TWAS
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Models
Genes
Traits
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Traits
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Leg fat percentage (right)
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chr11:7,714,238-11,013,472
Best TWAS P=7.12e-11 · Best GWAS P=9.17e-12 conditioned to 0.00232
8M
8.5M
9M
9.5M
10M
10.5M
11M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Thyroid Carcinoma
STK33
0.14
0.08
lasso
6
0.10
1.0e-09
-6.2
6.5
7.1e-11
-0.69
0.05
0.95
TRUE
3
GTEx
Prostate
SBF2
0.21
0.05
lasso
7
0.03
6.7e-02
-4.9
-5.2
1.5e-07
0.02
0.04
0.75
TRUE
2
GTEx
Brain Caudate basal ganglia
RP11-152H18.3
0.23
0.01
enet
1
0.06
1.1e-02
-6.2
-6.2
6.7e-10
0.78
0.03
0.74
FALSE
1
CommonMind
Brain Pre-frontal Cortex
STK33
0.18
0.18
lasso
9
0.20
3.8e-24
-5.0
6.1
8.8e-10
-0.70
0.92
0.08
FALSE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
STK33
0.05
0.03
lasso
2
0.03
2.5e-04
-5.5
5.4
5.7e-08
-0.45
0.47
0.13
FALSE