TWAS
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Usage
Models
Genes
Traits
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Traits
:
Leg fat percentage (right)
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chr16:3,301,360-5,627,737
Best TWAS P=1.5e-11 · Best GWAS P=9.77e-14 conditioned to 0.000247
3.5M
4M
4.5M
5M
5.5M
0
5
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
RP11-462G12.1
0.11
0.07
enet
18
0.06
1.1e-08
-7.0
-6.7
1.5e-11
0.86
0
1
TRUE
1
GTEx
Esophagus Muscularis
UBN1
0.18
0.19
lasso
4
0.19
9.1e-12
5.3
-5.2
1.9e-07
-0.04
0
1
TRUE
2
GTEx
Nerve Tibial
UBN1
0.14
0.12
lasso
4
0.11
5.6e-08
5.2
-5.2
2.4e-07
-0.04
0
1
FALSE