[Hub]/) : Traits : Leg fat percentage (right) :

chr10:133,309,117-135,192,153

Best TWAS P=1.82e-12 · Best GWAS P=1.63e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DPYSL4 0.09 0.03 enet 16 0.05 9.9e-07 7.0 5.7 1.3e-08 0.80 0.01 0.99 FALSE
2 GTEx Adrenal Gland DPYSL4 0.38 0.21 lasso 5 0.39 3.4e-15 2.6 5.4 5.3e-08 0.75 0.06 0.94 FALSE
3 GTEx Cells EBV-transformed lymphocytes DPYSL4 0.51 0.20 enet 67 0.18 2.0e-06 6.9 5.4 5.1e-08 0.72 0.01 0.99 FALSE
4 GTEx Cells Transformed fibroblasts DPYSL4 0.53 0.39 enet 14 0.58 1.1e-52 7.0 5.7 1.1e-08 0.88 0.00 1.00 FALSE
5 GTEx Esophagus Mucosa DPYSL4 0.42 0.21 enet 30 0.36 1.2e-24 7.0 5.3 1.5e-07 0.84 0.00 1.00 FALSE
6 GTEx Pituitary DPYSL4 0.24 0.11 lasso 4 0.26 3.0e-07 3.9 6.3 2.3e-10 0.63 0.02 0.79 FALSE
7 The Cancer Genome Atlas Bladder Urothelial Carcinoma DPYSL4 0.28 0.22 enet 19 0.25 3.0e-21 -6.2 5.7 1.0e-08 0.83 0.04 0.96 FALSE
8 The Cancer Genome Atlas Breast Invasive Carcinoma DPYSL4 0.19 0.30 enet 19 0.37 3.1e-79 6.9 5.7 9.6e-09 0.89 0.00 1.00 FALSE
9 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma DPYSL4 0.31 0.19 lasso 10 0.18 3.4e-09 6.9 6.5 7.2e-11 0.91 0.00 1.00 FALSE
10 The Cancer Genome Atlas Esophageal Carcinoma DPYSL4 0.21 0.07 blup 60 0.09 8.2e-04 -6.3 5.3 1.1e-07 0.78 0.01 0.94 FALSE
11 The Cancer Genome Atlas Glioblastoma Multiforme STK32C 0.13 -0.01 blup 107 0.08 1.6e-03 3.3 -6.3 4.1e-10 -0.35 0.04 0.08 TRUE
12 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DPYSL4 0.16 0.24 blup 60 0.27 7.6e-31 -6.3 5.8 5.0e-09 0.91 0.01 0.99 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DPYSL4 0.16 0.21 enet 16 0.24 7.1e-27 6.9 6.2 6.1e-10 0.91 0.00 1.00 FALSE
14 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma DPYSL4 0.17 0.24 lasso 3 0.23 2.4e-13 7.0 6.8 9.7e-12 0.98 0.00 1.00 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma DPYSL4 0.13 0.12 lasso 7 0.16 3.1e-17 7.0 6.4 1.2e-10 0.93 0.00 1.00 FALSE
16 The Cancer Genome Atlas Liver Hepatocellular Carcinoma DPYSL4 0.13 0.11 enet 7 0.08 2.0e-04 6.9 7.0 1.8e-12 0.96 0.01 0.98 TRUE
17 The Cancer Genome Atlas Lung Adenocarcinoma DPYSL4 0.17 0.16 enet 18 0.23 1.5e-26 7.1 6.3 4.0e-10 0.86 0.00 1.00 FALSE
18 The Cancer Genome Atlas Lung Adenocarcinoma GPR123 0.05 0.00 blup 56 0.02 8.0e-04 3.2 5.4 8.0e-08 0.00 0.00 0.03 TRUE
19 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DPYSL4 0.11 0.07 blup 60 0.13 1.0e-14 6.9 5.5 4.2e-08 0.83 0.01 0.99 FALSE
20 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma DPYSL4 0.24 0.21 lasso 7 0.28 2.5e-19 6.9 5.8 6.9e-09 0.84 0.00 1.00 FALSE
21 The Cancer Genome Atlas Prostate Adenocarcinoma DPYSL4 0.34 0.37 enet 15 0.46 2.2e-53 -6.7 6.2 5.6e-10 0.92 0.01 0.99 FALSE
22 The Cancer Genome Atlas Rectum Adenocarcinoma DPYSL4 0.34 0.03 enet 16 0.21 1.2e-05 6.9 5.3 1.1e-07 0.69 0.01 0.79 FALSE
23 The Cancer Genome Atlas Soft Tissue Sarcoma DPYSL4 0.14 0.12 lasso 7 0.13 2.5e-08 3.4 5.3 1.5e-07 0.83 0.02 0.98 FALSE
24 The Cancer Genome Atlas Skin Cutaneous Melanoma DPYSL4 0.27 0.07 blup 64 0.07 7.1e-03 6.9 5.8 6.0e-09 0.88 0.01 0.75 FALSE
25 The Cancer Genome Atlas Testicular Germ Cell Tumors DPYSL4 0.17 0.12 blup 64 0.11 1.3e-04 -6.3 6.4 1.7e-10 0.85 0.01 0.97 FALSE
26 The Cancer Genome Atlas Thyroid Carcinoma DPYSL4 0.30 0.24 enet 15 0.38 1.7e-38 2.7 6.0 2.4e-09 0.77 0.01 0.99 FALSE