[Hub]/) : Traits : Leg fat percentage (right) :

chr11:26,818,083-29,054,545

Best TWAS P=1.37e-18 · Best GWAS P=5.13e-23 conditioned to 0.000117

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LIN7C 0.08 0.06 lasso 1 0.04 4.1e-04 8.80 8.8 1.4e-18 0.65 0.67 0.22 TRUE
2 GTEx Brain Putamen basal ganglia BDNF-AS 0.22 0.17 lasso 4 0.13 5.5e-04 -6.58 7.6 2.2e-14 0.33 0.23 0.07 TRUE
3 GTEx Cells Transformed fibroblasts LIN7C 0.26 0.22 lasso 6 0.25 1.4e-18 8.80 6.9 4.0e-12 0.64 0.98 0.02 FALSE
4 GTEx Esophagus Muscularis LIN7C 0.14 0.08 enet 11 0.07 5.4e-05 1.99 5.8 8.4e-09 0.62 0.66 0.20 FALSE
5 GTEx Liver METTL15 0.18 0.05 lasso 3 0.09 1.9e-03 0.85 -7.1 1.1e-12 -0.69 0.02 0.83 FALSE
6 GTEx Thyroid LIN7C 0.08 0.04 lasso 4 0.04 6.0e-04 8.80 8.2 3.2e-16 0.71 0.39 0.52 FALSE
7 NTR Blood LIN7C 0.01 0.00 lasso 3 0.01 2.2e-03 8.63 -8.3 7.0e-17 -0.74 0.10 0.80 FALSE
8 ROSMAP Brain Pre-frontal Cortex METTL15 0.04 0.03 blup 364 0.03 4.6e-05 -3.25 -5.3 8.9e-08 -0.19 0.72 0.01 TRUE
9 The Cancer Genome Atlas Bladder Urothelial Carcinoma LIN7C 0.04 0.01 lasso 3 0.02 1.0e-02 -1.48 5.2 1.9e-07 0.48 0.02 0.81 FALSE
10 The Cancer Genome Atlas Colon Adenocarcinoma LIN7C 0.10 0.03 blup 32 0.08 2.8e-05 9.06 6.8 9.3e-12 0.56 0.01 0.95 FALSE
11 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LIN7C 0.05 0.02 lasso 3 0.03 2.9e-04 9.11 7.9 2.5e-15 0.65 0.01 0.98 FALSE