Best TWAS P=1.68e-08 · Best GWAS P=3.33e-08 conditioned to 0.191
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | FOXN2 | 0.24 | 0.11 | lasso | 6 | 0.16 | 2.8e-06 | -4.9 | 5.6 | 1.7e-08 | -0.86 | 0.02 | 0.97 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | FOXN2 | 0.18 | 0.15 | lasso | 4 | 0.14 | 7.3e-11 | 4.6 | 5.1 | 2.8e-07 | -0.45 | 0.24 | 0.75 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | FOXN2 | 0.14 | 0.06 | lasso | 3 | 0.08 | 2.2e-05 | 4.6 | 5.2 | 1.9e-07 | -0.39 | 0.24 | 0.68 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | FOXN2 | 0.26 | 0.21 | lasso | 6 | 0.21 | 2.4e-26 | 4.6 | 5.1 | 3.1e-07 | -0.44 | 0.25 | 0.74 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KLRAQ1 | 0.15 | 0.08 | lasso | 7 | 0.13 | 3.6e-14 | -5.4 | -5.2 | 2.1e-07 | 0.79 | 0.00 | 1.00 | FALSE |