[Hub]/) : Traits : Leg fat percentage (right) : ← →

chr7:74,016,979-75,842,792

Best TWAS P=2.54e-12 · Best GWAS P=1.76e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
69	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PMS2L3	0.23	0.14	lasso	2	0.14	1.3e-04	-6.7	-7.0	2.5e-12	0.98	0.00	0.92	TRUE
31	GTEx	Esophagus Mucosa	PMS2P3	0.14	0.15	lasso	2	0.14	9.7e-10	-6.7	-6.8	7.7e-12	1.00	0.00	1.00	FALSE
49	GTEx	Skin Sun Exposed Lower leg	STAG3L1	0.27	0.15	lasso	5	0.15	1.3e-12	-6.7	-6.8	1.2e-11	0.98	0.00	1.00	FALSE
58	GTEx	Whole Blood	STAG3L1	0.08	0.06	lasso	3	0.07	2.8e-07	-6.7	-6.8	1.3e-11	1.00	0.00	1.00	FALSE
38	GTEx	Lung	POM121C	0.13	0.10	lasso	3	0.10	7.8e-08	-6.7	-6.8	1.4e-11	0.98	0.00	1.00	FALSE
48	GTEx	Skin Sun Exposed Lower leg	PMS2P3	0.38	0.30	lasso	3	0.29	1.9e-24	-6.7	-6.8	1.4e-11	1.00	0.00	1.00	FALSE
13	GTEx	Artery Tibial	STAG3L1	0.25	0.19	lasso	4	0.19	8.3e-15	-6.7	-6.7	1.5e-11	1.00	0.00	1.00	FALSE
26	GTEx	Cells Transformed fibroblasts	POM121C	0.15	0.06	lasso	5	0.07	1.2e-05	-6.7	-6.7	1.6e-11	0.99	0.00	1.00	FALSE
41	GTEx	Muscle Skeletal	PMS2P3	0.07	0.07	lasso	2	0.06	3.8e-06	-6.7	-6.7	1.6e-11	1.00	0.00	1.00	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	GTF2IP1	0.09	0.06	lasso	3	0.05	1.7e-07	-6.7	-6.7	1.7e-11	1.00	0.00	1.00	FALSE
12	GTEx	Artery Tibial	POM121C	0.12	0.10	lasso	1	0.10	6.8e-08	-6.7	-6.7	1.8e-11	1.00	0.00	1.00	FALSE
21	GTEx	Breast Mammary Tissue	STAG3L1	0.16	0.15	lasso	2	0.14	8.7e-08	-6.7	-6.7	1.8e-11	0.98	0.00	1.00	FALSE
23	GTEx	Breast Mammary Tissue (Female)	STAG3L1	0.04	0.12	lasso	1	0.04	2.9e-02	-6.7	-6.7	1.8e-11	1.00	0.00	0.96	FALSE
29	GTEx	Colon Transverse	STAG3L1	0.22	0.18	lasso	1	0.16	4.0e-08	-6.7	-6.7	1.8e-11	1.00	0.00	1.00	FALSE
32	GTEx	Esophagus Mucosa	POM121C	0.13	0.10	lasso	1	0.07	1.0e-05	-6.7	-6.7	1.8e-11	1.00	0.00	1.00	FALSE
33	GTEx	Esophagus Mucosa	STAG3L1	0.19	0.19	lasso	1	0.18	2.4e-12	-6.7	-6.7	1.8e-11	1.00	0.00	1.00	FALSE
37	GTEx	Heart Left Ventricle	POM121C	0.13	0.12	lasso	1	0.09	2.2e-05	-6.7	-6.7	1.8e-11	1.00	0.00	1.00	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	STAG3L1	0.13	0.19	lasso	1	0.18	2.6e-10	-6.7	-6.7	1.8e-11	1.00	0.00	1.00	FALSE
59	METSIM	Adipose	POM121C	0.11	0.08	lasso	1	0.08	1.6e-11	-6.7	-6.7	1.8e-11	1.00	0.00	1.00	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	PMS2P3	0.05	0.04	lasso	1	0.03	4.6e-05	-6.7	-6.7	1.8e-11	1.00	0.00	1.00	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	STAG3L1	0.46	0.32	lasso	4	0.32	2.2e-42	-6.7	-6.7	1.9e-11	1.00	0.00	1.00	FALSE
27	GTEx	Cells Transformed fibroblasts	STAG3L1	0.22	0.17	lasso	4	0.18	2.6e-13	-6.7	-6.7	2.0e-11	0.96	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	POM121C	0.04	0.04	lasso	2	0.03	1.2e-07	-6.7	-6.7	2.0e-11	1.00	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	POM121C	0.08	0.07	lasso	3	0.07	3.6e-07	-6.7	-6.7	2.1e-11	0.99	0.00	1.00	FALSE
53	GTEx	Testis	TRIM73	0.20	0.21	lasso	2	0.19	6.2e-09	-6.7	-6.7	2.2e-11	1.00	0.00	1.00	FALSE
44	GTEx	Nerve Tibial	POM121C	0.22	0.14	lasso	5	0.14	6.9e-10	-6.7	-6.7	2.3e-11	0.97	0.00	1.00	FALSE
9	GTEx	Adipose Visceral Omentum	STAG3L1	0.20	0.19	lasso	3	0.17	2.3e-09	-6.7	-6.7	2.5e-11	1.00	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	POM121C	0.08	0.05	lasso	2	0.04	1.1e-05	-6.7	-6.6	2.9e-11	0.99	0.00	1.00	FALSE
14	GTEx	Brain Cerebellar Hemisphere	POM121C	0.33	0.32	lasso	3	0.30	1.4e-08	-6.7	-6.7	2.9e-11	1.00	0.00	1.00	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	POM121C	0.36	0.26	lasso	7	0.27	2.8e-34	-6.7	-6.6	3.5e-11	0.99	0.00	1.00	FALSE
10	GTEx	Artery Aorta	STAG3L1	0.18	0.03	lasso	4	0.08	3.9e-05	-6.7	-6.6	5.7e-11	1.00	0.00	1.00	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	PMS2P3	0.26	0.19	lasso	3	0.17	1.3e-09	-6.7	-6.5	5.9e-11	0.99	0.00	1.00	FALSE
55	GTEx	Thyroid	POM121C	0.14	0.08	lasso	3	0.07	3.4e-06	-6.7	-6.5	7.3e-11	0.96	0.00	1.00	FALSE
6	GTEx	Adipose Subcutaneous	STAG3L1	0.30	0.24	enet	24	0.27	2.4e-22	-6.7	-6.5	8.1e-11	0.92	0.00	1.00	FALSE
51	GTEx	Stomach	TRIM73	0.23	0.09	lasso	5	0.09	3.2e-05	-6.7	-6.4	1.1e-10	0.96	0.00	0.99	FALSE
28	GTEx	Colon Sigmoid	STAG3L1	0.30	0.18	lasso	4	0.18	8.5e-07	-6.7	-6.4	1.3e-10	0.97	0.00	1.00	FALSE
40	GTEx	Lung	STAG3L1	0.28	0.12	enet	35	0.16	3.3e-12	-6.7	-6.4	1.9e-10	0.79	0.00	1.00	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	PMS2P2	0.17	0.08	enet	8	0.08	6.0e-10	-6.7	-6.3	3.3e-10	0.90	0.00	1.00	FALSE
57	GTEx	Thyroid	STAG3L1	0.36	0.24	enet	17	0.27	8.0e-21	-6.7	-6.3	3.9e-10	0.92	0.00	1.00	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	STAG3L1	0.43	0.21	enet	21	0.23	3.8e-08	-6.7	-6.2	4.4e-10	0.86	0.00	1.00	FALSE
22	GTEx	Breast Mammary Tissue (Female)	POM121C	0.17	-0.01	lasso	3	0.02	6.3e-02	-6.7	-6.2	4.9e-10	0.90	0.01	0.62	FALSE
50	GTEx	Stomach	PMS2P3	0.16	0.07	lasso	5	0.09	3.7e-05	-5.9	-6.2	5.6e-10	0.91	0.00	0.99	FALSE
25	GTEx	Cells Transformed fibroblasts	PMS2P3	0.23	0.15	lasso	6	0.15	1.4e-11	-6.0	-6.2	6.0e-10	0.94	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	PMS2P3	0.15	0.12	lasso	3	0.10	9.8e-09	-6.0	-6.2	6.1e-10	0.96	0.00	1.00	FALSE
42	GTEx	Muscle Skeletal	TRIM73	0.08	0.05	enet	11	0.06	3.4e-06	-6.7	-6.1	8.1e-10	0.88	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	POM121C	0.20	0.11	enet	18	0.12	1.2e-09	-6.7	-6.1	9.8e-10	0.80	0.00	1.00	FALSE
56	GTEx	Thyroid	TRIM73	0.21	0.17	lasso	4	0.18	1.6e-13	-6.7	-6.1	1.0e-09	0.97	0.00	1.00	FALSE
11	GTEx	Artery Coronary	STAG3L1	0.28	0.13	lasso	4	0.17	1.8e-06	-5.9	-6.1	1.2e-09	0.86	0.01	0.99	FALSE
35	GTEx	Esophagus Muscularis	STAG3L1	0.30	0.15	lasso	4	0.16	4.3e-10	-6.7	-6.1	1.3e-09	0.94	0.00	1.00	FALSE
52	GTEx	Stomach	STAG3L1	0.35	0.20	lasso	5	0.18	4.2e-09	-5.9	-6.0	1.5e-09	0.86	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	STAG3L1	0.23	0.14	enet	13	0.17	1.0e-19	-6.7	-6.0	1.7e-09	0.91	0.00	1.00	FALSE
54	GTEx	Testis	STAG3L1	0.24	0.24	enet	14	0.27	1.4e-12	-6.7	-6.0	2.1e-09	0.88	0.00	1.00	FALSE
34	GTEx	Esophagus Muscularis	TRIM73	0.12	0.07	lasso	2	0.05	3.5e-04	-6.0	-6.0	2.3e-09	0.96	0.00	0.98	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	STAG3L1	0.36	0.16	lasso	5	0.16	1.7e-06	-6.7	-6.0	2.4e-09	0.93	0.00	1.00	FALSE
20	GTEx	Breast Mammary Tissue	PMS2P3	0.19	0.14	lasso	4	0.19	3.5e-10	-6.0	-6.0	2.5e-09	0.88	0.00	1.00	FALSE
60	METSIM	Adipose	TRIM73	0.11	0.11	lasso	5	0.12	8.6e-18	-6.0	-5.9	3.1e-09	0.95	0.01	0.99	FALSE
45	GTEx	Nerve Tibial	TRIM73	0.19	0.20	enet	6	0.20	6.3e-14	-6.7	-5.9	3.3e-09	0.96	0.00	1.00	FALSE
16	GTEx	Brain Cerebellum	POM121C	0.30	0.15	lasso	8	0.08	2.4e-03	-6.7	-5.8	7.1e-09	0.90	0.00	0.97	FALSE
36	GTEx	Heart Atrial Appendage	STAG3L1	0.14	0.04	enet	12	0.04	5.0e-03	-6.0	-5.8	7.7e-09	0.76	0.00	0.95	FALSE
39	GTEx	Lung	TRIM73	0.14	0.03	enet	8	0.06	2.9e-05	-6.0	-5.7	1.3e-08	0.79	0.00	0.99	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	TRIM73	0.34	0.16	enet	11	0.29	1.5e-08	4.4	-5.7	1.4e-08	0.82	0.00	1.00	FALSE
15	GTEx	Brain Cerebellar Hemisphere	TRIM73	0.35	0.28	enet	25	0.25	3.6e-07	-6.7	-5.5	3.0e-08	0.84	0.00	1.00	FALSE
7	GTEx	Adipose Visceral Omentum	POM121C	0.16	0.10	lasso	5	0.12	7.2e-07	4.4	-5.5	3.2e-08	0.80	0.02	0.98	FALSE
43	GTEx	Nerve Tibial	PMS2P3	0.29	0.13	enet	4	0.18	1.1e-12	-5.9	-5.5	3.9e-08	0.87	0.02	0.98	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	STAG3L1	0.29	0.09	enet	13	0.18	1.9e-05	-6.7	-5.4	6.2e-08	0.79	0.00	0.97	FALSE
8	GTEx	Adipose Visceral Omentum	TRIM73	0.17	0.19	lasso	3	0.22	1.4e-11	-6.0	-5.4	6.8e-08	0.92	0.00	1.00	FALSE
5	GTEx	Adipose Subcutaneous	TRIM73	0.20	0.12	enet	26	0.12	2.0e-10	-6.7	-5.4	6.9e-08	0.82	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POM121C	0.07	0.02	enet	3	0.04	5.8e-03	-6.7	-5.4	8.3e-08	0.85	0.00	0.67	FALSE
19	GTEx	Brain Putamen basal ganglia	PMS2P3	0.37	0.13	lasso	6	0.18	6.0e-05	-5.9	-5.2	2.2e-07	0.73	0.01	0.85	FALSE