Best TWAS P=7.12e-11 · Best GWAS P=9.17e-12 conditioned to 0.00232
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STK33 | 0.18 | 0.18 | lasso | 9 | 0.20 | 3.8e-24 | -5.0 | 6.1 | 8.8e-10 | -0.70 | 0.92 | 0.08 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-152H18.3 | 0.23 | 0.01 | enet | 1 | 0.06 | 1.1e-02 | -6.2 | -6.2 | 6.7e-10 | 0.78 | 0.03 | 0.74 | FALSE |
| 3 | GTEx | Prostate | SBF2 | 0.21 | 0.05 | lasso | 7 | 0.03 | 6.7e-02 | -4.9 | -5.2 | 1.5e-07 | 0.02 | 0.04 | 0.75 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STK33 | 0.05 | 0.03 | lasso | 2 | 0.03 | 2.5e-04 | -5.5 | 5.4 | 5.7e-08 | -0.45 | 0.47 | 0.13 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | STK33 | 0.14 | 0.08 | lasso | 6 | 0.10 | 1.0e-09 | -6.2 | 6.5 | 7.1e-11 | -0.69 | 0.05 | 0.95 | TRUE |