TWAS hub - PMS2P2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.391	0.0915	1.4e-03	0.036	NA	0.058	NA	0.111	1.9e-02	NA	3.9e-03	NA	8.4e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.173	0.0475	4.1e-07	0.077	0.055	0.075	0.055	0.074	4.2e-10	1.2e-07	6.0e-10	1.4e-07	9.2e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI	10.5	61.0	121.0	-1.0	-11.0
Body mass index (BMI)	10.2	43.5	86.7	-0.6	-9.3
Qualifications: NVQ or HND or HNC or equivalent	7.5	9.0	11.0	2.7	-3.3
Waist circumference	7.4	26.9	53.9	-0.0	-7.3
Arm fat mass (right)	7.3	29.9	59.8	0.1	-7.7
Arm fat percentage (left)	7.1	28.4	56.7	0.3	-7.5
Arm fat mass (left)	7.0	28.6	57.3	-0.0	-7.6
Leg fat mass (right)	6.9	26.9	53.5	-0.6	-7.3
Leg fat mass (left)	6.9	26.8	53.0	-0.7	-7.3
Arm fat percentage (right)	6.7	26.5	52.9	0.4	-7.3
Age when periods started (menarche)	6.3	15.2	27.7	-1.6	5.3
Diabetes (mother)	5.9	7.5	8.8	3.0	-2.5
Relative age voice broke	5.9	9.0	9.8	-3.1	2.9
Impedance of leg (left)	5.6	27.3	54.4	-0.5	7.4
Hip circumference	5.6	24.2	48.2	-0.4	-6.9
Leg fat percentage (right)	5.6	20.3	39.5	-1.0	-6.3
Leg fat percentage (left)	5.6	20.4	39.4	-1.2	-6.3
Maternal smoking around birth	5.4	7.9	14.4	-1.1	-3.8
Birth weight of first child	5.4	9.8	19.5	-0.4	4.4
Body fat percentage	5.4	21.5	42.8	-0.3	-6.5
Whole body fat mass	5.4	22.4	44.8	-0.2	-6.7
Weight	5.2	25.8	51.1	-0.6	-7.2
Impedance of leg (right)	5.1	24.8	49.3	-0.6	7.0
Medication: Ramipril	5.1	6.5	11.6	-1.2	-3.4
Impedance of whole body	5.0	25.6	51.2	0.2	7.2
Trunk fat mass	4.6	19.9	39.8	-0.3	-6.3
High blood pressure	4.5	12.6	23.8	-1.2	-4.9
Diastolic blood pressure, automated reading	4.5	14.1	26.6	-1.2	-5.2
Systolic blood pressure, automated reading	4.4	12.9	25.7	0.1	-5.1
Trunk fat percentage	4.4	17.6	35.2	-0.2	-5.9
Average weekly red wine intake	4.4	6.5	8.1	-2.8	2.2
Hypertension (Self-reported)	4.1	11.5	22.0	-1.0	-4.7
Impedance of arm (right)	4.0	18.8	36.0	1.3	6.0
Chest pain or discomfort	4.0	5.8	8.2	-1.9	-2.9
Vascular/heart problems diagnosed by doctor	4.0	10.9	19.4	1.5	4.4
Cardiovascular Disease	3.9	12.9	23.7	-1.4	-4.9
Qualifications: A levels/AS levels or equivalent	3.9	8.6	17.0	0.5	4.1
High blood pressure (siblings)	3.9	5.7	10.8	-0.7	-3.3
Medication: Blood pressure	3.9	7.0	12.6	-1.1	-3.5
Ever had bowel cancer screening	3.9	4.6	7.8	-1.2	2.8
Impedance of arm (left)	3.8	17.6	33.8	1.1	5.8
Qualifications: O levels/GCSEs or equivalent	3.8	6.1	11.8	-0.6	3.4
Qualifications: College or University degree	3.8	12.0	22.4	-1.2	4.7
Mother’s age at death	3.8	4.7	8.9	-0.8	3.0
Wears glasses or contact lenses	3.6	4.1	6.7	-2.6	1.2
Qualifications: None of the above	3.4	7.3	14.1	0.6	-3.8
Vitamin and mineral supplements	3.3	4.4	7.9	1.0	-2.8
Townsend deprivation index at recruitment	3.3	4.7	9.3	-0.1	-3.1
Mineral and other dietary supplements	3.3	4.4	6.4	1.5	-2.5
Pack years adult smoking proportion	3.2	4.9	8.2	1.3	-2.9
Supplements: Glucosamine	3.2	4.2	6.9	-1.2	2.6
Leg predicted mass (left)	3.2	16.8	33.5	0.3	-5.8
Qualifications: nursing, teaching	3.2	5.0	9.1	0.9	3.0
Alcohol drinker status: Previous	3.2	3.6	3.9	1.8	-2.0
Leg fat-free mass (left)	3.1	16.4	32.8	0.2	-5.7
Systolic Blood Pressure	3.0	15.2	27.0	1.9	-5.2
Number of full brothers	3.0	3.8	6.4	1.1	-2.5
Overall health rating	2.9	6.3	12.5	-0.3	-3.5
Hair/balding pattern: Pattern 2	2.7	3.5	6.6	-0.6	-2.6
Illnesses of siblings	2.7	3.8	7.5	0.4	2.7
Leg fat-free mass (right)	2.7	14.4	28.7	0.4	-5.4
Leg predicted mass (right)	2.7	14.2	28.2	0.4	-5.3
Pulse rate, automated reading	2.6	8.5	15.4	1.3	-3.9
Medication: Paracetamol	2.6	3.9	5.3	1.6	2.3
Supplements: Calcium	2.6	2.9	4.8	1.0	2.2
Heart disease (siblings)	2.6	3.2	5.9	-0.7	-2.4
Age at First Birth	2.5	3.6	5.1	1.5	2.3
Diabetes (self-reported)	2.5	3.8	6.7	1.0	-2.6
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	3.9	1.6	-2.0
Wheeze or whistling in the chest in last year	2.5	4.5	8.9	0.3	-3.0
Medication: Co-codamol	2.4	2.8	5.4	0.4	-2.3
Qualifications: CSEs or equivalent	2.4	3.1	4.6	2.1	-1.3
Age at first live birth	2.4	4.3	8.2	0.7	2.9
Illnesses of siblings: Diabetes	2.4	3.0	3.4	1.8	-1.6
Commuting to job workplace: Public transport	2.4	2.9	5.2	-2.3	-0.7
Pack years of smoking	2.4	3.6	6.5	0.8	-2.6
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	3.8	-1.9	-1.1
Basal metabolic rate	2.3	12.9	25.7	-0.2	-5.1
Current tobacco smoking	2.2	3.7	7.3	-0.1	-2.7
Mouth/teeth dental problems: Dentures	2.2	3.7	3.8	1.9	-2.0
Birth weight	2.2	4.9	9.6	0.3	3.1
Medication: Allopurinol	2.2	2.9	5.7	-2.4	-0.3
Primary Biliary Cirrhosis	2.1	3.0	5.8	-0.6	2.4
Angina	2.1	2.7	5.4	-2.3	-0.0
Medication: Amlodipine	2.1	2.9	4.6	-1.1	-2.1
Forced vital capacity (FVC), Best measure	2.1	7.7	14.9	0.7	3.9
Angina (self-reported)	2.1	2.8	5.5	-2.3	0.3
Age at last live birth	2.1	3.0	5.8	0.5	2.4
Miserableness	2.1	3.7	4.1	1.8	-2.0
Medication: Blood pressure	2.1	4.0	6.7	-1.1	-2.6
Smoking Status	2.0	4.7	9.5	0.1	-3.1
Nervous feelings	2.0	3.7	4.2	2.0	1.8
Time employed in main current job	2.0	2.3	2.5	-1.5	1.6
Worrier / anxious feelings	2.0	3.8	5.4	2.3	1.5
Supplements: Fish oil (including cod liver oil)	2.0	2.6	2.7	-1.7	1.6
Relative age of first facial hair	1.9	4.0	7.9	-0.2	2.8
Financial difficulties in last 2 years	1.9	2.6	4.8	0.6	-2.2
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	3.0	1.7	1.4
Smoking status: Current	1.9	2.9	5.4	-0.7	-2.3
Medication: Lisinopril	1.9	2.4	3.6	-1.1	-1.9
Arm fat-free mass (left)	1.9	9.7	18.9	-0.6	-4.3
Unable to work because of sickness or disability	1.9	2.5	5.0	-0.2	-2.2
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	3.3	-1.8	-0.9
Multivitamins +/- minerals	1.8	2.3	3.3	-1.1	1.8
Father’s age at death	1.8	2.5	4.5	0.7	2.1
Tense / ‘highly strung’	1.8	3.0	3.0	1.7	1.7
Headache pain in last month	1.8	3.1	6.1	2.5	0.2
Arm predicted mass (right)	1.8	9.3	18.3	-0.5	-4.3
Breast cancer (self-reported)	1.8	2.1	3.8	-1.9	-0.6
Average weekly champagne plus white wine intake	1.8	2.4	4.9	-2.2	-0.1
Arm predicted mass (left)	1.8	9.4	18.5	-0.5	-4.3
Ulcerative Colitis (UC)	1.7	3.1	6.2	-0.0	2.5
Supplements: Zinc	1.7	1.9	2.2	-1.2	1.5
Had other major operations	1.7	2.1	3.0	-1.1	-1.7
Asthma	1.7	3.4	6.1	-0.9	-2.5
Depression (self-reported)	1.7	2.1	2.6	-1.3	-1.6
Medication: Ibuprofen	1.7	2.0	3.3	1.8	0.8
Ever smoked	1.7	2.9	5.9	-0.2	-2.4
Number of operations (self-reported)	1.7	2.5	4.5	0.7	-2.1
LDL Cholesterol	1.6	2.5	5.1	2.3	0.0
Blood clot in the leg (DVT)	1.6	2.1	4.2	0.1	-2.0
Arm fat-free mass (right)	1.6	8.4	16.6	-0.4	-4.1
Shortness of breath walking on level ground	1.6	1.9	2.6	1.1	-1.6
Asthma (self-reported)	1.6	3.2	6.1	-0.6	-2.5
Medication: Atorvastatin	1.6	1.9	3.0	1.7	-0.9
Respiratory disease	1.5	3.3	4.7	-1.4	-2.2
Medication: Metformin	1.5	2.2	4.3	-0.3	-2.1
Fed-up feelings	1.5	2.7	5.4	0.1	-2.3
Alcohol usually taken with meals	1.5	2.5	4.4	-0.7	2.1
Medication: Cholesterol lowering	1.5	2.3	2.5	1.4	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	9.3	0.6	3.0
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.9	-0.0	2.2
Medication: Aspirin	1.5	1.9	3.8	-0.1	-2.0
Whole body fat-free mass	1.5	8.7	17.5	-0.0	-4.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.3	-1.8	0.7
Back pain experienced in last month	1.5	2.2	4.2	2.0	-0.5
Whole body water mass	1.5	8.7	17.4	-0.1	-4.2
Type 2 Diabetes (T2D) (2018)	1.4	2.6	4.1	-1.0	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.9	0.5	-2.0
Gout (self-reported)	1.4	1.9	3.6	-1.9	0.3
Chronic bronchitis/emphysema (mother)	1.4	1.7	2.0	-1.2	-1.4
Medication: Seretide 50 evohaler	1.4	1.6	1.7	1.2	-1.3
Leg pain on walking	1.4	1.8	3.6	-1.9	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.6	0.8	-1.6
Ever taken oral contraceptive pill	1.4	1.6	3.2	-1.8	-0.0
Irritable Bowel Disease (IBD)	1.3	3.2	6.3	-0.2	2.5
Medication: Levothyroxine sodium	1.3	2.3	4.5	-2.1	0.2
Family relationship satisfaction	1.3	1.6	1.7	1.3	1.2
Long-standing illness, disability or infirmity	1.3	1.9	3.4	-0.7	-1.8
Commuting to job workplace: Walk	1.3	1.5	1.7	1.3	-1.1
Medication for cholesterol	1.3	2.0	3.6	0.6	1.9
Illnesses of father: High blood pressure	1.3	1.6	1.7	-1.3	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.4	0.2	-1.9
Allergy or Eczema	1.2	3.2	4.7	1.3	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.9	1.7	-0.0
Diabetes diagnosed by doctor	1.2	2.0	3.9	-0.1	-2.0
Worry (Nagel 2018)	1.1	2.3	2.9	1.7	1.3
Mouth/teeth dental problems	1.1	1.7	2.4	-1.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	1.9	1.4	1.0
Average weekly beer plus cider intake	1.1	1.6	2.3	1.5	-0.9
Depressed Affect (Nagel 2018)	1.0	2.2	4.0	0.5	-2.0
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.9	-0.1	2.4
Forced vital capacity (FVC)	1.0	3.7	7.0	0.7	2.6
Number of live births	1.0	1.4	1.9	-1.0	-1.4
Pulse wave Arterial Stiffness index	1.0	1.1	2.1	1.5	0.4
Loud music exposure frequency	1.0	1.1	1.9	0.6	1.4
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.8	-1.9	-0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.7	-1.6	-0.0
Alcohol intake frequency.	1.0	2.4	3.2	1.3	-1.8
Supplements: Vitamin C	1.0	1.2	2.1	-0.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	1.6	1.3	0.8
Loneliness, isolation	1.0	1.4	2.6	0.4	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.9	-0.6	1.7
Medication: Gliclazide	1.0	1.1	2.2	-0.3	-1.5
Age started oral contraceptive pill	1.0	1.3	2.6	-1.6	-0.2
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	-0.2	1.5
Taking other prescription medications	0.9	1.4	2.2	0.7	-1.5
Length of working week for main job	0.9	1.0	2.0	1.4	0.1
Eye problems/disorders: None of the above	0.9	1.0	1.8	1.4	0.4
Crohns Disease (2017)	0.8	1.7	3.3	-0.3	1.8
Ovarian Cancer	0.8	1.0	1.3	0.8	-1.1
Fasting Glucose	0.8	0.9	1.8	1.3	0.1
Lupus	0.8	1.3	2.5	1.6	0.0
Blood White Count	0.8	6.2	12.3	0.4	-3.5
Height	0.8	14.8	29.4	-0.5	5.4
Chronotype (morning person)	0.8	1.9	2.6	-1.0	-1.6
Average weekly spirits intake	0.8	1.0	1.9	0.2	1.4
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	-0.4	-1.3
High blood pressure (mother)	0.8	1.1	2.1	1.4	-0.4
Medication: Simvastatin	0.8	1.1	1.7	1.3	-0.7
Fluid intelligence score	0.8	1.6	3.0	-0.5	1.7
Medication: Lansoprazole	0.8	0.9	1.5	-1.2	-0.6
Standing height	0.8	8.1	16.2	-0.3	4.0
Medication: Paracetamol	0.8	1.3	1.5	1.0	1.2
Pulse wave peak to peak time	0.8	1.0	1.9	-1.4	-0.2
Medication: Aspirin	0.8	1.0	1.9	-0.3	-1.4
Hearing aid user	0.8	0.9	1.8	1.4	0.1
Fractured/broken bones in last 5 years	0.8	1.1	1.7	-1.3	0.7
Breast Cancer	0.7	1.7	3.2	-0.3	1.8
HbA1C	0.7	0.8	1.3	1.1	-0.5
Medication for hormone replacement therapy	0.7	0.8	1.6	0.1	-1.3
Diabetes (father)	0.7	0.9	1.4	1.2	0.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.3	1.1	-0.3
Serious illness, injury or assault to yourself	0.7	0.9	1.7	-1.3	-0.2
Past tobacco smoking	0.7	1.3	2.3	0.5	1.5
Trunk fat-free mass	0.7	4.2	8.3	-0.2	-2.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	-1.3	-0.0
Trunk predicted mass	0.7	4.0	7.9	-0.3	-2.8
Number of self-reported non-cancer illnesses	0.7	1.2	1.4	-1.0	-1.2
Ever depressed for a whole week	0.7	0.9	1.5	1.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.6	1.3	2.7	0.1	1.6
Blood Red Count	0.6	6.0	9.4	1.6	-3.1
Hand grip strength (left)	0.6	1.6	2.2	1.0	1.5
Number of treatments/medications taken	0.6	1.0	1.6	1.3	-0.6
Stomach or abdominal pain in last month	0.6	0.8	1.5	0.0	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.0	0.6	-1.0
Pulse rate	0.6	1.0	1.8	0.5	-1.3
Migraine (self-reported)	0.6	0.8	1.2	1.1	-0.6
Had major operations	0.6	0.7	1.0	0.6	1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	0.9	0.9	-0.7
Osteoporosis (self-reported)	0.6	0.8	0.9	0.9	-0.9
Myopia	0.6	0.9	1.8	-0.1	-1.3
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	1.2	0.0
HDL Cholesterol	0.5	0.8	1.6	-1.3	0.0
Triglycerides	0.5	0.8	1.6	1.3	0.0
Sensitivity / hurt feelings	0.5	0.9	1.8	1.3	-0.1
Average weekly fortified wine intake	0.5	0.6	1.2	-0.2	1.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.2	1.1	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.2	1.1	0.7
Neuroticism score	0.5	1.1	2.1	1.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	-0.2	-1.3
Glaucoma (self-reported)	0.5	0.6	0.8	-0.6	-0.9
Knee pain experienced in last month	0.5	0.8	1.3	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.1	-0.3	1.4
Eye problems/disorders: Cataract	0.5	0.6	0.7	-0.8	-0.7
Financial situation satisfaction	0.5	0.7	1.1	1.0	-0.5
High cholesterol (Self-reported)	0.5	0.8	1.5	0.4	-1.2
Depression (Nagel 2018)	0.4	0.5	0.9	0.9	-0.4
Hypothyroidism (self reported)	0.4	0.9	1.8	-1.3	-0.2
Lung FEV1/FVC ratio	0.4	2.0	3.9	-0.4	-2.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	1.1	-0.2
Severe depression (siblings)	0.4	0.4	0.9	-0.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.8	-1.4	-0.5
Medication: Atenolol	0.4	0.5	0.9	-0.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.9	-1.4	0.2
Heart attack	0.4	0.5	0.6	-0.8	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.9	0.4	1.7
Prospective memory result	0.4	0.4	0.4	0.7	-0.7
Peak expiratory flow (PEF)	0.4	0.9	1.8	-1.3	0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.6	0.6	-0.8
Exposure to tobacco smoke outside home	0.4	0.5	0.7	-0.5	-0.8
Number of children fathered	0.4	0.4	0.8	0.4	-0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	0.8	-0.6
Emphysema/chronic bronchitis	0.4	0.5	0.5	-0.7	-0.7
Mean time to correctly identify matches	0.4	0.7	1.3	-0.2	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	0.3	-1.0
Medication: Bendroflumethiazide	0.4	0.7	1.2	-0.4	-1.1
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.1	1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.0	-0.3	1.0
Reaction Time	0.3	0.6	1.2	-0.1	1.1
Waist Hip Ratio (WHR)	0.3	1.6	1.7	1.3	1.2
Hair Pigment	0.3	7.6	8.8	3.0	-2.5
Hearing difficulty/problems: Yes	0.3	0.5	0.9	1.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.9	-0.0
Ever had hysterectomy (womb removed)	0.3	0.4	0.4	0.6	-0.6
Hand grip strength (right)	0.3	0.7	1.1	0.6	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.9	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	0.8	-0.2
Hearing difficulty/problems with background noise	0.3	0.5	1.0	0.2	1.0
Allergy	0.3	0.8	1.1	-1.0	0.7
Worry too long after embarrassment	0.3	0.4	0.5	-0.7	-0.6
Illnesses of father: Heart disease	0.3	0.4	0.5	-0.7	0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	0.8	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.5	-0.5	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	0.4	-0.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.5	0.7	0.4
Schizophrenia (2018)	0.2	0.5	0.9	-1.0	0.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.0	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.6	0.0
Heel T-Score	0.2	1.6	2.2	-1.5	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.2	0.5	-0.4
Number of incorrect matches in round	0.2	0.4	0.7	-0.9	-0.3
Had menopause	0.2	0.2	0.4	0.1	-0.6
Alcohol intake versus 10 years previously	0.2	0.4	0.5	0.7	0.5
Happiness	0.2	0.2	0.5	0.7	-0.1
Illnesses of mother	0.2	0.3	0.5	-0.3	0.7
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.7	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	-0.9	-0.5
Pulse wave reflection index	0.2	0.2	0.4	0.6	0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.3	-0.5	0.6
Suffer from ‘nerves’	0.2	0.4	0.7	0.8	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	-0.4	0.9
Bipolar Disorder (2018)	0.1	0.2	0.4	0.6	0.0
Neuroticism (Nagel 2018)	0.1	0.3	0.4	0.7	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.1	-0.6
Prostate Cancer	0.1	0.2	0.3	-0.3	0.5
Blood Platelet Count	0.1	1.4	2.4	0.6	1.6
Lung FVC	0.1	0.4	0.7	0.8	0.3
Neuroticism	0.1	0.1	0.2	0.4	-0.2
Sitting height	0.1	0.5	0.9	-1.0	-0.0
Pain all over the body in last month	0.1	0.1	0.1	-0.0	-0.3
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.5	-0.2
Noisy workplace	0.1	0.2	0.2	-0.3	-0.5
Lung cancer (father)	0.1	0.1	0.2	-0.2	-0.5
Comparative body size at age 10	0.1	0.4	0.5	-0.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	-0.5
Health satisfaction	0.1	0.1	0.2	0.2	-0.4
Medication: Omeprazole	0.1	0.1	0.3	0.5	-0.2
Heart disease (mother)	0.1	0.1	0.3	0.1	-0.5
Comparative height size at age 10	0.1	0.5	0.8	-0.5	0.9
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.5	0.3
Mood swings	0.1	0.2	0.4	0.7	-0.2
Friendships satisfaction	0.1	0.2	0.2	0.5	0.2
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.4	-0.0
Guilty feelings	0.1	0.1	0.2	-0.1	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.1	0.6
Alcohol drinker status: Never	0.1	0.1	0.2	0.2	0.4
Irritability	0.1	0.1	0.2	-0.3	-0.4
Risk taking	0.1	0.2	0.3	-0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.1	0.3
Pain experienced in last month	0.1	0.1	0.2	-0.3	0.4
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	-0.2	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.1	0.3	0.0
Neuroticism (2016)	0.0	0.1	0.1	-0.3	0.0
Rheumatoid Arthritis	0.0	0.1	0.1	0.3	0.0
Schizophrenia (2014)	0.0	0.1	0.2	-0.4	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	-0.2	0.0
Blood Eosinophil Count	0.0	0.2	0.4	0.7	-0.1
Tanning	0.0	0.5	0.8	0.9	0.3
Falls in the last year	0.0	0.0	0.0	0.1	-0.1
Breastfed as a baby	0.0	0.0	0.0	-0.1	-0.1
Neck or shoulder pain in last month	0.0	0.0	0.1	0.0	0.3
Number of full sisters	0.0	0.0	0.1	-0.3	0.1
Smoking status: Previous	0.0	0.1	0.1	0.1	-0.3
Cholesterol lowering medication	0.0	0.1	0.1	0.4	-0.1

Hub : Genes

PMS2P2

Models

Trait associations