Best TWAS P=3.48e-09 · Best GWAS P=1.76e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Male) | RP11-54A4.2 | 0.07 | 0.01 | enet | 2 | 0.03 | 7.4e-02 | 5.4 | 5.4 | 7.1e-08 | 0.07 | 0.03 | 0.23 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | SEMA6C | 0.03 | -0.01 | lasso | 1 | -0.01 | 8.7e-01 | 5.6 | 5.6 | 1.8e-08 | 1.00 | 0.02 | 0.27 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | GABPB2 | 0.12 | 0.02 | enet | 10 | 0.04 | 2.7e-03 | 5.4 | 5.5 | 3.6e-08 | 0.93 | 0.01 | 0.98 | FALSE |
| 4 | METSIM | Adipose | BNIPL | 0.05 | 0.01 | blup | 313 | 0.03 | 9.7e-05 | 3.7 | 5.7 | 1.2e-08 | 0.65 | 0.09 | 0.87 | FALSE |
| 5 | YFS | Blood | RPRD2 | 0.14 | 0.20 | lasso | 8 | 0.20 | 1.2e-63 | 5.3 | 5.2 | 2.2e-07 | 0.14 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEMA6C | 0.01 | 0.01 | enet | 6 | 0.01 | 1.5e-03 | 5.6 | 5.5 | 3.9e-08 | 0.95 | 0.00 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SEMA6C | 0.06 | 0.05 | blup | 33 | 0.07 | 3.7e-04 | 5.6 | 5.5 | 2.9e-08 | 0.91 | 0.01 | 0.94 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BNIPL | 0.03 | 0.02 | blup | 35 | 0.02 | 6.4e-03 | 4.0 | 5.2 | 2.4e-07 | 0.68 | 0.02 | 0.26 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPRD2 | 0.03 | 0.01 | blup | 19 | 0.02 | 2.6e-03 | -4.2 | 5.4 | 8.1e-08 | -0.04 | 0.01 | 0.65 | FALSE |
| 10 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RPRD2 | 0.14 | 0.13 | enet | 8 | 0.13 | 1.5e-04 | 5.2 | 5.9 | 3.5e-09 | 0.07 | 0.00 | 0.86 | TRUE |