Best TWAS P=6.7e-12 · Best GWAS P=1.3e-08 conditioned to 0.0268
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC26A1 | 0.12 | 0.06 | bslmm | 400 | 0.08 | 8.0e-10 | 4.8 | 5.7 | 9.6e-09 | 0.51 | 0.15 | 0.84 | TRUE |
2 | GTEx | Adipose Subcutaneous | RP11-440L14.1 | 0.58 | 0.38 | enet | 36 | 0.48 | 1.9e-43 | -3.2 | 5.2 | 2.6e-07 | 0.16 | 0.94 | 0.01 | FALSE |
3 | GTEx | Artery Tibial | GAK | 0.19 | 0.03 | enet | 29 | 0.10 | 2.4e-08 | -3.1 | 5.3 | 1.1e-07 | 0.59 | 0.01 | 0.99 | FALSE |
4 | GTEx | Brain Cerebellum | SLC26A1 | 0.61 | 0.41 | enet | 22 | 0.46 | 2.1e-15 | 4.8 | 5.6 | 2.3e-08 | 0.57 | 0.12 | 0.87 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | SLC26A1 | 0.36 | 0.22 | enet | 24 | 0.26 | 1.4e-19 | 4.9 | 5.2 | 1.7e-07 | 0.62 | 0.15 | 0.84 | FALSE |
6 | GTEx | Nerve Tibial | CPLX1 | 0.26 | 0.05 | lasso | 5 | 0.09 | 1.1e-06 | -4.9 | 5.1 | 3.1e-07 | 0.16 | 0.16 | 0.83 | FALSE |
7 | GTEx | Pituitary | SLC26A1 | 0.37 | 0.38 | enet | 14 | 0.33 | 3.9e-09 | 4.9 | 5.4 | 7.4e-08 | 0.65 | 0.10 | 0.88 | FALSE |
8 | GTEx | Stomach | SLC26A1 | 0.26 | 0.17 | enet | 14 | 0.16 | 4.0e-08 | 4.8 | 6.2 | 6.2e-10 | 0.63 | 0.09 | 0.90 | FALSE |
9 | NTR | Blood | PCGF3 | 0.07 | 0.00 | enet | 33 | 0.02 | 7.7e-08 | 4.7 | 5.5 | 4.2e-08 | 0.27 | 0.25 | 0.69 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCGF3 | 0.03 | 0.00 | blup | 69 | 0.01 | 3.7e-03 | 4.7 | 6.9 | 6.7e-12 | 0.34 | 0.01 | 0.56 | TRUE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCGF3 | 0.08 | 0.02 | lasso | 4 | 0.07 | 1.9e-08 | -4.0 | 5.3 | 1.1e-07 | 0.14 | 0.04 | 0.68 | FALSE |
12 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PCGF3 | 0.13 | 0.00 | blup | 69 | 0.04 | 1.4e-02 | -4.9 | 5.7 | 1.5e-08 | 0.10 | 0.01 | 0.59 | FALSE |