TWAS
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Usage
Models
Genes
Traits
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Traits
:
Leg fat percentage (right)
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chr16:86,671-1,032,776
Best TWAS P=8.73e-09 · Best GWAS P=3.09e-08 conditioned to 0.129
0.2M
0.4M
0.6M
0.8M
1M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
PDIA2
0.15
0.07
lasso
8
0.10
5.2e-13
-5.5
-5.8
8.7e-09
0.81
0.00
1.00
TRUE
1
GTEx
Nerve Tibial
PDIA2
0.12
0.01
enet
13
0.06
4.4e-05
-5.5
5.3
1.1e-07
-0.70
0.00
0.99
FALSE
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
AXIN1
0.03
0.01
blup
88
0.01
7.7e-03
-4.8
5.3
1.3e-07
-0.66
0.02
0.66
FALSE