Pulse wave reflection index 0.6 0.8 1.6 -0.1 1.3
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.3 1.1 0.4
Loud music exposure frequency 0.0 0.0 0.1 -0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.6 -0.5 1.2
Mouth/teeth dental problems: Bleeding gums 1.4 1.9 3.1 -0.7 -1.8
Blood clot in the leg (DVT) 0.3 0.4 0.7 -0.2 -0.8
Medication: Paracetamol 1.7 2.8 4.5 -1.1 -2.1
Headache pain in last month 0.0 0.1 0.1 0.2 -0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.6 0.4 -1.3
Glaucoma (self-reported) 0.5 0.6 1.3 -0.0 -1.1
Gout (self-reported) 0.1 0.1 0.2 -0.4 0.1
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 2.5 0.8 -1.6
Medication: Amlodipine 0.5 0.7 1.4 -1.2 -0.2
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.0 -1.0 -0.3
Birth weight 0.7 1.5 3.0 0.2 1.7
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.6 1.3 0.4
High blood pressure (siblings) 0.6 0.9 1.6 -1.2 0.5
Forced vital capacity (FVC), Best measure 1.5 5.6 7.7 -1.9 -2.8
Body fat percentage 4.4 17.5 18.9 -4.0 -4.3
Leg fat percentage (right) 6.3 22.7 29.1 -4.0 -5.4
Arm fat-free mass (right) 0.4 1.8 2.0 -1.3 -1.4
Exposure to tobacco smoke outside home 0.2 0.3 0.3 0.4 -0.6
Comparative body size at age 10 2.5 6.8 12.2 -3.5 -1.2
Number of full brothers 0.7 0.8 1.6 -0.3 1.3
Worry too long after embarrassment 1.7 2.9 4.3 1.2 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.4 5.2 -1.2 -2.3
Wheeze or whistling in the chest in last year 0.5 0.8 1.6 1.2 0.4
Number of children fathered 1.1 1.2 2.5 -1.6 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 4.1 -2.0 -0.2
Age at first live birth 0.1 0.1 0.2 0.1 0.5
Pulse wave peak to peak time 1.2 1.4 2.1 1.4 -0.8
Health satisfaction 0.0 0.0 0.1 -0.1 -0.2
Shortness of breath walking on level ground 0.3 0.4 0.7 -0.2 -0.8
Qualifications: College or University degree 0.0 0.0 0.1 0.1 -0.3
Eye problems/disorders: None of the above 1.2 1.4 1.8 1.0 1.3
Mouth/teeth dental problems: Loose teeth 1.3 1.5 1.8 1.4 1.1
Emphysema/chronic bronchitis 0.0 0.0 0.1 0.2 -0.1
Medication for pain relief, constipation, heartburn 0.1 0.2 0.5 0.7 -0.1
Neck or shoulder pain in last month 0.1 0.1 0.2 -0.4 -0.3
Medication: Blood pressure 0.6 1.0 2.0 -0.1 1.4
Angina (self-reported) 1.5 2.0 2.9 1.7 1.1
Migraine (self-reported) 0.0 0.0 0.0 0.2 0.0
Medication: Ibuprofen 0.4 0.5 0.9 -0.9 -0.3
Medication: Allopurinol 0.9 1.2 2.0 -1.4 -0.6
Medication: Omeprazole 0.3 0.3 0.6 0.2 0.8
Medication: Seretide 50 evohaler 0.4 0.4 0.7 -0.5 -0.8
Mean time to correctly identify matches 0.6 1.1 2.1 -0.0 -1.5
Heart disease (mother) 0.5 0.6 0.7 0.9 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.7 0.0 0.9
Whole body fat mass 3.6 15.2 16.0 -3.8 -4.0
Leg fat mass (right) 4.6 17.7 21.8 -3.7 -4.7
Arm predicted mass (right) 0.3 1.7 1.8 -1.3 -1.3
Pulse rate, automated reading 0.3 1.0 1.7 -0.4 1.3
Alcohol intake frequency. 0.9 2.1 2.9 1.7 1.1
Comparative height size at age 10 0.0 0.0 0.0 0.0 -0.1
Number of full sisters 1.9 2.3 2.4 1.5 1.5
Suffer from ‘nerves’ 0.5 0.8 1.2 0.6 1.1
Overall health rating 0.1 0.2 0.3 -0.6 -0.4
Chest pain or discomfort 0.1 0.1 0.2 0.2 -0.4
Had major operations 0.7 0.8 1.2 1.1 0.7
Age at last live birth 0.0 0.1 0.1 -0.3 0.0
Family relationship satisfaction 2.8 3.5 6.5 -0.6 -2.6
Leg pain on walking 0.8 1.0 1.5 -1.2 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.4 -0.7 -0.2
Commuting to job workplace: Car/motor vehicle 12.3 14.1 19.2 -3.0 -4.4
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 3.3 0.2 1.8
Medication: Aspirin 0.9 1.2 1.7 0.8 1.3
Supplements: Vitamin C 2.6 3.1 5.9 -0.5 -2.4
Knee pain experienced in last month 0.1 0.2 0.3 0.0 -0.6
Hypertension (Self-reported) 2.0 5.7 11.3 -0.2 3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.4 -0.6 -0.6
Illnesses of father: Heart disease 0.5 0.7 1.4 -1.2 -0.2
Illnesses of siblings: Diabetes 0.6 0.7 1.2 -1.1 -0.6
Smoking status: Previous 0.6 0.9 0.9 -0.9 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.5 1.6 0.3
Whole body fat-free mass 0.0 0.2 0.3 -0.4 -0.6
Leg fat-free mass (right) 0.0 0.2 0.4 0.2 0.7
Arm fat percentage (left) 2.0 8.0 8.8 -2.7 -3.0
Average weekly red wine intake 1.6 2.4 3.2 1.8 1.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 0.1 0.7
Mood swings 0.2 0.4 0.5 0.5 -0.7
Loneliness, isolation 0.3 0.4 0.8 -0.9 0.2
Long-standing illness, disability or infirmity 0.2 0.3 0.5 0.3 -0.7
Ever had bowel cancer screening 0.9 1.1 1.5 -0.8 -1.2
Diabetes diagnosed by doctor 0.0 0.0 0.1 0.3 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 0.9 0.6 1.0
Friendships satisfaction 1.8 2.2 3.8 -0.8 -1.9
Qualifications: nursing, teaching 0.0 0.1 0.1 -0.3 -0.1
Commuting to job workplace: Walk 4.4 4.7 6.5 1.7 2.6
Eye problems/disorders: Cataract 2.0 2.3 3.2 -1.8 -1.2
Mouth/teeth dental problems: Mouth ulcers 5.0 7.9 12.5 -3.5 -1.8
Medication for cholesterol 0.4 0.6 1.1 -0.2 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 4.1 4.8 5.0 2.2 2.2
Back pain experienced in last month 0.4 0.5 0.8 0.9 0.5
Mineral and other dietary supplements 0.2 0.2 0.4 -0.6 0.3
Breast cancer (self-reported) 0.9 1.1 1.8 -1.3 -0.7
Asthma (self-reported) 0.5 1.1 2.2 -0.1 -1.5
Osteoporosis (self-reported) 0.9 1.1 2.2 -1.5 -0.1
Osteoarthritis (self-reported) 0.8 1.0 1.2 -1.1 -0.9
Medication: Aspirin 0.5 0.7 1.1 0.5 1.1
Medication: Gliclazide 0.7 0.8 0.8 0.9 0.9
Illnesses of father: None of the above (group 1) 0.7 0.9 1.3 0.8 1.1
Smoking status: Current 1.7 2.6 5.2 0.3 2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.8 -0.1 -1.3
Whole body water mass 0.0 0.2 0.3 -0.3 -0.6
Leg predicted mass (right) 0.0 0.2 0.4 0.2 0.6
Arm fat mass (left) 2.1 8.8 9.4 -2.8 -3.1
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 0.4 -0.5
Average weekly champagne plus white wine intake 1.3 1.8 2.6 -1.6 -1.0
Miserableness 0.6 1.0 1.9 1.4 0.1
Guilty feelings 1.2 1.8 3.6 1.9 0.2
Wears glasses or contact lenses 0.9 1.1 2.0 1.4 -0.3
Ever taken oral contraceptive pill 1.4 1.6 1.8 1.3 1.2
Hearing aid user 1.9 2.2 3.8 -0.8 -1.9
Mother’s age at death 2.0 2.5 2.6 -1.5 -1.6
Financial situation satisfaction 0.3 0.4 0.5 -0.7 -0.6
Tinnitus: Yes, now most or all of the time 1.7 2.0 2.8 1.7 1.1
Commuting to job workplace: Public transport 2.3 2.8 4.3 1.1 2.1
Eye problems/disorders: Glaucoma 0.9 1.0 1.4 -0.8 -1.2
Medication: Blood pressure 0.9 1.6 3.3 0.1 1.8
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.3 -0.5 -0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.6 0.9 0.5 0.9
High cholesterol (Self-reported) 0.8 1.4 2.6 0.3 1.6
Medication: Bendroflumethiazide 0.2 0.4 0.5 -0.4 0.7
Medication: Paracetamol 0.4 0.7 1.1 -0.5 -1.1
Medication: Lisinopril 2.3 3.0 4.7 1.1 2.2
Medication: Atorvastatin 0.2 0.3 0.5 0.7 -0.1
Illnesses of father: High blood pressure 1.6 2.0 4.0 -2.0 -0.1
Alcohol drinker status: Never 0.9 1.0 2.0 -0.1 1.4
Ever smoked 0.3 0.6 0.6 -0.8 0.7
Basal metabolic rate 0.3 1.4 1.7 -1.1 -1.3
Leg fat percentage (left) 5.1 18.3 21.8 -3.8 -4.7
Arm fat-free mass (left) 0.7 3.4 3.6 -1.8 -1.9
Number of operations (self-reported) 0.0 0.0 0.1 -0.0 -0.3
Average weekly beer plus cider intake 0.6 0.9 1.0 0.9 1.0
Irritability 0.4 0.6 0.8 -0.6 -0.9
Risk taking 0.1 0.2 0.3 -0.2 0.6
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.0 0.2 -1.0
Fractured/broken bones in last 5 years 1.9 2.4 3.4 1.2 1.8
Age started oral contraceptive pill 0.2 0.2 0.4 -0.2 0.6
Diastolic blood pressure, automated reading 1.8 5.6 10.7 -0.6 3.3
Ever depressed for a whole week 0.6 0.8 0.8 0.8 0.9
Unable to work because of sickness or disability 0.4 0.5 1.1 0.1 -1.0
Commuting to job workplace: Cycle 0.6 0.7 1.4 0.0 1.2
Myopia 0.1 0.1 0.2 -0.4 0.4
Vascular/heart problems diagnosed by doctor 2.1 5.7 11.1 -0.5 -3.3
Cholesterol lowering medication 0.4 0.6 1.1 1.0 0.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 0.3 0.9
Pain experienced in last month 0.7 1.2 1.6 -0.9 1.3
Supplements: Calcium 0.3 0.3 0.6 -0.8 0.1
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 -0.2 -0.4
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.7 0.4 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 1.6 -0.3 -1.3
Heart disease (siblings) 0.6 0.7 1.3 -1.1 -0.3
Alcohol drinker status: Previous 0.3 0.3 0.6 -0.8 -0.1
Pack years of smoking 0.5 0.7 0.9 0.7 1.0
Impedance of whole body 0.5 2.6 3.7 -1.3 -1.9
Leg fat mass (left) 3.8 15.0 17.8 -3.5 -4.2
Arm predicted mass (left) 0.6 2.9 3.0 -1.7 -1.7