TWAS
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Models
Genes
Traits
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Traits
:
Leg fat percentage (right)
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chr7:43,821,453-45,498,400
Best TWAS P=9.64e-11 · Best GWAS P=1.58e-13 conditioned to 4.84e-05
43.8M
44M
44.2M
44.4M
44.6M
44.8M
45M
45.2M
45.4M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Cells Transformed fibroblasts
ZMIZ2
0.12
0.09
lasso
4
0.06
2.3e-05
-6.4
-6.5
9.6e-11
0.68
0.03
0.96
TRUE
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
PPIA
0.05
0.02
enet
5
0.03
7.7e-05
-7.4
-6.1
8.4e-10
0.82
0.00
0.94
FALSE
1
GTEx
Brain Hypothalamus
AC004453.8
0.54
0.13
lasso
7
0.16
1.8e-04
-1.9
-5.4
7.9e-08
0.55
0.04
0.36
FALSE