Best TWAS P=2.27e-08 · Best GWAS P=1.86e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | FAM160B2 | 0.18 | 0.09 | lasso | 5 | 0.10 | 4.0e-08 | -5.6 | 5.4 | 6.8e-08 | -0.98 | 0.00 | 1.00 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | AC091171.1 | 0.15 | 0.06 | lasso | 2 | 0.05 | 2.2e-04 | -5.6 | 5.6 | 2.3e-08 | -1.00 | 0.00 | 0.99 | TRUE |
3 | GTEx | Esophagus Mucosa | NUDT18 | 0.21 | 0.23 | enet | 8 | 0.23 | 3.9e-15 | -5.1 | -5.1 | 2.8e-07 | 0.94 | 0.03 | 0.97 | FALSE |
4 | GTEx | Esophagus Mucosa | AC091171.1 | 0.14 | 0.07 | lasso | 4 | 0.05 | 2.2e-04 | 5.0 | 5.2 | 2.2e-07 | -0.71 | 0.02 | 0.97 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | NUDT18 | 0.31 | 0.15 | enet | 13 | 0.22 | 4.6e-12 | -5.1 | -5.2 | 2.6e-07 | 0.90 | 0.03 | 0.96 | FALSE |
6 | GTEx | Testis | NUDT18 | 0.42 | 0.40 | lasso | 4 | 0.41 | 1.3e-19 | -5.1 | -5.2 | 2.6e-07 | 0.95 | 0.03 | 0.97 | FALSE |
7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NUDT18 | 0.09 | 0.03 | blup | 45 | 0.08 | 1.3e-04 | -5.2 | -5.5 | 3.0e-08 | 0.90 | 0.02 | 0.97 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | NUDT18 | 0.10 | 0.16 | lasso | 2 | 0.16 | 2.3e-09 | -5.2 | -5.2 | 2.2e-07 | 0.96 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAM160B2 | 0.04 | 0.01 | lasso | 4 | 0.01 | 2.6e-02 | -5.1 | 5.3 | 9.2e-08 | -0.95 | 0.01 | 0.89 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NUDT18 | 0.11 | 0.22 | lasso | 6 | 0.22 | 3.6e-24 | -5.6 | -5.5 | 2.9e-08 | 0.96 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NUDT18 | 0.06 | 0.08 | lasso | 3 | 0.07 | 1.6e-08 | -5.2 | -5.2 | 2.6e-07 | 0.96 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM160B2 | 0.05 | 0.01 | enet | 11 | 0.03 | 1.7e-04 | -5.5 | 5.2 | 1.8e-07 | -0.80 | 0.01 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUDT18 | 0.17 | 0.25 | blup | 45 | 0.27 | 6.2e-28 | -5.1 | -5.3 | 1.1e-07 | 0.96 | 0.01 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM160B2 | 0.08 | 0.06 | lasso | 4 | 0.05 | 1.4e-05 | -5.6 | 5.5 | 4.7e-08 | -0.93 | 0.00 | 1.00 | FALSE |
15 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NUDT18 | 0.15 | 0.17 | lasso | 4 | 0.12 | 2.3e-04 | -5.5 | -5.5 | 4.1e-08 | 0.94 | 0.01 | 0.98 | FALSE |