Best TWAS P=1.72e-09 · Best GWAS P=1.9e-08 conditioned to 0.189
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RC3H1 | 0.12 | 0.06 | lasso | 2 | 0.06 | 3.2e-03 | 5.4 | -5.3 | 8.9e-08 | -0.98 | 0.04 | 0.78 | FALSE |
| 2 | GTEx | Artery Tibial | RC3H1 | 0.09 | 0.07 | lasso | 2 | 0.07 | 2.6e-06 | 5.4 | -5.5 | 4.9e-08 | -0.98 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | RC3H1 | 0.17 | 0.05 | enet | 30 | 0.05 | 2.2e-03 | 4.9 | -5.3 | 1.1e-07 | -0.77 | 0.05 | 0.92 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | RC3H1 | 0.07 | 0.11 | enet | 3 | 0.07 | 9.9e-03 | 5.6 | -5.6 | 2.7e-08 | -1.00 | 0.02 | 0.60 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | RABGAP1L | 0.19 | 0.00 | lasso | 3 | 0.01 | 2.0e-01 | 5.4 | 5.9 | 4.8e-09 | 0.92 | 0.06 | 0.41 | FALSE |
| 6 | GTEx | Nerve Tibial | RC3H1 | 0.09 | 0.06 | enet | 7 | 0.07 | 7.0e-06 | 4.9 | -5.4 | 8.1e-08 | -0.97 | 0.04 | 0.95 | FALSE |
| 7 | GTEx | Ovary | RC3H1 | 0.32 | 0.03 | lasso | 8 | 0.07 | 8.6e-03 | 5.5 | -5.6 | 2.1e-08 | -0.82 | 0.03 | 0.56 | FALSE |
| 8 | METSIM | Adipose | SERPINC1 | 0.10 | 0.09 | bslmm | 271 | 0.09 | 1.2e-13 | 5.2 | 5.8 | 6.6e-09 | 0.95 | 0.04 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SERPINC1 | 0.11 | 0.06 | blup | 47 | 0.05 | 3.7e-06 | 5.2 | 5.2 | 1.8e-07 | 0.88 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CACYBP | 0.11 | 0.05 | lasso | 2 | 0.04 | 9.6e-04 | 5.1 | 5.1 | 2.7e-07 | 0.95 | 0.00 | 0.93 | FALSE |
| 11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RC3H1 | 0.13 | -0.01 | blup | 58 | 0.01 | 1.4e-01 | 5.4 | 6.0 | 1.7e-09 | 0.80 | 0.01 | 0.24 | TRUE |