Best TWAS P=2.14e-09 · Best GWAS P=6.44e-08 conditioned to 0.435
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | GRK4 | 0.38 | 0.25 | lasso | 5 | 0.29 | 5.1e-11 | -4.7 | 5.7 | 1.3e-08 | -0.88 | 0.10 | 0.89 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | NOP14 | 0.12 | 0.06 | enet | 11 | 0.09 | 2.9e-07 | -4.1 | 6.0 | 2.1e-09 | -0.77 | 0.08 | 0.91 | TRUE |
| 3 | GTEx | Colon Transverse | GRK4 | 0.27 | 0.25 | enet | 18 | 0.25 | 2.4e-12 | -4.9 | 5.6 | 2.0e-08 | -0.95 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | GRK4 | 0.37 | 0.23 | lasso | 9 | 0.22 | 2.2e-08 | -5.0 | 5.1 | 2.7e-07 | -0.96 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Lung | ADD1 | 0.09 | 0.02 | enet | 6 | 0.01 | 3.5e-02 | 3.7 | 5.1 | 3.1e-07 | -0.71 | 0.25 | 0.51 | FALSE |
| 6 | GTEx | Pituitary | GRK4 | 0.17 | 0.00 | enet | 6 | -0.01 | 5.6e-01 | -5.4 | 5.3 | 1.5e-07 | -0.99 | 0.03 | 0.64 | FALSE |
| 7 | GTEx | Stomach | GRK4 | 0.22 | 0.19 | lasso | 7 | 0.19 | 2.6e-09 | -5.1 | 5.2 | 2.2e-07 | -0.96 | 0.04 | 0.96 | FALSE |
| 8 | GTEx | Whole Blood | HTT | 0.10 | 0.00 | enet | 15 | 0.03 | 1.4e-03 | 5.1 | 5.5 | 3.9e-08 | -0.40 | 0.07 | 0.56 | FALSE |
| 9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GRK4 | 0.09 | 0.12 | blup | 76 | 0.12 | 1.7e-06 | -4.6 | 5.2 | 2.4e-07 | -0.93 | 0.04 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RNF4 | 0.14 | 0.02 | blup | 47 | 0.07 | 3.1e-04 | 4.3 | 5.2 | 1.8e-07 | -0.22 | 0.00 | 0.12 | TRUE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf44 | 0.03 | 0.02 | blup | 42 | 0.02 | 8.0e-04 | -4.9 | 5.6 | 2.4e-08 | -0.32 | 0.01 | 0.95 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GRK4 | 0.09 | 0.18 | lasso | 5 | 0.20 | 1.5e-22 | -5.4 | 5.3 | 1.4e-07 | -0.95 | 0.01 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | C4orf44 | 0.03 | 0.04 | lasso | 4 | 0.05 | 2.9e-06 | -5.0 | 5.6 | 2.2e-08 | -0.36 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Rectum Adenocarcinoma | GRK4 | 0.27 | 0.10 | blup | 76 | 0.13 | 7.3e-04 | -4.7 | 5.4 | 8.6e-08 | -0.87 | 0.04 | 0.76 | FALSE |
| 15 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GRK4 | 0.08 | 0.07 | blup | 77 | 0.09 | 4.4e-06 | -4.5 | 5.2 | 1.8e-07 | -0.90 | 0.06 | 0.93 | FALSE |
| 16 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | GRK4 | 0.11 | 0.12 | lasso | 1 | 0.10 | 8.4e-04 | -5.2 | 5.2 | 2.4e-07 | -0.98 | 0.01 | 0.90 | FALSE |