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chr10:133,309,117-135,192,153

Best TWAS P=1.82e-12 · Best GWAS P=1.63e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DPYSL4	0.13	0.11	enet	7	0.08	2.0e-04	6.9	7.0	1.8e-12	0.96	0.01	0.98	TRUE
11	The Cancer Genome Atlas	Glioblastoma Multiforme	STK32C	0.13	-0.01	blup	107	0.08	1.6e-03	3.3	-6.3	4.1e-10	-0.35	0.04	0.08	TRUE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	GPR123	0.05	0.00	blup	56	0.02	8.0e-04	3.2	5.4	8.0e-08	0.00	0.00	0.03	TRUE
14	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DPYSL4	0.17	0.24	lasso	3	0.23	2.4e-13	7.0	6.8	9.7e-12	0.98	0.00	1.00	FALSE
9	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DPYSL4	0.31	0.19	lasso	10	0.18	3.4e-09	6.9	6.5	7.2e-11	0.91	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	DPYSL4	0.13	0.12	lasso	7	0.16	3.1e-17	7.0	6.4	1.2e-10	0.93	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DPYSL4	0.17	0.12	blup	64	0.11	1.3e-04	-6.3	6.4	1.7e-10	0.85	0.01	0.97	FALSE
6	GTEx	Pituitary	DPYSL4	0.24	0.11	lasso	4	0.26	3.0e-07	3.9	6.3	2.3e-10	0.63	0.02	0.79	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	DPYSL4	0.17	0.16	enet	18	0.23	1.5e-26	7.1	6.3	4.0e-10	0.86	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPYSL4	0.34	0.37	enet	15	0.46	2.2e-53	-6.7	6.2	5.6e-10	0.92	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPYSL4	0.16	0.21	enet	16	0.24	7.1e-27	6.9	6.2	6.1e-10	0.91	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	DPYSL4	0.30	0.24	enet	15	0.38	1.7e-38	2.7	6.0	2.4e-09	0.77	0.01	0.99	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DPYSL4	0.16	0.24	blup	60	0.27	7.6e-31	-6.3	5.8	5.0e-09	0.91	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Skin Cutaneous Melanoma	DPYSL4	0.27	0.07	blup	64	0.07	7.1e-03	6.9	5.8	6.0e-09	0.88	0.01	0.75	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DPYSL4	0.24	0.21	lasso	7	0.28	2.5e-19	6.9	5.8	6.9e-09	0.84	0.00	1.00	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	DPYSL4	0.19	0.30	enet	19	0.37	3.1e-79	6.9	5.7	9.6e-09	0.89	0.00	1.00	FALSE
7	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DPYSL4	0.28	0.22	enet	19	0.25	3.0e-21	-6.2	5.7	1.0e-08	0.83	0.04	0.96	FALSE
4	GTEx	Cells Transformed fibroblasts	DPYSL4	0.53	0.39	enet	14	0.58	1.1e-52	7.0	5.7	1.1e-08	0.88	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DPYSL4	0.09	0.03	enet	16	0.05	9.9e-07	7.0	5.7	1.3e-08	0.80	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DPYSL4	0.11	0.07	blup	60	0.13	1.0e-14	6.9	5.5	4.2e-08	0.83	0.01	0.99	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	DPYSL4	0.51	0.20	enet	67	0.18	2.0e-06	6.9	5.4	5.1e-08	0.72	0.01	0.99	FALSE
2	GTEx	Adrenal Gland	DPYSL4	0.38	0.21	lasso	5	0.39	3.4e-15	2.6	5.4	5.3e-08	0.75	0.06	0.94	FALSE
10	The Cancer Genome Atlas	Esophageal Carcinoma	DPYSL4	0.21	0.07	blup	60	0.09	8.2e-04	-6.3	5.3	1.1e-07	0.78	0.01	0.94	FALSE
22	The Cancer Genome Atlas	Rectum Adenocarcinoma	DPYSL4	0.34	0.03	enet	16	0.21	1.2e-05	6.9	5.3	1.1e-07	0.69	0.01	0.79	FALSE
5	GTEx	Esophagus Mucosa	DPYSL4	0.42	0.21	enet	30	0.36	1.2e-24	7.0	5.3	1.5e-07	0.84	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Soft Tissue Sarcoma	DPYSL4	0.14	0.12	lasso	7	0.13	2.5e-08	3.4	5.3	1.5e-07	0.83	0.02	0.98	FALSE